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Selective Estrogen Receptor Degrader (SERDs) Market, Dosage, Price & Clinical Trials Insight 2025

  • ID: 5232603
  • Report
  • January 2021
  • Region: Global
  • 120 Pages
  • Kuick Research
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until Jan 31st 2021
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FEATURED COMPANIES

  • AsteraZeneca
  • Eli Lilly
  • G1 Therapeutics
  • Novartis
  • Olema Oncology
  • Radius Therapeutics
  • MORE

Selective Estrogen Receptor Degrader (SERDs) Market, Dosage, Price & Clinical Trials Insight 2025 Report Highlights:

  • Global SERD Market Opportunity: > US$ 2 Billion By 2025
  • USA To dominate Global SERD Market
  • SERD In Clinical Trials: > 15 Drugs
  • Detailed Clinical insight on All Drugs in clinical Trials
  • Clinical Pipeline Insight by Company, Country, Indication & Patient Segment
  • Branded & Generic Drug Dosage, Price & Sales Insight
  • 150 Page Report: Commercial & Clinical Opportunity Insight

The research report, “Selective Estrogen Receptor Degrader (SERDs) Market, Dosage, Price & Clinical Trials Insight 2025” provides detailed insight on clinical and non clinical parameters involved in the development and expansion of the global SERD market. In addition to it, the research report also describes the impact of novel drug launches on the other available therapies for breast cancer as well as growth rate of the specific drugs available under the therapy. Other than the market forecast, the research report also highlights the future trends and opportunities that will highly impact the use of expensive drugs for the treatment of breast cancer. Some of the areas that are highlighted in the research report involves the market fragmentation based on the real-world evidence of the therapy at clinical and pre-clinical level.

The global selective estrogen receptor degrader therapy market is witnessed to exceed by a double-digit CAGR rate over the next few years, which will positively impact the other commercially available therapies and cause a notable slowdown in their market growth rate. The major key drivers for the therapy market are estimated to be the US market as well as emerging markets upto some extent, which in the future years will also continue to be the major drivers for the market. The current research and development pipeline for the therapy market is growing at a splendid rate, and the success rate for the market are accelerating at historic level, thus resulting in more launches of potential candidates in the upcoming years. The future novel products approved under selective estrogen receptor degrader therapy market are believed to contribute a large net sales and revenue generation, as the market brand will grow at extensive rate.

The current market is observed to lift the share of the oncology sector to the global pharmaceutical market to new extent, which will continue to increase with time. In addition to it, the overall market at global level has also observed a large influx in the number of market players and government initiatives so that large number of patients could receive benefits from such selective cancer therapy. The highly advanced satisfactory applications and benefits received from the therapy is believed to expand the market to become one standard care for patients suffering from breast cancer.

As per the research conducted for Global selective estrogen receptor degrader therapy market, it is estimated that the therapy when compared with other commercially available therapies can provide maximum potential returns to the breast cancer patients in terms of healthcare benefits as well as to the investors and bio-pharmaceutical companies in terms of total sales and revenue generation. The market due to strong and robust clinical pipeline is also brewing up to become more independently and economically strong. It is observed for the market, that the long-term healthcare benefits available will push the researchers towards conducting more complex clinical research studies in order to generate more applications for the breast cancer patients.

Note: Product cover images may vary from those shown
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FEATURED COMPANIES

  • AsteraZeneca
  • Eli Lilly
  • G1 Therapeutics
  • Novartis
  • Olema Oncology
  • Radius Therapeutics
  • MORE

1. Introduction to Selective Estrogen Receptor Degraders (SERDs)
1.1 Overview
1.2 Evolution of SERDs

2. Selective Estrogen Receptor  Degraders - Mechanism of Action

3. Selective Estrogen Receptor Inhibitors as Combinational Therapy
3.1 SERD with CDK 4/6 Inhibitors
3.2 SERD with PI3K Inhibitors
3.3 SERD with Aromatase Inhibitors
3.4 SERDs with mTOR Inhibitors

4. Role of SERDs in Cancer Treatment

5. Selective Estrogen Receptor Degraders in Breast Cancer
5.1 Impact of SERDs in Breast Cancer Treatment
5.2 Ongoing Research & Development
5.2.1 AZD 9833
5.2.2 Rintodestrant (G1T48)
5.2.3 ZN-c5
5.2.4 Elacestrant (RAD1901)
5.2.5 LSZ 102
5.2.6 OP-1250
5.2.7 LY3484356
5.2.8 GDC-9545 (RG6171)
5.2.9 SHR9549
5.2.10 AZD9496

6. Selective Estrogen Receptor Degrader Market Analysis
6.1 Current Market Scenario
6.2 Impact of COVID-19 on Selective Estrogen Receptor Degrader Market
6.3 Market Opportunity

7. Selective Estrogen Receptor Degrader - Market Trends
7.1 Zentalis Pharma Collaborated with Eli Lily to Evaluate the Combination of SERD with CDK4/6 Inhibitors
7.2 Olema Oncology & Novartis Announces Clinical Collaboration to Evaluate SERD
as Combinational Therapy
7.3 New SERD Combinational Therapy Shows Promising Results against HR+/HER2 Negative Breast Cancer
7.4 Radius & Menarini Collaborates for Development & Commercialization of Elacestrant
7.5 SERD Combination Can Target the Neurofibromatosis Gene for Treating Breast Cancer

8. Selective Estrogen Receptor Degrader (SERD) Inhibitors Clinical Trials Overview
8.1 By Company
8.2 By Indication
8.3 By Patient Segment
8.4 By Phase

9. Selective Estrogen Receptor Degrader (SERD) Clinical Trials Insight
9.1 Preclinical
9.2 Phase-I
9.3 Phase-I/II
9.4 Phase-II
9.5 Phase-III

10. Marketed Selective Estrogen Receptor Degrader (SERD) Insight: Fulvestrant

11. Faslodex (Fulvastrant)- Commercially Available Selective Estrogen Receptor Inhibitor Drug
11.1 Approval & Patent Dispute
11.2 Pricing & Dosage Analysis
11.3 Sales Analysis
11.4 Faslodex - Reimbursement Scenario

12. Generic Fulvestrant - Availability & Price Analysis
12.1 Fulviglen
12.2 Fulvenat
12.3 Fulvetraz
12.4 Fuvesterol
12.5 Strantas
12.6 Celvestrant
12.7 Faslomax
12.8 Fasnorm

13. Competitive Landscape
13.1 AsteraZeneca
13.2 Eli Lilly
13.3 G1 Therapeutics
13.4 Novartis
13.5 Olema Oncology
13.6 Radius Therapeutics
13.7 Roche
13.8 Sage Therapeutics
13.9 Zeno Pharma
13.10 Zentalis

List of Figures

Figure 1-1: Evolution of SERDs Drugs
Figure 2-1: Role of Estrogen Receptor in Tumor Development
Figure 2-2: Mechanism of Selective Estrogen Receptor Degraders
Figure 2-3: Mechanism of SERDs in Combination with other Cancer Therapeutics
Figure 3-1: CDK 4/6 Inhibitors Used in Combination with SERDs
Figure 3-2: PI3K Inhibitors Used in Combination with SERDs
Figure 3-3: Aromatase Inhibitors Used in Combination with SERDs
Figure 4-1: Global – Breast Cancer Cases by Nature of Estrogen Receptor (%), 2020
Figure 4-2: Role of SERDs in Cancer Management
Figure 5-1: Global – Newly Diagnosed Cases & Deaths related to Breast Cancer (Million), 2020
Figure 5-2: Global – Breast Cancer Cases by Type (Million), 2020
Figure 5-3: Investigational SERDs Candidates & Their Manufacturers
Figure 5-4: SERENA-2 Trial – Study Initiation & Expected Completion Year For Primary Breast Cancer
Figure 5-5: SERENA-2 Trial – Study Initiation & Expected Completion Year for Advanced Breast Cancer
Figure 5-6: SERENA-1 Trial – Study Initiation & Expected Completion Year
Figure 5-7: AZD9833 Japan Trial – Study Initiation & Expected Completion Year
Figure 5-8: Rintodestrant Phase I Trial – Study Initiation & Expected Completion Year
Figure 5-9: ZN-c5 Monotherapy Trial – Study Initiation & Expected Completion Year
Figure 5-10: ZN-c5/Abemaciclib Combination Trial– Study Initiation & Expected Completion Year
Figure 5-11: ZN-c5/ Palbociclib Trial– Study Initiation & Expected Completion Year
Figure 5-12: Elacestrant Phase 3 Trial– Study Initiation & Expected Completion Year
Figure 5-13: Elacestrant – Study Initiation & Completion Year
Figure 5-14: LSZ102 Phase I/II Trial– Study Initiation & Completion Year
Figure 5-15: OP-1250 Phase I/II Trial – Study Initiation & Completion Year
Figure 5-16: EMBER-2 Trial – Study Initiation & Expected Completion Year
Figure 5-17: LY3484356 Phase I Trial – Study Initiation & Expected Completion Year
Figure 5-18: GDC-9545 Phase I Trial– Study Initiation & Expected Completion Year
Figure 5-19: GDC-9545/Fulvestrant Combinational Trial – Study Initiation & Expected Completion Year
Figure 5-20: SHR 9549 Phase I Trial – Study Initiation & Completion Year
Figure 6-1: Global – SERD Market Size (US$ Million), 2016 - 2020
Figure 6-2: Global – SERD Market Size by Type of Product (US$ Million), 2019
Figure 6-3: Global – SERD Market Size by Type of Product (%), 2019
Figure 6-4: Global – Number of Pharmaceutical Organization Impacted by COVID-19 by Intensity, 2020
Figure 6-5: Global – Number of Pharmaceutical Organization Impacted by COVID-19 by Intensity (%), 2020
Figure 6-6: Global – Estimated Breast Cancer Cases (Million), 2020, 2025 & 2030
Figure 6-7: Global – Estimated Breast Cancer Cases (Million), 2020, 2025 & 2030
Figure 6-8: Global – Estimated ER Positive Breast Cancer Cases (Million), 2020, 2025 & 2030
Figure 6-9: Global – SERD Market Opportunity (US$ Billion), 2020 - 2025
Figure 6-10: US – SERD Market Opportunity (US$ Million), 2020 - 2025
Figure 6-11: Europe – SERD Market Opportunity (US$ Million), 2020 - 2025
Figure 8-1: SERD -  Clinical Trials by Company (Number of Drugs),  2020 - 2025
Figure 8-2: SERD -  Clinical Trials by Indication (Number of Drugs),  2020 - 2025
Figure 8-3: SERD -  Clinical Trials by Patient Segment (Number of Drugs),  2020 - 2025
Figure 8-4: SERD -  Clinical Trials by Phase (Number of Drugs),  2020 - 2025
Figure 11-1: Faslodex – FDA Approval Year by Type of Breast Cancer
Figure 11-2: Faslodex – FDA Approval Year & First Generic Approval Year
Figure 11-3: Faslodex - Patent Issue & Expiration Year
Figure 11-4: Faslodex – Price for 10 ml & Price per ml of Intramuscular Injection (US$), January’2021
Figure 11-5: Faslodex – Recommended & Reduced Dose (mg)
Figure 11-6: Faslodex – Number of Doses by Treatment Phase
Figure 11-7: Faslodex – Cost For First & Subsequent Treatment Cycle (US$)
Figure 11-8: Global - Faslodex Annual Sales Value (US$ Million), 2016 - 2019
Figure 11-9: Global - Faslodex Annual Sales Values (US$ Million), 2002 - 2015
Figure 11-10: Global - Faslodex Quarterly Sales Value (US$ Million), 2018 & 2019
Figure 11-11: US - Faslodex Annual Sales Value (US$ Million), 2017 - 2019
Figure 11-12: Europe - Faslodex Annual Sales Value (US$ Million), 2017 - 2019
Figure 11-13: Global - Faslodex Annual Sales Value by Region (US$ Million), 2019
Figure 11-14: Global - Faslodex Annual Sales Value by Region (%), 2019
Figure 11-15: Global - Faslodex Quarterly Sales Value (US$ Million), Q1 – Q3, 2020
Figure 11-16: Global - Faslodex 9 Month Sales Value by Region (US$ Million), 2020
Figure 11-17: Global - Faslodex 9 Month Sales Value by Region (%), 2019
Figure 11-18: US - Faslodex Quarterly Sales Value (US$ Million), Q1 – Q3, 2020
Figure 11-19: Europe - Faslodex Quarterly Sales Value (US$ Million), Q1 – Q3, 2020
Figure 11-20: US – Typical Co-Pay Range of Branded & Generic Fulvestrant (US$), January’2021
Figure 12-1: Fulviglen – Price for a Supply of 3 Injection & Price per unit of 250mg Intramuscular Injection (US$), January’2021
Figure 12-2: Fulviglen – Price for a Supply of 6 Injection & Price per unit of 250mg Intramuscular Injection (US$), January’2021
Figure 12-3: Fulviglen – Price for a Supply of 9 Injection & Price per unit of 250mg Intramuscular Injection (US$), January’2021
Figure 12-4: Fulvenat – Price for a Supply of 2 Injection & Price per unit of 250mg Intramuscular Injection (US$), January’2021
Figure 12-5: Fulvenat – Price for a Supply of 6 Injection & Price per unit of 250mg Intramuscular Injection (US$), January’2021
Figure 12-6: Fulvenat – Price for a Supply of 6 Injection & Price per unit of 250mg Intramuscular Injection (US$), January’2021
Figure 12-7: Fulvetraz – Price for a Supply of 2 Injection & Price per unit of 250mg Intramuscular Injection (US$), January’2021
Figure 12-8: Fulvetraz – Price for a Supply of 6 Injection & Price per unit of 250mg Intramuscular Injection (US$), January’2021
Figure 12-9: Fulvetraz – Price for a Supply of 6 Injection & Price per unit of 250mg Intramuscular Injection (US$), January’2021
Figure 12-10: Fuvesterol – Price for a Supply of 2 Injection & Price per unit of 250mg Intramuscular Injection (US$), January’2021
Figure 12-11: Fuvesterol – Price for a Supply of 6 Injection & Price per unit of 250mg Intramuscular Injection (US$), January’2021
Figure 12-12: Fuvesterol – Price for a Supply of 6 Injection & Price per unit of 250mg Intramuscular Injection (US$), January’2021
Figure 12-13: Strantas – Price for a Supply of 2 Injection & Price per unit of 250mg Intramuscular Injection (US$), January’2021
Figure 12-14: Strantas – Price for a Supply of 6 Injection & Price per unit of 250mg Intramuscular Injection (US$), January’2021
Figure 12-15: Strantas – Price for a Supply of 6 Injection & Price per unit of 250mg Intramuscular Injection (US$), January’2021
Figure 12-16: Celvestrant – Price for a Supply of 2 Injection & Price per unit of 250mg Intramuscular Injection (US$), January’2021
Figure 12-17: Celvestrant – Price for a Supply of 6 Injection & Price per unit of 250mg Intramuscular Injection (US$), January’2021
Figure 12-18: Celvestrant – Price for a Supply of 6 Injection & Price per unit of 250mg Intramuscular Injection (US$), January’2021
Figure 12-19: Faslomax – Price for a Supply of 2 Injection & Price per unit of 250mg Intramuscular Injection (US$), January’2021
Figure 12-20: Faslomax – Price for a Supply of 6 Injection & Price per unit of 250mg Intramuscular Injection (US$), January’2021
Figure 12-21: Faslomax – Price for a Supply of 6 Injection & Price per unit of 250mg Intramuscular Injection (US$), January’2021
Figure 12-22: Fasnorm – Price for a Supply of 2 Injection & Price per unit of 250mg Intramuscular Injection (US$), January’2021
Figure 12-23: Fasnorm – Price for a Supply of 6 Injection & Price per unit of 250mg Intramuscular Injection (US$), January’2021
Figure 12-24: Fasnorm – Price for a Supply of 6 Injection & Price per unit of 250mg Intramuscular Injection (US$), January’2021

Note: Product cover images may vary from those shown
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  • AsteraZeneca
  • Eli Lilly
  • G1 Therapeutics
  • Novartis
  • Olema Oncology
  • Radius Therapeutics
  • Roche
  • Sage Therapeutics
  • Zeno Pharma
  • Zentalis
Note: Product cover images may vary from those shown
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