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Down Syndrome Drugs in Development by Stages, Target, MoA, RoA, Molecule Type and Key Players, 2022 Update

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    Report

  • 74 Pages
  • February 2022
  • Region: Global
  • Global Markets Direct
  • ID: 5553771
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This pipeline guide Down Syndrome Drugs in Development by Stages, Target, MoA, RoA, Molecule Type and Key Players, 2022 Update, provides an overview of the Down Syndrome (Genetic Disorders) pipeline landscape.

Down syndrome is a genetic disorder that causes lifelong mental retardation, developmental delays and other problems. Down syndrome varies in severity, so developmental problems range from moderate to serious. Children with Down syndrome have a distinct facial appearance. Though not all children with Down syndrome have the same features, some of the more common features are flattened facial features, small head, short neck, protruding tongue, upward slanting eyes, unusual for the child's ethnic group and unusually shaped ears. Children with Down syndrome may also have poor muscle tone, broad, short hands with a single crease in the palm, relatively short fingers and excessive flexibility.

Report Highlights


This pipeline guide Down Syndrome Drugs in Development by Stages, Target, MoA, RoA, Molecule Type and Key Players, 2022 Update, provides comprehensive information on the therapeutics under development for Down Syndrome (Genetic Disorders), complete with analysis by stage of development, drug target, mechanism of action (MoA), route of administration (RoA) and molecule type. The guide covers the descriptive pharmacological action of the therapeutics, its complete research and development history and latest news and press releases.

The Down Syndrome (Genetic Disorders) pipeline guide also reviews of key players involved in therapeutic development for Down Syndrome and features dormant and discontinued projects. The guide covers therapeutics under Development by Companies /Universities /Institutes, the molecules developed by Companies in Phase III, Phase I, Preclinical, Discovery and Unknown stages are 1, 5, 10, 3 and 1 respectively. Similarly, the Universities portfolio in Preclinical and Discovery stages comprises 3 and 2 molecules, respectively.

Down Syndrome (Genetic Disorders) pipeline guide helps in identifying and tracking emerging players in the market and their portfolios, enhances decision making capabilities and helps to create effective counter strategies to gain competitive advantage. The guide is built using data and information sourced from proprietary databases, company/university websites, clinical trial registries, conferences, SEC filings, investor presentations and featured press releases from company/university sites and industry-specific third party sources. Additionally, various dynamic tracking processes ensure that the most recent developments are captured on a real time basis.

Note: Certain content / sections in the pipeline guide may be removed or altered based on the availability and relevance of data.

Scope


  • The pipeline guide provides a snapshot of the global therapeutic landscape of Down Syndrome (Genetic Disorders).
  • The pipeline guide reviews pipeline therapeutics for Down Syndrome (Genetic Disorders) by companies and universities/research institutes based on information derived from company and industry-specific sources.
  • The pipeline guide covers pipeline products based on several stages of development ranging from pre-registration till discovery and undisclosed stages.
  • The pipeline guide features descriptive drug profiles for the pipeline products which comprise, product description, descriptive licensing and collaboration details, R&D brief, MoA & other developmental activities.
  • The pipeline guide reviews key companies involved in Down Syndrome (Genetic Disorders) therapeutics and enlists all their major and minor projects.
  • The pipeline guide evaluates Down Syndrome (Genetic Disorders) therapeutics based on mechanism of action (MoA), drug target, route of administration (RoA) and molecule type.
  • The pipeline guide encapsulates all the dormant and discontinued pipeline projects.
  • The pipeline guide reviews latest news related to pipeline therapeutics for Down Syndrome (Genetic Disorders)

Reasons to Buy


  • Procure strategically important competitor information, analysis, and insights to formulate effective R&D strategies.
  • Recognize emerging players with potentially strong product portfolio and create effective counter-strategies to gain competitive advantage.
  • Find and recognize significant and varied types of therapeutics under development for Down Syndrome (Genetic Disorders).
  • Classify potential new clients or partners in the target demographic.
  • Develop tactical initiatives by understanding the focus areas of leading companies.
  • Plan mergers and acquisitions meritoriously by identifying key players and it’s most promising pipeline therapeutics.
  • Formulate corrective measures for pipeline projects by understanding Down Syndrome (Genetic Disorders) pipeline depth and focus of Indication therapeutics.
  • Develop and design in-licensing and out-licensing strategies by identifying prospective partners with the most attractive projects to enhance and expand business potential and scope.
  • Adjust the therapeutic portfolio by recognizing discontinued projects and understand from the know-how what drove them from pipeline.

Table of Contents

IntroductionReport CoverageOverview
Therapeutics Development
  • Pipeline Overview
  • Pipeline by Companies
  • Pipeline by Universities/Institutes
  • Products under Development by Companies
  • Products under Development by Universities/Institutes

Therapeutics Assessment
  • Assessment by Target
  • Assessment by Mechanism of Action
  • Assessment by Route of Administration
  • Assessment by Molecule Type

Companies Involved in Therapeutics Development
  • AC Immune SA
  • Aelis Farma SAS
  • Alzheon Inc
  • Annovis Bio Inc
  • Avanti Biosciences Inc
  • Balance Therapeutics Inc
  • Eisai Co Ltd
  • Elixirgen Therapeutics Inc
  • F. Hoffmann-La Roche Ltd
  • Felicitex Therapeutics Inc
  • KinoPharma Inc
  • Laminar Pharmaceuticals SA
  • Les Laboratoires Servier SAS
  • ManRos Therapeutics
  • NeuroCircuit Therapeutics Inc
  • NeuroNascent Inc
  • Perha Pharmaceuticals SAS
  • Prothena Corp Plc
  • SanBio Co Ltd

Drug Profiles
  • ABI-02 - Drug Profile
  • Product Description
  • Mechanism Of Action
  • ACI-24 - Drug Profile
  • Product Description
  • Mechanism Of Action
  • History of Events
  • AEF-0217 - Drug Profile
  • Product Description
  • Mechanism Of Action
  • History of Events
  • ANVS-405 - Drug Profile
  • Product Description
  • Mechanism Of Action
  • ARN-23746 - Drug Profile
  • Product Description
  • Mechanism Of Action
  • buntanetap - Drug Profile
  • Product Description
  • Mechanism Of Action
  • History of Events
  • D-217 - Drug Profile
  • Product Description
  • Mechanism Of Action
  • DYR-219 - Drug Profile
  • Product Description
  • Mechanism Of Action
  • FX-8546 - Drug Profile
  • Product Description
  • Mechanism Of Action
  • Gene Therapy to Activate ZSCAN4 for Chromosomal Disorders - Drug Profile
  • Product Description
  • Mechanism Of Action
  • History of Events
  • KPO-1143 - Drug Profile
  • Product Description
  • Mechanism Of Action
  • History of Events
  • LAM-226 - Drug Profile
  • Product Description
  • Mechanism Of Action
  • LCTB-21 - Drug Profile
  • Product Description
  • Mechanism Of Action
  • lecanemab - Drug Profile
  • Product Description
  • Mechanism Of Action
  • History of Events
  • minocycline hydrochloride - Drug Profile
  • Product Description
  • Mechanism Of Action
  • NNI-351 - Drug Profile
  • Product Description
  • Mechanism Of Action
  • pegaspargase - Drug Profile
  • Product Description
  • Mechanism Of Action
  • History of Events
  • pentylenetetrazol - Drug Profile
  • Product Description
  • Mechanism Of Action
  • History of Events
  • RO-4938581 - Drug Profile
  • Product Description
  • Mechanism Of Action
  • Small Molecule for Alzheimer's Disease and Down Syndrome - Drug Profile
  • Product Description
  • Mechanism Of Action
  • Small Molecule to Inhibit DYRK1A for Alzheimer’s Disease and Down Syndrome - Drug Profile
  • Product Description
  • Mechanism Of Action
  • Small Molecule to Inhibit DYRK1A for Down Syndrome - Drug Profile
  • Product Description
  • Mechanism Of Action
  • History of Events
  • Small Molecules for Down Syndrome - Drug Profile
  • Product Description
  • Mechanism Of Action
  • Small Molecules to Inhibit OLIG2 for Down Syndrome - Drug Profile
  • Product Description
  • Mechanism Of Action
  • valiltramiprosate - Drug Profile
  • Product Description
  • Mechanism Of Action
  • History of Events

Dormant ProjectsDiscontinued ProductsProduct Development Milestones
Featured News & Press Releases
  • Jan 05, 2022: Annovis Bio announces official unique name buntanetap for lead candidate ANVS401
  • May 13, 2021: Annovis Bio files for FDA Orphan Drug Designation for ANVS401 for the treatment of Alzheimer's disease in persons with Down syndrome
  • Apr 29, 2021: Annovis Bio to study potential of ANVS401 to normalize brain development in Down syndrome
  • Mar 16, 2021: AC Immune announces new clinical results in Down syndrome and plans for future development of anti-Amyloid-Beta vaccine
  • Mar 15, 2021: BioArctic and Eisai presented latest data regarding lecanemab at AD/PD 2021
  • Mar 11, 2021: Annovis Bio signs GMP manufacturing agreement to support planned late-stage studies
  • Mar 05, 2021: Latest lecanemab data to be presented at the AD/PD congress
  • Feb 02, 2021: Annovis bio's lead candidate ANVS401 improves cognitive and functional outcomes in stroke mice study
  • Dec 15, 2020: Annovis Bio showcases its unique approach to Alzheimer’s at the New York Academy of Sciences
  • Sep 29, 2020: Annovis Bio demonstrates improved axonal transport in nerve cells and brain of down syndrome mice, an animal model of Alzheimer’s disease
  • Jul 23, 2020: AC Immune to present advances in two of the company’s world leading programs at the upcoming Alzheimer’s Association International Conference
  • Jul 10, 2020: Discovery of a novel drug candidate to develop effective treatments for brain disorders
  • Jul 11, 2019: AC Immune hosts KOL event and reports initial interim clinical data for ACI-24 vaccine to treat Alzheimer’s Disease-like symptoms in subjects with Down Syndrome
  • Aug 20, 2018: AC Immune announces important clinical milestones for ACI-24 vaccine in alzheimers disease and down syndrome
  • Sep 12, 2017: AC Immune Completes Recruitment For Low-Dose Cohort In World's First Clinical Trial For Anti-Abeta Vaccine Targeting Alzheimer's Disease-Like Characteristics In Individuals With Down Syndrome

Appendix
  • Methodology
  • Coverage
  • Secondary Research
  • Primary Research
  • Expert Panel Validation
  • Contact the Analyst
  • Disclaimer

List of Tables
  • Number of Products under Development for Down Syndrome, 2022
  • Number of Products under Development by Companies, 2022
  • Number of Products under Development by Universities/Institutes, 2022
  • Products under Development by Companies, 2022
  • Products under Development by Universities/Institutes, 2022
  • Number of Products by Stage and Target, 2022
  • Number of Products by Stage and Mechanism of Action, 2022
  • Number of Products by Stage and Route of Administration, 2022
  • Number of Products by Stage and Molecule Type, 2022
  • Down Syndrome - Pipeline by AC Immune SA, 2022
  • Down Syndrome - Pipeline by Aelis Farma SAS, 2022
  • Down Syndrome - Pipeline by Alzheon Inc, 2022
  • Down Syndrome - Pipeline by Annovis Bio Inc, 2022
  • Down Syndrome - Pipeline by Avanti Biosciences Inc, 2022
  • Down Syndrome - Pipeline by Balance Therapeutics Inc, 2022
  • Down Syndrome - Pipeline by Eisai Co Ltd, 2022
  • Down Syndrome - Pipeline by Elixirgen Therapeutics Inc, 2022
  • Down Syndrome - Pipeline by F. Hoffmann-La Roche Ltd, 2022
  • Down Syndrome - Pipeline by Felicitex Therapeutics Inc, 2022
  • Down Syndrome - Pipeline by KinoPharma Inc, 2022
  • Down Syndrome - Pipeline by Laminar Pharmaceuticals SA, 2022
  • Down Syndrome - Pipeline by Les Laboratoires Servier SAS, 2022
  • Down Syndrome - Pipeline by ManRos Therapeutics, 2022
  • Down Syndrome - Pipeline by NeuroCircuit Therapeutics Inc, 2022
  • Down Syndrome - Pipeline by NeuroNascent Inc, 2022
  • Down Syndrome - Pipeline by Perha Pharmaceuticals SAS, 2022
  • Down Syndrome - Pipeline by Prothena Corp Plc, 2022
  • Down Syndrome - Pipeline by SanBio Co Ltd, 2022
  • Down Syndrome - Dormant Projects, 2022

Down Syndrome - Discontinued Products
, 2022
List of Figures
  • Number of Products under Development for Down Syndrome, 2022
  • Number of Products under Development by Companies, 2022
  • Number of Products under Development by Universities/Institutes, 2022
  • Number of Products by Targets, 2022
  • Number of Products by Stage and Targets, 2022
  • Number of Products by Mechanism of Actions, 2022
  • Number of Products by Stage and Mechanism of Actions, 2022
  • Number of Products by Routes of Administration, 2022
  • Number of Products by Stage and Routes of Administration, 2022
  • Number of Products by Molecule Types, 2022
  • Number of Products by Stage and Top 10 Molecule Types, 2022

Companies Mentioned (Partial List)

A selection of companies mentioned in this report includes, but is not limited to:

  • AC Immune SA
  • Aelis Farma SAS
  • Alzheon Inc
  • Annovis Bio Inc
  • Avanti Biosciences Inc
  • Balance Therapeutics Inc
  • Eisai Co Ltd
  • Elixirgen Therapeutics Inc
  • F. Hoffmann-La Roche Ltd
  • Felicitex Therapeutics Inc
  • KinoPharma Inc
  • Laminar Pharmaceuticals SA
  • Les Laboratoires Servier SAS
  • ManRos Therapeutics
  • NeuroCircuit Therapeutics Inc
  • NeuroNascent Inc
  • Perha Pharmaceuticals SAS
  • Prothena Corp Plc
  • SanBio Co Ltd