Human Aging. From Cellular Mechanisms to Therapeutic Strategies

Table of Contents

1. Aging and longevity: An evolutionary approach
2. Demographic aspects of aging
3. Pathobiology of aging: An introduction to age-related diseases
4. Cellular senescence and senescence-associated secretory phenotype (SASP) in aging process
5. The role of inflammaging in the development of chronic diseases of older people
6. A new perspective on ROS in aging with an integrated view of the gut microbiota
7. Aging of immune system
8. Vaccination in old age: Challenges and promises
9. Resilience signaling and hormesis in brain health and disease
10. Different components of frailty in the aging subjects-The role of sarcopenia
11. Hormones in aging
12. Chronobiology and chrononutrition: Relevance for aging
13. Nutraceutical approach to age-related diseases-The clinical evidence on cognitive decline
14. Ways to become old: Role of lifestyle in modulation of the hallmarks of aging
15. Nutritional biomarkers in aging research
16. The role of cytomegalovirus in organismal and immune aging
17. Ethics of aging
18. Conclusions. Slowing aging and fighting age-related diseases, from bench to bedside?

Authors

Calogero Caruso Professor Emeritus, Department of Biomedicine, Neurosciences and Advanced Diagnostics, University of Palermo, Italy. Calogero Caruso is Professor Emeritus in the Department of Biomedicine, Neurosciences and Advanced Diagnostics at the University of Palermo. He has authored over 415 papers, mostly on ageing, age-related diseases, and longevity. He was founder and editor in chief of Immunity & Ageing from 2004 to 2018, Coordinator of the PhD program in Molecular Medicine and Biotechnology (formerly Pathobiology) from 1998-2018, and National Coordinator of Italian Ministerial Project on Centenarians and Longevity from 2016-2019. Finally, with Prof. Giuseppina Candore he is responsible for the local unit of the project "Improved Vaccination Strategies for Older Adults (ISOLDA)� funded by the European Commission. The national and international recognition of his scientific achievements in the field of Biogerontology is documented by funded projects, by the number of citations of his papers, by invitations to national and international congresses and meetings, by his activity as a project reviewer and by organization of international conferences. Giuseppina Candore Associate Professor of General Pathology, Laboratory of Immunopathology and Immunosenescence, Department of Biomedicine, Neurosciences and Advanced Diagnostics, University of Palermo, Italy. Giuseppina Candore is an Associate Professor of General Pathology with the Laboratory of Immunopathology and Immunosenescence in the Department of Biomedicine, Neurosciences and Advanced Diagnostics at University of Palermo. She has authored 244 papers, mostly on ageing and longevity. She is Co-coordinator of Italian Ministerial Project on Centenarians and Longevity, and with Prof. Calogero Caruso she is responsible for the local unit of the project "Improved Vaccination Strategies for Older Adults (ISOLDA)� just funded by European Commission. She is Director of School od Specialty in Clinical Biochemistry and Pathology. The national and international recognition of her scientific achievements in the field of Biogerontology is documented by the number of citations of her papers and by organization of national and international conferences.