Essential tremor - Pipeline Insight, 2024

This Essential tremor - Pipeline Insight, 2024,” report provides comprehensive insights about 7+ companies and 10+ pipeline drugs in Essential tremor pipeline landscape. It covers the pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.

Geography Covered

• Global coverage

Essential tremor Understanding

Essential tremor: Overview

Essential tremor (ET) is a chronic, progressive neurologic disease. The hallmark motor feature of ET is a 4-12-Hz kinetic tremor (i.e., a tremor that occurs during voluntary movements such as writing or eating) that involves the hands and arms, but which may also eventually spread to involve the head (i.e., neck), voice, jaw, and other body regions. Given the presence of etiologic, clinical, pharmacologic response profile and pathologic heterogeneity, there is increasing support for the notion that ET may be a family of diseases whose central defining feature is kinetic tremor of the arms, and which might more appropriately be referred to as “the essential tremors.

Essential tremor - Pipeline Insight, 2024 report outlays comprehensive insights of present scenario and growth prospects across the indication. A detailed picture of the Essential tremor pipeline landscape is provided which includes the disease overview and Essential tremor treatment guidelines. The assessment part of the report embraces, in depth Essential tremor commercial assessment and clinical assessment of the pipeline products under development. In the report, detailed description of the drug is given which includes mechanism of action of the drug, clinical studies, NDA approvals (if any), and product development activities comprising the technology, Essential tremor collaborations, licensing, mergers and acquisition, funding, designations and other product related details.

Report Highlights

• The companies and academics are working to assess challenges and seek opportunities that could influence Essential tremor R&D. The therapies under development are focused on novel approaches to treat/improve Essential tremor.

This segment of the Essential tremor report encloses its detailed analysis of various drugs in different stages of clinical development, including phase II, I, preclinical and Discovery. It also helps to understand clinical trial details, expressive pharmacological action, agreements and collaborations, and the latest news and press releases.

Essential tremor Drugs
SAGE-324: Sage therapeuticsSAGE-324 is an investigational oral neuroactive steroid (NAS) GABAA receptor positive allosteric modulator (PAM). NAS GABAA receptor PAMs bind to both synaptic and extrasynaptic GABAA receptors, enhancing inhibitory activity of the GABAergic system, the major inhibitory neurotransmission system in the brain. GABA is the primary inhibitory neurotransmitter in the central nervous system and plays a critical role in maintaining balanced neuronal activity in the brain. GABA dysregulation has been implicated in the pathophysiology of ET. It is currently being evaluated in Phase II stage of development.

Essential tremor: Therapeutic Assessment

This segment of the report provides insights about the Essential tremor drugs segregated based on following parameters that define the scope of the report, such as:

Major Players in Essential tremor

There are approx. 7+ key companies which are developing the therapies for Essential tremor. The companies which have their Essential tremor drug candidates in the most advanced stage, i.e. Phase II include Sage therapeutics.

Phases

This report covers around 10+ products under different phases of clinical development like

• Late stage products (Phase III)
• Mid-stage products (Phase II)
• Early-stage product (Phase I) along with the details of
• Pre-clinical and Discovery stage candidates
• Discontinued & Inactive candidates

Route of Administration

Essential tremor pipeline report provides the therapeutic assessment of the pipeline drugs by the Route of Administration. Products have been categorized under various ROAs such as

• Intranasal
• Intrathecal
• Intravenous
• Oral
• Oral/Intravenous
• Parenteral
• Subcutaneous
• Subcutaneous/Intramuscular
• Transdermal

Molecule Type

Products have been categorized under various Molecule types such as

• Antisense oligonucleotide
• Gene therapy
• Hormones
• Neuropeptides
• Oligonucleotides
• Small Molecule
• Triglyceride

Product Type

Drugs have been categorized under various product types like Mono, Combination and Mono/Combination.

Essential tremor: Pipeline Development Activities

The report provides insights into different therapeutic candidates in phase II, I, preclinical and discovery stage. It also analyses Essential tremor therapeutic drugs key players involved in developing key drugs.

Pipeline Development Activities

The report covers the detailed information of collaborations, acquisition and merger, licensing along with a thorough therapeutic assessment of emerging Essential tremor drugs.

Essential tremor Report Insights

• Essential tremor Pipeline Analysis
• Therapeutic Assessment
• Unmet Needs
• Impact of Drugs

Essential tremor Report Assessment

• Pipeline Product Profiles
• Therapeutic Assessment
• Pipeline Assessment
• Inactive drugs assessment
• Unmet Needs

Key Questions

Current Treatment Scenario and Emerging Therapies:

• How many companies are developing Essential tremor drugs?
• How many Essential tremor drugs are developed by each company?
• How many emerging drugs are in mid-stage, and late-stage of development for the treatment of Essential tremor?
• What are the key collaborations (Industry-Industry, Industry-Academia), Mergers and acquisitions, licensing activities related to the Essential tremor therapeutics?
• What are the recent trends, drug types and novel technologies developed to overcome the limitation of existing therapies?
• What are the clinical studies going on for Essential tremor and their status?
• What are the key designations that have been granted to the emerging drugs?

Key Players

• Merz Pharma
• SAGE Therapeutics
• GE Healthcare
• Praxis Precision Medicines
• OB Pharmaceuticals
• Novartis
• Jazz Pharmaceuticals

Key Products

• Botulinum toxin A
• Zuranolone
• Ioflupane 123I
• PRAX 114
• TD 567

Research programme: epilepsy and essential tremor therapeutics- SAGE 324

• Rimtuzalcap
• Suvecaltamide

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