Thoroughly updated to reflect today's recent advances in adult and pediatric endocrinology, DeGroot's Endocrinology, 8th Edition, remains the comprehensive, international reference of choice for today's endocrinologists and fellows. A full peer review of the previous edition, conducted by a largely new group of renowned editors, was used to update this trusted, two-volume resource. In-depth coverage of both basic and clinical aspects of endocrinology and up-to-date information on the treatment and management of endocrine disorders are provided by a diverse group of expert contributors from six continents. A full-color format and helpful algorithms summarize clinical decision-making and practical approaches to patient management.
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Organizes content by all the glands that regulate the endocrine system while integrating basic science and clinical presentations of disease.�
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Includes new chapters: Anatomy and Physiology of the Hypothalmus and Pituitary, Differentiated Thyroid Cancer, Medullary Thyroid Cancer, Drugs that Affect Thyroid Function, Genetic Disorders of the Adrenal Cortex, Adrenal Pathology, Primary Aldosteronism, Transgender Healthcare, Erectile Dysfunction, Prevalence and Causes of Male Infertility, Sexual Dysfunction in the Female, Glucose Toxicity and Oxidative Stress.�
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Emphasizes basic science and evidence-based practice throughout.�
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Features extensive updates to content on thyroid and adrenal disfunction, endocrine-disrupting chemicals and human disease, clinical management of diabetes, and advances in genetics.�
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Includes algorithms to outline effective treatment protocols.�
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Contains new emphasis boxes that highlight key points in each chapter.��
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Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.�
Table of Contents
1�Principles of Endocrinology2�Regulation of Islet Hormone Synthesis and Secretion
2�Principles of Endocrine Measurements
3�Applications of Genetics in Endocrinology
3�Endocrine-Disrupting Chemicals and Human Disease
3�Endocrine Rhythms, the Sleep-Wake Cycle, and Biological Clocks
4�Prolactinomas and Disorders of Prolactin Secretion
5�Hypopituitarism including Growth Hormone Deficiency
6�Acromegaly
7�Development of the Pituitary
7�Cushing's Disease
8�CLINICALLY NONFUNCTIONING SELLAR MASSES
9�TSH-Producing Pituitary Tumors
10�Pituitary Surgery
11�CRANIOPHARYNGIOMAS AND PARASELLAR MASSES
12�DISORDERS OF SODIUM, DIABETES INSIPIDUS AND HYPONATRAEMIA
13�Anatomy and Physiology of the Hypothalmus and Pituitary
14�Genetic Disorders of the Pituitary
15�Aggressive Pituitary Tumors
16�Radiotherapy in Pituitary Tumors
17�Somatic Growth and Maturation: Growth hormone and Other Growth Factors
18�Growth Hormone Deficiency in Children
19�Basic and Clinical Aspects of Appetite Regulation and Energy Expenditure
20�Obesity: Risk, Risk Factors, and Medical Management
21�GENETIC OBESITY SYNDROMES
22�Regulation of Intermediary Metabolism During Fasting, Feeding, and Exercise
23�Adipose Tissue Function: Metabolic and Endocrine
24�Lipodystrpohy Syndromes
25�Lipoprotein Metabolism and the Treatment of Lipid Disorders
26�Metabolic Syndrome
27�Bariatric Procedures and Operations
28�Development of the Endocrine Pancreas
29�Regulation of Islet Hormone Synthesis and Secretion
30�Mechanisms of Insulin Action
31�Classification and Diagnosis of Diabetes Mellitus
32�Autoimmune (Type 1)Diabetes Mellitus: Etiology, Pathogenesis, Prediction, and Prevention
33�Type 2 Diabetes Mellitus: Etiology, Pathogenesis, and Natural History
34�Diabetes Mellitus and Pregnancy
35�Hyperglycemia Secondary to Non-Traditional Diabetic Conditions and Therapies
36�Beta-cell Glucose Toxicity and Oxidative Stress
37�DIABETIC KETOACIDOSIS AND HYPERGLYCEMIC HYPEROSMOLAR STATE
38�Hypoglycemia and Hypoglycemic Syndromes
39�Treatment of Type 1 Diabetes Mellitus in Adults
40�Clinical Management of Type 2 Diabetes Mellitus
41�Pancreas and Islet Transplantation
42�Diabetes and Long-Term Complications
43�Diabetic Eye Disease
44�Diabetic Neuropathy
45�Glucose Sensors and Insulin Pumps
45�Diabetic Kidney Disease
46�Diabetic Foot and Vascular Complications
47�Parathyroid Hormone and the Parathyroid Hormone Receptor Type 1 in the Regulation of Calcium and Phosphate Homeostasis and Bone Metabolism
48�Parathyroid Hormone-Related Protein
49�Calcitonin
50�Vitamin D: From Photosynthesis, Metabolism, and Action to Clinical Applications
51�Bone Development and Remodeling
52�Regulation of Calcium Homeostasis and Genetic Disorders that Affect Calcium Metabolism
53�Genetic Disorders of Phosphate Homeostasis
54�Primary Hyperparathyroidism
55�Hypercalcemia of Malignancy
56�Surgical Management of Hyperparathyroidism
57�PSEUDOHYPOPARATHYROIDISM, ALBRIGHT'S HEREDITARY OSTEODYSTROPHY, AND PROGRESSIVE OSSEOUS HETEROPLASIA: DISORDERS CAUSED BY GNAS MUTATIONS THAT REDUCE Gsa ACTIVITY
58�Genetic Defects in Vitamin D Metabolism and Action
59�Hereditary Disorders of the Skeleton
60�Osteoporosis
61�CKD-MBD Syndrome: Chronic Kidney Disease Produced Disorders in Skeletal, Vascular, and Cardiac Tissues and Mineral Metabolism
62�Disorders of Mineralization
63�Paget's Disease of Bone
64�Anatomy and Development of the Thyroid
65�Thyroid-Stimulating Hormone and TSH Receptor
66�Thyroid Hormone Transporters and Metabolism
67�Thyroid Hormone Action
68�Thyroid Function Testing (TSH, T3, and T4)
69�Thyroid Imaging
70�Pathology of the Thyroid Gland
71�Graves' Disease
72�Graves' Orbitopathy
73�Thyroiditis
74�Hypothyroidism
75�Thyroid and Pregnancy
76�Iodine Nutrition and the Thyroid
77�Euthyroid and hyperthyroid nodules and goiter
78�Differentiated Thyroid Cancer - Streamlining Diagnosis And Optimizing Management
79�Medullary Thyroid Cancer
80�Anaplastic (Undifferentiated) Thyroid Carcinoma
81�RESISTANCE TO THYROID HORMONE & GENETIC DEFECTS OF THE THYROID
82�Surgical Management of Thyroid Disease
83�Nonthyroidal Illness Syndrome
84�Drugs that Affect Thyroid Function
85�Adrenal� development and Homeostasis
86�Genetic Disorders of the Adrenal Cortex
87�The Principles, Enzymes, and Pathways of Human Steroidogenesis
88�Mineralocorticoids: Physiology, metabolism, receptors and resistance
89�Glucocorticoid Receptors: Mechanisms of Action in Health and Disease
90�Adrenal Androgens Adrenarche and Adrenopause
91�Adrenal Pathology
92�Adrenal Gland Imaging
93�Adrenal Insufficiency
94�Defects of Adrenal Steroidogenesis
95�Adrenal Genomics II: Familial and sporadic neoplasia
96�Primary Aldosteronism
97�Adrenal Cushing's Syndrome
98�Adrenocortical Carcinoma
99�Pheochromocytoma
100�Adrenal Surgery
101�Hypothalamic Regulation of GnRH
101�Differences of Sex Development
102�Endocrinology of Sexual Maturation and Puberty
103�Endocrinology of Pubertal Disorders
�TBD
104�Transgender Health Care
105�Gonadotropin regulation, Androgen and estrogen physiology
106�Hypogonadism - Pathogenesis, Diagnosis and Treatment
107�Testosterone Deficiency: Aging and Chronic Disease
108�Gynecomastia
109�Erectile dysfunction
110�Misuse and Abuse of Anabolic Hormones
111�Regulation of Spermatogenesis
112�Clinical Management of Male Infertility
113�Male Contraception
114�Testicular Dysgenesis Syndrome and Testicular Tumors
115�Prevalence and Causes of Male Infertility
116�Benign Prostatic Hyperplasia and Prostate Cancer
117�The Menstrual Cycle and Disorders of Ovulation
118�Prostate Cancer
118�Folliculogenesis, Ovulation, and Luteogenesis
119�Ovarian Hormone Synthesis
120�Estrogen and Progesterone Action
121�Prostate BPH and Prostate Cancer
121�Contraception
122�Menopause and Perimenopause
123�Female Infertility: Evaluation and Management
124�Androgen Excess Disorders in Women
125�ENDOMETRIOSIS
126�Uterine Fibroids and Adenomyosis.
127�Hormonal Control of Breast Development
128�Sexual Dysfunction in the Female
129�Hormonal Control of Human Pregnancy and Parturition
130�Fetal and Neonatal Endocrinology
131�Hormonal Changes and Pregnancy Testing
132�Autoimmune Polyglandular Syndromes
133�Multiple Endocrine Neoplasia Type 1
134�Multiple Endocrine Neoplasia Types 2 and 3, and Medullary Thyroid Carcinoma
135�Neuroendocrine Tumor Syndromes
136�Ectopic Hormone Syndromes
137�Endocrine-Disrupting Chemicals and Human Health
Authors
R. Paul Robertson R. Paul Robertson, M.D. is an Emeritus Professor of Medicine at the University of Washington and at the University of Minnesota.Dr. Robertson has published 395 peer-reviewed manuscripts with primary emphasis on pancreatic islet function in humans, animals, and clonal cell lines. His early studies were the first to demonstrate defects involving the adverse effects of glucose toxicity on the critical insulin promoters Pdx-1 and MafA associated with glucose toxicity. More recent research demonstrated adverse metabolic consequences of using the liver as a transplant site for pancreatic islet transplantation in patients with type 1 diabetes mellitus and in autoislet recipients following pancreatectomy for chronic, painful pancreatitis.
