Leon Chesley's Hypertensive Disorders in Pregnancy was initially published in 1978. Four decades later, hypertension complications in pregnancy are still a major cause of fetal and maternal morbidity and death, especially in less developed nations. It is also a leading cause of preterm birth now known to be a risk factor in remote cardiovascular disease. Despite this, hypertensive disorders remain marginally studied and management is often controversial. Chesley's Hypertensive Disorders in Pregnancy, Fifth Edition continues its tradition as one of the beacons to guide the field of preeclampsia research, recognized for its uniqueness and utility. This revision focuses on prediction, prevention, and management for clinicians, and is an essential reference text for clinical and basic investigators alike. It provides a superb analysis of the multiple topics that relate to hypertension in pregnancy, especially of preeclampsia.
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Table of Contents
1.?The Spectrum of Hypertensive Disorders in Pregnancy: Dr. Leon Chesley's Legacy2.?Epidemiology of Pregnancy-Related Hypertension
3. Genetic Factors in the Etiology of Preeclampsia/Eclampsia
4. Preconceptional and Periconceptional Pathways to Preeclampsia
5. Placentation and Placental Function in Normal and Preeclamptic Pregnancies
6. Unbiased Approaches for Addressing the Complexities of the Placenta's Role in the Preeclampsia Syndrome
7. The Immunology of Preeclampsia
8. Trophoblast Extracellular Vesicles in Preeclampsia
9. Angiogenesis and Preeclampsia
10. Vascular Endothelial Cell Dysfunction in Preeclampsia
11. Cardiovascular Alterations in Normal and Preeclamptic Pregnancy
12. Cardiometabolic Antecedents of Preeclampsia
13. Cerebrovascular Pathophysiology in Preeclampsia and Eclampsia
14. The Kidney in Normal Pregnancy and Preeclampsia
15. Salt, Aldosterone, and the Renin- Angiotensin System in Pregnancy
16. Platelets, Coagulation, and the Liver
17. Clinical Management and Antihypertensive Treatment of Hypertensive Disorders of Pregnancy
18. Prediction and Prevention of Preeclampsia
19. Long-Term Effects of Preeclampsia on Mothers and Offspring
20. Animal Models Used for Investigating Pathophysiology of Preeclampsia and Identifying Therapeutic Targets
21. Harmonization of Data and Biobanks for Preeclampsia Research
Authors
Robert N. Taylor Professor of Obstetrics and Gynecology and Assistant Dean for Student and Academic Affairs, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY, USA. Robert N. Taylor, MD, PhD is Professor of Obstetrics and Gynecology at the Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY. Previously, he was Professor of Obstetrics and Gynecology at The University of Utah, Wake Forest School of Medicine, Emory University, and Director of the Center for Reproductive Sciences at the University of California, San Francisco. Taylor received his undergraduate education at Stanford University and the combined MD-PhD at Baylor College of Medicine. He is a board-certified obstetrician-gynecologist and reproductive endocrinologist whose major research foci have included the role of placental angiogenesis and endothelial cell activation in preeclampsia, and the molecular actions of estrogen and progesterone on endometrial differentiation and neuroangiogenesis as they relate to endometriosis. Dr. Taylor served on executive committees of the American Board of Obstetrics and Gynecology, NIH Reproductive Scientist Development Program, the World Endometriosis Society and the California Institute for Regenerative Medicine. Kirk P. Conrad Professor of Physiology, Department of Physiology and Functional Genomics / Obstetrics and Gynecology, University of Florida College of Medicine, Gainesville, FL, USA. Dr. Conrad has had a longstanding research interest in the hormonal, cellular and molecular mechanisms underlying maternal renal and systemic vasodilation, and increased arterial compliance during normal pregnancy with emphasis on the ovarian hormone, relaxin. More recently, he has been PD/PI of a NIH Program Project Grant designed to explore maternal pregnancy physiology and outcome in women conceiving through in vitro fertilization with focus on the contribution of the corpus luteum. Finally, Dr. Conrad has been exploring a role for dysregulated (pre)decidualization in the genesis of preeclampsia, and in the larger context of "endometrium spectrum disorders�. Dr. Conrad has combined preclinical and clinical research throughout his career to translate findings in animal models, tissues and cells to humans or vice versa. The main disease focus of his pregnancy research has been preeclampsia-a hypertensive syndrome peculiar to human pregnancy. Sandra T. Davidge Executive Director, Women and Children's Health Research Institute; Distinguished University Professor, University of Alberta, Canada. Dr. Davidge is a Distinguished University Professor in the Faculty of Medicine & Dentistry at the University of Alberta and Executive Director of the Women and Children's Health Research Institute, Edmonton, Alberta, Canada. Davidge received her PhD from the University of Vermont and completed her postdoctoral fellowship training at the Magee Womens Research Institute in Pittsburgh, PA, USA. Davidge's research program is focused on understanding mechanisms for vascular dysfunction in pregnancy complications, particularly preeclampsia, and subsequent impact on later-life cardiovascular health. Her fundamental studies are currently focused on developing early intervention strategies for improving pregnancy outcomes to enhance life-long maternal and offspring cardiovascular health. Davidge is a Fellow in the Canadian Academy of Health Science and a past president of Society for Reproductive Investigation (2017-2018). Anne Cathrine Staff Division of Obstetrics and Gynaecology, Oslo University Hospital; Institute for Clinical Medicine, Faculty of Medicine, University of Oslo, Norway. Anne Cathrine (Annetine) Staff, MD, PhD, is a full-time Professor of Obstetrics and Gynaceology at the Faculty of Medicine, University of Oslo, Norway. She is also Head of Research at the Division of Obstetrics and Gynaecology at Oslo University Hospital, Norway. She obtained her Medical Degree in 1987 at The University of Oslo, where she also did her PhD in 2000 on "Preeclampsia and uteroplacental tissues: lipids, oxidative stress, and trophoblast invasion�. She is a board certified specialist in Gynecology and Obstetrics since 1996, and have worked clinically in the field since 1989. Dr. Staff is head of a research group in Oslo, where one main research area is within molecular understanding of pregnancy complications associated with placental dysfunction, including preeclampsia, and its relation to future maternal cardiovascular health.Dr. Staff was previously the EPG (European Placenta Group) Spokesperson 2011-17 and the Vice-President of the ISSHP (International Society for the Study of Hypertension in Pregnancy) 2012-16, and is currently an ISSHP Executive Committee member and part of the Global Pregnancy Collaboration team. James M. Roberts Senior Scientist, Magee Women's Research Institute, Professor, Obstetrics, Gynecology, Reproductive Sciences, Epidemiology, and Clinical and Translational ResearchUniversity of Pittsburgh, Pittsburgh, PA, USA. Dr. Roberts' research is interdisciplinary and involves fundamental, clinical, behavioral and epidemiological studies. He has been involved in several seminal studies of preeclampsia including the recognition of preeclampsia as involving endothelial dysfunction and being more than hypertension in pregnancy. He currently is involved in global health research as part of the Global Pregnancy Collaboration, a consortium of 40 centers world-wide that facilitates collaborative research. He is a co-investigator on studies in Brazil and South Africa. He chaired the ACOG Hypertension Task Force and was co-chair of the NHLBI NIH workshop on research on pregnancy hypertension.
