Tissue Engineering. Current Status and Challenges

Table of Contents

1. Preface 2. Introductory Chapter

Section 1: Regenerative Technologies 3. Overview of current technologies for TE and RM 4. Myocardial tissue engineering: Fundamentals and advanced technologies 5. Oro-dental regeneration 6. Tissue Regeneration: Fetal to adult transition 7. Chronic wounds and tissue engineering: Prospects and promise

Section 2: Stem Cell Research and Tissue Engineering 8. Emerging bioengineering strategies for regulating stem cell fate: Scaffold physical and biochemical cues 9. Stem cell research and tissue engineering

Section 3: Tissue Engineering and Nanomedicine 10. Nanomatrix and organ regeneration 11. Future of nanotechnology in tissue engineering 12. Green Nanotechnology in cardiovascular tissue engineering

Section 4: Soft Tissue Engineering 13. Retinal repair in tissue engineering perspectives 14. Dental pulp tissue regeneration 15. Prospects of collagen scaffolds for muscle regeneration 16. Nerve tissue engineering on degradable scaffold 17. Bioengineering of brain organoids: Advancements and challenges 18. 3D bio printing/additive manufacturing in tissue engineering 19. Biosensors in tissue engineering 20. Cardiovascular regenerations

Section 5: Hard Tissue Engineering 21. Bone tissue engineering 22. Dental tissue engineering 23. Musculoskeletal tissue engineering

Section 6: Regulatory guidelines, modeling, management, and ethical issues in translational tissue engineering 24. Translational tissue engineering 25. Tissue engineered products translational avenues 26. 3D Modeling of the lung in health and disease 27. Modeling viral infection with tissue engineering: Covid-19 and the next outbreaks 28. Ethical issues

Authors

Chandra P. Sharma Adjunct Professor, Department of Pharmaceutical Biotechnology, Manipal College of Pharmaceutical Sciences, Manipal University, India. Dr. Chandra P. Sharma is Adjunct Professor, Department of Pharmaceutical Biotechnology, Manipal College of Pharmaceutical Sciences, Manipal University, and Hon. Emeritus Professor, College of Biomedical Engineering & Applied Sciences, Purbanchal University, Kathmandu, Nepal. Dr. Sharma is a Solid-State Physicist from IIT Delhi and received his training in Biomaterials area in the University of Utah with Prof. D.J. Lyman as a graduate student and in the University of Liverpool, England with Prof. D.F. Williams as a Post-Doctoral Research Associate. Dr. Sharma has been awarded FBSE (Fellow Biomaterials Science & Engineering) by The International Union of Societies for Biomaterials Science & Engineering (IUS-BSE) in 2008 and FBAO (Fellow Biomaterials and Artificial Organs) by Society for Biomaterials & Artificial Organs (India) (SBAOI) in 2011 and shares Whitaker and National Science Foundation Award - International Society for Artificial Organs (ISAO) USA, invited member ACS (2015-2018). Thomas Chandy Senior Test Engineer and Project Lead, Phillips Medisize, Hudson, Wisconsin, USA. Dr. Thomas Chandy is a biomaterial expert with unique combination of medical device and technical knowledge. He has strong academic credentials in human physiology and bio-compatible materials with test methods and model development. Dr. Chandy has published over 80 scientific papers in international Journals and 3 patents in the medical device and drug delivery area. Reviewer to 7+ international journals of repute in Drug delivery and Biomedical Research. Twenty-Five years of experience as a project lead in medical device and technology development. Strong experience with broad range of medical products including polymeric and tissue-based implantable, site specific drug delivery, medical diagnostics and combination devices. Product/process development skills with demonstrated success from concept through commercialization involving selection of materials, characterization, biological evaluation of materials, bench, feasibility tests and pre-clinical (animal) testing. Vinoy Thomas Assistant Professor, Department of Materials Science and Engineering, University of Alabama, Birmingham, USA. Dr. Vinoy Thomas is an assistant professor in the Department of Materials Science and Engineering at the University of Alabama at Birmingham. training spans from Chemistry/Polymers to Materials Science and Nanotechnology with specific training and expertise in Polymers and Biomaterials. He also holds secondary appointments at the Department of Biomedical Engineering and Department of Environmental Science & Health. He is also a Senior Research Scientist at the Center for Nanoscale Materials and Biointegration. After his PhD in Biomaterials & Technology he completed postdoctoral training at Friedrich-Schiller University, Germany, and at the National Institute of Standards & Technology (NIST). His research focuses on biomaterials processing-property relationships, nanomaterials for tissue engineering, and nanodiamonds for joint-implants. Finosh G. Thankam Assistant Professor, Tissue Engineering and Regenerative Medicine, Department of Translational Research, Western University of Health Sciences, Pomona, California, USA. Dr. Finosh Thankam is an assistant professor and researcher in Tissue Engineering and Regenerative Medicine, in the Department of Translational Research, at the Western University of Health Sciences, in Pomona, CA. His undergraduate studies were in Biochemistry, before completing his post-graduate degree in Medical Biochemistry from Mahatma Gandhi University, in India. As a research fellow he was exposed to the new world of tissue engineering and regenerative medicine and published many original articles on various aspects of cardiac tissue engineering. His current research interests include investigating the pathogenesis of various musculoskeletal disorders, and cardiovascular diseases, and applying the knowledge and principles of tissue engineering to develop artificial tissue constructs to improve the care for the sufferers.