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Single-Use Bioreactors Market by Type of Reactor, Cell Culture System, End-User, and Geography: Industry Trends and Global Forecasts, 2020-2030

  • ID: 5306287
  • Report
  • January 2021
  • Region: Global
  • 267 Pages
  • Roots Analysis


  • 3Dnamics
  • Biosan
  • Emerson
  • LevTech Consulting
  • Premas Biotech
  • Siemens
  • MORE


The modern biopharmaceutical industry, which is poised for significant growth over the coming years, is characterized by several blockbuster therapies (such as Humira®, Rituxan®, Lantus®, Avastin®, Herceptin® and Remicade®) and a robust pipeline of product/therapy candidates. Traditionally, stainless steel bioreactors were the preferred choice for production of biologics; however, over the past couple of decades, biopharmaceutical manufacturing has gradually witnessed a shift towards the use of single-use technologies. Apart from low contamination risk and better product yield, single-use bioreactors are easy-to-install and have a much smaller footprint, compared to the traditional stainless steel systems. In addition to enabling substantial cost savings (by eliminating the need for additional steps, such as sterilization, cleaning, and maintenance), single-use bioreactors are also less demanding of energy and are known to help conserve resources, such as water and CO2. Moreover, the upfront cost of such bioprocessing solutions is also not very high. 

To date, many biopharmaceutical companies and contract service providers have upgraded their manufacturing infrastructure and facilities to include more of single-use systems. In addition, there are a number of companies that are now involved in the development and production of single-use bioreactors. Several of these players are now focusing on incorporating a variety of additional features, including provisions for alerts/alarms, built-in system process control sensors, electronic process logs, remote monitoring features, touch screens, and advanced safety provisions, in their proprietary offerings. We are also led to believe that the COVID-19 pandemic is likely to result in an increased demand for advanced biomanufacturing solutions. In fact, single-use bioreactors are extensively being used for the production of various COVID-19 vaccines. This presents lucrative opportunities for companies engaged in single-use bioreactors domain. The overall single-use bioreactors market is anticipated to witness substantial growth, primarily driven by the increasing adoption of such manufacturing solutions among small companies and startups in the coming years.

Scope of the Report

The “Single-Use Bioreactors Market (2nd Edition), 2020-2030: Distribution by Type of Reactor (Stirred Tank, Pneumatically Mixed, Rocker/Rotating, Wave-Induced, Paddle Sleeve, Fixed-Bed, Hollow Fiber, Diffusion, and Orbitally Shaken), Scale of Operation (Small Scale and Large Scale), Cell Culture System (Mammalian, Insect, Microbial, Viral, Plant and Bacterial), Type of Molecule (Vaccine, Monoclonal Antibody, Recombinant Protein, Stem Cell, Cell Therapy, and Gene Therapy), Application Area (Cancer Research, Drug Discovery and Toxicology, Stem Cell Research, Tissue Engineering and Regenerative Medicine), Purpose (R&D and Manufacturing), End-User (Biopharmaceutical/Pharmaceutical Industries, Academic/Research Institutes), and Geography (North America, Europe, Asia-Pacific, Latin America, MENA and Rest of the World)” report features an extensive study of the current landscape and the likely future potential of single-use bioreactors, over the next decade. The study also features an in-depth analysis, highlighting the capabilities of various industry stakeholders engaged in this field. 

In addition to other elements, the study includes:

  • A detailed assessment of the overall market landscape of single-use bioreactors based on a number of relevant parameters, such as status of development (commercially available and under development), type of single-use bioreactor (stirred tank, pneumatically mixed, rocker/rotating, wave-induced, paddle sleeve, fixed-bed, hollow fiber, diffusion, orbitally shaken, and others), scale of operation (laboratory scale, pilot scale, and large scale), area of application (cancer research, drug discovery/toxicology testing, stem cell research, tissue engineering/regenerative medicine, and others), typical working volume, weight of the bioreactor, stirrer speed, cell culture system (mammalian, insect, microbial, viral, plant, bacterial, and others), and type of molecule (vaccine, monoclonal antibody, recombinant protein, stem cell, cell therapy, gene therapy, and others). In addition, it presents details of the companies manufacturing single-use bioreactors, highlighting their year of establishment, size of employee base, and geographical presence.
  • A contemporary market trend analysis, which include [A] a tree map, comparing the type of single-use bioreactor and company size, [B] an insightful grid representation based on scale of operation, area of application and type of cell culture, [C] heat map representation analyzing type of single-use bioreactor and area of application, and [D] a world map representation highlighting the regional distribution of players based on the location of headquarters.
  • Elaborate profiles of prominent players (shortlisted based on number of products being offered) engaged in the development of single-use bioreactors. Each company profile features a brief overview of the company, along with information on year of establishment, number of employees, location of headquarters and key members of the executive team. It also includes details of their respective product portfolio, and recent developments and an informed future outlook.
  • An analysis of the various partnerships related to single-use bioreactors, which have been established till September 2020, based on several parameters, such as year of agreement, type of partnership (full business acquisition, product/technology development agreement, product/technology integration agreement, product distribution/marketing agreement, product portfolio acquisition, service alliance, and supply agreement), focus area (expansion/upgrade of manufacturing facility, incorporation of automation solutions, product development/testing, product maintenance, product portfolio expansion, supply of cell media products/equipment), and most active players. It also provides the regional distribution of the players involved in the collaborations.
  • A detailed competitiveness analysis of single-use bioreactors, taking into consideration several relevant parameters, such as the supplier power (based on expertise of the manufacturer) and key product-related specifications, including status of development, working volume, stirrer speed, weight of the product, scale of operation, type of cell culture, type of molecule, and area(s) of application.
  • An insightful three-dimensional bubble chart representation, highlighting the competitiveness analysis of single-use bioreactor manufacturers, taking into consideration the supplier power (based on expertise of the manufacturer), product portfolio strength, portfolio diversity, and number of area(s) of application.
  • A detailed brand positioning analysis of the key industry players, highlighting the current perceptions regarding their proprietary products by taking into consideration several relevant aspects, such as experience of the manufacturer (in terms of number of years), number of products offered, product diversity, number of area(s) of application, number of patents and number of partnerships inked. 
  • An in-depth analysis of over 2,800 patents that have been filed/granted for single-use bioreactors, between 1995 and 2020 (till September), highlighting key trends associated with these patents, across type of patents, publication year, issuing authorities involved, emerging focus area, patent age, CPC symbols, leading patent assignees (in terms of number of patents granted/filed), patent characteristics and geography. It also includes a detailed patent benchmarking and an insightful valuation analysis. 
  • A discussion on the key technological innovations, such as built-in system control sensors, advanced alarm systems, electronic-log records, touch screens, real-time tracking, remote monitoring, and advanced mixing technologies in the single-use bioreactors industry.
  • A discussion on affiliated trends, key drivers and challenges, under a SWOT framework, which are likely to impact the industry’s evolution, including a Harvey ball analysis, highlighting the relative effect of each SWOT parameter on the overall single-use bioreactors industry.

One of the key objectives of the report was to understand the primary growth drivers and estimate the future size of single-use bioreactors market. Based on multiple parameters, such as overall biopharmaceutical manufacturing market, share of single-use technologies, price of single-use bioreactors, and likely adoption trends, we have provided an informed estimate of the evolution of the market for the period 2020-2030. Our year-wise projections of the current and future opportunity have further been segmented on the basis of [A] type of cell culture system (mammalian, insect, microbial, viral, plant, bacterial, and others), [B] type of molecule (vaccines, monoclonal antibodies, recombinant proteins, stem cells, cell therapies, gene therapies, and others), [C] area of application (cancer research, drug discovery/toxicology testing, stem cell research, and tissue engineering/regenerative medicine), [D] scale of operation (small scale, large scale), [E] purpose (R&D and manufacturing), [F] end-user (biopharmaceutical/pharmaceutical industries and academic/research institutes), and [G] key geographical regions (North America, Europe, Asia-Pacific, Latin America, MENA (Middle East and North Africa) and rest of the world). In order to account for future uncertainties and to add robustness to our model, we have provided three forecast scenarios, namely conservative, base and optimistic scenarios, representing different tracks of the industry’s growth.

The opinions and insights presented in this study were also influenced by discussions held with senior stakeholders in the industry.

The report features detailed transcripts of interviews held with the following industry and non-industry players: 

  • Per Stobbe (Chief Executive Officer, Marketing, Technical Support, CerCell)
  • Torsten Due Bryld (Chief Commercial Officer, CelVivo)

All actual figures have been sourced and analyzed from publicly available information forums and primary research discussions. Financial figures mentioned in this report are in USD, unless otherwise specified. 

Key Questions Answered

  • Who are the leading manufacturers engaged in the development of single-use bioreactors?
  • What are the different applications for which single-use bioreactors are currently being used?
  • Which partnership models are commonly adopted by stakeholders in this industry?
  • Which features of single-use bioreactors are most important to end-users?
  • What are the challenges currently faced by stakeholders in this industry?
  • What are the key factors that are likely to influence the evolution of this market?
  • How is the COVID-19 pandemic likely to impact single-use bioreactors market?
  • How is the current and future opportunity likely to be distributed across key market segments?
  • What are the anticipated future trends related to single-use bioreactors market?
Note: Product cover images may vary from those shown


  • 3Dnamics
  • Biosan
  • Emerson
  • LevTech Consulting
  • Premas Biotech
  • Siemens
  • MORE

1.1. Scope of the Report
1.2. Research Methodology
1.3. Key Questions Answered
1.4. Chapter Outlines


3.1. Chapter Overview
3.2. Overview of Single Use-Bioreactors 
3.2.1. Historical Evolution
3.2.2. Single-Use vs Traditional Bioreactors
3.3. Types of Single-Use Bioreactors 
3.3.1. Based on Cell Culture
3.3.2. Based on Agitation Mechanism
3.4. Advantages of Single-Use Bioreactors 
3.5. Challenges Associated with Single-Use Bioreactors 
3.6. Key Applications Areas 
3.7. Prevalent Regulatory Standards
3.8. Future Prospects 

4.1. Chapter Overview
4.2. Single-Use Bioreactors: Overall Market Landscape
4.2.1. Analysis by Status of Development
4.2.2. Analysis by Type of Single-Use Bioreactor
4.2.3. Analysis by Scale of Operation
4.2.4. Analysis by Area of Application
4.2.5. Analysis by Working Volume 
4.2.6. Analysis by Weight of Bioreactor 
4.2.7. Analysis by Stirrer Speed
4.2.8. Analysis by Type of Cell Culture Handled
4.2.9. Analysis by Type of Molecule
4.3. Single-Use Bioreactor Manufacturers: Overall Market Landscape
4.3.1. Analysis by Year of Establishment
4.3.2. Analysis by Company Size
4.3.3. Analysis by Location of Headquarters
4.4. Leading Manufacturers: Analysis by Number of Products

5.1. Chapter Overview
5.2. Tree Map Representation: Analysis by Type of Single-Use Bioreactor and Company Size
5.3. Grid Representation: Analysis by Scale of Operation, Area of Application and Type of Cell Culture
5.4. Heat Map Representation: Analysis by Type of Single-Use Bioreactor and Area of Application
5.5. World Map Representation: Analysis by Location of Headquarters 

6.1. Chapter Overview
6.2. Leading Players based in North America
6.2.1. Celartia Company Overview Product Portfolio Recent Developments and Future Outlook
6.2.2. Cell Culture Company Company Overview Product Portfolio Recent Developments and Future Outlook
6.2.3. Cytiva Company Overview Product Portfolio Recent Developments and Future Outlook
6.2.4. Merck Millipore Company Overview Product Portfolio Recent Developments and Future Outlook
6.2.5. Pall Corporation Company Overview Product Portfolio Recent Developments and Future Outlook
6.2.6. PBS Biotech Company Overview Product Portfolio Recent Developments and Future Outlook
6.2.7. Synthecon Company Overview Product Portfolio Recent Developments and Future Outlook
6.2.8. Thermo Fisher Scientific Company Overview Product Portfolio Recent Developments and Future Outlook
6.3. Leading Players based in Europe
6.3.1. Cellexus Company Overview Product Portfolio Recent Developments and Future Outlook
6.3.2. CerCell Company Overview Product Portfolio Recent Developments and Future Outlook
6.3.3. Eppendorf Company Overview Product Portfolio Recent Developments and Future Outlook
6.3.4. Pierre Guerin Company Overview Product Portfolio Recent Developments and Future Outlook
6.3.5. ProlifeCell Company Overview Product Portfolio Recent Developments and Future Outlook
6.3.6. Sartorius Stedim Biotech Company Overview Product Portfolio Recent Developments and Future Outlook
6.3.7. Solaris Biotech Company Overview Product Portfolio Recent Developments and Future Outlook
6.4. Leading Players based in Asia-Pacific and Rest of the World
6.4.1. CESCO Bioengineering Company Overview Product Portfolio Recent Developments and Future Outlook

7.1. Chapter Overview
7.2. Partnership Models
7.3. Single-Use Bioreactors: Recent Partnerships and Collaborations 
7.3.1. Analysis by Year of Partnership
7.3.2. Analysis by Type of Partnership Analysis by Year of Partnership and Type of Partnership Analysis by Company Size and Type of Partnership
7.3.3. Analysis by Focus Area Analysis by Year of Partnership and Focus Area
7.3.4. Analysis by Type of Partner Analysis by Year of Partnership and Type of Partner Analysis by Type of Partnership and Type of Partner
7.3.5. Most Active Players: Analysis by Number of Partnerships
7.3.6. Regional Analysis Intercontinental and Intracontinental Agreements

8.1. Chapter Overview
8.2. Methodology 
8.3. Assumptions/Key Parameters
8.4. Product Competitiveness Analysis: Stirred Tank Single-Use Bioreactors
8.5. Product Competitiveness Analysis: Pneumatically Mixed Single-Use Bioreactors
8.6. Product Competitiveness Analysis: Wave-Induced Single-Use Bioreactors
8.7. Product Competitiveness Analysis: Paddle Sleeve Single-Use Bioreactors
8.8. Product Competitiveness Analysis: Other Types of Single-Use Bioreactors

9.1. Chapter Overview
9.2. Methodology 
9.3. Assumptions/Key Parameters
9.4. Competitiveness Analysis: Single-Use Bioreactor Manufacturers
9.5. Competitiveness Analysis: Companies Developing Stirred Tank Single-Use Bioreactor Manufacturers
9.6. Competitiveness Analysis: Companies Developing Pneumatically Mixed Single-Use Bioreactor Manufacturers
9.7. Competitiveness Analysis: Companies Developing Wave-Induced Single-Use Bioreactor Manufacturers
9.8. Competitiveness Analysis: Companies Developing Other Types of Single-Use Bioreactor Manufacturers
9.9. Competitiveness Analysis: Benchmarking of Top 10 Players

10.1. Chapter Overview
10.2. Key Parameters and Methodology
10.3. Brand Positioning Matrix: Cytiva
10.4. Brand Positioning Matrix: Eppendorf
10.5. Brand Positioning Matrix: Merck Millipore
10.6. Brand Positioning Matrix: Pall Corporation
10.7. Brand Positioning Matrix: Pierre Guerin
10.8. Brand Positioning Matrix: Sartorius Stedim Biotech
10.9. Brand Positioning Matrix: Thermo Fisher Scientific

11.1. Chapter Overview
11.2. Scope and Methodology
11.3. Single-Use Bioreactors: Patent Analysis
11.3.1. Analysis by Type of Patent
11.3.2. Analysis by Publication Year
11.3.3. Analysis by Granted Patents
11.3.4. Analysis by Year-wise Filed Patent Applications
11.3.5. Analysis by Issuing Authority
11.3.6. Analysis by Patent Focus
11.3.7. Analysis by Patent Age
11.3.8. Analysis by CPC Symbols
11.3.9. Analysis by Type of Applicant
11.3.10. Leading Players: Analysis by Number of Patents
11.4. Single-Use Bioreactors: Patent Benchmarking Analysis
11.4.1. Analysis by Patent Characteristics
11.5. Single-Use Bioreactors: Patent Valuation Analysis

12.1. Chapter Overview
12.2. Forecast Methodology and Key Assumptions
12.3. Impact of COVID-19 Pandemic on Single-Use Bioreactors Market
12.4. Global Single-Use Bioreactors Market, 2020-2030
12.5. Global Single-Use Bioreactors Market: Distribution by Type of Cell Culture
12.5.1. Single-Use Bioreactors Market for Bacterial Cell Cultures, 2020-2030
12.5.2. Single-Use Bioreactors Market for Insect Cell Cultures, 2020-2030
12.5.3. Single-Use Bioreactors Market for Mammalian Cell Cultures, 2020-2030
12.5.4. Single-Use Bioreactors Market for Microbial Cell Cultures, 2020-2030
12.5.5. Single-Use Bioreactors Market for Plant Cell Cultures, 2020-2030
12.5.6. Single-Use Bioreactors Market for Viral Cell Cultures, 2020-2030
12.5.7. Single-Use Bioreactors Market for Other Cell Cultures, 2020-2030
12.6. Global Single-Use Bioreactors Market: Distribution by Type of Molecule
12.6.1. Single-Use Bioreactors Market for Cell Therapies 2020-2030
12.6.2. Single-Use Bioreactors Market for Gene Therapies, 2020-2030
12.6.3. Single-Use Bioreactors Market for Monoclonal Antibodies, 2020-2030
12.6.4. Single-Use Bioreactors Market for Recombinant Proteins, 2020-2030
12.6.5. Single-Use Bioreactors Market for Stem Cell Therapies, 2020-2030
12.6.6. Single-Use Bioreactors Market for Vaccines, 2020-2030
12.6.7. Single-Use Bioreactors Market for Other Molecules, 2020-2030
12.7. Global Single-Use Bioreactors Market: Distribution by Area of Application
12.7.1. Single-Use Bioreactors Market for Cancer Research, 2020-2030
12.7.2. Single-Use Bioreactors Market for Drug Discovery/Toxicity Testing, 2020-2030
12.7.3 Single-Use Bioreactors Market for Regenerative Medicine/Tissue Engineering, 2020-2030
12.7.4. Single-Use Bioreactors Market for Stem Cell Research, 2020-2030
12.7.5. Single-Use Bioreactors Market for Other Application Areas, 2020-2030
12.8. Global Single-Use Bioreactors Market: Distribution by Scale of Operation
12.8.1. Single-Use Bioreactors Market for Small Scale Operations, 2020-2030
12.8.2. Single-Use Bioreactors Market for Large Scale Operations, 2020-2030
12.9. Global Single-Use Bioreactors Market: Distribution by Purpose
12.9.1. Single-Use Bioreactors Market for Research and Development, 2020-2030
12.9.2. Single-Use Bioreactors Market for Biopharmaceutical Manufacturing, 2020-2030
12.10. Global Single-Use Bioreactors Market: Distribution by End-User
12.10.1. Single-Use Bioreactors Market for Biopharmaceutical/Pharmaceutical Industries, 2020-2030
12.10.2. Single-Use Bioreactors Market for Academic/Research Institutes, 2020-2030
12.11. Global Single-Use Bioreactors Market: Distribution by Key Geographical 
12.11.1. Single-Use Bioreactors Market in North America, 2020-2030
12.11.2 Single-Use Bioreactors Market in Europe, 2020-2030
12.11.3. Single-Use Bioreactors Market in Asia-Pacific, 2020-2030
12.11.4. Single-Use Bioreactors Market in Latin America, 2020-2030
12.11.5. Single-Use Bioreactors Market in Middle East and North Africa (MENA), 2020-2030
12.11.6. Single-Use Bioreactors Market in Rest of the World, 2020-2030
12.12. Concluding Remarks

13.1. Chapter Overview
13.2. Innovations in Bioreactor Display/Control Features
13.2.1. Built-in System Control Sensors
13.2.2. Advanced Alarm Systems
13.2.3. Electronic-Log Records and Touch Screens
13.2.4. Real-Time Tracking and Remote Monitoring
13.3. Innovation in Mixing Technologies
13.4. Concluding Remarks

14.1. Chapter Overview
14.2. Strengths
14.3. Weaknesses
14.4. Opportunities
14.5. Threats
14.6. Comparison of SWOT Factors


16.1. Chapter Overview
16.2. CerCell
16.2.1. Company Snapshot
16.2.2. Interview Transcript: Per Stobbe, CEO, Marketing, Technical Support
16.3. CelVivo 
16.3.1. Company Snapshot
16.3.2. Interview Transcript: Torsten Due Bryld, Chief Commercial Officer




Note: Product cover images may vary from those shown
  • 3Dnamics
  • ABEC
  • ABL Europe
  • Abzena
  • Adello Biologics
  • Advanced Scientifics
  • AdvantaPure
  • Aetos Biologics
  • Alector
  • Applikon Biotechnology
  • Artelis
  • ARTeSYN Biosolutions
  • ATMI LifeSciences
  • Baxter International
  • Bayer Technology Services
  • bbi-biotech
  • Biobrain
  • BioInvent International
  • Biosan
  • Brammer Bio
  • Broadley-James
  • Catalent
  • Celartia
  • Cell Culture Company
  • Cellexus
  • Celltainer Biotech
  • CELLution Biotech
  • CelVivo
  • CerCell
  • CESCO Bioengineering
  • Charter Medical
  • Cobra Biologics
  • Commonwealth Serum Laboratories (CSL)
  • Cytiva
  • Dana-Farber Cancer Institute
  • Danaher
  • Distek
  • EirGenix
  • Emergent BioSolutions
  • Emerson
  • Eppendorf
  • Esco Aster
  • ExcellGene
  • Finesse
  • Freeline
  • G & G Technologies
  • Gallus BioPharmaceuticals
  • G-Con Manufacturing
  • GE Healthcare
  • Getinge
  • Hamilton
  • Hamilton Process Analytics
  • Hyclone Laboratories
  • Hynetic
  • Icahn School of Medicine at Mount Sinai
  • Infors HT
  • INTEGRA Biosciences
  • Integrity CMI
  • Invitrogen
  • Kuhner Shaker
  • Leland Stanford Junior University
  • LevTech Consulting
  • LFB Biomanufacturing
  • Lonza
  • Massachusetts Institute of Technology
  • MedImmune
  • Meissner Filtration Products
  • Merck Millipore
  • Merck Sharp & Dohme
  • NewAge Industries
  • New Brunswick Scientific
  • Nova Biomedical
  • OmniBRx Biotechnologies
  • Pall Corporation
  • Paragon Bioservices
  • Parker Hannifin
  • Passage Bio
  • PBS Biotech
  • PerfuseCell
  • Pierre Guerin
  • Polestar Technologies
  • Precision Biologics
  • Premas Biotech
  • PreSens Precision Sensing
  • Progenitor Cell Therapy
  • ProlifeCell
  • Protalix BioTherapeutics
  • RealBio Technology
  • Refine Technology
  • Rentschler Biopharma
  • Repligen
  • ReproCell
  • RoosterBio
  • Rosemount
  • SAFC Biosciences
  • SaniSure
  • Sarepta Therapeutics
  • Sartorius Stedim Biotech
  • SATAKE MultiMix
  • Scinus Cell Expansion 
  • Siemens 
  • Solaris Biotech
  • Solida Biotech
  • State Key Laboratory of Experimental Hematology
  • Südpack Medica
  • Swiss Federal Institutes of Technology Lausanne (EPFL)
  • Synthecon
  • Tarom Applied Technologies
  • Texas Tech University Health Science Center
  • The Scripps Research Institute
  • The Texas A&M University System
  • The University of Alberta
  • Thermo Fisher Scientific
  • Triumvirate Environmental
  • Univercells
  • University of Brescia
  • University of California
  • University of Colorado Board of Regents
  • University of Florida
  • University of Milan
  • University Of Texas
  • University of Zurich
  • Vanderbilt University
  • Voyager Therapeutics
  • Wake Forest Institute for Regenerative Medicine
  • Wave Biotech
  • Wave Biotech (Based in Switzerland)
  • Whitehead Institute for Biomedical Research
  • WuXi Biologics
  • Xcellerex
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