Contains new chapters on sleep in intersex and transgender individuals; sleep telemedicine and remote PAP adherence monitoring; and sleep and the menstrual cycle, as well as increased coverage of treatment and management of pediatric patients.
Includes expanded sections on pharmacology, sleep in individuals with other medical disorders, and methodology.
Discusses updated treatments for sleep apnea and advancements in CPAP therapy.
Offers access to 95 video clips online, including expert interviews and sleep study footage of various sleep disorders.
Meets the needs of practicing clinicians as well as those preparing for the sleep medicine fellowship examination or recertification exams, with more than 950 self-assessment questions, answers, and rationales online.
Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.
Table of Contents
1 Normal Sleep and Its Variants 1. History of Sleep Physiology and Medicine 2. Normal Human Sleep: An Overview 3. Normal Aging 4. Daytime Sleepiness and Alertness 5. Sleep Deprivation
2 Sleep Mechanisms and Phylogeny 6. Introduction/Defining Sleep 7. Neural Control of Sleep in Mamma Is 8. Rapid Eye Movement Sleep Control and Function 9. Deep-Brain Imaging of Brain Neurons and Glia during Sleep 10. Evolution of Mammalian Sleep 11. Sleep in Nonmammalian Vertebrates
3 Genetics and Genomic Basis of Sleep 12. Introduction: Genetics and Genomics of Sleep 13. Genetics and Genomics of Circadian Clocks 14. Genetics and Genomic Basis of Sleep in Simple Model Organisms 15. Genetic and Genomic Basis of Sleep in Rodents 16. Genetics and Genomic Basis of Sleep in Healthy Humans 17. Genetics and Genomic Basis of Sleep Disorders in Humans
4 Physiology in Sleep 18. Introduction to Physiology in Sleep 19. What Neuroimaging Reveals about the Brain Areas Generating, Maintaining, and Regulating Sleep 20. Cardiovascular Physiology and Coupling with Respiration: Central and Autonomic Regulation 21. Cardiovascular Physiology: Autonomic Control in Health and in Sleep Disorders 22. Respiratory Physiology. Central Neural Control of Respiratory Neurons and Motoneurons during Sleep 23. Respiratory Physiology Understanding the Control of Ventilation 24. Physiology of Upper and lower Airways 25. 5 Respiratory Physiology Sleep at High Altitude 26. Sleep and Host Defense 27. Endocrine Physiology in Relation to Sleep and Sleep Disturbances 28. Thermoregulation in Sleep and Hibernation 29. Memory Processing in Relation to Sleep 30. Sensory and Motor Processing during Sleep and Wakefulness 31. Local and Use-Dependent Aspects of Sleep 32. Pathophysiology of Sleep-Wake Disturbances after Traumatic Brain Injury
5 Chronobiology 33. Introduction 34. Master Circadian Clock and Master Circadian Rhythm 35. Anatomy of the Mammalian Circadian Sys tern 36. Physiology of the Mammalian Circadian System 37. Human Circadian Timing System and Sleep-Wake Regulation 38. Sleep Homeostasis and Models of Sleep Regulation 39. Circadian Rhythms in Sleepiness, Alertness, and Performance 40. Central and Peripheral Circadian Clocks 41. Circadian Dysregulation and Cardiometabolic and Immune Health 42. Circadian Dysregulation in Brain Aging and Neuropsychiatrie Health 43. Circadian Disorders of the Sleep-Wake Cycle
6 Pharmacology 44. Introduction 45. Adenosinergic Control of Sleep 46. Catecholamines 47. GABA: Its Metabolism, Receptors, and the Drugs for Treating Insomnias and Hypersomnias 48. Histamine 49. Orexin/Hypocretin 50. Serotonin and Sleep 51. Melatonin 52. Opioid Actions on Sleep and Breathing 53. Clinical Pharmacology of Drugs that Affect Sleep and Wake
7 Psychobiology and Dreaming 54. Introduction 55. Why We Dream 56. Dream Content: Quantitative Findings 57. Neural Correlates of Dreaming 58. The Neurobiology of Dreaming 59. Lucid Dreaming 60. What Is the Function of Nightmares? 61. Dreams and Nightmares in Posttraumatic Stress Disorder 62. Incorporation of Waking Experiences into Dreams 63. Emotion, Motivation, and Reward in Relation to Dreaming 64. Dreaming during Pregnancy
8 Impact, Presentation, and Diagnosis 65. Approach to the Patient with Disordered Sleep 66. Cardinal Manifestations of Sleep Disorders 67. Physical Examination in Sleep Medicine 68. Clinical Tools and Tests in Sleep Medicine 69. Classification of Sleep Disorders 70. Epidemiology of Sleep Medicine 71. Sleep Medicine, Public Policy, and Public Health
9 Legal Aspects of Sleep Medicine 72. Introduction 73. Sleep Forensics: Criminal Culpability for Sleep-Related Violence 74. Legal Obligations of Persons Who Have Sleep Disorders or Who Treat or Hire Them 75. Legal Aspects of Fatigue- and Safety-Sensitive Professions 76. Sleep Medicine Clinical Practice and Compliance- United States 77. Sleep Medicine Clinical Practice and Compliance-Europe
10 Occupational Sleep Medicine 78. Introduction 79. Performance Deficits During Sleep Loss and Their Operational Consequences 80. Sleep and Sleep Disorders in Operational Settings 81. Shift Work, Shift-Work Disorder, Jet Lag. and Jet Lag Disorder 82. Fatigue Countermeasures 83. Sleep, Sleepiness, and Performance Prediction Modeling 84. Fatigue RiskManagemen f Systems 85. Safety Cases and Assessing Alternative Means of Regulatory Compliance in Fatigue RiskManagemenf 86. Fatigue Proofing 87. Sleep Health in Athlete Populations: Unique Challenges and Practical Solutions 88. Assessment of the Occupational Sleep Medicine Field
11 Insomnia 89. Advances in Insomnia Pathophysiology and Treatment: An Introduction 90. Insomnia: Epidemiology, Risk Factors, and Health Disparities 91. Etiology and Pathophysiology of Insomnia 92. Pediatric Insomnia and Its Developmental Trajectories 93. Insomnia Diagnosis, Assessment, and Evaluation 94. Insomnia with Short Sleep Duration and Multidimensional Sleep Health 95. Behavioral Treatment I: Therapeutic Approaches and Implementation 96. Behavioral Treatment II: Efficacy, Effectiveness, and Dissemination 97. Behavioral Treatment III: Digital and Telehealth Approaches 98. Pharmacologic Treatment I: Therapeutic Approaches and Implementation 99. Pharmacologic Treatment II: Efficacy, Effectiveness, and Contraindications 100. Pharmacologic Treatment III: Sequenced and Combined Psychologic and Pharmacologic Treatments for Insomnia
12 Neurologic Disorders 101. Introduction 102. Parkinsonism 103. Sleep-Wake Disturbances and Stroke 104. Sleep and Neuromuscular Diseases 105. Alzheimer Disease and Other Demen tias 106. Epilepsy, Sleep, and Sleep Disorders 107. Sleep and Headache 108. Sleep Disorders after Traumatic Brain Injury 109. Autoimmune Disorders (Autoimmune Encephalitides and Multiple Sclerosis)
13 Hypersomnias 110. Central Disorders of Hypersomnolence 111. Narcolepsy: Pathophysiology and Genetic Predisposition 112. Narcolepsy: Diagnosis and Management 113. Idiopathic Hypersomnia 114. Kleine-Levin Syndrome
14 Parasomnias 115. Parasomnias and Sleep-Related Movement Disorders: Overview and Approach 116. Disorders of Arousal 117. Sleep-Related Eating Disorder 118. Rapid Eye Movement Sleep Parasomnias 119. Nightmares and Dream Disturbances 120. Other Parasomnias 121. Restless Legs Syndrome /Willis-Ekbom Disease) and Periodic Limb Movements during Sleep 122. Sleep-Related Movement Disorders and Their Unique Motor Manifestations
15 Sleep Breathing Disorders 123. Introduction 124. Central Sleep Apnea: Definitions, Pathophysiology, Genetics, and Epidemiology 125. Central Sleep Apnea: Diagnosis and Management 126. Anatomy and Physiology of Upper Airway Obstruction 127. Snoring and Pathologic Upper Airway Resistance Syndromes 128. Obstructive Sleep Apnea: Heritable Phenotypes and Genetics 129. Deep Phenotyping of Sleep Apnea 130. Clinical and Physiologic Heterogeneity of Obstructive Sleep Apnea 131. Obstructive Sleep Apnea: Clinical Features, Evaluation, and Principles of Management 132. Positive Airway Pressure Treatment for Obstructive Sleep Apnea 133. Pharmacologic Treatments for Obstructive Sleep Apnea 134. Alternative Strategies to Management of Sleep-Disordered Breathing 135. Brain Health in Sleep Apnea: Cognition, Performance, Mechanisms, and Treatment 136. Obstructive Sleep Apnea and Metabolic Disorders 137. Overlap Syndromes of Sleep and Breathing Disorders 138. Obesity-Hypoventilation Syndrome 139. Obstructive Sleep Apnea, Obesity, and Bariatric Surgery 140. Advanced Modes of Positive Pressure Therapy for Sleep-Disordered Breathing 141. Sleep and Breathing at High Altitude 142. Evolution of Sleep-Disordered Breathing across the Adult Years
16 Cardiovascular Disorders 143. Introduction 144. Sleep-Related Cardiac Risk 145. Cardiac A rrhythmogenesis during Sleep: Mechanisms, Diagnosis, and Therapy 146. Cardiovascular Effects of Sleep-Related Breathing Disorders 147. Systemic and Pulmonary Hypertension in Obstructive Sleep Apnea 148. Coronary Artery Disease and Obstructive Sleep Apnea 149. Heart Failure 150. Sleep-Disordered Breathing and Stroke 151. Insomnia and Cardiovascular Disease
17 Other Medical Disorders 152. Introduction 153. Sleep and Cancer across the Life Span 154. Fibromyalgia and Chronic Fatigue Syndromes 155. Endocrine Disorders 156. Pain and Sleep 157. Sleep and Chronic Kidney Disease 158. Sleep in the Critically III Patient 159. Perioperative Sleep Medicine 160. Sleep and Gastrointestinal Health
18 Psychiatric Disorders 161. Introduction 162. Emotion and Sleep 163. Anxiety Disorders and Posttraumatic Stress Disorder 164. Affearve Disorders 165. Schizophrenia and Sleep 166. Substance Abuse
19 Dentistry and Otorhinolaryngology 167. Dentistry and Otorhinolaryngology in Sleep Medicine: Below the BraiAtttpd Above the Larynx 168. Oronasopharyngeal Growth and Malformations with Orthodontic Management 169. Sleep Bruxism: Definition, Prevalence, Classification, Etiology, and Consequences 170. Assessment of Sleep Bruxism 171. Management of Sleep Bruxism: Psychological, DentaL and Medical Approaches in Adults 172. Orofacial Pain/Temporomandibular Disorders in Relation to Sleep Bruxism and Breathing Disorders 173. Oral Appliances for the Treatment of Sleep-Disordered Breathing 174. Anesthesia in Upper Airway Surgery 175. Upper Airway Surgery to Treat Obstructive Sleep- Disordered Breathing 176. Pharmacotherapy and Behavioral Complementary, and Alternative Medicine for Sleep Bruxism
20 From Childhood to Adulthood 177. Overview: Transition from Pediatric-Oriented to Adult-Oriented Health Care in Sleep Medicine 178. Sleep-Related Breathing Disorders in Children 179. Neuromuscular and Neurological Disorders 180. Transitional Care for Adolescents with Narcolepsy and Other Central Disorders of Hypersomnolence 181. Congenital Heart Disease 182. Sleep in Intersex and Transgender Individuals
21 Sleep in Women 183. Introduction 184. Sex Effects and Differences in Circadian Rhythms and Sleep 185. The Menstrual Cycle, Sleep, and Circadian Rhythms 186. Sleep and Sleep Disorders Associated with Pregnancy 187. Sleep-Disordered Breathing in Pregnancy 188. Postpartum Period and Early Parenthood 189. Sleep and Menopause
22 Sleep Medicine in the Elderly 190. Introduction 191. Psychiatric and Medical Comorbidities and E ffects oiMedications in Older Adults 192. Obstructive Sleep Apnea in Older Adults 193. Insomnia in Older Adults 194. Orcadian Rhythms in Older Adults 195. Sleep in Long-Term Care Settings
23 Methodology 196. Section Introduction: Polysomnography and Beyond 197. Sleep Stage Scoring 198. Central Nervous System Arousals and the Cyclic Alternating Pattern 199. Neurologic Monitoring Techniques 200. Monitoring Techniques for Evaluating Suspected Sleep-Related Breathing and Cardiovascular Disorders 201. Sleep Telemedicine and Remote PAP Adherence Monitoring 202. Cardiopulmonary Coupling 203. Pulse Wave Analysis 204. Recording and Scoring Sleep-Related Movements 205. Home Sleep Testing for Sleep-Related Breathing Disorders 206. Consumer Sleep Tracking: Landscape and CTA/ANSI Performance Standards 207. Evaluating Sleepiness and Fatigue 208. The Assessment of Insomnia 209. Surveys, Sampling, and Polling Methods for Sleep and Public Health 210. Techniques for Clinical Assessment of Circadian Rhythm Disorders 211. Actigraphy Methods and Technical Issues 212. Imaging 213. COVID-19 and Sleep