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Engineering Technologies and Clinical Translation

  • ID: 5308639
  • Book
  • September 2021
  • 525 Pages
  • Elsevier Science and Technology
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Engineering Technologies and Clinical Translation: Volume 3: Delivery Strategies and Engineering Technologies in Cancer Immunotherapy examines the challenges of delivering immuno-oncology therapies, focusing specifically on the development of solutions for drug delivery and its clinical outcomes. Immuno-oncology (IO) is a growing field of medicine at the interface of immunology and cancer biology leading to development of novel therapeutic approaches, such as chimeric antigen receptor T-cell (CAR-T) and immune checkpoint blockade antibodies, that are clinically approved approaches for cancer therapy. Although currently approved IO approaches have shown tremendous promise for select types of cancers, broad application of IO strategies could even further improve the clinical success, especially for diseases such as pancreatic cancer, brain tumors where the success of IO so far has been limited. This volume of Delivery Strategies and Engineering Technologies in Cancer Immunotherapy discusses biomaterial, microfluidic, and biodegradable devices, engineered microbes, personalized medicine, clinical approval process, and many other IO technologies.

Engineering Technologies and Clinical Translation: Volume 3: Delivery Strategies and Engineering Technologies in Cancer Immunotherapy creates a comprehensive treaty that engages the scientific and medical community who are involved in the challenges of immunology, cancer biology, and therapeutics with possible solutions from the nanotechnology and drug delivery side.

  • Explores engineering technologies and their clinical translation in a comprehensive way
  • Presents forecasting on the future of nanotechnology and drug delivery for IO
  • Engages the scientific and medical community who are involved in the challenges of immunology, cancer biology, and therapeutics with possible solutions from the nanotechnology and drug delivery side
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1. Engineering solutions for generating CAR-T cells 2. Engineered microbes for cancer immunotherapy 3. Biodegradable scaffolds for priming the immune cells 4. Biomaterials and devices for immunotherapy 5. Engineered devices for tumor immune modulation 6. Microfluidic devices for cancer immunotherapy and vaccination 7. Tumor-on-a-chip devices for immunotherapy 8. Engineered 3D models for cancer immunotherapy 9. Opportunities and challenges of using nanotechnology for cancer immunotherapy 10. Stromal modulation to improve immunotherapy response in cancer 11. Mapping the tumor immune microenvironment 12. Personalized cancer immunotherapy 13. Image-guided cancer immunotherapy 14. Clinical approval process and challenges for cancer immunotherapies

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Amiji, Mansoor M.
Mansoor M. Amiji is the Distinguished Professor and Chairman of the Department of Pharmaceutical Sciences at the Bouvé College of Health Sciences at Northeastern University. Dr. Amiji has edited a number of books and is a frequently published author. His research focuses on the synthesis of novel polymeric materials for medical and pharmaceutical applications, drug delivery systems and nanomedical technologies, and his contributions in research advising, grant reviews for various organizations and editorial work for journals are invaluable.
Milane, Lara Scheherazade
Dr. Lara Milane is Assistant Teaching Professor in Biotechnology at the Bouvé College of Health Sciences at Northeastern University. She is interested in Mitochondrial Medicine. She is working on developing nanomedicines for a range of diseases (cancer, neurodegenerative disease, aging) that manipulate mitochondria for therapeutic outcomes. Dr. Milane was trained as a National Cancer Institute/ National Science Foundation Nanomedicine Fellow at Northeastern University, Boston, MA. Dr. Milane is an intuitive cancer biologist with research interests in developing translational nanomedicines that exploit the hallmarks of cancer.
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