*Association of American Publishers (AAP) PROSE Award Finalist in Clinical Medicine, 2024* Anti-Aging Pharmacology provides an overview of current research aimed at the pharmacological modulation of aging, including a discussion of the growing number of novel drug classes with promising anti-aging potential. The aging process is the main risk factor for all chronic diseases affecting the elderly. With lifespans extending across the globe, these chronic diseases are placing a larger burden on individuals and health care systems. Therefore, slowing down the aging rate could be more effective in delaying aging-associated chronic disorders than combating them one by one, which is the conventional approach in a current disease-based pharmacological paradigm.
This book contains the work of the world's leading researchers in the field, including sections on the conceptual and methodological background of anti-aging pharmacology, the basic classes of anti-aging drugs, phytochemicals, outcomes of anti-aging developments and future directions. This book will be of interest to a wide audience, ranging from pharmacologists, medicinal chemists and academic researchers in gerontology, biomedical sciences and those in medical practice.
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Table of Contents
SECTION I. Conceptual and Methodological Backgrounds 1. Can Aging be Cured as a Disease? 2. Geroscience Conceipt 3. Mechanistic Pathways of Aging 4. Biomarkers of Aging Rate 5. Artificial Intelligence-Based Approach in Anti-Aging Pharmacology 6. Big Data Approach 7. OMICs Approaches
SECTION II. Basic Classes of Anti-Aging Drugs 8. Antioxidant Paradox 9. Melatonin 10. Calorie Restriction Mimetics 11. Metformin 12. Rapamycin and rapalogs 13. Nonsteroidal Anti-Inflammatory Drugs 14. Statins 15. Senolytics 16. Epigenetic Drugs 17. Sirtuin Activating Compounds 18. Autophagy Inducers 19. Mitophagy Modulators 20. Telomerase Activators
SECTION III. Phytochemicals 21. Resveratrol 22. Curcumin 23. Quercetin 24. Genistein 25. Epigallocatechin Gallate 26. Berberine 27. Nanodelivery of phytobioactive compounds: a promise in anti-aging medicine
SECTION IV. Outcomes and Concluding Thoughts 28. Ethical perspectives on advances in biogerontology 29. Implications for Public Health Policy 30. The Business of Anti-Aging Science
