Principles and Technologies for Electromagnetic Energy Based Therapies covers the theoretical foundations of electromagnetic-energy based therapies, principles for design of practical devices and systems, techniques for in vitro and in vivo testing of devices, and clinical application examples of contemporary therapies employing non-ionizing electromagnetic energy. The book provides in-depth coverage of: pulsed electric fields, radiofrequency heating systems, tumor treating fields, and microwave heating technology. Devices and systems for electrical stimulation of neural and cardiac issue are covered as well. Lastly, the book describes and discusses issues that are relevant to engineers who develop and translate these technologies to clinical applications.
Readers can access information on incorporation of preclinical testing, clinical studies and IP protection in this book, along with in-depth technical background for engineers on electromagnetic phenomena within the human body and selected therapies. It covers both engineering and biological/medical materials and gives a full perspective on electromagnetics therapies. Unique features include content on tumor treating fields and the development and translation of biomedical devices.
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Table of Contents
Section 1: Introduction and Theoretical Foundations 1. History, development and application of electromagnetic fields in medicine 2. Biophysical principles of electromagnetic field interactions with biological tissues 3. Computational methods for the modeling of electromagnetic fields in biological tissues 3a. Low frequency, electrical spectrum (pulsed electric fields, TTF, RF) 3b. High frequency, electromagnetic spectrum (MW) 4. Thermal effects of electromagnetic fields 5. Tissue property determinants of electromagnetic therapies
Section 2: Pulsed Electric Fields 6. Introduction to PEF therapy and its applications 7. Working principles of PEF therapy 8. Instrumentation for PEF therapy 9. In vitro and in vivo testing of PEF therapy 10. Clinical application of PEF: Oncology 11. Clinical application of PEF: Other
Section 3: Radiofrequency Energy 12. Introduction to RF energy and its applications 13. Working principles of RF therapy 14. Instrumentation for RF therapy 15. In vitro and in vivo testing of RF therapy 16. Clinical application of PEF: Oncology 17. Clinical application of PEF: Other
Section 3: Tumor Treating Fields 18. Introduction to TTF and its applications 19. Working principles of TTF therapy 20. Instrumentation for TTF therapy 21. In vitro and in vivo testing of TTF therapy 22. Clinical application of TTF: Oncology
Section 4: Microwave Energy 23. Introduction to MW energy and its applications 24. Working principles of MW therapy 25. Instrumentation for MW therapy 26. In vitro and in vivo testing of MW therapy 27. Clinical application of MW: Oncology 28. Clinical application of MW: Other
Section 5: Non-Ablative Applications 29. Brain stimulation 30. Peripheral nerve stimulation 31. Cardiac pacemaker and defibrillators 32. Pain control 33. Emerging topics
Section 6: Development and Translation 34. Regulatory and approvals 35. Preclinical testing 36. Clinical trials and design 37 IP protection 38. Case study 1 39. Case study 2