Human Aging: From Cellular Mechanisms to Therapeutic Strategies offers an exhaustive picture of all the biological aspects of human aging by describing the key mechanisms associated with human aging and covering events that could disrupt the normal course of aging. Each chapter includes a summary of the salient points covered, along with futures prospects. The book provides readers with the information they need to gain or deepen the skills needed to evaluate the mechanisms of aging and age-related diseases and to monitor the effectiveness of therapies aimed at slowing aging.
The book encourages PhD and Postdoc students, researchers, health professionals and others interested in the biology of aging to explore the fascinating and challenging questions about why and how we age as well as what can and cannot be done about it.
- Concentrates on different processes, e.g., oxidative stress, cellular senescence and Inflammaging
- Offers the ability to access cross-sectional knowledge more easily
- Written by expert researchers in biogerontology who are actively involved in various fields within aging research
2. Demographic aspects of ageing
3. Pathobiology of ageing. An introduction to age-related diseases
4. Cellular senescence: Secretory phenotypes and senescence-associated microRNAs
6. Oxidative stress
7. Ageing of immune system
9. Homeostasis and hormesis
10. Frailty and sarcopenia
11. Hormones in ageing
12. Circadian rhythms and their impact on ageing
13. Nutraceutical approach to age-related disease. The clinical evidence for cognitive decline
14. Lifestyle, successful and unsuccessful ageing
15. Nutritional biomarkers in ageing research
16. Ethics of ageing
Calogero Caruso is Professor Emeritus in the Department of Biomedicine, Neurosciences and Advanced Diagnostics at University of Palermo. He has authored 371 papers, mostly on ageing and longevity. He was founder and editor in chief of Immunity & Ageing from 2004 to 2018. He was Coordinator of the PhD program in Molecular Medicine and Biotechnology (formerly Pathobiology) (1998-2018). Finally, with Prof. Giuseppina Candore he is responsible for the local unit of the project "Improved Vaccination Strategies for Older Adults (ISOLDA) just funded by European Commission. The national and international recognition of his scientific achievements in the field of Biogerontology is documented by funded projects, by the number of citations of his papers, by invitations to national and international congresses and meetings, by his activity as a project reviewer and by organization of international conferences.
Giuseppina Candore is an Associate Professor of General Pathology with the Laboratory of Immunopathology and Immunosenescence in the Department of Biomedicine, Neurosciences and Advanced Diagnostics at University of Palermo. She has authored 244 papers, mostly on ageing and longevity. She is Co-coordinator of Italian Ministerial Project on Centenarians and Longevity, and with Prof. Calogero Caruso she is responsible for the local unit of the project "Improved Vaccination Strategies for Older Adults (ISOLDA) just funded by European Commission. She is Director of School od Specialty in Clinical Biochemistry and Pathology. The national and international recognition of her scientific achievements in the field of Biogerontology is documented by the number of citations of her papers and by organization of national and international conferences.