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Chronic Periodontitis - Pipeline Insight, 2020

  • ID: 5215143
  • Drug Pipelines
  • December 2020
  • Region: Global
  • 60 pages
  • DelveInsight
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FEATURED COMPANIES

This “Chronic Periodontitis - Pipeline Insight, 2020,” report provides comprehensive insights about 10+ companies and 10+ pipeline drugs in Chronic Periodontitis pipeline landscape. It covers the pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.

Geography Covered
  • Global coverage
Chronic Periodontitis Understanding

Chronic Periodontitis: Overview

Chronic periodontitis (ChP), an inflammatory disease that is initiated by dysbiotic bacteria that activate the host's local immune response, thereby destroying connective tissue and bone, forming periodontal pockets, and eventually causing tooth loss. These events lead to chronic inflammation of periodontal soft and hard tissues sharing many features with other chronic inflammatory diseases. Chronic periodontitis is characterized by deregulated inflammatory interactions, involving both innate and adaptive responses that lead to a chronic inflammation in periodontal tissues. Chronic inflammation is driven by various mediators, of which an important part is attributed to the interactions within cytokine networks.

Symptoms

The symptoms of Chronic Periodontitis include:
  • Inflamed gums
  • Odorous breath
  • Unpleasant taste
  • Bleeding, receding or sensitive gums
  • Loose teeth
  • Appearance of lengthening of teeth because of gum recession
  • changes in the placement of teeth while biting
Diagnosis

Probing pocket depth overestimates the actual depth when periodontitis is present and underestimates it when the periodontal tissues are healthy. Radiographic measurements underestimate alveolar bone loss. The degree of underestimation depends on the extent of bone loss and its location in the dental arch.

Treatment

Dentifrices containing stannous fluoride, amine fluoride / stannous fluoride, chlorhexidine or triclosan / copolymer are more effective than conventional fluoridated dentifrices for reducing gingivitis. Mouth-rinsing with a chlorhexidine solution (0.12-0.2 percent) or essential oils as an adjunct to tooth brushing is more effective than tooth brushing alone for reducing gingivitis. Mechanical infection control (scaling and root planing) reduces probing pocket depth and improves probing attachment level. Mechanical infection control combined with flap surgery eliminates 10-15 percent more pockets deeper than 4 mm than mechanical infection control alone. Adjunctive therapy with guided tissue regeneration (GTR) or with enamel matrix derivative (EMD) in individual angular bone defects results in improved probing attachment level and bone level. Adjunctive therapy with coralline calcium carbonate in individual angular bone defects improves bone level more effectively than flap surgery alone.

Chronic Periodontitis Emerging Drugs Chapters

This segment of the Chronic Periodontitis report encloses its detailed analysis of various drugs in different stages of clinical development, including phase II, I, preclinical and Discovery. It also helps to understand clinical trial details, expressive pharmacological action, agreements and collaborations, and the latest news and press releases.

Chronic Periodontitis Emerging Drugs

ALH-L 1005: AngioLab

ALH-L 1005 is in Phase 2 of clinical trial. ALH-L 1005 is being developed by AngioLab for the treatment of Chronic Periodontitis.

Chronic Periodontitis: Therapeutic Assessment

This segment of the report provides insights about the different Chronic Periodontitis drugs segregated based on following parameters that define the scope of the report, such as:

Major Players in Chronic Periodontitis

There are approx. 10+ key companies which are developing the therapies for Chronic Periodontitis. The companies which have their Chronic Periodontitis drug candidates in the most advanced stage, i.e. phase III include, AngioLab.

Phases

This report covers around 10+ products under different phases of clinical development like
  • Late stage products (Phase III)
  • Mid-stage products (Phase II)
  • Early-stage product (Phase I) along with the details of
  • Pre-clinical and Discovery stage candidates
  • Discontinued & Inactive candidates
  • Route of Administration
Chronic Periodontitis pipeline report provides the therapeutic assessment of the pipeline drugs by the Route of Administration. Products have been categorized under various ROAs such as
  • Oral
  • Parenteral
  • intravitreal
  • Subretinal
  • Topical.
  • Molecule Type
Products have been categorized under various Molecule types such as
  • Monoclonal Antibody
  • Peptides
  • Polymer
  • Small molecule
  • Gene therapy
  • Product Type
The drugs have been categorized under various product types like Mono, Combination and Mono/Combination.

Chronic Periodontitis: Pipeline Development Activities

The report provides insights into different therapeutic candidates in phase II, I, preclinical and discovery stage. It also analyses Chronic Periodontitis therapeutic drugs key players involved in developing key drugs.

Pipeline Development Activities

The report covers the detailed information of collaborations, acquisition and merger, licensing along with a thorough therapeutic assessment of emerging Chronic Periodontitis drugs.

Report Highlights
  • The companies and academics are working to assess challenges and seek opportunities that could influence Chronic Periodontitis R&D. The therapies under development are focused on novel approaches to treat/improve Chronic Periodontitis.
Chronic Periodontitis Report Insights
  • Chronic Periodontitis Pipeline Analysis
  • Therapeutic Assessment
  • Unmet Needs
  • Impact of Drugs
Chronic Periodontitis Report Assessment
  • Pipeline Product Profiles
  • Therapeutic Assessment
  • Pipeline Assessment
  • Inactive drugs assessment
  • Unmet Needs
Key Questions Answered

Current Treatment Scenario and Emerging Therapies:
  • How many companies are developing Chronic Periodontitis drugs?
  • How many Chronic Periodontitis drugs are developed by each company?
  • How many emerging drugs are in mid-stage, and late-stage of development for the treatment of Chronic Periodontitis?
  • What are the key collaborations (Industry-Industry, Industry-Academia), Mergers and acquisitions, licensing activities related to the Chronic Periodontitis therapeutics?
  • What are the recent trends, drug types and novel technologies developed to overcome the limitation of existing therapies?
  • What are the clinical studies going on for Chronic Periodontitis and their status?
  • What are the key designations that have been granted to the emerging drugs?
Key Players
  • AngioLab
Key Products
  • ALH-L1005

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Note: Product cover images may vary from those shown
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FEATURED COMPANIES

Introduction

Executive Summary

Chronic Periodontitis: Overview
  • Causes
  • Mechanism of Action
  • Signs and Symptoms
  • Diagnosis
  • Disease Management
Pipeline Therapeutics
  • Comparative Analysis
Therapeutic Assessment
  • Assessment by Product Type
  • Assessment by Stage and Product Type
  • Assessment by Route of Administration
  • Assessment by Stage and Route of Administration
  • Assessment by Molecule Type
  • Assessment by Stage and Molecule Type
Chronic Periodontitis- Analytical Perspective

In-depth Commercial Assessment
  • Chronic Periodontitis companies’ collaborations, Licensing, Acquisition -Deal Value Trends
Chronic Periodontitis Collaboration Deals
  • Company-Company Collaborations (Licensing / Partnering) Analysis
  • Company-University Collaborations (Licensing / Partnering) Analysis
Late Stage Products (Phase III)
  • Comparative Analysis
Drug Name: Company Name
  • Product Description
  • Research and Development
  • Product Development Activities
Mid Stage Products (Phase II)
  • Comparative Analysis
ALH-L 1005: AngioLab
  • Product Description
  • Research and Development
  • Product Development Activities
Early Stage Products (Phase I)
  • Comparative Analysis
Drug Name: Company Name
  • Product Description
  • Research and Development
  • Product Development Activities
Pre-clinical and Discovery Stage Products
  • Comparative Analysis
Drug Name: Company Name
  • Product Description
  • Research and Development
  • Product Development Activities
Inactive Products
  • Comparative Analysis
Chronic Periodontitis Key Companies

Chronic Periodontitis Key Products

Chronic Periodontitis- Unmet Needs

Chronic Periodontitis- Market Drivers and Barriers

Chronic Periodontitis- Future Perspectives and Conclusion

Chronic Periodontitis Analyst Views

Chronic Periodontitis Key Companies

Appendix

List of Tables
Table 1 Total Products for Chronic Periodontitis
Table 2 Late Stage Products
Table 3 Mid Stage Products
Table 4 Early Stage Products
Table 5 Pre-clinical & Discovery Stage Products
Table 6 Assessment by Product Type
Table 7 Assessment by Stage and Product Type
Table 8 Assessment by Route of Administration
Table 9 Assessment by Stage and Route of Administration
Table 10 Assessment by Molecule Type
Table 11 Assessment by Stage and Molecule Type
Table 12 Inactive Products

List of Figures
Figure 1 Total Products for Chronic Periodontitis
Figure 2 Late Stage Products
Figure 3 Mid Stage Products
Figure 4 Early Stage Products
Figure 5 Preclinical and Discovery Stage Products
Figure 6 Assessment by Product Type
Figure 7 Assessment by Stage and Product Type
Figure 8 Assessment by Route of Administration
Figure 9 Assessment by Stage and Route of Administration
Figure 10 Assessment by Molecule Type
Figure 11 Assessment by Stage and Molecule Type
Figure 12 Inactive Products
Note: Product cover images may vary from those shown
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  • AngioLab
Note: Product cover images may vary from those shown
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