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Polo-Like Kinase 1 (PLK1) Inhibitor - Pipeline Insight, 2022

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    Clinical Trials

  • 60 Pages
  • January 2022
  • Region: Global
  • DelveInsight
  • ID: 5262042
This “Polo-Like Kinase 1 (PLK1) Inhibitor - Pipeline Insight, 2022” report provides comprehensive insights about 8+ companies and 8+ pipeline drugs in Polo-Like Kinase 1 (PLK1) Inhibitor pipeline landscape. It covers the pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.

Geography Covered

  • Global coverage

Polo-Like Kinase 1 (PLK1) Inhibitor Understanding

Polo-Like Kinase 1 (PLK1) Inhibitor: Overview


Polo-like kinase 1 (Plk1) is a serine/threonine kinase that is a key regulator of multiple stages of mitotic progression. PLK1 is one of the five members of the PLK family and are found in the nuclei of all dividing cells. PLKs are defined by two conserved features: an N terminal Ser/Thr kinase domain and a C-terminal duplicated Polo-box region. PLK1 is the most extensively studied of five members of the polo-like family and is primarily known for operating as a pleiotropic master regulator of the cell cycle from entry into mitosis to the initiation of cytokinesis. This includes regulating the activity of proteins involved in establishing centromeres, initiating spindle checkpoint signaling and coordinating the activity of the spindle checkpoint. PLK1 inhibition has been shown to cause mitotic block and apoptosis of tumor cells. The potential of PLK1 inhibitors as cancer therapeutic has been widely explored, which resulted in several PLK1 inhibitors in clinical trials following their preclinical successes.

Report Highlights
  • The companies and academics are working to assess challenges and seek opportunities that could influence Polo-Like Kinase 1 (PLK1) Inhibitor R&D. The therapies under development are focused on novel approaches for Polo-Like Kinase 1 (PLK1) Inhibitor.

Polo-Like Kinase 1 (PLK1) Inhibitor Emerging Drugs Chapters


This segment of the Polo-Like Kinase 1 (PLK1) Inhibitor report encloses its detailed analysis of various drugs in different stages of clinical development, including phase III, II, I, preclinical and Discovery. It also helps to understand clinical trial details, expressive pharmacological action, agreements and collaborations, and the latest news and press releases.

Polo-Like Kinase 1 (PLK1) Inhibitor Emerging Drugs

Onvansertib: Cardiff Oncology

Onvansertib is a first-In-class, third-generation, oral and highly-selective PLK1 inhibitor. Onvansertib selectively inhibits PLK1, a proven therapeutic target that is over-expressed in most cancers. Onvansertib works synergistically in combination with chemotherapies and targeted therapeutics. In May 2020, FDA has granted Fast Track designation to onvansertib (PCM-075) for the second-line treatment of patients with KRAS-mutated metastatic colorectal cancer (mCRC).

CYC-140: Cyclacel Pharmaceuticals

CYC140 is a novel, small molecule, selective, ATP-competitive, Plk1 inhibitor. CYC140 shows selective target inhibition, impressive efficacy and cures human tumor xenografts at non-toxic doses. The molecule is in clinical evaluation for the treatment of acute myeloid leukemia and myelodysplastic syndrome.

Polo-Like Kinase 1 (PLK1) Inhibitor: Therapeutic Assessment


This segment of the report provides insights about the different Polo-Like Kinase 1 (PLK1) Inhibitor drugs segregated based on following parameters that define the scope of the report.

Major Players working on Polo-Like Kinase 1 (PLK1) Inhibitor


There are approx. 8+ key companies which are developing the Polo-Like Kinase 1 (PLK1) Inhibitor. The companies which have their Polo-Like Kinase 1 (PLK1) Inhibitor drug candidates in the most advanced stage, i.e. Phase II include, Cardiff Oncology.

Phases


This report covers around 8+ products under different phases of clinical development like

  • Late-stage products (Phase III and
  • Mid-stage products (Phase II and
  • Early-stage products (Phase I/II and Phase I) along with the details of
  • Pre-clinical and Discovery stage candidates
  • Discontinued & Inactive candidates
  • Route of Administration

Polo-Like Kinase 1 (PLK1) Inhibitor pipeline report provides the therapeutic assessment of the pipeline drugs by the Route of Administration. Products have been categorized under various ROAs such as

  • Infusion
  • Intradermal
  • Intramuscular
  • Intranasal
  • Intravaginal
  • Oral
  • Parenteral
  • Subcutaneous
  • Topical
  • Molecule Type

Products have been categorized under various Molecule types such as

  • Vaccines
  • Monoclonal Antibody
  • Peptides
  • Polymer
  • Small molecule
  • Product Type

The drugs have been categorized under various product types like Mono, Combination and Mono/Combination.

Polo-Like Kinase 1 (PLK1) Inhibitor: Pipeline Development Activities

The report provides insights into different therapeutic candidates in phase III, II, I, preclinical and discovery stage. It also analyses Polo-Like Kinase 1 (PLK1) Inhibitor therapeutic drugs key players involved in developing key drugs.

Pipeline Development Activities

The report covers the detailed information of collaborations, acquisition and merger, licensing along with a thorough therapeutic assessment of emerging Polo-Like Kinase 1 (PLK1) Inhibitor drugs.

Polo-Like Kinase 1 (PLK1) Inhibitor Report Insights

  • Polo-Like Kinase 1 (PLK1) Inhibitor Pipeline Analysis
  • Therapeutic Assessment
  • Unmet Needs
  • Impact of Drugs

Polo-Like Kinase 1 (PLK1) Inhibitor Report Assessment

  • Pipeline Product Profiles
  • Therapeutic Assessment
  • Pipeline Assessment
  • Inactive drugs assessment
  • Unmet Needs

Key Questions


Current Scenario and Emerging Therapies:

  • How many companies are developing Polo-Like Kinase 1 (PLK1) Inhibitor drugs?
  • How many Polo-Like Kinase 1 (PLK1) Inhibitor drugs are developed by each company?
  • How many emerging drugs are in mid-stage, and late-stage of development for Polo-Like Kinase 1 (PLK1) Inhibitor?
  • What are the key collaborations (Industry-Industry, Industry-Academia), Mergers and acquisitions, licensing activities related to the Polo-Like Kinase 1 (PLK1) Inhibitor therapeutics?
  • What are the recent trends, drug types and novel technologies developed to overcome the limitation of existing therapies?
  • What are the clinical studies going on for Polo-Like Kinase 1 (PLK1) Inhibitor and their status?
  • What are the key designations that have been granted to the emerging drugs?

Key Players

  • Oncoheroes Biosciences
  • Cyclacel Pharmaceuticals
  • Cardiff Oncology
  • Onconova Therapeutics
  • Sentinel oncology

Key Products

  • Volasertib
  • CYC-140
  • Onvansertib
  • Rigosertib
  • SOL686

Table of Contents

Introduction

Executive Summary

Polo-Like Kinase 1 (PLK1) Inhibitor: Overview
  • Structure
  • Mechanism of Action

Pipeline Therapeutics
  • Comparative Analysis

Therapeutic Assessment
  • Assessment by Product Type
  • Assessment by Stage and Product Type
  • Assessment by Route of Administration
  • Assessment by Stage and Route of Administration
  • Assessment by Molecule Type
  • Assessment by Stage and Molecule Type

Polo-Like Kinase 1 (PLK1) Inhibitor - Analytical Perspective

In-depth Commercial Assessment
  • Polo-Like Kinase 1 (PLK1) Inhibitor companies’ collaborations, Licensing, Acquisition -Deal Value Trends

Polo-Like Kinase 1 (PLK1) Inhibitor Collaboration Deals
  • Company-Company Collaborations (Licensing / Partnering) Analysis
  • Company-University Collaborations (Licensing / Partnering) Analysis

Late Stage Products (Phase III)
  • Comparative Analysis

Drug name: Company name
  • Product Description
  • Research and Development
  • Product Development Activities

Mid Stage Products (Phase II)
  • Comparative Analysis

Onvansertib: Cardiff Oncology
  • Product Description
  • Research and Development
  • Product Development Activities

Early Stage Products (Phase I)
  • Comparative Analysis

CYC-140: Cyclacel Pharmaceuticals
  • Product Description
  • Research and Development
  • Product Development Activities

Pre-clinical and Discovery Stage Products
  • Comparative Analysis

Volasertib: Oncoheroes Biosciences
  • Product Description
  • Research and Development
  • Product Development Activities

Inactive Products
  • Comparative Analysis

Polo-Like Kinase 1 (PLK1) Inhibitor Key Companies

Polo-Like Kinase 1 (PLK1) Inhibitor Key Products

Polo-Like Kinase 1 (PLK1) Inhibitor- Unmet Needs

Polo-Like Kinase 1 (PLK1) Inhibitor- Market Drivers and Barriers

Polo-Like Kinase 1 (PLK1) Inhibitor- Future Perspectives and Conclusion

Polo-Like Kinase 1 (PLK1) Inhibitor Analyst Views

Polo-Like Kinase 1 (PLK1) Inhibitor Key Companies

AppendixList of Tables
Table 1 Total Products for Polo-Like Kinase 1 (PLK1) Inhibitor
Table 2 Late Stage Products
Table 3 Mid Stage Products
Table 4 Early Stage Products
Table 5 Pre-clinical & Discovery Stage Products
Table 6 Assessment by Product Type
Table 7 Assessment by Stage and Product Type
Table 8 Assessment by Route of Administration
Table 9 Assessment by Stage and Route of Administration
Table 10 Assessment by Molecule Type
Table 11 Assessment by Stage and Molecule Type
Table 12 Inactive Products

List of Figures
Figure 1 Total Products for Polo-Like Kinase 1 (PLK1) Inhibitor
Figure 2 Late Stage Products
Figure 3 Mid Stage Products
Figure 4 Early Stage Products
Figure 5 Preclinical and Discovery Stage Products
Figure 6 Assessment by Product Type
Figure 7 Assessment by Stage and Product Type
Figure 8 Assessment by Route of Administration
Figure 9 Assessment by Stage and Route of Administration
Figure 10 Assessment by Molecule Type
Figure 11 Assessment by Stage and Molecule Type
Figure 12 Inactive Products

Companies Mentioned

A selection of companies mentioned in this report includes:

  • Oncoheroes Biosciences
  • Cyclacel Pharmaceuticals
  • Cardiff Oncology
  • Onconova Therapeutics
  • Sentinel oncology