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Osteonecrosis - Pipeline Insight, 2021

  • ID: 5306343
  • Drug Pipelines
  • March 2021
  • Region: Global
  • 60 pages
  • DelveInsight
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FEATURED COMPANIES

  • Enzo Biochem
  • K-STEMCELL
  • Sclnow Biotechnology
  • Vericel
  • MORE
This “Osteonecrosis - Pipeline Insight, 2021,” report provides comprehensive insights about 6+ companies and 6+ pipeline drugs in Osteonecrosis pipeline landscape. It covers the pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.

Geography Covered
  • Global coverage
Osteonecrosis Understanding

Osteonecrosis: Overview

Osteonecrosis, also known as avascular necrosis (AVN), aseptic necrosis or ischemic bone necrosis, is a disease resulting in the death of bone cells. The amount of disability that results from osteonecrosis depends on what part of the bone is affected, how large an area is involved, how far the disease has progressed. Commonly involved bones are the upper femur (ball part of the hip socket) the lower femur (a part of the knee joint), the upper humerus (upper arm bone involving the shoulder joint), and the bones of ankle joint. There are two general categories of osteonecrosis: traumatic (following an injury) and non-traumatic. Diagnosis of the condition is done through X-rays, and magnetic resonance imaging. Often, treatment starts with pain medications and by limiting weight-bearing (such as walking) on affected areas. This type of conservative treatment may work well for patients with early osteonecrosis in small areas of bone. Patients whose osteonecrosis is getting worse may need a procedure called core decompression. It removes a piece (core) of bone from the affected area, to try to improve blood flow.

"Osteonecrosis - Pipeline Insight, 2021" report outlays comprehensive insights of present scenario and growth prospects across the indication. A detailed picture of the Osteonecrosis pipeline landscape is provided which includes the disease overview and Osteonecrosis treatment guidelines. The assessment part of the report embraces, in depth Osteonecrosis commercial assessment and clinical assessment of the pipeline products under development. In the report, detailed description of the drug is given which includes mechanism of action of the drug, clinical studies, NDA approvals (if any), and product development activities comprising the technology, Osteonecrosis collaborations, licensing, mergers and acquisition, funding, designations and other product related details.

Report Highlights

The companies and academics are working to assess challenges and seek opportunities that could influence Osteonecrosis R&D. The therapies under development are focused on novel approaches to treat/improve Osteonecrosis.

Osteonecrosis Emerging Drugs Chapters

This segment of the Osteonecrosis report encloses its detailed analysis of various drugs in different stages of clinical development, including phase III, II, I, preclinical and Discovery. It also helps to understand clinical trial details, expressive pharmacological action, agreements and collaborations, and the latest news and press releases.

Osteonecrosis Emerging Drugs

Autologous cultured chondrocytes: Vericel

Autologous cultured chondrocytes (MACI) is made up of own (autologous) cells that are expanded and placed onto a film that is implanted into the area of the cartilage damage and absorbed back into your own tissue. MACI is used for the repair of symptomatic cartilage damage of the adult knee. The amount of MACI applied depends on the size of the cartilage damage.

Research programme: small molecule and peptide therapeutics: Enzo Biochem

Enzo Biochem’s research candidate is a small molecule based LDL receptor modulators. When delivered orally, Enzo's candidate compound has shown to prevent alveolar bone loss in an endotoxin-induced periodontitis rat model.

Osteonecrosis: Therapeutic Assessment

This segment of the report provides insights about the different Osteonecrosis drugs segregated based on following parameters that define the scope of the report, such as:

Major Players in Osteonecrosis

There are approx. 6+ key companies which are developing the therapies for Osteonecrosis. The companies which have their Osteonecrosis drug candidates in the most advanced stage, i.e. Phase II include, Vericel.

Phases

This report covers around 6+ products under different phases of clinical development like
  • Late stage products (Phase III)
  • Mid-stage products (Phase II)
  • Early-stage product (Phase I) along with the details of
  • Pre-clinical and Discovery stage candidates
  • Discontinued & Inactive candidates
  • Route of Administration
Osteonecrosis pipeline report provides the therapeutic assessment of the pipeline drugs by the Route of Administration. Products have been categorized under various ROAs such as
  • Oral
  • Parenteral
  • Intravitreal
  • Subretinal
  • Topical
  • Molecule Type
Products have been categorized under various Molecule types such as
  • Monoclonal Antibody
  • Peptides
  • Polymer
  • Small molecule
  • Gene therapy
  • Product Type
The drugs have been categorized under various product types like Mono, Combination and Mono/Combination.

Osteonecrosis: Pipeline Development Activities

The report provides insights into different therapeutic candidates in phase II, I, preclinical and discovery stage. It also analyses Osteonecrosis therapeutic drugs key players involved in developing key drugs.

Pipeline Development Activities

The report covers the detailed information of collaborations, acquisition and merger, licensing along with a thorough therapeutic assessment of emerging Osteonecrosis drugs.

Osteonecrosis Report Insights
  • Osteonecrosis Pipeline Analysis
  • Therapeutic Assessment
  • Unmet Needs
  • Impact of Drugs
Osteonecrosis Report Assessment
  • Pipeline Product Profiles
  • Therapeutic Assessment
  • Pipeline Assessment
  • Inactive drugs assessment
  • Unmet Needs
Key Questions Answered

Current Treatment Scenario and Emerging Therapies:
  • How many companies are developing Osteonecrosis drugs?
  • How many Osteonecrosis drugs are developed by each company?
  • How many emerging drugs are in mid-stage, and late-stage of development for the treatment of Osteonecrosis?
  • What are the key collaborations (Industry-Industry, Industry-Academia), Mergers and acquisitions, licensing activities related to the Osteonecrosis therapeutics?
  • What are the recent trends, drug types and novel technologies developed to overcome the limitation of existing therapies?
  • What are the clinical studies going on for Osteonecrosis and their status?
  • What are the key designations that have been granted to the emerging drugs?
Key Players
  • Enzo Biochem
  • Vericel
  • K-STEMCELL
  • Sclnow Biotechnology
  • Regenerative Arthritis & Bone Medicine Inc
Key Products

Research program: small molecule and peptide therapeutics
  • Autologous cultured chondrocytes
  • Stem cell therapies
  • Umbilical cord-derived allogeneic mesenchymal stem cells therapy
  • RAB-001
Note: Product cover images may vary from those shown
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FEATURED COMPANIES

  • Enzo Biochem
  • K-STEMCELL
  • Sclnow Biotechnology
  • Vericel
  • MORE
Introduction

Executive Summary

Osteonecrosis: Overview
  • Causes
  • Mechanism of Action
  • Signs and Symptoms
  • Diagnosis
  • Disease Management
Pipeline Therapeutics
  • Comparative Analysis
Therapeutic Assessment
  • Assessment by Product Type
  • Assessment by Stage and Product Type
  • Assessment by Route of Administration
  • Assessment by Stage and Route of Administration
  • Assessment by Molecule Type
  • Assessment by Stage and Molecule Type
Osteonecrosis - Analytical Perspective

In-depth Commercial Assessment
  • Osteonecrosis companies’ collaborations, Licensing, Acquisition -Deal Value Trends
Osteonecrosis Collaboration Deals
  • Company-Company Collaborations (Licensing/Partnering) Analysis
  • Company-University Collaborations (Licensing/Partnering) Analysis
Late Stage Products (Phase III)
  • Comparative Analysis
Drug name: Company name
  • Product Description
  • Research and Development
  • Product Development Activities
Mid Stage Products (Phase II)
  • Comparative Analysis
Autologous cultured chondrocytes - Vericel
  • Product Description
  • Research and Development
  • Product Development Activities
Early Stage Products (Phase I)
  • Comparative Analysis
Drug name: Company name
  • Product Description
  • Research and Development
  • Product Development Activities
Preclinical and Discovery Stage Products
  • Comparative Analysis
Research program: small molecule and peptide therapeutics: Enzo Biochem
  • Product Description
  • Research and Development
  • Product Development Activities
Inactive Products
  • Comparative Analysis
Osteonecrosis Key Companies

Osteonecrosis Key Products

Osteonecrosis- Unmet Needs

Osteonecrosis- Market Drivers and Barriers

Osteonecrosis- Future Perspectives and Conclusion

Osteonecrosis Analyst Views

Osteonecrosis Key Companies

Appendix

List of Tables
Table 1 Total Products for Osteonecrosis
Table 2 Late Stage Products
Table 3 Mid Stage Products
Table 4 Early Stage Products
Table 5 Pre-clinical & Discovery Stage Products
Table 6 Assessment by Product Type
Table 7 Assessment by Stage and Product Type
Table 8 Assessment by Route of Administration
Table 9 Assessment by Stage and Route of Administration
Table 10 Assessment by Molecule Type
Table 11 Assessment by Stage and Molecule Type
Table 12 Inactive Products

List of Figures
Figure 1 Total Products for Osteonecrosis
Figure 2 Late Stage Products
Figure 3 Mid Stage Products
Figure 4 Early Stage Products
Figure 5 Preclinical and Discovery Stage Products
Figure 6 Assessment by Product Type
Figure 7 Assessment by Stage and Product Type
Figure 8 Assessment by Route of Administration
Figure 9 Assessment by Stage and Route of Administration
Figure 10 Assessment by Molecule Type
Figure 11 Assessment by Stage and Molecule Type
Figure 12 Inactive Products
Note: Product cover images may vary from those shown
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  • Enzo Biochem
  • Vericel
  • K-STEMCELL
  • Sclnow Biotechnology
  • Regenerative Arthritis & Bone Medicine Inc
Note: Product cover images may vary from those shown
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