The Coronavirus disease 2019 (COVID-19) outbreak has spread throughout the globe and much time has passed since it was declared as a pandemic by the World Health Organization (WHO). COVID-19: Diagnosis and Management provides clinicians and scholars all the information on this disease in 2 volumes. Readers will find a concise and visual reference for this viral disease and will be equipped with the knowledge to assess and manage Sar-Cov-2 infection cases in clinical settings.
This book is divided into two parts (I and II). Part I provides comprehensive information about 1) History of Coronaviruses, 2) Epidemiology of COVID-19, 3) Clinical presentation of this viral disease and 4) COVID-19 diagnosis. Part II covers broader topics about this communicable disease including 1) the prevention and treatment methodology, 2) mortality and long-term complications, 3) COVID-19 vaccines and future perspectives.
Key Features:
This book is an essential textbook reference for medical students, scientists (virologists, pulmonologists) and public health officials who are required to understand COVDI-19 diagnosis and management as part of their clinical training or professional work.
This book is divided into two parts (I and II). Part I provides comprehensive information about 1) History of Coronaviruses, 2) Epidemiology of COVID-19, 3) Clinical presentation of this viral disease and 4) COVID-19 diagnosis. Part II covers broader topics about this communicable disease including 1) the prevention and treatment methodology, 2) mortality and long-term complications, 3) COVID-19 vaccines and future perspectives.
Key Features:
- Covers all the aspects of COVID-19 making this a perfect textbook for virology and medical students
- Chapter wise description and segregation of topics from pathophysiology to diagnosis and management of COVID-19.
- Six chapters in the first part which focus on clinical basics of COVID-19.
- Six chapters in the second part which cover broader topics for practical infection control.
- Multiple tables and figures which summarize and highlight important points.
- Presents a summary of the current standards for the evaluation and diagnosis of COVID-19.
- Features a detailed list of references, abbreviations, and symbols.
This book is an essential textbook reference for medical students, scientists (virologists, pulmonologists) and public health officials who are required to understand COVDI-19 diagnosis and management as part of their clinical training or professional work.
Table of Contents
Chapter 1 History of Pandemics- Introduction
- The Athenian Plague
- Plague of Justinian
- The Black Death
- Spanish Flu
- Aids
- Smallpox
- Sars
- Swine Flu or H1N1 Pandemic
- Ebola
- COVID-19
- Origin of Coronavirus
- Types of Coronaviruses
- Disease Associated with Coronaviruses
- Murine Hepatitis Virus (Mhv)
- Central Nervous System
- Hepatitis
- Pneumonitis
- Bovine Coronavirus
- Human Coronavirus
- Abbreviations
- Consent for Publication
- Conflict of Interest
- Acknowledgements
- References
Chapter 2 Introduction to COVID-19
- Introduction
- Genomic Structure of Coronavirus
- Structural Proteins
- Spike Protein
- Small Membrane Protein
- Membrane Protein
- Hemagglutinin-Esterase
- Nucleocapsid and Internal Proteins
- Replicase Protein
- Viral Cycle
- Outbreaks of Coronavirus
- Porcine Coronavirus
- Avian Coronavirus
- Feline Coronavirus
- Bovine Coronavirus
- Sunishtha, Govind Singh and Sanju Nanda
- Hitesh Malhotra, Anjoo Kamboj and Peeyush Kaushik
- Murine Coronavirus
- Human Coronavirus
- Sars-Cov
- Mers-Cov
- COVID-19
- Introduction
- Chronology of COVID-19
- Symptoms
- Transmission
- Treatment
- List of Abbreviations
- Consent for Publication
- Conflict of Interest
- Acknowledgements
- References
Chapter 3 COVID-19: Epidemiology
- Introduction
- Geographical Distribution
- Global Epidemiology of COVID-19
- Effect of Age, Sex and Other Factors on COVID-19-Related Deaths
- COVID-19 Case Comparisons in Different Region of World (World
- Health Organization, 2020)
- COVID-19 in India
- Report by Icmr on COVID-19 About Containment Zone in India
- National Responses on COVID-19 Worldwide
- Asia
- China
- South Korea
- Middle Eastern
- Iran
- Europe
- Spain
- France
- North America
- United States
- South America
- Africa
- Oceania
- Effect of Lockdown on COVID-19 Cases in Top Ten Most Affected
- Countries of World
- The Role of Who and Ingos for Providing Data in COVID-19
- Outcomes from Some Published Reports on COVID-19 Epidemiology 74
- Herd Immunity-COVID-19
- Conclusion
- List of Abbreviations
- Consent for Publication
- Conflict of Interest
- Acknowledgements
- Kamya Goyal, Shammy Jindal, Tarun Kumar, Jugnu Goyal, Reena Sharma,
- Ravinder Singh and Samir Mehndiratta
- References
Chapter 4 Pathophysiology
- Introduction
- Transmission of Cov
- Virus Life Cycle
- Role of Structural Proteins in the Pathogenesis
- A. Spike Protein
- B. Hemagglutinin-Esterase (He) Protein
- C. Membrane (M) Protein
- D. Small Envelop (E) Protein
- E. Nucleocapsid (N) Protein and Internal (I) Protein
- F. Replicase Proteins
- G. Cov Associated Protein
- Pathophysiology from a Cell Biology Perspective
- Phase I. Asymptomatic Stage (First 1-2 Days of Infection)
- Phase Ii. Upper Airway and Conducting Airway Response (Next Few Days)
- Phase Iii. Hypoxia, Ground-Glass Infiltrates, Progression to Ards
- Conclusion
- List of Abbreviations
- Consent for Publication
- Conflict of Interest
- Acknowledgements
- References
Chapter 5 Clinical Presentation and Comorbidities
- Introduction
- Clinical Presentations of COVID-19 Infection
- Inter-Individual Variations in Clinical Presentations due To
- Differential Susceptibility Towards COVID-19
- Neonates or Newborns (Upto 1 Month); Infants (1 Month-2 Years), Children (2-10 Years) 120
- Adolescent (11-19 Years), Young (20-35 Years) and Middle Aged (36-59 Years) Patients 128
- Elderly (>60 Years) and Older (>80 Years) Patients
- Ace2
- Gender
- Blood Group
- Previous Immunization
- Comorbidity
- Conclusion
- List of Abbreviations
- Consent for Publication
- Conflict of Interest
- Acknowledgements
- References
Chapter 6 Diagnosis
- COVID-19: a Pandemic Disease
- COVID-19: Early Detection Based on Symptoms
- Clinical Analysis
- Anirban Ghosh and Shamsher Singh
- Jasleen Kaur, Baljinder Singh, Bikash Medhi and Gurpreet Kaur
- Richa Deshpande, Aishwarya Joshi, Nikunj Tandel and Rajeev K. Tyagi
- Hematological Analysis
- Chest Ct
- COVID-19: Molecular Detection of Virus
- Rt-Pcr Based Assays
- Loop Mediated Isothermal Amplification (Lamp)
- Crispr-Isothermal Amplification Based Assays
- Microarrays
- Metagenomic Sequencing Based Methods
- Gold Nanoparticles-Based Colorimetric Assay
- COVID-19: Seriological and Immunological Based Detection
- Biomarker Identification: Approach of Serological Platform
- Antibody Biomarkers
- Antigen Biomarkers
- Procalcitonin and Interleukin-6 as Prognostic COVID-19 Biomarkers
- Serological and Immunological Assays
- Enzyme-Linked Immunosorbent Assay (Elisa)
- Lateral Flow Immunoassay
- Neutralization Assays
- Luminescence-Based Immunoassays
- Biosensor Tests
- Rapid Antigen Tests
- Concluding Remarks
- List of Abbreviations
- Consent for Publication
- Conflict of Interest
- Acknowledgements
- References
- Subject Index
Author
- Neeraj Mittal
- Sanjay Kumar Bhadada
- O. P. Katare
- Varun Garg
