Through recent researches, there has been a significant number of findings involving the biology of macrophages. Beyond the 1st line of defense, macrophages have several specific characteristics across different tissues, organs, and systems. Macrophages comprehend a heterogeneous phagocytic population with wide range phenotypes, and tissue-specific functions, such as bone resorption, extracellular matrix production, red blood cells and bacteria removal, among others. Through innate immune receptors macrophages can modulate several pathways that culminate in the production of various types of inflammatory mediators such as chemokines, cytokines, oxygen reactive species, and lipid mediators which ultimately altered the behavior of other cells. Moreover, environment signals modify and induce metabolic reprograming that its alters phenotype and functions
Macrophages in the Human Body: A Tissue Level Approach presents a current overview of the diversity of macrophages across multiple human body systems, their phenotype, function and metabolic characteristics. It covers translational aspects where there is research support to indicate the therapeutic potential.
- Covers translational aspects where there is research support to indicate potential therapeutic potential
- Aims at presenting a current overview of the diversity of macrophages across multiple human body systems, their phenotype, function and metabolic characteristics
- Introduces Macrophages generally and dive into the organ/tissue/specific representations covering their phenotype, function, and metabolic characteristics
- Brings updated aspects of macrophages biology
1. Ontogeny of macrophages 2. Differentiation of macrophages 3. Metabolic requirement for macrophages 4. Sensor and effector mechanisms of macrophages 5. Spleen, lymph nodes and lymphoid tissues
Inflammatory system 6. Kidney
Inflammatory and remodeling system 7. Skin
Inflammatory and epithelial system 8. Bones and cartilage
Inflammatory and skeletal system 9. Brain
Inflammatory and nervous system 10. Intestines
Inflammatory and digestive system 11. Lungs
Inflammatory and respiratory system 12. Liver
Inflammatory and liver system 13. Heart and vessels
Inflammatory and cardiovascular system 14. Male and female reproductive organs
Inflammatory and reproductive system 15. Targeting macrophages in systemic diseases
Dr. Niels Olson Sairava Camara: Currently full professor of Department of Immunology at the Institute of Biomedical Sciences at the University of São Paulo (since 2011). Visiting Professor at the University of Tours, France in 2006. His laboratory has experience in nephrology area and in cellular and applied immunology, acting on the following topics: kidney transplantation, experimental models of acute and chronic kidney diseases, ischemia and reperfusion injury, regulatory cells and stem cells in kidney diseases. More recently, the laboratory has been studying the microbiota interface, cellular metabolism and inflammation in models of autoimmunity.
Dr. Tarcio Braga: Currently full professor of the Department of Pathology at the Federal University of Parana. Has experience with research on Inflammation, fibrosis, and inborn immunology. His laboratory has experience in the immunology of fibrotic and regenerative processes. Adjunct Professor at Federal University of Paraná (UFPR). Concluded the Biomedical course at the Federal University of Triângulo Mineiro. He holds a PhD in Sciences from the Department of Immunology of the University of São Paulo-SP, with a sandwich period at the University of Maryland and at the University of California, San Francisco.