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Sepsis - Epidemiology Forecast to 2030

  • ID: 5322340
  • Report
  • May 2021
  • Region: Global
  • 108 pages
  • DelveInsight
This ‘Sepsis - Epidemiology Forecast-2030' report delivers an in-depth understanding of the Sepsis , historical and forecasted epidemiology as well as the Sepsis trends in the United States, EU5 (Germany, France, Italy, Spain, and the United Kingdom) and Japan.

Sepsis Disease Understanding

As per the Sepsis Alliance, Sepsis is the body's overwhelming and life-threatening response to infection that can lead to tissue damage, organ failure, and death.

In the past, septicemia, blood poisoning, and other vague terminology, meaning different things to different people, were used frequently, hampering attempts to identify septic patients properly. In 1991, a consensus conference developed definitions of Sepsis that linked infection with a systemic inflammatory response - the systemic inflammatory response syndrome (SIRS) - which was defined using simple clinical and laboratory parameters. Although Sepsis detection was challenging, the definition of SIRS was rather unspecific since similar inflammatory responses were seen as part of the physiological response to noninfectious insults, such as surgery and pancreatitis. Besides, the SIRS criteria performed poorly in identifying patients who required critical care and who had significant morbidity and mortality.

These issues led to a recent new consensus definition for Sepsis and Septic shock. This international task force defined Sepsis as ‘life-threatening organ dysfunction caused by a dysregulated host response to infection.' The United States has not adopted these definitions since they have not been tested prospectively. All of the research and improvement in mortality has been based on utilization of the SEP-2 definitions that have been used since 1992 (in all of the clinical research as well as in clinical practice) and its associated screening and early management bundles. One of the greatest concerns is that waiting till the organ dysfunction before intervening makes it harder to treat and more likely to have poor outcomes.

Sepsis Epidemiology Perspective

The disease epidemiology covered in the report provides historical as well as forecasted epidemiology segmented by Total Incident Cases of Sepsis, Gender-Specific Incident Cases of Sepsis, Severity-Specific Incident Cases of Sepsis, Origin-Specific Incident Cases of Sepsis scenario in the 7MM covering the United States, EU5 countries (Germany, France, Italy, Spain, and the United Kingdom) and Japan from 2018 to 2030.

Sepsis Detailed Epidemiology Segmentation
  • In 2020, the total estimated Incident Cases of Sepsis were 3,400,940 cases in the 7MM, which is expected to increase in the forecast period.
  • US is the major contributor (55.01%, in 2020) to the incident population of Sepsis in the 7MM, with 1,870,897 cases.
  • Out of EU5 countries, Germany had the highest incident cases in 2020 followed by the UK and Spain. France accounted for the least number of cases in 2020.
  • Assessments indicate that lung infection, UTI infection, gut infection, and skin infection are the leading four infection sites in patients with Sepsis, accounting for 35%, 25%, 11%, and 11% of all sites of infection, respectively in the United States in 2020. In 2020, there were 654,814, 467,724, 205,799, and 205,799 Sepsis cases due to lung infection followed by UTI, gut infection, and skin infection in the US.
  • In 2020, there were 1,066,411 cases of Sepsis without organ dysfunction followed by severe Sepsis and septic shock, accounting for 18.4% and 24.6% of the total cases respectively in the US.
“From several epidemiology studies, it was observed that the disease is more common in males as compared to females, but this trend is opposite in the US. In EU, and Japan, 50-65% of sepsis cases are contributed by males, and 35-50% of the cases are contributed by females. But in the US, around 49% of the cases are of males, and 51% are of females. Additionally, There are several infections that lead to sepsis, but it has been seen that lung infection, UTI infection, gut infection, and skin infection were the leading four infection sites in patients with sepsis.”

Scope of the Report
  • The report covers the descriptive overview of Sepsis, explaining its causes, symptoms, pathophysiology, and genetic basis.
  • The report provides insight into the 7MM historical and forecasted patient pool covering the United States, EU5 countries (Germany, France, Italy, Spain, and the United Kingdom), and Japan.
  • The report assesses the disease risk and burden and highlights the unmet needs of Sepsis.
  • The report helps to recognize the growth opportunities in the 7MM with respect to the patient population.
  • The report provides the segmentation of the disease epidemiology for 7MM by Total Incident Cases of Sepsis, Gender-specific Incident Cases of Sepsis, Severity-specific Incident Cases of Sepsis, Origin-specific Incident Cases of Sepsis.
Report Highlights
  • 10-Year Forecast of Sepsis
  • 7MM Coverage
  • Total Incident Cases of Sepsis
  • Male and Female Cases of Sepsis
  • Sepsis Patients among different age groups
Key Questions Answered
  • What are the disease risk, and burden of Sepsis ?
  • What is the historical Sepsis patient pool in the United States, EU5 (Germany, France, Italy, Spain, and the UK), and Japan?
  • What would be the forecasted patient pool of Sepsis at the 7MM level?
  • What will be the growth opportunities across the 7MM with respect to the patient population pertaining to Sepsis ?
  • Out of the above-mentioned countries, which country would have the highest incident population of Sepsis during the forecast period (2021-2030)?
  • At what CAGR the population is expected to grow across the 7MM during the forecast period (2021-2030)?
Reasons to Buy

The Sepsis report will allow the user to -
  • Develop business strategies by understanding the trends shaping and driving the 7MM Sepsis epidemiology forecast.
  • The Sepsis epidemiology report and model were written and developed by Masters and Ph.D. level epidemiologists.
  • The Sepsis epidemiology model developed by the publisher is easy to navigate, interactive with dashboards, and epidemiology based on transparent and consistent methodologies. Moreover, the model supports data presented in the report and showcases disease trends over the 10-year forecast period using reputable sources.
Key Assessments
  • Patient Segmentation
  • Disease Risk and Burden
  • Risk of disease by the segmentation
  • Factors driving growth in a specific patient population
Geographies Covered
  • The United States
  • EU5 (Germany, France, Italy, Spain, and the United Kingdom)
  • Japan
Study Period: 2018-2030
Note: Product cover images may vary from those shown
1 Key Insights

2 Report Introduction

3 Executive Summary of Sepsis

4 Disease Background and Overview
4.1 Introduction
4.2 Causes and Risk Factors
4.3 Symptoms of Sepsis
4.4 Pathogenesis of Sepsis
4.5 Biomarkers of Sepsis
4.6 Diagnosis of Sepsis
4.6.1 Diagnostic algorithm of Sepsis
4.6.1.1 Diagnostic algorithm of Sepsis in children
4.6.1.2 Diagnostic algorithm of Sepsis
4.6.2 Diagnostic Guidelines of Sepsis
4.6.2.1 Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016
4.6.2.2 The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock

5 Epidemiology and Patient Population
5.1 Assumptions and rationale
5.2 Key Findings
5.3 Methodology of Epidemiology
5.4 Total Incident Cases of Sepsis in the 7MM
5.5 The United States
5.5.1 Incident Cases of Sepsis in the US
5.5.2 Gender-specific Incident Cases of Sepsis in the US
5.5.3 Severity-specific Incident Cases of Sepsis in the US
5.5.4 Origin-specific Incident Cases of Sepsis in the US
5.6 EU5
5.6.1 Germany
5.6.1.1 Incident Cases of Sepsis in Germany
5.6.1.2 Gender-specific Incident Cases of Sepsis in Germany
5.6.1.3 Severity-specific Incident Cases of Sepsis in Germany
5.6.1.4 Origin-specific Incident Cases of Sepsis in Germany
5.6.2 France
5.6.2.1 Incident Cases of Sepsis in France
5.6.2.2 Gender-specific Incident Cases of Sepsis in France
5.6.2.3 Severity-specific Incident Cases of Sepsis in France
5.6.2.4 Origin-specific Incident Cases of Sepsis in France
5.6.3 Italy
5.6.3.1 Incident Cases of Sepsis in Italy
5.6.3.2 Gender-specific Incident Cases of Sepsis in Italy
5.6.3.3 Severity-specific Incident Cases of Sepsis in Italy
5.6.3.4 Origin-specific Incident Cases of Sepsis in Italy
5.6.4 Spain
5.6.4.1 Incident Cases of Sepsis in Spain
5.6.4.2 Gender-specific Incident Cases of Sepsis in Spain
5.6.4.3 Severity-specific Incident Cases of Sepsis in Spain
5.6.4.4 Origin-specific Incident Cases of Sepsis in Spain
5.6.5 The United Kingdom
5.6.5.1 Incident Cases of Sepsis in the United Kingdom
5.6.5.2 Gender-specific Incident Cases of Sepsis in the United Kingdom
5.6.5.3 Severity-specific Incident Cases of Sepsis in the United Kingdom
5.6.5.4 Origin-specific Incident Cases of Sepsis in the United Kingdom
5.7 Japan
5.7.1 Incident Cases of Sepsis in Japan
5.7.2 Gender-specific Incident Cases of Sepsis in Japan
5.7.3 Severity-specific Incident Cases of Sepsis in Japan
5.7.4 Origin-specific Incident Cases of Sepsis in Japan

6 Patient Journey

7 Appendix
7.1 Report Methodology

8 Publisher Capabilities

9 Disclaimer

10 About the Publisher

List of Tables
Table 1: Summary of Sepsis Epidemiology (2018–2030)
Table 2: General recommendations and levels of evidence
Table 3: Recommendations for the diagnosis of Sepsis and Sepsis shock
Table 4: Total Incident Cases of Sepsis in the 7MM (2018–2030)
Table 5: Incident Cases of Sepsis in the United States (2018–2030)
Table 6: Gender-specific Incident Cases of Sepsis in the United States (2018–2030)
Table 7: Severity-specific Incident Cases of Sepsis in the United States (2018–2030)
Table 8: Origin-specific Incident Cases of Sepsis in the United States (2018–2030)
Table 9: Incident Cases of Sepsis in Germany (2018–2030)
Table 10: Gender-specific Incident Cases of Sepsis in Germany (2018–2030)
Table 11: Severity-specific Incident Cases of Sepsis in Germany (2018–2030)
Table 12: Origin-specific Incident Cases of Sepsis in Germany (2018–2030)
Table 13: Incident Cases of Sepsis in France (2018–2030)
Table 14: Gender-specific Incident Cases of Sepsis in France (2018–2030)
Table 15: Severity-specific Incident Cases of Sepsis in France (2018–2030)
Table 16: Origin-specific Incident Cases of Sepsis in France (2018–2030)
Table 17: Incident Cases of Sepsis in Italy (2018–2030)
Table 18: Gender-specific Incident Cases of Sepsis in Italy (2018–2030)
Table 19: Severity-specific Incident Cases of Sepsis in Italy (2018–2030)
Table 20: Origin-specific Incident Cases of Sepsis in Italy (2018–2030)
Table 21: Incident Cases of Sepsis in Spain (2018–2030)
Table 22: Gender-specific Incident Cases of Sepsis in Spain (2018–2030)
Table 23: Severity-specific Incident Cases of Sepsis in Spain (2018–2030)
Table 24: Origin-specific Incident Cases of Sepsis in Spain (2018–2030)
Table 25: Incident Cases of Sepsis in the United Kingdom (2018–2030)
Table 26: Gender-specific Incident Cases of Sepsis in the United Kingdom (2018–2030)
Table 27: Severity-specific Incident Cases of Sepsis in the United Kingdom (2018–2030)
Table 28: Origin-specific Incident Cases of Sepsis in the United Kingdom (2018–2030)
Table 29: Incident Cases of Sepsis in Japan (2018–2030)
Table 30: Gender-specific Incident Cases of Sepsis in Japan (2018–2030)
Table 31: Severity-specific Incident Cases of Sepsis in Japan (2018–2030)
Table 32: Origin-specific Incident Cases of Sepsis in Japan (2018–2030)

List of Figures
Figure 1: Disease Continuum
Figure 2: Development of Sepsis
Figure 3: Symptoms of adult Sepsis
Figure 4: Symptoms of Sepsis in children
Figure 5: Pathophysiological changes of Sepsis and how these combine to produce multiorgan failure
Figure 6: Initial resuscitation algorithm for children
Figure 7: Diagnostic algorithm for the management of a patient with Sepsis in internal medicine wards
Figure 8: Total Incident Cases of Sepsis in the 7MM (2018–2030)
Figure 9: Incident Cases of Sepsis in the United States (2018–2030)
Figure 10: Gender-specific Incident Cases of Sepsis in the United States (2018–2030)
Figure 11: Severity-specific Incident Cases of Sepsis in the United States (2018–2030)
Figure 12: Origin-specific Incident Cases of Sepsis in the United States (2018–2030)
Figure 13: Incident Cases of Sepsis in Germany (2018–2030)
Figure 14: Gender-specific Incident Cases of Sepsis in Germany (2018–2030)
Figure 15: Severity-specific Incident Cases of Sepsis in Germany (2018–2030)
Figure 16: Origin-specific Incident Cases of Sepsis in Germany (2018–2030)
Figure 17: Incident Cases of Sepsis in France (2018–2030)
Figure 18: Gender-specific Incident Cases of Sepsis in France (2018–2030)
Figure 19: Severity-specific Incident Cases of Sepsis in France (2018–2030)
Figure 20: Origin-specific Incident Cases of Sepsis in France (2018–2030)
Figure 21: Incident Cases of Sepsis in Italy (2018–2030)
Figure 22: Gender-specific Incident Cases of Sepsis in Italy (2018–2030)
Figure 23: Severity-specific Incident Cases of Sepsis in Italy (2018–2030)
Figure 24: Origin-specific Incident Cases of Sepsis in Italy (2018–2030)
Figure 25: Incident Cases of Sepsis in Spain (2018–2030)
Figure 26: Gender-specific Incident Cases of Sepsis in Spain (2018–2030)
Figure 27: Severity-specific Incident Cases of Sepsis in Spain (2018–2030)
Figure 28: Origin-specific Incident Cases of Sepsis in Spain (2018–2030)
Figure 29: Incident Cases of Sepsis in the United Kingdom (2018–2030)
Figure 30: Gender-specific Incident Cases of Sepsis in the United Kingdom (2018–2030)
Figure 31: Severity-specific Incident Cases of Sepsis in the United Kingdom (2018–2030)
Figure 32: Origin-specific Incident Cases of Sepsis in the United Kingdom (2018–2030)
Figure 33: Incident Cases of Sepsis in Japan (2018–2030)
Figure 34: Gender-specific Incident Cases of Sepsis in Japan (2018–2030)
Figure 35: Severity-specific Incident Cases of Sepsis in Japan (2018–2030)
Figure 36: Origin-specific Incident Cases of Sepsis in Japan (2018–2030)
Figure 37: Patient Journey
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