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Scattering Methods in Structural Biology Part B. Methods in Enzymology Volume 678

  • Book
  • January 2023
  • Elsevier Science and Technology
  • ID: 5576629

Scattering Methods in Structural Biology, Part B, Volume 676 in the Methods in Enzymology serial, highlights advances in the field, presenting chapters on Quality controls, Refining biomolecular structures and ensembles by SAXS-driven molecular dynamics simulations, Data analysis and modelling of small-angle scattering data with contrast variation, Observing protein degradation in solution by the PAN-20S proteasome complex: state-of-the-art and future perspectives of TR-SANS as a complementary tool to NMR, crystallography and Cryo-EM, Extracting structural insights from chemically-specific soft X-ray scattering, Reconstruction of 3D density of biological macromolecules from solution scattering, ATSAS- present state and new developments in computational methods, and much more.

Additional chapters cover Modeling Structure and Dynamics of Protein Complexes with SAXS Profiles (FoXSDock and MultiFoXS), Validation of macromolecular flexibility in solution by SAXS, Combining NMR, SAXS and SANS to characterize the structure and dynamics of protein complexes, Application of Molecular Simulation Methods to Analyze SAS Data, and more.

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Table of Contents

1. Quality controls Jill Trewhalla 2. Refining biomolecular structures and ensembles by SAXS-driven molecular dynamics simulations Jochen S. Hub 3. Data analysis and modelling of small-angle scattering data with contrast variation Cy Jeffries and Andrew Whitten 4. Observing protein degradation in solution by the PAN-20S proteasome complex: state-of-the-art and future perspectives of TR-SANS as a complementary tool to NMR, crystallography and Cryo-EM Frank Gabel 5. Extracting structural insights from chemically-specific soft X-ray scattering Esther W. Gomez 6. Reconstruction of 3D density of biological macromolecules from solution scattering Thomas Grant 7. ATSAS- present state and new developments in computational methods Dmitri Svergun and Haydyn Mertens 8. Modeling Structure and Dynamics of Protein Complexes with SAXS Profiles (FoXSDock and MultiFoXS) Dina Schneidman 9. Validation of macromolecular flexibility in solution by SAXS Michal Hammel 10. Combining NMR, SAXS and SANS to characterize the structure and dynamics of protein complexes Michael Sattler 11. Application of Molecular Simulation Methods to Analyze SAS Data Susan Krueger and Joseph Curtis 12. From dilute to concentrated solutions of intrinsically disordered proteins: Interpretation and analysis of collected data Marie Skepo 13. Allosteric Inhibitors and drug discovery Chris Brosey 14. SAXS and Fold Prediction Susan Tsutakawa 15. SAXS Data-Assisted Modeling of Multidomain Protein Structures Janlin Cheng 16. FRET methods for ion channels/binding Manu Ben-Johny 17. Interpretation of solution scattering data for Protein Fibrillation Bente Vestergaard and Annette Langkilde 18. Measuring similarity and conformational changes Greg Hura 19. Insights from SAXS on disordered proteins on biological mechanisms: from protein folding to phase separation Joshua A. Riback 20. Lipid/peptide interactions from molecules to microbes Georg Pabst