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Site Specific and Global Epigenomic Editing. Principles and Applications. Translational Epigenetics Volume 33

  • Book
  • November 2022
  • Region: Global
  • Elsevier Science and Technology
  • ID: 5527202

Site Specific and Global Epigenomic Editing: Principles and Applications, Volume 33 highlights the expanding role that epigenetics plays in pathogenesis, the full range of sites for possible epigenetic modification, and the potential to target these sites to modulate disease progression. The book answers key questions, including which of the hundreds of epigenomic marks and features are relevant, and which are likely to serve a role in regulating gene expression, cell behavior and phenotypic outcomes. This volume is the first to provide a thorough, conceptual introduction to epigenetic regulation and a thorough accounting of sites for possible epigenetic edits and disease modulation.

Included protocols and applied case studies examine early disease targets and likely pathways of therapeutic significance while also outlining common challenges in the field. The book addresses its topic in a comprehensive, but accessible manner, highlighting practical tools and burning questions remaining in the field to enable fresh research.

Table of Contents

Part I EPIGENETICS AND EPIGENOMICS 1. Epigenetic editing: Progress and Challenges  2. Epigenetic dynamics: Normal progression and abnormal alteration  3. Epigenomic landscape  4. Histone coding and its compounding influence on gene expression 5. microRNA as a tool for gene regulation 6. RNA editing and genetic influence  7. Epitranscription: Scope and engineering ability

Part II GLOBAL EPIGENETIC EDITING 8. Global epigenetic editing uses methods of DNA methylation alteration drugs 9. Regulating DNA methylation for developmental disorders 10. Histone modification drug the HDACi: Selectivity and promise 11. Histone modification in cancer treatment 12. Alteration of DNA Methylation in gastric cancer 13. Epigenetic therapy for the treatment of epithelial ovarian cancer 14. Epigenetic application on allergy treatment 15. HDACi therapy for the treatment of depression 16. Histone modification on neurodevelopmental and neuropsychiatric disorders 17. Epigenetics and Addiction 18. Epigenetic Treatment of Persistent Viral Infections 19. MicroRNA as strategy of gene regulation

Part III SITE SPECIFIC EPIGENETIC EDITING 20. Strategy and Molecular tools for site-specific editing  21. Site-specific recruitment of epigenetic factors for spatio-temporal epigenetic editing.  22. Monitoring CRISPR-Cas9 mediated DNA-methylation-editing  23. Locus-specific editing of histone modifications 24. Functional DNA methylation and epigenetic editing on proneuron genes during neuroglial differentiation 25. Epigenetic editing through regulating CRISPR-Cas9 mediated non-coding RNA 26. Epigenetic editing targeting a parkinsonian gene   27. Cancer gene epigenetic editing  28. Epigenetic editing to unveil epigenetic mechanism of breast cancer 29. Editing DNA Methylation on Fragile X syndrome  30. Can RNA editing be engineered? 31. Genetic and epigenetic interactive approaches

Part IV TRANSLATIONAL AND CLINIC APPLICATION 32. Tuning DNA methylation in treating breast cancer:  33. Imminent Epigenetic editing in cancer treatment 34. Epigenetic editing for developmental disorders 35. Epigenetic editing on genetic imprinting 36. Prospective epigenetic treatment on Neurological disease 37. Epigenetic alterations and personalized treatment in cancer

Part V CLOSING VIEW 38. Obstacles and prospective of changing epigenetic codes 39. Ethical matters in modification of epigenetic codes 40. Future epigenetic treatment

Authors

Feng C Zhou Professor of Anatomy, Cell Biology, Neuroscience, and Psychology, Emeritus; Adjunct Professor of Behavioral Psychology, Northwestern University, Indianapolis, IN, USA. Dr. Feng C. Zhou is Professor Emertus of Anatomy and Cell Biology at Indiana University School of Medicine, Indianapolis, Indiana. In his research, Dr. Zhou studies genetic contributions to gene expression that underpin the neurochemical and neuroanatomical differences contributing to alcohol addiction. His previous research has demonstrated that alcohol alters expression cohorts of neural specification genes, and cell cycling genes in the canonical developmental pathways. In recent years, Dr. Zhou has expanded his research to include the genomics and epigenetics of alcoholism, epigenetic editing by optogenetics, cell-wide DNA de-methylation and re-methylation of purkinje neurons in the developing cerebellum, and environmental alterations of epigenetics prior to the birth, among other topics. Dr. Zhou has published widely in scientific, peer reviewed journals including Scientific Reports, PLoS ONE, Oncotarget, Frontiers in Genetics, Brain Research, Cell Transplantation, and Alcohol.