Biomarkers in Kidney Transplantation. Clinical Aspects and Laboratory Determination

Table of Contents

1. Organ transplantation: Past, Present and Future
2. Trends in organ transplantation
3. Immunobiology in organ transplantation
4. Immunosuppression in solid organ transplantation
5. Challenges in therapeutic drug monitoring of immunosuppressants
6. Biomarkers in transplantation: An overview
7. Biomarkers for risk of rejection
8. Biomarkers predicting the response to immunosuppressant therapy
9. Biomarkers predicting risk of recurrence of the primary renal disease
10. Biomarkers for detecting opportunistic infections
11. Biomarkers detecting organ toxicity with immunosupressant drugs
12. Biomarkers for drug development in organ transplantation
13. Commercially available biomarkers for renal transplantation
14. The current challenges, unmet need and future directions

Authors

Dr Smita Pattanaik Additional Professor of Clinical Pharmacology Department of Pharmacology, Post Graduate Institute of Medical Education and Research, Chandigarh, India. Smita Pattanaik received her MBBS from Utkal University, an MD in Pharmacology from PGIMER Chandigarh, DNB in Pharmacology from National Board of Examination New Delhi and DM in Clinical Pharmacology from PGIMER Chandigarh. Her current research focuses on concentrate on clinical pharmacology of immunosuppressant drugs, therapeutic drug monitoring and dose individualization (PK/PD) modeling and pharmacogenomics, clinical research methodology and biostatistics, clinical pharmacology of genitourinary system and bladder cancer chemotherapy. Dr Ashish Sharma Professor and Head, Department of Renal Transplant Surgery, Post Graduate Institute of Medical Education and Research, Chandigarh, India. Ashish Sharma is a Professor and Head of the Institution Department of Research and Transplantation Surgey, Postgraduate Institute of Medical Education and Research. He has contributed more than 50 publications in national and international journals. He started laparoscopic donor nephrectomy at the Institute and has trained transplant surgeons from different part of India in this technique. His active involvement in promoting deceases donors and improving protocols for identification and counselling of brainstem dead donors has led to increased deceased organ donations. He also initiated simultaneous kidney pancreas transplantation.