Nano-Pharmacokinetics and Theranostics: Advancing Cancer Therapy addresses from a comprehensive and multidisciplinary approach the translational aspects and clinical perspectives of nano-pharmacokinetics using cancer as a model disease. Nano-pharmacokinetics is emerging as an important sub discipline of nanoscience and medical sciences because of the increasing safety issues of nanosystems on living organisms. This book reports the dynamics of nanosystems in living organisms for better understanding of nanotoxicity, pharmacology, biochemistry, physiology and medicine perspectives. It further examines current progress of state-of-the art pharmacokinetics mechanisms, which will be of great help to develop more clinical-oriented nanosystems with a wide safety margin. The book is divided into three sections: the first section focuses on the concept of pharmacokinetics with state-of-the-art Nano-Pharmacokinetics (NPK). The second section looks at the engineering of nanoparticles and pharmacokinetics clinical development. The final section focuses on Nano-Pharmacokinetics and Theranostics, elaborating the basic question of how pharmacokinetics of nanomaterials relate to their end applications such as cancer therapy. Nano-Pharmacokinetics and Theranostics: Advancing Cancer Therapy will be useful to researchers in the field of nanoparticle based targeted drug delivery including pharmaceutical scientists, material scientists, chemists, nanotechnologists, biomedical scientists, and clinicians.
- Includes contributions from highly qualified scientists, regulatory entities, enterprises and medical practitioners?to explain the long and inherently multidisciplinary pathway of nano-pharmacokinetics
- Describes assessment methods of nano-pharmacokinetics
- Examines the interface between nanomedicine and pharmacokinetics to diagnose and treat cancer
Section I: Nano-Pharmacokinetics Current state of the art 1. Introduction 2. Nano-Pharmacokinetics (NPK): Current state of the art 3. Engineered Nanomaterials and Pharmacokinetics
Section II: Nano-Pharmacokinetics Clinical development 4. Nano-Pharmacokinetics: Bio distribution and toxicology 5. Biological systems and Nano-Pharmacokinetics 6. Nano-Pharmacokinetics Assessment
Section III: Nano-Pharmacokinetics and cancer 7. Clinical significance of nanomaterials in cancer treatment 8. Nano-Pharmacokinetics and Theranostics: Co relation 9. Nano-Pharmacokinetics key role in cancer theranostics 10. Nano-Pharmacokinetics key role in in vivo imaging Nano-pharmacokinetics, pharmacodynamics (PK/PD) and clinical relationship 11. Nano-Pharmacokinetics Preclinical to Clinical Translation 12. Current pre-clinical stage of Nano-Pharmacokinetics 13. Advances in Clinical translation of Nano-Pharmacokinetics 14. Future Outlook and Conclusion
Dr. Nanasaheb Thorat is an outstanding Experienced Researcher currently working as a Marie Curie Fellow Research Scientist at the University of Oxford, Medical Science Division. Dr. Thorat is a two-time winner of the World's most prestigious fellowship, i.e. Marie Curie Fellowships and also working as an evaluation panel member of the Marie Curie Fellowships applications, for life and engineering sciences since the year 2019. Dr. Thorat has published 55 peer-reviewed journal research papers and articles, 1 international and European patent filled, 2 European innovations/inventions registered, 5 Books, 10 book chapters, presented 5 Keynote Speech, 20 invited lectures, and 5 oral presentations at prestigious scientific peer-conferences in Singapore, France, Germany, USA, Ireland, Poland, South Korea, and India, received international acclaims and awards for research contribution, generated research fund in excess of > ?750,000, supervised students/junior researchers and actively participated in outreach and scientific dissemination for the service of the wider community. Dr. Thorat is the first Indian awardee of the European Commissions' Innovation Radar "Grand Prix of the Innovation Radar Prize 2020 and many other national and international acclaims on his name. Dr. Thorat is also the winner of other prestigious fellowships including, the Japanese Society for the Promotion of Science (JSPS) Fellowship in Japan (2017), PBC-Outstanding Fellowship, Israel (2016), and also worked as Senior Research Fellow at Samsung Biomedical Research Institute, South Korea (2014-2015). At the University of Oxford, He is working in the Medical Science Division jointly with the Engineering Science Division. His current research work involves designing new light-activated nanomedicine therapy and Raman imaging techniques for brain cancer of pediatric patients.
Dr. Nitesh Kumar, M Pharm, PhD Assistant Professor, Department of Pharmacology and Toxicology, National Institute of Pharmaceutical, Education and Research, Hajipur (NIPER-H), Export Promotions Industrial Park (EPIP), Industrial Area Hajipur, Dist: Vaishali 844102, BIHAR, INDIA. Dr. Kumar has published 61 articles (both research and review papers) in peer reviewed journals, with total citations - 709 and H-index - 16, delivered talks and oral presentations at several scientific conferences and received awards for his research contributions. Dr. Kumar has about 10 years of teaching experience and currently guides and co-guides 12 PhD students on their thesis work. The work in biomedical devices includes biocompatibility and toxicological evaluations of dialysis catridges, tooth implant and electrical stimulator for glioma treatment. In addition to his scientific contributions, Dr. Kumar collaborated with several government agencies and other companies in India and successfully implemented effective projects of high impact value with successful research outcomes as a lead investigator and co-investigator.