+353-1-416-8900REST OF WORLD
+44-20-3973-8888REST OF WORLD
1-917-300-0470EAST COAST U.S
1-800-526-8630U.S. (TOLL FREE)

Novel Cardiovascular Drug Delivery Devices Market, Distribution by Type of Drug Eluted, Stent Material, and Key Geographical Regions: Industry Trends and Global Forecasts, 2022-2035

  • PDF Icon

    Report

  • 315 Pages
  • April 2022
  • Region: Global
  • Roots Analysis
  • ID: 5574829
Cardiovascular diseases (CVD) are reported to be one of the leading causes of deaths across the globe, surpassing conditions, such as cancer and respiratory disorders. According to the WHO, around one third of the annual global deaths (an estimated 18 million) can be attributed to cardiac disorders. Specifically, coronary artery disease (CAD) is the most common form of cardiovascular disorder; around 11 million deaths were linked to this indication in 2020. It is worth mentioning that, in 2020 (post the onset of the pandemic), a more than 3% increase in the deaths related to heart diseases was reported. Further, according to the Centers for Disease Control and Prevention, the financial burden (in terms of annual medical costs and loss of productivity) associated with cardio vascular diseases is expected to be surpass USD 1,000 billion, in 2030. In order to prevent the critical effects of vessel narrowing and plaque buildup in arteries, various coronary interventional devices are being used; cardiovascular stents have emerged as one of the most preferred solutions to mitigate the aforementioned concerns. Traditionally, bare-metal stent (BMS) was used extensively to open the blocked passages and restore adequate blood flow to the heart. In recent years, a shift in preference has been observed towards the use of drug-eluting stent (DES), which are coated with a polymer carrying an antiproliferative drug. Such stents have been demonstrated to reduce / prevent in-stent restenosis (re-narrowing of the arteries previously opened using angioplasty), which was a major complication associated with the use of bare-metal stents. Drug eluting stents are considered to be revolutionary in the interventional cardiology domain, as they enable improved revascularization rates and reduced risk of thrombosis.

Presently, over 90 cardiovascular drug eluting stents are being offered by around 40 players located across the globe. Majority of such devices employ the use of metals, such as platinum chromium and stainless steel. Further, the patents focused on cardiovascular drug eluting stents and associated technologies have been filed / granted at a CAGR of 13%, in the past two decades. In this context, it is important to note that, over the past few years, there have been significant innovations in cardiovascular therapeutics domain, in terms of development of advanced bioresorbable stents, drug combinations, polymer and nanomaterial coatings, to further increase the safety and efficacy of these treatment options. For instance, recently, an implantable biocompatible stent containing miniaturized ultrasonic transducers have been proposed by a group of researchers, which can be used for real-time monitoring of restenosis in the patients. Moreover, recent advancements related to the use of augmented reality and deep learning can enable the development of patient-specific stents, paving the way for personalized-treatment for patients suffering from cardiovascular disorders. Given the ongoing pace of innovation in this field, adoption of cutting-edge technologies by device developers, the ever-increasing incidence of heart diseases and the rise in demand for associated treatments, we believe that the cardiovascular drug eluting stent market is likely to evolve at a rapid pace, over the coming years.


Scope of the Report


The “Novel Cardiovascular Drug Delivery Devices Market, Distribution by Type of Drug Eluted (Sirolimus, Paclitaxel, Everolimus, Zotarolimus and Others), Stent Material (Platinum Chromium, Cobalt Chromium, Stainless Steel and Others) and Key Geographical Regions (North America, Europe, Asia, Middle East and North Africa, Latin America, and Rest of the World): Industry Trends and Global Forecasts, 2022-2035” report features an extensive study of the current landscape, offering an informed opinion on the likely adoption of cardiovascular drug eluting stents in the healthcare domain, till 2035. The report features an in-depth analysis, highlighting the capabilities of various stakeholders engaged in this market space.


Amongst other elements, the report includes:

  • A detailed overview of the current market landscape of the players engaged in developing / manufacturing cardiovascular drug eluting stents, including information on their respective year of establishment, company size (in terms of number of employees), number of products offered and location of headquarters. Further, it provides a detailed assessment of the overall landscape of over 90 cardiovascular drug eluting stents, based on several relevant parameters, such as type of eluted drug, type of stent material, post dilatation limit, stent length, stent diameter, nominal pressure, rated burst pressure and administered drug concentration.
  • An in-depth analysis, highlighting the contemporary market trends, using five schematic representations, including a heat map representation (based on type of drug eluted and administered drug concentration), a stacked bar chart representation (by the type of drug eluted and stent material), a tree map representation (based on maximum stent length and maximum stent diameter), a 4D bubble chart representation comparing the players engaged in cardiovascular drug eluting stents domain (based on several relevant parameters (such as year of establishment, company size, number of products offered and location of headquarters)) and a grid representation (based on company size, number of products offered, maximum stent length, maximum stent diameter and location of headquarters).
  • An insightful company competitiveness analysis of cardiovascular drug eluting stent developers, taking into consideration various relevant parameters, such as year of experience and portfolio strength (in terms of number of products offered, stent material, maximum stent length, maximum stent diameter, maximum nominal pressure, maximum rated burst pressure, and lowest strut thickness).
  • Elaborate profiles of various prominent players that are currently engaged in developing / manufacturing drug eluting stents employed for the treatment of cardiovascular disorders, featuring a brief overview of the company (including information on its year of establishment, number of employees, location of headquarters, key members of the executive team and cardiovascular drug delivery device portfolio), recent developments and an informed future outlook.
  • An in-depth analysis of the various patents that have been filed / granted related to cardiovascular drug eluting stents, based on various parameters, such as patent type, publication year, geographical location, CPC symbol, emerging focus areas, type of applicant and leading industry / non-industry players (in terms of the size of intellectual property portfolio). Further, it features a three-dimensional bubble analysis (based on patent citation count, publication year, extended geographical reach), patent benchmarking analysis and a detailed patent valuation analysis.
  • An insightful case study focused on novel cardiovascular therapeutics (such as gene therapy, next generation complements, oral proteins and peptides, regulatory t-cell (tregs) therapies and subcutaneous biologics) and novel cardiovascular-based services / solutions (such as biopharmaceutical contract research offerings, digital therapeutics and precision medicine software). It also features a list of developers, along with details on their year of establishment, company size and location of headquarters. 
  • An elaborate analysis in order to estimate the current and future demand for cardiovascular drug eluting stents, based on several relevant parameters, such as type of drug eluted (sirolimus, paclitaxel, everolimus, zotarolimus and others), type of stent material (platinum chromium, cobalt chromium, stainless steel and others) and key geographical regions (North America, Europe, Asia, Middle East and North Africa, Latin America, and Rest of the World) for the period 2022-2035. Kindly note that input parameters considered for this analysis include number of patients suffering from cardiovascular disorders that can be treated using cardiovascular drug eluting stents and average price of such stents across various geographies.


One of the key objectives of the report was to estimate the existing market size and future opportunities associated with cardiovascular drug eluting stents over the next decade. Based on several parameters, such as annual cases reported for cardiovascular disorders, percutaneous coronary interventions performed (in terms of number of patients) to treat such disorders, and average price for associated drug eluting stents across various geographical regions, we have provided an informed estimate on the evolution of the market for the period 2022-2035. The report also features the likely distribution of the current and forecasted opportunity related to cardiovascular drug eluting stents market across type of drug eluted (sirolimus, paclitaxel, everolimus, zotarolimus and others), type of stent material (platinum chromium, cobalt chromium, stainless steel and others) and key geographical regions (North America, Europe, Asia, Middle East and North Africa, Latin America, and Rest of the World). In order to account for future uncertainties and add robustness to our forecast model, we have provided three forecast scenarios, portraying the conservative, base and optimistic scenarios, representing different tracks of the industry’s growth.

The opinions and insights presented in the report were influenced by discussions held with multiple stakeholders in this domain. The report features detailed transcripts of interviews held with several industry stakeholders.

All actual figures have been sourced and analyzed from publicly available information forums and primary research discussions. Financial figures mentioned in this report are in USD, unless otherwise specified.


Key Questions Answered

  • Who are the leading players offering cardiovascular drug eluting stents?
  • Which type of drug eluting stent is most commonly offered by developers engaged in this market space?
  • What is the relative competitiveness of different players engaged in the development / manufacturing of cardiovascular drug eluting stents?
  • How has the patent landscape in this domain evolved over the last two decades?
  • What is the present and likely future demand for cardiovascular drug eluting stents in the overall healthcare sector?
  • What are the anticipated future trends related to cardiovascular drug eluting stents market?
  • How is the current and future opportunity likely to be distributed across key market segments?

Table of Contents

1. PREFACE
1.1. Scope of the Report
1.2. Research Methodology
1.3. Key Questions Answered
1.4. Chapter Outlines
2. EXECUTIVE SUMMARY
3. INTRODUCTION
3.1 Chapter Overview
3.2. Overview of Cardiovascular Drug Delivery Devices
3.2.1. Types of Cardiovascular Drug Delivery Devices
3.2.1.1. Drug Eluting Stents (DES)
3.2.1.2. Drug Eluting Balloons (DEB)
3.3. Key Indications Targeted by Cardiovascular Drug Delivery Devices
3.3.1. Atherosclerosis
3.3.2. Heart Failure
3.3.3. In-Stent Restenosis
3.4. Potential Risks Associated with Drug Eluting Stents and Balloons
3.5. Recent Advancements Related to Cardiovascular Drug Delivery Devices
3.6. Concluding Remarks
4. MARKET LANDSCAPE
4.1. Chapter Overview
4.2. Cardiovascular Drug Eluting Stents: Overall Market Landscape
4.2.1. Analysis by Type of Drug Eluted
4.2.2. Analysis by Stent Material
4.2.3. Analysis by Maximum Post Dilatation Limit
4.2.4. Analysis by Maximum and Minimum Stent Length
4.2.5. Analysis by Maximum and Minimum Stent Diameter
4.2.6. Analysis by Maximum Nominal Pressure
4.2.7. Analysis by Maximum Rated Burst Pressure
4.2.8. Analysis by Administered Drug Concentration
4.2.9. Analysis by Minimum Strut Thickness
4.3. Cardiovascular Drug Eluting Stents: Developers Landscape
4.3.1. Analysis by Year of Establishment
4.3.2. Analysis by Company Size
4.3.3. Analysis by Location of Headquarters
4.3.4. Leading Players: Analysis by Number of Products
5. KEY INSIGHTS
5.1. Chapter Overview
5.2. Analysis by Eluted Drug and Administered Drug Concentration (Heat Map)
5.3. Analysis by Eluted Drug and Stent Material (Stacked Bar Chart)
5.4. Analysis by Maximum Stent Length and Maximum Stent Diameter (Tree Map)
5.5. Analysis by Year of Establishment, Company Size, Number of Products Offered
and Region (4D Bubble Chart)
5.6. Analysis by Company Size, Region, Number of Products Offered, Maximum
Stent Length and Maximum Stent Diameter (Grid Representation)
6. COMPANY COMPETITIVENESS
6.1. Chapter Overview
6.2. Key Assumptions and Parameters
6.3. Methodology
6.3.1. Company Competitiveness Analysis: Small Companies
6.3.2. Company Competitiveness Analysis: Mid-sized Companies
6.3.3. Company Competitiveness Analysis: Large Companies
6.3.4. Company Competitiveness Analysis: Very Large Companies
7. COMPANY PROFILES
7.1. Chapter Overview
7.2. Alvimedica
7.2.1. Company Overview
7.2.2. Cardiovascular Drug Delivery Device Portfolio
7.2.3. Recent Developments and Future Outlook
7.3. B. Braun
7.3.1. Company Overview
7.3.2. Cardiovascular Drug Delivery Device Portfolio
7.3.3. Recent Developments and Future Outlook
7.4. Boston Scientific
7.4.1. Company Overview
7.4.2. Cardiovascular Drug Delivery Device Portfolio
7.4.3. Recent Developments and Future Outlook
7.5 Cook Medical
7.5.1. Company Overview
7.5.2. Cardiovascular Drug Delivery Device Portfolio
7.5.3. Recent Developments and Future Outlook
7.6. Endocor
7.6.1. Company Overview
7.6.2. Cardiovascular Drug Delivery Device Portfolio
7.6.3. Recent Developments and Future Outlook
7.7. Eurocor
7.7.1. Company Overview
7.7.2. Cardiovascular Drug Delivery Device Portfolio
7.7.3. Recent Developments and Future Outlook
7.8. iVascular
7.8.1. Company Overview
7.8.2. Cardiovascular Drug Delivery Device Portfolio
7.8.3. Recent Developments and Future Outlook
7.9. Lepu Medical
7.9.1. Company Overview
7.9.2. Cardiovascular Drug Delivery Device Portfolio
7.9.3. Recent Developments and Future Outlook
7.10. Medinol
7.10.1. Company Overview
7.10.2. Cardiovascular Drug Delivery Device Portfolio
7.10.3. Recent Developments and Future Outlook
7.11. Medtronic
7.11.1. Company Overview
7.11.2. Cardiovascular Drug Delivery Device Portfolio
7.11.3. Recent Developments and Future Outlook
7.12. Meril
7.12.1. Company Overview
7.12.2. Cardiovascular Drug Delivery Device Portfolio
7.12.3. Recent Developments and Future Outlook
7.13. Relisys Medical Devices
7.13.1. Company Overview
7.13.2. Cardiovascular Drug Delivery Device Portfolio
7.13.3. Recent Developments and Future Outlook
7.14. Sahajanand Medical Technologies
7.14.1. Company Overview
7.14.2. Cardiovascular Drug Delivery Device Portfolio
7.14.3. Recent Developments and Future Outlook
7.15. Sinomed
7.15.1. Company Overview
7.15.2. Cardiovascular Drug Delivery Device Portfolio
7.15.3. Recent Developments and Future Outlook
7.16. Vascular Concepts
7.16.1. Company Overview
7.16.2. Cardiovascular Drug Delivery Device Portfolio
7.16.3. Recent Developments and Future Outlook
8. PATENT ANALYSIS
8.1. Chapter Overview
8.2. Scope and Methodology
8.3. Cardiovascular Drug Eluting Stents: Patent Analysis
8.3.1. Analysis by Type of Patent
8.3.2. Analysis by Publication Year
8.3.3. Analysis by Year of Granted Patents
8.3.4. Analysis by Year of Filed Patent Applications
8.3.5. Analysis by Issuing Authority
8.3.6. Analysis by Patent Focus
8.3.7. Analysis by Patent Age
8.3.8. Analysis by CPC Symbols
8.3.9. Leading Players: Analysis by Number of Patents
8.4. Cardiovascular Drug Eluting Stents: Patent Benchmarking Analysis
8.4.1. Analysis by Patent Characteristics
8.4.2. Analysis by Geography
8.5. Cardiovascular Drug Eluting Stents: Patent Valuation Analysis
9. CASE STUDY: NOVEL CARDIOVASCULAR THERAPEUTICS AND SERVICES / SOLUTIONS
9.1. Chapter Overview
9.2. Novel Cardiovascular Therapeutics
9.2.1. Gene Therapy
9.2.2. Next Generation Complement Therapeutics
9.2.3. Oral Proteins and Peptides Therapies
9.2.4. Regulatory T-Cell Therapies (Tregs) Therapies
9.2.5. Subcutaneous Biologics
9.3. Novel Cardiovascular-based Services / Solutions
9.3.1. Biopharmaceutical Contract Research Offerings
9.3.2. Digital Therapeutics Services
9.3.3. Precision Medicine Software
9.3.4. Virtual Clinical Trial Services
10. DEMAND ANALYSIS
10.1. Chapter Overview
10.2. Key Assumptions and Methodology
10.3. Global Demand for Cardiovascular Drug Eluting Stents
10.3.1. Analysis by Type of Drug Eluted
10.3.1.1. Global Demand for Sirolimus Eluting Stents
10.3.1.2. Global Demand for Paclitaxel Eluting Stents
10.3.1.3. Global Demand for Everolimus Eluting Stents
10.3.1.4. Global Demand for Zotarolimus Eluting Stents
10.3.1.5. Global Demand for Other Drugs Eluting Stents
10.3.2. Analysis by Stent Material
10.3.2.1. Global Demand for Platinum Chromium Stents
10.3.2.2. Global Demand for Cobalt Alloy Stents
10.3.2.3. Global Demand for Stainless Steel Stents
10.3.2.4. Global Demand for Other Stents
10.3.3. Analysis by Geography
10.3.3.1. Demand for Cardiovascular Drug Eluting Stents in North America
10.3.3.1.1. Demand for Cardiovascular Drug Eluting Stents in the US
10.3.3.1.2. Demand for Cardiovascular Drug Eluting Stents in Canada
10.3.3.2. Demand for Cardiovascular Drug Eluting Stents in Europe
10.3.3.2.1. Demand for Cardiovascular Drug Eluting Stents in France
10.3.3.2.2. Demand for Cardiovascular Drug Eluting Stents in Germany
10.3.3.2.3. Demand for Cardiovascular Drug Eluting Stents in Italy
10.3.3.2.4. Demand for Cardiovascular Drug Eluting Stents in the Netherlands
10.3.3.2.5. Demand for Cardiovascular Drug Eluting Stents in Spain
10.3.3.2.6. Demand for Cardiovascular Drug Eluting Stents in the UK
10.3.3.3. Demand for Cardiovascular Drug Eluting Stents in Asia
10.3.3.3.1. Demand for Cardiovascular Drug Eluting Stents in China
10.3.3.3.2. Demand for Cardiovascular Drug Eluting Stents in India
10.3.3.3.3. Demand for Cardiovascular Drug Eluting Stents in Japan
10.3.3.3.4. Demand for Cardiovascular Drug Eluting Stents in South Korea
10.3.3.4. Demand for Cardiovascular Drug Eluting Stents in Middle East and North Africa
10.3.3.4.1. Demand for Cardiovascular Drug Eluting Stents in Israel
10.3.3.4.2. Demand for Cardiovascular Drug Eluting Stents in Turkey
10.3.3.5. Demand for Cardiovascular Drug Eluting Stents in Latin America
10.3.3.5.1. Demand for Cardiovascular Drug Eluting Stents in Brazil
10.3.3.6. Demand for Cardiovascular Drug Eluting Stents in Rest of the World
10.3.3.6.1. Demand for Cardiovascular Drug Eluting Stents in Australia
10.3.3.6.2. Demand for Cardiovascular Drug Eluting Stents in New Zealand
11. MARKET FORECAST
11.1. Chapter Overview
11.2. Key Assumptions and Methodology
11.3. Global Cardiovascular Drug Eluting Stents Market, 2022-2035
11.3.1. Analysis by Type of Drug Eluted
11.3.1.1. Global Sirolimus Eluting Stents Market
11.3.1.2. Global Paclitaxel Eluting Stents Market
11.3.1.3. Global Everolimus Eluting Stents Market
11.3.1.4. Global Zotarolimus Eluting Stents Market
11.3.1.5. Global Other Drugs Eluting Stents Market
11.3.2. Analysis by Stent Material
11.3.2.1. Global Platinum Chromium Stents Market
11.3.2.2. Global Cobalt Alloy Stents Market
11.3.2.3. Global Stainless Steel Stents Market
11.3.2.4. Global Other Stents Market
11.3.3. Analysis by Geography
11.3.3.1. Cardiovascular Drug Eluting Stents Market in North America
11.3.3.1.1. Cardiovascular Drug Eluting Stents Market in the US
11.3.3.1.2. Cardiovascular Drug Eluting Stents Market in Canada
11.3.3.2. Cardiovascular Drug Eluting Stents Market in Europe
11.3.3.2.1. Cardiovascular Drug Eluting Stents Market in France
11.3.3.2.2. Cardiovascular Drug Eluting Stents Market in Germany
11.3.3.2.3. Cardiovascular Drug Eluting Stents Market in Italy
11.3.3.2.4. Cardiovascular Drug Eluting Stents Market in the Netherlands
11.3.3.2.5. Cardiovascular Drug Eluting Stents Market in Spain
11.3.3.2.6. Cardiovascular Drug Eluting Stents Market in the UK
11.3.3.3. Cardiovascular Drug Eluting Stents Market in Asia
11.3.3.3.1. Cardiovascular Drug Eluting Stents Market in China
11.3.3.3.2. Cardiovascular Drug Eluting Stents Market in India
11.3.3.3.3. Cardiovascular Drug Eluting Stents Market in Japan
11.3.3.3.4. Cardiovascular Drug Eluting Stents Market in South Korea
11.3.3.4. Cardiovascular Drug Eluting Stents Market in Middle East and North Africa
11.3.3.4.1. Cardiovascular Drug Eluting Stents Market in Israel
11.3.3.4.2. Cardiovascular Drug Eluting Stents Market in Turkey
11.3.3.5. Cardiovascular Drug Eluting Stents Market in Latin America
11.3.3.5.1. Cardiovascular Drug Eluting Stents Market in Brazil
11.3.3.6. Cardiovascular Drug Eluting Stents Market in Rest of the World
11.3.3.6.1. Cardiovascular Drug Eluting Stents Market in Australia
11.3.3.6.2. Cardiovascular Drug Eluting Stents Market in New Zealand
12. CONCLUSION
13. EXECUTIVE INSIGHTS
13.1. Chapter Overview
13.2. Scitech Medical
13.2.1. Company Snapshot
13.2.2. Interview Transcript: Luciano Curado, Chief Technology Officer
13.3. Translumina
13.3.1. Company Snapshot
13.3.2. Interview Transcript: Harish Rawat, Production Executive
14. APPENDIX I: TABULATED DATA15. APPENDIX II: LIST OF COMPANIES AND ORGANIZATIONS

Companies Mentioned

  • AaviGen
  • Abbott
  • Abiogenesis Clinpharm
  • Acceleron (Acquired by Merck)
  • Accura Medizintechnik
  • Aesculap (Acquired by B. Braun)
  • Aesculape CRO 
  • Alexion
  • Alnylam
  • Alvimedica
  • Ambulero
  • American Heart Association
  • amg International
  • Amgen
  • Amsino
  • Anaeropharma Science
  • AnGes
  • Angionetics
  • Anlong Bio
  • Asklepios BioPharmaceutical
  • Astellas 
  • AstraZeneca
  • B. Braun
  • Balton
  • BioMarin
  • Biosensors International
  • BIOTRONIK
  • Boston Scientific
  • Breakthrough Genomics
  • Bristol Myers Squibb
  • California Institute of Technology
  • Cambridge University Hospitals NHS Foundation Trust
  • Cardionovum
  • CiVi Biopharma
  • Cohesic
  • Consip
  • Cook Medical
  • Corvidia Therapeutics
  • DiNAQOR
  • Dyno Therapeutics
  • Eli Lilly
  • Elixir Medical
  • ENDOCOR
  • Eucatech
  • Eurocor
  • Excelya
  • Genedata
  • Genelife Clinical Research
  • Genoss
  • Helixmith
  • HP
  • Huapont Life Sciences
  • Human Longevity
  • Human Stem Cells Institute
  • Hygea Precision Medicine 
  • Infraredx
  • Innovent Biologics
  • InSitu Technologies
  • Integer
  • Ionis Pharmaceuticals
  • iVascular
  • Jiangsu Hengrui Medicine
  • Johnson & Johnson
  • Lepu Medical
  • LEXEO Therapeutics
  • Liaoning Yinyi Biological Technology
  • LIB Therapeutics
  • LifeOmic
  • Medinol
  • Medipredict
  • Medtronic
  • Meril 
  • Metabolon
  • MicroPort
  • Minvasys
  • Mitsubishi Tanabe Pharma
  • Multimedics
  • Nuevocor
  • Novartis
  • N-ovative Health Technologies
  • Numed Technologies
  • Oracle
  • Perceiv AI
  • Pharming
  • PhaseBio
  • Precigen
  • QAscent Research Solutions
  • QualiMed
  • Regeneron
  • Relisys Medical Devices
  • Renalytix
  • Renova Therapeutics
  • REVA Medical
  • REYON Pharmaceuticals
  • Rontis
  • R-Pharm
  • S3V Vascular Technologies
  • Sahajanand Laser Technology
  • Sahajanand Medical Technologies
  • SalioGen Therapeutics
  • Sarepta Therapeutics
  • SCITECH Medical
  • Siguler Guff
  • SINOMED
  • Skyline Therapeutics
  • SOPHiA GENETICS
  • Steel Partners
  • Strand Life Sciences
  • StrideBio
  • Tenaya Therapeutics
  • Terumo
  • Translumina
  • uniQure
  • University of Florida
  • USM Healthcare
  • Vascular Concepts (Acquired by Sahajanand Medical Technologies)
  • VBL Therapeutics
  • Verily
  • XBiotech
  • Xcene Research
  • XyloCor Therapeutics
  • Zarek Distribuidora De Produtos Hospitalares (Acquired by Sahajanand Medical Technologies)
  • Zensun

Methodology

 

 

Loading
LOADING...