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Potassium channel antagonists - Pipeline Insight, 2022

  • ID: 5310596
  • Clinical Trials
  • January 2022
  • Region: Global
  • 60 Pages
  • DelveInsight

FEATURED COMPANIES

  • 4SC
  • Bayer
  • Boston Pharmaceuticals
  • Catalyst pharma
  • Pierre Fabre
  • selection
This “Potassium channel antagonists - Pipeline Insight, 2022” report provides comprehensive insights about 10+ companies and 10+ pipeline drugs in Potassium channel antagonists pipeline landscape. It covers the pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.

Geography Covered

  • Global coverage

Potassium channel antagonists Understanding

Potassium channel antagonists: Overview


Potassium channel blockers are agents which interfere with conduction through potassium channels. Potassium is the chief ion in the repolarization. At the end of depolarization, potassium efflux occurs following the opening of the potassium channels. This group of drugs binds to the channel which is responsible for the potassium movement and blocks it. Once the blocking has happened, the refractory period increases.

Function - Potassium-channel blockers comprise the Class III antiarrhythmic compounds according to the Vaughan-Williams classification scheme. These drugs bind to and block the potassium channels that are responsible for phase 3 repolarization. Therefore, blocking these channels slows (delays) repolarization, which leads to an increase in action potential duration and an increase in the effective refractory period (ERP).

Potassium channel antagonists - Potassium Channel antagonist act by inhibition of potassium efflux through cell membranes. Blockade of potassium channels prolongs the duration of Action potentials. They are used as Anti-Arrhythmia agents and Vasodilator agents.

Potassium channel antagonists Emerging Drugs Chapters


This segment of the Potassium channel antagonists report encloses its detailed analysis of various drugs in different stages of clinical development, including phase III, II, I, preclinical and Discovery. It also helps to understand clinical trial details, expressive pharmacological action, agreements and collaborations, and the latest news and press releases.

Potassium channel antagonists Emerging Drugs

Amifampridine: BioMarin

Amifampridine (Firdapse) is an orally administered potassium channel antagonist and acetylcholine release stimulant that has been developed by BioMarin. It is being studied in Phase III clinical trials for Myasthenia gravis. The drug has also received orphan drug designation for Myasthenia gravis, Lambert-Eaton myasthenic syndrome; Congenital myasthenic syndromes.

Sleep apnoea therapeutic: Bayer

Sleep apnoea therapeutic is a potassium channel antagonists, currently being studied in Phase II stage of development for the treatment of patients with Sleep apnoea syndrome.

Potassium channel antagonists: Therapeutic Assessment


This segment of the report provides insights about the different Potassium channel antagonists drugs segregated based on following parameters that define the scope of the report.

Major Players working on Potassium channel antagonists


There are approx. 10+ key companies which are developing the Potassium channel antagonists. The companies which have their Potassium channel antagonists drug candidates in the most advanced stage, i.e. Phase III include, BioMarin.

Phases


This report covers around 10+ products under different phases of clinical development like

  • Late-stage products (Phase III )
  • Mid-stage products (Phase II )
  • Early-stage products (Phase I/II and Phase I) along with the details of
  • Pre-clinical and Discovery stage candidates
  • Discontinued & Inactive candidates
  • Route of Administration

Potassium channel antagonists pipeline report provides the therapeutic assessment of the pipeline drugs by the Route of Administration. Products have been categorized under various ROAs such as

  • Infusion
  • Intradermal
  • Intramuscular
  • Oral
  • Parenteral
  • Subcutaneous
  • Topical.
  • Molecule Type

Products have been categorized under various Molecule types such as

  • Vaccines
  • Monoclonal Antibody
  • Peptides
  • Polymer
  • Small molecule
  • Product Type

The drugs have been categorized under various product types like Mono, Combination and Mono/Combination.

Potassium channel antagonists: Pipeline Development Activities

The report provides insights into different therapeutic candidates in phase II, I, preclinical and discovery stage. It also analyses Potassium channel antagonists therapeutic drugs key players involved in developing key drugs.

Pipeline Development Activities

The report covers the detailed information of collaborations, acquisition and merger, licensing along with a thorough therapeutic assessment of emerging Potassium channel antagonists drugs.

Report Highlights
  • The companies and academics are working to assess challenges and seek opportunities that could influence Potassium channel antagonists R&D. The therapies under development are focused on novel approaches for Potassium channel antagonists.

Potassium channel antagonists Report Insights

  • Potassium channel antagonists Pipeline Analysis
  • Therapeutic Assessment
  • Unmet Needs
  • Impact of Drugs

Potassium channel antagonists Report Assessment

  • Pipeline Product Profiles
  • Therapeutic Assessment
  • Pipeline Assessment
  • Inactive drugs assessment
  • Unmet Needs

Key Questions


Current Scenario and Emerging Therapies:

  • How many companies are developing Potassium channel antagonists drugs?
  • How many Potassium channel antagonists drugs are developed by each company?
  • How many emerging drugs are in mid-stage, and late-stage of development for Potassium channel antagonists?
  • What are the key collaborations (Industry-Industry, Industry-Academia), Mergers and acquisitions, licensing activities related to the Potassium channel antagonists therapeutics?
  • What are the recent trends, drug types and novel technologies developed to overcome the limitation of existing therapies?
  • What are the clinical studies going on for Potassium channel antagonists and their status?
  • What are the key designations that have been granted to the emerging drugs?
Note: Product cover images may vary from those shown

FEATURED COMPANIES

  • 4SC
  • Bayer
  • Boston Pharmaceuticals
  • Catalyst pharma
  • Pierre Fabre
  • selection

IntroductionExecutive Summary
Potassium channel antagonists: Overview
  • Structure
  • Mechanism of Action

Pipeline Therapeutics
  • Comparative Analysis

Therapeutic Assessment
  • Assessment by Product Type
  • Assessment by Stage and Product Type
  • Assessment by Route of Administration
  • Assessment by Stage and Route of Administration
  • Assessment by Molecule Type
  • Assessment by Stage and Molecule Type

Potassium channel antagonists - Analytical Perspective
In-depth Commercial Assessment
  • Potassium channel antagonists companies’ collaborations, Licensing, Acquisition -Deal Value Trends

Potassium channel antagonists Collaboration Deals
  • Company-Company Collaborations (Licensing / Partnering) Analysis
  • Company-University Collaborations (Licensing / Partnering) Analysis

Late Stage Products (Phase III)
  • Comparative Analysis

Amifampridine: BioMarin
  • Product Description
  • Research and Development
  • Product Development Activities

Mid Stage Products (Phase II)
  • Comparative Analysis

Sleep apnoea therapeutic: Bayer
  • Product Description
  • Research and Development

Pre-clinical and Discovery Stage Products
  • Comparative Analysis

Research programme Kv1.3 potassium channel inhibitors: 4SC
  • Product Description
  • Research and Development
  • Product Development Activities

Inactive Products
  • Comparative Analysis

Potassium channel antagonists Key CompaniesPotassium channel antagonists Key ProductsPotassium channel antagonists- Unmet NeedsPotassium channel antagonists- Market Drivers and BarriersPotassium channel antagonists- Future Perspectives and ConclusionPotassium channel antagonists Analyst ViewsPotassium channel antagonists Key CompaniesAppendix
List of Tables
Table 1 Total Products for Potassium channel antagonists
Table 2 Late Stage Products
Table 3 Mid Stage Products
Table 4 Early Stage Products
Table 5 Pre-clinical & Discovery Stage Products
Table 6 Assessment by Product Type
Table 7 Assessment by Stage and Product Type
Table 8 Assessment by Route of Administration
Table 9 Assessment by Stage and Route of Administration
Table 10 Assessment by Molecule Type
Table 11 Assessment by Stage and Molecule Type
Table 12 Inactive Products
List of Figures
Figure 1 Total Products for Potassium channel antagonists
Figure 2 Late Stage Products
Figure 3 Mid Stage Products
Figure 4 Early Stage Products
Figure 5 Preclinical and Discovery Stage Products
Figure 6 Assessment by Product Type
Figure 7 Assessment by Stage and Product Type
Figure 8 Assessment by Route of Administration
Figure 9 Assessment by Stage and Route of Administration
Figure 10 Assessment by Molecule Type
Figure 11 Assessment by Stage and Molecule Type
Figure 12 Inactive Products
Note: Product cover images may vary from those shown

A selection of companies mentioned in this report includes:

  • Bayer
  • 4SC
  • selection
  • Boston Pharmaceuticals
  • Pierre Fabre
  • Catalyst pharma
Note: Product cover images may vary from those shown