Variety of bacteria are present in our environment but only a few of these bacteria causes diseases in their hosts including humans. These bacteria face different stresses in the environment as well as inside the host and adapt number of strategies for their survival. In 5 parts Bacterial Survival in the Hostile Environment covers all tactics and strategies adopted by bacteria for their survival under stressed conditions and will be focused on mechanistic insights of pathogenic adaptations to host environments (acidic environment, microaerobic conditions, immune system stress, metal stress etc., modulation of host pathways by pathogens for survival, dormancy, drug tolerance and resistance, proteins for stress survival). The content also includes different adaptation mechanisms of extremophiles to extreme environment, provides a complete and globally available advance knowledge related to bacterial survival from different perspectives and reviews the knowledge gaps and future prospects in the field of microbial adaptation for sustainable development of in the field of infection biology and pharmaceutics.
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Table of Contents
Part 1: 1. Pathogenic adaptation to host environment 2. Adaptation to acidic environment 3. Microaerobic conditions 4. Immune system stress 5. Metal stress
Part 2: Modulation of host pathways by pathogens for adaptation/survival 6. Modulation in glycolytic flux 7. Endoplasmic reticulum stress 8. Host Mitochondria 9. Apoptosis 10. Necrosis 11. Phagosome maturation 12. Autophagy regulation
Part 3: Dormancy, Drug Tolerance and Resistance 13. Growth regulation by microbes 14. Survival and reactivation strategies of pathogens in stress through heterogeneous population generation 15. Persisters 16. Antimicrobial resistance
Part 4: Proteins for stress survival 17. Chaperones 18. Ribosome associated proteins 19. Methyltransferases 20. Proteins responsible for growth regulation of bacteria during unfavourable conditions 21. Proteins involved in biofilm
Part 5: Adaptation to Extreme Environment 22. Adaptations to Ph 23. Temperature 24. Pressure 25. Halophilic adaptations 26. Radiation adaptation
Authors
Shivendra Tenguria Project Scientist, Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center (UCLA), Los Angeles, CA, United States. Dr. Tenguria is an active researcher and currently working as Project Scientist in Cedars-Sinai Medical Center, Los Angeles, CA USA. He has been actively involved in research and training of graduate and undergraduate students. He received his MSc in Life Sciences from University of Rajasthan, Jaipur and PhD in Biotechnology from University of Hyderabad, Hyderabad, India. He received his postdoctoral training from Purdue University, Indiana, USA and Cedars-Sinai Medical Center (UCLA), Los Angeles, California, USA. Currently, he is working in the area of molecular innate immunity to unravel molecular signaling mechanics for sensing danger (infectious pathogens) signals through cytosolic receptors of the innate immune system of human and mouse hosts. With his doctoral and postdoctoral fellowships and research in the area of host-microbe interactions, bacterial survival and pathogenesis, he made seminal contributions by publishing in international Jr (Cell Host-Microbe, Nature Commun, Frontiers). Ashutosh Kumar Assistant Professor, Institute of Life Sciences, Ahmedabad University, Ahmedabad, India. Ashutosh Kumar works as an Assistant Professor in the Division of Biological and Life Sciences, School of Arts and Sciences, Ahmedabad University, Gujarat, India. He obtained his Master's degree in Applied Microbiology from Vellore Institute of Technology, Vellore in 2008 and worked at CSIR-Indian Institute of Toxicology Research, Lucknow for his Doctorate degree and was involved in understanding the fate of nanomaterials on biological systems. His current research areas of interest includes, nanomedicines for cancer and arthritis therapy, DNA Biochip for pathogen detection, nanobased drug and gene delivery, nanoemulsions for food industries, environmental nanotechnology and nanotoxicology.Ashutosh has established several new methods for nanomaterial toxicology in India. He developed a novel method for the detection of uptake of nanoparticles in live bacteria for several generations. He also unravelled the mechanism of metal oxide nanoparticles induced genotoxicity and apoptosis in prokaryotic as well as in eukaryotic cells using the state of art techniques such as flow cytometry, electron and confocal microscopy, biochemical enzyme assays, genomics and proteomics. The work conducted by him is in the frontiers of nanomaterial safety area worldwide. His studies shall have far reaching applications in predicting the adverse health effects of nanoparticles and safe use of ENMs to protect human and environmental health.
He has published more than 40 research papers and 12 book chapters in internationally reputed peer reviewed journals. He has received several national and international awards including the "INSA Medal For Young Scientist 2014� in the area of Health Sciences, NASI-Young Scientist Platinum Jubilee Award (2015) in the field of Bio-medical, Molecular Biology and Bio-technology, DBT Young Investigator Award, Ahmedabad University - Excellence in Research Award - 2015, among others for his scientific contributions.
