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TIM-3 Inhibitor - Pipeline Insight, 2021

  • ID: 5262051
  • Drug Pipelines
  • February 2021
  • Region: Global
  • 60 pages
  • DelveInsight
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FEATURED COMPANIES

  • Bristol-Myers Squibb
  • GlaxoSmithKline
  • Interprotein
  • Novarits
  • Roche
  • Symphogen
  • MORE
This “TIM-3 inhibitor - Pipeline Insight, 2021,” report provides comprehensive insights about 15+ companies and 15+ pipeline drugs in TIM-3 inhibitor pipeline landscape. It covers the pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.

Geography Covered
  • Global coverage
TIM-3 inhibitor Understanding

TIM-3 inhibitor: Overview

T-cell immunoglobulin and mucin domain 3 (Tim-3) is an immunoglobulin and mucin domain-containing cell surface molecule. The protein is characterized by a common structural organization consisting of an amino-terminal immunoglobulin variable domain (V domain) with five noncanonical cysteines, a mucin stalk, a transmembrane domain and a cytoplasmic tail. TIM-3 is known to interact with four ligands, galectin-9, phosphatidylserie (PtdSer), CEACAM-1and HMGB1 (high mobility group box-1). Tim-3 is a checkpoint receptor expressed by a wide variety of immune cells as well as leukemic stem cells. Various preclinical data support the therapeutic modulation of TIM3 in multiple disease contexts including autoimmunity, infection, and cancer. The blocking of Tim-3 and PD-1 together can result in reduced tumor progression in preclinical models and can improve antitumor T-cell responses in cancer patients.

Report Highlights
  • The companies and academics are working to assess challenges and seek opportunities that could influence TIM-3 inhibitor R&D. The therapies under development are focused on novel approaches for TIM-3 inhibitor.
TIM-3 inhibitor Emerging Drugs Chapters

This segment of the TIM-3 inhibitor report encloses its detailed analysis of various drugs in different stages of clinical development, including phase III, II, I, preclinical and Discovery. It also helps to understand clinical trial details, expressive pharmacological action, agreements and collaborations, and the latest news and press releases.

TIM-3 inhibitor Emerging Drugs
  • Cobolimab: GlaxoSmithKline
Cobolimab is a novel IgG4 anti-TIM-3 monoclonal antibody. It is under clinical investigation in clinical trial in combination with Dostarlimab and Docetaxel in Advanced Non-small cell lung cancer (NSCLC). By binding to and blocking TIM-3, Cobolimab allows for T-cells to become activated so as to enhance T-cell-mediated attacks on tumors. These attacks reduce their growth.
  • BMS-986258: Bristol-Myers Squibb
BMS-986258 (anti-TIM-3) is a fully-human monoclonal antibody targeting TIM-3 (T cell immunoglobulin and mucin domain-3). It is the first clinical candidate from the discovery collaboration between Five Prime Therapeutics and BMS that includes targets in three immune checkpoint pathways.

TIM-3 inhibitor: Therapeutic Assessment

This segment of the report provides insights about the different TIM-3 inhibitor drugs segregated based on following parameters that define the scope of the report, such as:

Major Players working on TIM-3 inhibitor

There are approx. 15+ key companies which are developing the TIM-3 inhibitor. The companies which have their TIM-3 inhibitor drug candidates in the most advanced stage, i.e. Phase III include, Novarits Oncology.

The report covers around 15+ products under different phases of clinical development like
  • Late-stage products (Phase III and
  • Mid-stage products (Phase II and
  • Early-stage products (Phase I/II and Phase I) along with the details of
  • Pre-clinical and Discovery stage candidates
  • Discontinued & Inactive candidates
  • Route of Administration
TIM-3 inhibitor pipeline report provides the therapeutic assessment of the pipeline drugs by the Route of Administration. Products have been categorized under various ROAs such as
  • Infusion
  • Intradermal
  • Intramuscular
  • Intranasal
  • Intravaginal
  • Oral
  • Parenteral
  • Subcutaneous
  • Topical
  • Molecule Type
Products have been categorized under various Molecule types such as
  • Vaccines
  • Monoclonal Antibody
  • Peptides
  • Polymer
  • Small molecule
  • Product Type
The drugs have been categorized under various product types like Mono, Combination and Mono/Combination.

TIM-3 inhibitor: Pipeline Development Activities

The report provides insights into different therapeutic candidates in phase III, II, I, preclinical and discovery stage. It also analyses TIM-3 inhibitor therapeutic drugs key players involved in developing key drugs.

Pipeline Development Activities

The report covers the detailed information of collaborations, acquisition and merger, licensing along with a thorough therapeutic assessment of emerging TIM-3 inhibitor drugs.

TIM-3 inhibitor Report Insights
  • TIM-3 inhibitor Pipeline Analysis
  • Therapeutic Assessment
  • Unmet Needs
  • Impact of Drugs
TIM-3 inhibitor Report Assessment
  • Pipeline Product Profiles
  • Therapeutic Assessment
  • Pipeline Assessment
  • Inactive drugs assessment
  • Unmet Needs
Key Questions Answered

Current Scenario and Emerging Therapies:
  • How many companies are developing TIM-3 inhibitor drugs?
  • How many TIM-3 inhibitor drugs are developed by each company?
  • How many emerging drugs are in mid-stage, and late-stage of development for TIM-3 inhibitor?
  • What are the key collaborations (Industry-Industry, Industry-Academia), Mergers and acquisitions, licensing activities related to the TIM-3 inhibitor therapeutics?
  • What are the recent trends, drug types and novel technologies developed to overcome the limitation of existing therapies?
  • What are the clinical studies going on for TIM-3 inhibitor and their status?
  • What are the key designations that have been granted to the emerging drugs?
Key Players
  • Novarits
  • GlaxoSmithKline
  • Roche
  • Incyte Corporation
  • Bristol-Myers Squibb
  • Novartis
  • Interprotein
  • TrueBinding
  • Celgene
  • Sutro Biopharma
  • Neologics Bioscience
  • Symphogen
Key Products
  • Sabatolimab
  • Cobolimab
  • RG-7769
  • INCAGN 02390
  • BMS 986258
  • MAS-825
  • Research program: anticancer peptide therapeutics
  • Anti-T-cell immunoglobulin and mucin domain-3 monoclonal antibody
  • Research program: antibody based therapeutics
  • NB 002
  • Sym-023
Note: Product cover images may vary from those shown
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FEATURED COMPANIES

  • Bristol-Myers Squibb
  • GlaxoSmithKline
  • Interprotein
  • Novarits
  • Roche
  • Symphogen
  • MORE
Introduction

Executive Summary

TIM-3 inhibitor: Overview
  • Structure
  • Mechanism of Action
Pipeline Therapeutics
  • Comparative Analysis
Therapeutic Assessment
  • Assessment by Product Type
  • Assessment by Stage and Product Type
  • Assessment by Route of Administration
  • Assessment by Stage and Route of Administration
  • Assessment by Molecule Type
  • Assessment by Stage and Molecule Type
TIM-3 inhibitor - Analytical Perspective

In-depth Commercial Assessment
  • TIM-3 inhibitor companies' collaborations, Licensing, Acquisition - Deal Value Trends
TIM-3 inhibitor Collaboration Deals
  • Company-Company Collaborations (Licensing / Partnering) Analysis
  • Company-University Collaborations (Licensing / Partnering) Analysis
Late Stage Products (Phase III)
  • Comparative Analysis
Sabatolimab: Novarits Oncology
  • Product Description
  • Research and Development
  • Product Development Activities
Mid Stage Products (Phase II)
  • Comparative Analysis
BMS 986258: Bristol-Myers Squibb
  • Product Description
  • Research and Development
  • Product Development Activities
Early Stage Products (Phase I)
  • Comparative Analysis
Sym 023: Symphogen
  • Product Description
  • Research and Development
  • Product Development Activities
Pre-clinical and Discovery Stage Products
  • Comparative Analysis
NB 002: Neologics Bioscience
  • Product Description
  • Research and Development
  • Product Development Activities
Inactive Products
  • Comparative Analysis
TIM-3 inhibitor Key Companies

TIM-3 inhibitor Key Products

TIM-3 inhibitor - Unmet Needs

TIM-3 inhibitor - Market Drivers and Barriers

TIM-3 inhibitor - Future Perspectives and Conclusion

TIM-3 inhibitor Analyst Views

TIM-3 inhibitor Key Companies

Appendix

List of Tables
Table 1 Total Products for TIM-3 inhibitor
Table 2 Late Stage Products
Table 3 Mid Stage Products
Table 4 Early Stage Products
Table 5 Pre-clinical & Discovery Stage Products
Table 6 Assessment by Product Type
Table 7 Assessment by Stage and Product Type
Table 8 Assessment by Route of Administration
Table 9 Assessment by Stage and Route of Administration
Table 10 Assessment by Molecule Type
Table 11 Assessment by Stage and Molecule Type
Table 12 Inactive Products

List of Figures
Figure 1 Total Products for TIM-3 inhibitor
Figure 2 Late Stage Products
Figure 3 Mid Stage Products
Figure 4 Early Stage Products
Figure 5 Preclinical and Discovery Stage Products
Figure 6 Assessment by Product Type
Figure 7 Assessment by Stage and Product Type
Figure 8 Assessment by Route of Administration
Figure 9 Assessment by Stage and Route of Administration
Figure 10 Assessment by Molecule Type
Figure 11 Assessment by Stage and Molecule Type
Figure 12 Inactive Products
Note: Product cover images may vary from those shown
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  • Novarits
  • GlaxoSmithKline
  • Roche
  • Incyte Corporation
  • Bristol-Myers Squibb
  • Novartis
  • Interprotein
  • TrueBinding
  • Celgene
  • Sutro Biopharma
  • Neologics Bioscience
  • Symphogen
Note: Product cover images may vary from those shown
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