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Gamma Delta T Cell Cancer Therapy Market & Clinical Trials Forecast 2028

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    Report

  • 180 Pages
  • April 2022
  • Region: Global
  • Kuick Research
  • ID: 5574917
UP TO OFF until Jun 30th 2024

Gamma Delta T Cell Therapy Represents One of the Most Promising T Cell Therapies in Clinical Development

The introduction of T cell-based immunotherapy has greatly revolutionized the paradigm of cancer treatment. The progress in clinical research and innovation has led to the identification of small subsets of T cells classified as gamma delta T cells. Gamma delta T cells are the minor subsets of T cells that constitutes only about 1% to 5% of T cell population. Their unique biology and conferred advantages over conventional T cells have enabled the researchers to utilize these novel cells as a promising candidate for adoptive immunotherapy. Since its identification, scientists have harnessed the potential of gamma delta T cells in the management of several cancers.  

The gamma delta T cell therapy represents one of the most promising T cell therapies in clinical development which can be suggested by the rapid research and development activities among the pharmaceutical companies. The major companies in the market are presenting promising preclinical and clinical data of gamma delta T cell therapies. For instance, in 2022, In8bio provided an update on ongoing phase-I clinical trial of INB-200. The novel gamma delta T cell product has shown a manageable safety profile and promising progression-free survival and overall survival rate. The encouraging data from a clinical trial suggest the promising future of gamma delta T cell therapy in the management of cancer. 

Apart from cancer, researchers are also expanding the role of gamma delta T cell therapy in the management of other diseases such as HIV, COVID-19, and other viral infections. Recently, Enochian Biosciences announced that US FDA has accepted a pre-investigational new drug request for a cell therapy treatment that combines autologous natural killer and gamma delta T-cells. Furthermore, several preclinical studies also indicate an innate involvement of gamma delta T cells in viral infections. The coming years will witness the translation of these investigations into clinical trials, which will further propel the growth of market. 

The rising investment from the pharmaceutical giants have led to the development of a strong clinical pipeline of gamma delta T cell therapy products. The key players operating in the market are Acopedia, Takeda Pharma, Lava Therapeutics, TC Biopharma, Cytomed Therapeutics, Gamma Delta Therapeutics, and Adapate Therapeutics. The major drugs in the clinical pipeline include INB-200, LAVA-051, ADI-001, TCB-007, ACE-1813, KB-PD1, and several others. Apart from this, several pharmaceutical giants have also entered into a collaboration, mergers, or other alliances to maintain their position in the market. In January 2022, Takeda Pharmaceutical announced the exercise of its option to acquire Adapate Therapeutics. Through this acquisition, Takeda will obtain Adapate antibody-based gamma delta T-cell engager platform including pre-clinical candidate and discovery pipeline programs. 

US is currently dominating the global initiatives in the development of gamma delta T cell therapy driven by a large number of ongoing clinical trials, presence of key players in the region, and increasing initiatives from various stakeholders in the industry. Apart from this, US FDA is also granting orphan drug designation to gamma T cell therapies which provides several financial and non-financial incentives to boost the drug development process. For instance, in 2021, US FDA granted orphan drug designation to two gamma delta T cell therapies including GDX012 for acute myeloid leukemia and LAVA-051 for chronic lymphocytic leukemia. 

As per our report findings, the global gamma delta T-cell therapy market is expected to surpass US$ 4 Million by 2028. The rise in cancer rates and the subsequent unavailability of effectively curing drugs will propel the growth of the market in the coming years. In addition, new product launches, continuous investment by pharmaceutical companies, and increasing government initiatives will also contribute in growth of market. The report provides a comprehensive analysis of the ongoing clinical trials in gamma delta T cell therapy. By analyzing the market dynamics, the future market opportunity of gamma delta T cell therapy in various cancers is also forecasted. 

The report highlights include:
  • Commercialization Market Potential After Market Launch: > USD 4 Billion
  • Insight on Key Drugs In Research & Development 
  • Global Gamma Delta T Cell Cancer Therapy Clinical Trials Insight 
  • Gamma Delta T Cell Cancer Therapy In clinical Trials: > 15 Therapies
  • Gamma Delta T Cell Cancer Therapy Market Opportunity By Cancer Type
  • Adopted Approaches for Gamma Delta T Cell Therapy

Table of Contents

1. Introduction to Gamma Delta T Cell Therapy
 1.1 Emerging Role of T Cell-Based Immunotherapies
 1.2 Overview to Gamma Delta T Cell Therapy

2. Gamma Delta T Cell Therapy Vs. Conventional Therapies
 2.1 Gamma Delta T Cell Therapy Vs. CAR T Cell Therapy
 2.2 Gamma Delta T Cell Therapy Vs. Tumor Infiltrating Lymphocyte Therapy
 2.3 Gamma Delta T Cell Therapy Vs. Immune Checkpoint Inhibitors
 2.4 Gamma Delta T Cell Therapy Vs. Monoclonal Antibodies
 2.5 Gamma Delta T Cell Therapy Vs. Others

3. Role of Gamma Delta T Cells in Cancer
 3.1 Gamma Delta T Cells in Cancer Progression
 3.2 Anti Tumor Activity of Gamma Delta T Cells

4. Adopted Approaches for Gamma Delta T Cell Therapy
 4.1 Gamma Delta T Cell as Bispecific Antibodies
 4.2 CAR Gamma Delta T Cells

5. Gamma Delta T Cell Therapy: Key Drugs In Research & Development

6. Global Gamma Delta T Cell Cancer Therapy Clinical Pipeline Overview
 6.1 By Company
 6.2 By Country
 6.3 By Indication
 6.4 By Phase

7. Global Gamma Delta T Cell Cancer Therapy Clinical Trials Insight by Company, Indication & Clinical Phase
 7.1 Research
 7.2 Preclinical
 7.3 Clinical
 7.4 Phase-I
 7.5 Phase-I/II

8. Gamma Delta T Cell Therapy in Leukemia
 8.1 Role of Gamma Delta T Cells in Leukemia
 8.2 Ongoing Clinical Research in Acute Leukemia
 8.3 Clinical Trials in Chronic Lymphocytic Leukemia
 8.4 Future Market Opportunity of Gamma Delta T Cells in Leukemia

9. Gamma Delta T Cell Therapy in Lung Cancer
 9.1 Overview
 9.2 Ongoing Research & Development
 9.3 Future Market Opportunity of Gamma Delta T Cell Therapy in Lung Cancer

10. Gamma Delta T Cells in Breast Cancer
 10.1 Overview
 10.2 Ongoing Research & Development in Breast Cancer
 10.3 Future Market Opportunity of Gamma Delta T Cell Therapy in Breast Cancer

11. Gamma Delta T Cells in Colorectal Cancer
 11.1 Function of Gamma Delta T Cells in Colorectal Cancer
 11.2 Ongoing Clinical Trials in Colorectal Cancer
 11.3 Future Market Potential of Gamma Delta T Cell Therapy in Colorectal Cancer

12. Gamma Delta T Cells in Pancreatic Cancer
 12.1 Overview
 12.2 Ongoing Research & Development in Pancreatic Cancer
 12.3 Future Market Potential of Gamma Delta Therapy in Pancreatic Cancer

13. Current Clinical Research in Other Cancers
 13.1 Ongoing Clinical Trials in Neuroblastoma
 13.2 Ongoing Clinical Trials in Glioblastoma
 13.3 Ongoing Research & Development in Head & Neck Cancer

14. Gamma Delta T Cell Therapy Market Overview
 14.1 Current Market Scenario
 14.2 Market Potential of Gamma Delta T Cell Therapy Market

15. Gamma Delta T Cell Therapy Market Dynamics
 15.1 Gamma Delta T Cell Therapy Market: Favorable Parameters
 15.2 Gamma Delta T Cell Therapy Market: Challenges

16. Gamma Delta T Cell Therapy Future Prospects

17. Competitive Landscape
 17.1 Acepodia
 17.2 Adaptate Therapeutics
 17.3 Adicet
 17.4 Cytomed Therapeutics
 17.5 Gadeta
 17.6 GammaDelta Therapeutics
 17.7 IN8bio
 17.8 Kiromic Biopharma
 17.9 Lava Therapeutics
 17.10 Takeda Pharmaceuticals
 17.11 TC Biopharm

List of Figures
 Figure 1-1: History of T cell Based Immunotherapy
 Figure 1-2: Gamma Delta T cell Therapy
 Figure 1-3: Stimulants of Gamma Delta T Cells
 Figure 2-1: Limitation of CAR T Cell Therapy
 Figure 2-2: Limitations of TIL
 Figure 2-3: Limitations of Monoclonal Antibodies
 Figure 2-4: Drawback of Chemotherapeutic Drugs
 Figure 3-1: Pro-Tumor Role of Gamma Delta T Cells
 Figure 3-2: Antigen Presentation Functions of Gamma Delta T-Cells
 Figure 3-3: Anti-Tumor Activity of Gamma Delta T-Cells
 Figure 4-1: Gamma Delta T Cell Bispecific Antibodies – Mechanism of Action
 Figure 4-2: Functional Advantages of γδ T Cells for CAR T Cancer Therapy
 Figure 4-3: CAR γδ T Cells – Mechanism of Action
 Figure 5-1: ADI-001 – Initiation & Completion Year of Phase-I Clinical Trial
 Figure 5-2: LAVA-051 – Initiation & Completion Year of Phase-I/II Clinical Trial
 Figure 5-3: DRI Cell Therapy – Initiation & Completion Year of Phase-I Clinical Trial
 Figure 5-4: Adoptive Cell Therapy – Initiation & Completion Year of Phase-I Clinical Trial
 Figure 5-5: GDX012 – Initiation & Completion Year of Phase-I Clinical Trial
 Figure 5-6: GDT002 – Initiation & Completion Year of Phase-I Clinical Trial
 Figure 6-1: Global - Gamma Delta T Cell Cancer Therapy in Clinical Pipeline by Company, 2022 till 2028
 Figure 6-2: Global - Gamma Delta T Cell Cancer Therapy in Clinical Pipeline by Country, 2022 till 2028
 Figure 6-3: Global - Gamma Delta T Cell Cancer Therapy in Clinical Pipeline by Indication, 2022 till 2028
 Figure 6-4: Global Gamma Delta T Cell Cancer Therapy in Clinical Pipeline by Phase, 2022 till 2028
 Figure 8-1: Global – Leukemia Incidences & Mortality (Million), 2020 & 2040
 Figure 8-2: Benefits of Gamma Delta T Cells in Leukemia
 Figure 8-3: Mechanism of Action of Vγ9/CD123 Bispecific Antibody
 Figure 8-4: Global – Estimated Leukemia Cancer Cases, 2021-2028
 Figure 8-5: US – Estimated Leukemia Cancer Cases, 2021-2028
 Figure 8-6: Europe – Estimated Leukemia Cancer Cases, 2021-2028
 Figure 8-7: China – Estimated Leukemia Cancer Cases, 2021-2028
 Figure 8-8: Japan – Estimated Leukemia Cancer Cases, 2021-2028
 Figure 9-1: Global – Lung Cancer Incidences & Mortality (Million), 2020 & 2040
 Figure 9-2: Role of Gamma Delta T Cells in Lung Cancer
 Figure 9-3: Global – Estimated Lung Cancer Cases, 2021-2028
 Figure 9-4: US – Estimated Lung Cancer Cases, 2021-2028
 Figure 9-5: Europe – Estimated Lung Cancer Cases, 2021-2028
 Figure 9-6: China – Estimated Lung Cancer Cases, 2021-2028
 Figure 9-7: Japan – Estimated Lung Cancer Cases, 2021-2028
 Figure 10-1: Global – Breast Cancer Incidences (Million), 2020 & 2040
 Figure 10-2: Global – Breast Cancer Mortality (Million), 2020 & 2040
 Figure 10-3: Global – Estimated Breast Cancer Cases, 2021-2028
 Figure 10-4: US – Estimated Breast Cancer Cases, 2021-2028
 Figure 10-5: Europe – Estimated Breast Cancer Cases, 2021-2028
 Figure 10-6: China – Estimated Breast Cancer Cases, 2021-2028
 Figure 10-7: Japan – Estimated Breast Cancer Cases, 2021-2028
 Figure 11-1: Role of Gamma Delta T Cells in Colorectal Cancer
 Figure 11-2: Mechanism Underlying B7-H3 Regulating γδ T Cells Killing Colon Cancer Cells
 Figure 11-3: Global – Estimated Colorectal Cancer Cases, 2021-2028
 Figure 11-4: US – Estimated Colorectal Cancer Cases, 2021-2028
 Figure 11-5: Europe – Estimated Colorectal Cancer Cases, 2021-2028
 Figure 11-6: China – Estimated Colorectal Cancer Cases, 2021-2028
 Figure 11-7: Japan – Estimated Colorectal Cancer Cases, 2021-2028
 Figure 12-1: Global – Pancreatic Cancer Incidences, 2020 & 2040
 Figure 12-2: Global – Pancreatic Cancer Mortality, 2020 & 2040
 Figure 12-3: Role of Gamma Delta T Cells in Pancreatic Cancer Progression
 Figure 12-4: Global – Estimated Pancreatic Cancer Cases, 2021-2028
 Figure 12-5: US – Estimated Pancreatic Cancer Cases, 2021-2028
 Figure 12-6: Europe – Estimated Pancreatic Cancer Cases, 2021-2028
 Figure 12-7: China – Estimated Pancreatic Cancer Cases, 2021-2028
 Figure 12-8: Japan – Estimated Pancreatic Cancer Cases, 2021-2028
 Figure 14-1: Global - Cell Therapy Market (US$ Billion), 2020 - 2028
 Figure 14-2: Global – Gamma Delta T Cell Therapy Market Opportunity by 1% of Total Cell Therapy Market (US$ Billion), 2022-2028
 Figure 14-3: Global – Gamma Delta T Cell Therapy Market Opportunity by 2% of Total Cell Therapy Market (US$ Billion), 2022-2028
 Figure 14-4: Global – Gamma Delta T Cell Therapy Market Opportunity by 3% of Total Cell Therapy Market (US$ Billion), 2022-2028
 Figure 14-5: Global – Gamma Delta T Cell Therapy Market Opportunity by 4% of Total Cell Therapy Market (US$ Billion), 2022-2028
 Figure 14-6: Global – Gamma Delta T Cell Therapy Market Opportunity by 5% of Total Cell Therapy Market (US$ Billion), 2022-2028
 Figure 14-7: Global – Gamma Delta T Cell Therapy Market Opportunity by 6% of Total Cell Therapy Market (US$ Billion), 2022-2028
 Figure 14-8: Global – Gamma Delta T Cell Therapy Market Opportunity by 7% of Total Cell Therapy Market (US$ Billion), 2022-2028
 Figure 14-9: Global – Gamma Delta T Cell Therapy Market Opportunity by 8% of Total Cell Therapy Market (US$ Billion), 2022-2028
 Figure 14-10: Global – Gamma Delta T Cell Therapy Market Opportunity by 9% of Total Cell Therapy Market (US$ Billion), 2022-2028
 Figure 14-11: Global – Gamma Delta T Cell Therapy Market Opportunity by 10% of Total Cell Therapy Market (US$ Billion), 2022-2028
 Figure 15-1: Global – Cancer Incidences & Mortality Rates (Billion), 2020 & 2040
 Figure 15-2: Gamma Delta T Cells Favorable Market Parameters
 Figure 15-3: Stages of Drug Development
 
 List of Tables
 Table 8-1: Global – Estimated Adoption Rate of Gamma Delta T Cell in Leukemia, 2022-2028
 Table 8-2: US – Estimated Adoption Rate of Gamma Delta T Cell in Leukemia, 2022-2028
 Table 8-3: Europe – Estimated Adoption Rate of Gamma Delta T Cell in Leukemia, 2022-2028
 Table 8-4: China – Estimated Adoption Rate of Gamma Delta T Cell in Leukemia, 2022-2028
 Table 8-5: Japan – Estimated Adoption Rate of Gamma Delta T Cell in Leukemia, 2022-2028
 Table 9-1: Global – Estimated Adoption Rate of Gamma Delta T Cell in Lung Cancer, 2022-2028
 Table 9-2: US – Estimated Adoption Rate of Gamma Delta T Cell in Lung Cancer, 2022-2028
 Table 9-3: Europe – Estimated Adoption Rate of Gamma Delta T Cell in Lung Cancer, 2022-2028
 Table 9-4: China – Estimated Adoption Rate of Gamma Delta T Cell in Lung Cancer, 2022-2028
 Table 9-5: Japan – Estimated Adoption Rate of Gamma Delta T Cell in Lung Cancer, 2022-2028
 Table 10-1: Global – Estimated Adoption Rate of Gamma Delta T Cell in Breast Cancer, 2022-2028
 Table 10-2: US – Estimated Adoption Rate of Gamma Delta T Cell in Breast Cancer, 2022-2028
 Table 10-3: Europe – Estimated Adoption Rate of Gamma Delta T Cell in Breast Cancer, 2022-2028
 Table 10-4: China – Estimated Adoption Rate of Gamma Delta T Cell in Breast Cancer, 2022-2028
 Table 10-5: Japan – Estimated Adoption Rate of Gamma Delta T Cell in Breast Cancer, 2022-2028
 Table 11-1: Global – Estimated Adoption Rate of Gamma Delta T Cell in Colorectal Cancer, 2022-2028
 Table 11-2: US – Estimated Adoption Rate of Gamma Delta T Cell in Colorectal Cancer, 2022-2028
 Table 11-3: Europe – Estimated Adoption Rate of Gamma Delta T Cell in Colorectal Cancer, 2022-2028
 Table 11-4: China – Estimated Adoption Rate of Gamma Delta T Cell in Colorectal Cancer, 2022-2028
 Table 11-5: Japan – Estimated Adoption Rate of Gamma Delta T Cell in Colorectal Cancer, 2022-2028
 Table 12-1: Global – Estimated Adoption Rate of Gamma Delta T Cell in Pancreatic Cancer, 2022-2028
 Table 12-2: US – Estimated Adoption Rate of Gamma Delta T Cell in Pancreatic Cancer, 2022-2028
 Table 12-3: Europe – Estimated Adoption Rate of Gamma Delta T Cell in Pancreatic Cancer, 2022-2028
 Table 12-4: China – Estimated Adoption Rate of Gamma Delta T Cell in Pancreatic Cancer, 2022-2028
 Table 12-5: Japan – Estimated Adoption Rate of Gamma Delta T Cell in Pancreatic Cancer, 2022-2028

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Companies Mentioned (Partial List)

A selection of companies mentioned in this report includes, but is not limited to:

  • Acepodia
  • Adaptate Therapeutics
  • Adicet
  • Cytomed Therapeutics
  • Gadeta
  • GammaDelta Therapeutics
  • IN8bio
  • Kiromic Biopharma
  • Lava Therapeutics
  • Takeda Pharmaceuticals
  • TC Biopharm