Emergence of new and deadly infectious diseases is significantly deteriorating the human health. Development of vaccine by the scientist has become an important weapon to control the spread of infectious diseases as well as to improve the life expectancy at global level in 20th-21st Century. This book will provide the in-depth knowledge of vaccine history, and development of new strategies to design efficacious and safe vaccine molecule. This book will cover the development of system vaccinology and their applications revolutionize the vaccine discovery. This will provide a resource for the basic and clinical researcher working to human life expectancy by their vaccine experiments and clinical trials.
My purpose to write this book to educate the students and researchers with modern development in the field of vaccinology and empowering the researcher with new tools and methodology for developing potential and immunogenic vaccines.
This book will be helpful to solve the curiosity of science and medical background students related with vaccinology and will be helpful to devise a new vaccine molecule to control the spread of new and emerging pathogens.
Systems biology is a rapidly expanding research discipline aiming to integrate multifaceted datasets generated using state-of-the-art high- throughput technologies such as arrays and next-generation sequencing. Combined with sophisticated computational analysis we are able to interrogate host responses to infections and vaccination on a systems level, thus generating important new hypotheses and discovering unknown associations between immunological parameters.
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Table of Contents
Part I History and Introduction
1. Vaccine: History and its perspective
2. Evolution of human infectious diseases and vaccine
Part II Immunology of Vaccine Designing
3. Omics and databases of vaccine
4. Adjuvant requirement for vaccines
5. Vaccine Engineering and Structural vaccinolog
6. Vaccine and genome
7. Vaccine and transcriptome
8. miRNA and immunization
9. Vaccine and proteome
10. Vaccine and microbiome
Part III Delivery and Vaccine efficacy
11. rDNA technology and vaccines
12. Developing delivery system for vaccines
13. Infection, immunity and vaccine
14. Animal model and vaccines pre-clinical testing
15. Vaccine human clinical trial
Part IV Vaccine future and Ethics
16. Future of system vaccinology
17. Vaccine regulation and ethics
Authors
Vijay Kumar Prajapati Department of Biochemistry, University of Delhi South Campus, India.Dr. Vijay Kumar Prajapati is an Associate Professor in the Department of Biochemistry at the University of Delhi South Campus, New Delhi, India. He specializes in cell-death research, parasitology, and therapeutic developments for infectious diseases. He has published extensively in international journals and contributed chapters to reputable publishers. He is a recipient of the INSA Medal for Young Scientist from the Indian National Science Academy and an Associate of the Indian Academy of Sciences, Bengaluru. His work has appeared in leading journals spanning infectious diseases and cellular physiology, reflecting a high scholarly impact and a broad research portfolio.
