Principles and Technologies for Electromagnetic Energy Based Therapies

Table of Contents

Section 1: Introduction and Theoretical Foundations 1. History, development and application of electromagnetic fields in medicine 2. Biophysical principles of electromagnetic field interactions with biological tissues 3. Computational methods for the modeling of electromagnetic fields in biological tissues 3a. Low frequency, electrical spectrum (pulsed electric fields, TTF, RF) 3b. High frequency, electromagnetic spectrum (MW) 4. Thermal effects of electromagnetic fields 5. Tissue property determinants of electromagnetic therapies

Section 2: Pulsed Electric Fields 6. Introduction to PEF therapy and its applications 7. Working principles of PEF therapy 8. Instrumentation for PEF therapy 9. In vitro and in vivo testing of PEF therapy 10. Clinical application of PEF: Oncology 11. Clinical application of PEF: Other

Section 3: Radiofrequency Energy 12. Introduction to RF energy and its applications 13. Working principles of RF therapy 14. Instrumentation for RF therapy 15. In vitro and in vivo testing of RF therapy 16. Clinical application of PEF: Oncology 17. Clinical application of PEF: Other

Section 3: Tumor Treating Fields 18. Introduction to TTF and its applications 19. Working principles of TTF therapy 20. Instrumentation for TTF therapy 21. In vitro and in vivo testing of TTF therapy 22. Clinical application of TTF: Oncology

Section 4: Microwave Energy 23. Introduction to MW energy and its applications 24. Working principles of MW therapy 25. Instrumentation for MW therapy 26. In vitro and in vivo testing of MW therapy 27. Clinical application of MW: Oncology 28. Clinical application of MW: Other

Section 5: Non-Ablative Applications 29. Brain stimulation 30. Peripheral nerve stimulation 31. Cardiac pacemaker and defibrillators 32. Pain control 33. Emerging topics

Section 6: Development and Translation 34. Regulatory and approvals 35. Preclinical testing 36. Clinical trials and design 37 IP protection 38. Case study 1 39. Case study 2

Authors

Punit Prakash Associate Professor, Kansas State University, Manhattan, USA. Dr. Prakash is Associate Professor and holder of the Paul L. Spainhour Professorship in Electrical Engineering at Kansas State University. He received a Bachelor of Science in Electrical and Computer Engineering from Worcester Polytechnic Institute in May 2004, and a PhD in biomedical engineering from the University of WisconsinMadison in 2008. He completed postdoctoral training in hyperthermia physics at the University of California, San Francisco. Since 2012, he has been with the Department of Electrical and Computer Engineering at Kansas State University, where he is also an affiliate of the Johnson Center for Cancer Research. Dr. Prakash's research is focused on developing technologies for enabling precise image-guided medical interventions. Current research thrusts include: (i) development of minimally-invasive microwave/radiofrequency devices with spatial control of energy delivery for thermal tissue ablation; (ii) multiphysics and multiscale computational modeling for analysis of thermal therapies; and (iii) integration of medical instrumentation with high-field MRI for characterization of therapeutic interventions in small-animal experimental models. His research is currently supported by grants from the National Institutes for Health (NIH), National Science Foundation (NSF), and the medical device industry. Govindarajan Srimathveeravalli University of Massachusetts Amherst, Amherst, USA.. Dr. Srimathveeravalli joined University of Massachusetts at Amherst in Spring 2019 after serving as a faculty in the Dept. of Radiology at Memorial Sloan Kettering Cancer Center for six years. His lab develops medical devices and technology to advance minimally invasive, image-guided therapy of cancer, and non-malignant diseases. His lab studies the interaction between non-ionizing energy and tissue biology, with emphasis on the differential response of various components of the tumor microenvironment to energy delivery. He uses computer based simulation models and mathematical models to optimize energy parameters and to guide applicator design for energy delivery in vitro and in vivo. His lab seeks to identify and understand signaling pathways evoked due to energy delivery and tests adjuvants to improve treatment outcomes. Findings from his lab has applications in tumor ablation, cancer immunotherapy, drug delivery and tissue engineering, with near-term translational potential. Dr. Srimathveeravalli got his PhD in mechanical engineering from the University at Buffalo and received postdoctoral training on cancer research and image-guided therapy at Memorial Sloan Kettering Cancer Center. His lab is supported by grants from the NIH, the Society of Interventional Radiology, Dept of Defense, industrial contracts, and various philanthropic foundations.