Frontiers in Clinical Drug Research - Anti-Allergy Agents is a book series comprising of a selection of updated review articles relevant to the recent development of pharmacological agents used for the treatment of allergies. The scope of the reviews includes clinical trials of anti-inflammatory and anti-allergic drugs, drug delivery strategies used to treat specific allergies (such as inflammation, asthma and dermatological allergies), lifestyle dependent modes of therapies and the immunological or metabolic mechanisms that are of interest to researchers as targets for new drugs.
Anti-Allergy Agents will be of interest to immunologists and drug discovery researchers interested in anti-allergic drug therapy as the series provides relevant cutting edge reviews written by experts in this rapidly expanding field.
The fifth volume of this series brings 5 reviews which cover the following topics:
- Resistin: an irresistible therapeutic target for inflammatory diseases, allergy-related disorders, and cancer
- Asthma in adults: evaluation, prevalence, and its clinical management
- Nitrogen-containing heterocycles as anti-allergy agents
- Experimental and clinical studies on the effects of nigella sativa and its constituents on allergic and immunological disorders
- Aspirin desensitization/challenge in patients with cardiovascular diseases: current trends and advances Frontiers in Clinical Drug Research
Anti-Allergy Agents will be of interest to immunologists and drug discovery researchers interested in anti-allergic drug therapy as the series provides relevant cutting edge reviews written by experts in this rapidly expanding field.
Table of Contents
PREFACE- i LIST OF CONTRIBUTORS
- ii CHAPTER 1 RESISTIN: AN IRRESISTIBLE THERAPEUTIC TARGET FOR INFLAMMATORY DISEASES, ALLERGY-RELATED DISORDERS, AND CANCER
- Erva Ozkan and Filiz Bakar Ates INTRODUCTION
- RESISTIN
- Structure and Function
- THE ROLE OF RESISTIN IN DISEASES
- Inflammatory Diseases
- Obesity
- Insulin Resistance and Type-2-Diabetes
- Atherosclerosis
- Rheumatoid Arthritis and Osteoarthritis
- Other Inflammatory Diseases
- Allergic Disorders
- Resistin at the Crossroad of Inflammation and Cancer
- The roles of Resistin in Cancer
- Invasion and Migration
- Chemoresistance
- CONCLUSION
- CONSENT FOR PUBLICATION
- CONFLICTS OF INTEREST
- ACKNOWLEDGEMENTS
- REFERENCES
CHAPTER 2 ASTHMA IN ADULTS: EVALUATION, PREVALENCE, AND ITS CLINICAL MANAGEMENT
- INTRODUCTION
- EPIDEMIOLOGY
- WHAT IS AN ALLERGY?
- FORM OF ASTHMA
- CONTROL AND SEVERITY OF ASTHMA
- CATEGORIZATION OF ASTHMA SEVERITY
- EVALUATING AN ADULT WITH SEVERE ASTHMA
- ALLERGIC ASTHMA
- Pathophysiology
- For example:
- The Immune Response
- Mast Cells
- Eosinophils
- Monocytes and Macrophages
- Basophils
- T-lymphocytes
- NONALLERGIC (LATE-ONSET/ INTRINSIC) ASTHMA
- FIBROBLASTS CELLS AND EPITHELIAL CELLS
- AIRWAY REMODELLING
- FEATURES OF AIRWAY WALL REMODELING IN ASTHMA
- PREVENTION
- CLINICAL MANAGEMENT
- Diagnosis of Asthma
- Diagnostic Tests
- Blood Cells and Serum Biomarkers
- Sputum Cells and Mediators
- Exhaled Breath Analysis
- TREATMENT GOALS
- ASTHMA TREATMENT PRINCIPLES
- TREATMENT
- Bronchodilators
- Anticholinergics
- Short-acting Anticholinergics
- Long Acting Anticholinergics
- Glucocorticoids (GC)
- Methylxanthines
- Leukotriene Receptor Antagonists and Synthase Blockers
- Combination Therapy
- Biologics in Asthma – Next Step of Treatment and their Experience in Severe Asthma
- Omalizumab (IgE-directed Treatment)
- Mepolizumab (Eosinophil-targeted Treatment)
- Secukinumab and Brodalumab
- Alternative Approach for Asthma Treatment: A Key Advance in Asthma Care
- Boswellia
- Tylophoraasthmatica
- Nigella Sativa
- Moringa Oleifera
- Ailanthus Altissima
- Allium Sativum
- Flavonoids
- Flavone Compounds
- Baicalin
- Luteolin
- Flavonol
- Natural Products Derived from Animal Sources
- Animal Sea Source
- Bullfrog Oil
- Animals Derived Other by Products
- Biologically Active Products Obtained from Different Microorganisms
- CONCLUSION
- Lesson to be Learnt After Studying this Article
- CONSENT FOR PUBLICATION
- CONFLICT OF INTEREST
- ACKNOWLEDGEMENTS
- REFERENCES
CHAPTER 3 NITROGEN-CONTAINING HETEROCYCLES AS ANTI-ALLERGY AGENTS
- INTRODUCTION
- SYNTHESIS OF N-CONTAINING COMPOUNDS AS ANTI-ALLERGIC ACTIVITIES 79 Benzimidazole and Imidazole Derivatives as H1/H2/H3-receptor Antagonist
- Antihistamine Activity of Synthesized Compounds (16-26)
- Antihistamine Activity of Synthesized Compounds (31a-j)
- Antihistamine Activity of Compounds (39a-p)
- Antihistamine Activity of Compounds (46a-b and 56a-f)
- Antihistamine Activity of Compounds (61a-n, 62a-d, and 63a-h)
- Synthesis of Quinazoline Derivatives as H1-antihistaminic Activity
- Antihistamine Activity and Sedative-hypnotic Activity of Synthesized Compounds (70I-X)
- Antihistamine Activity of Synthesized Compounds 102, 103 and 104
- Antihistamine Activity of Synthesized Compounds 107a-f
- Synthesis of 2-methylpropanamide and benzamide derivatives of carboxyterfenadine as antihistaminic activity
- Antihistamine Activity of Synthesized Compounds 108-112
- Synthesis of Sila-substituted 1,3,4-oxadiazoles as anti-histamine activity
- Antihistamine Activity of Synthesized Compounds 116a-c and 117a-c
- CONCLUSION
- CONSENT FOR PUBLICATION
- CONFLICT OF INTEREST
- ACKNOWLEDGEMENTS
- REFERENCES
CHAPTER 4 EXPERIMENTAL AND CLINICAL STUDIES ON THE EFFECTS OF NIGELLA SATIVA AND ITS CONSTITUENTS ON ALLERGIC AND IMMUNOLOGICAL DISORDERS
- Mohammad Hossein Boskabady, Saeideh Saadat and Vahideh Ghorani INTRODUCTION
- METHOD
- THE EFFECT OF N. SATIVA ON ALLERGIC AND IMMUNOLOGIC DISORDERS, EXPERIMENTAL STUDIES
- The Effect of N. Sativa and its Constituents on Animal Models of Allergic Rhinitis and Asthma
- The Effect of N. Sativa and Its Constituents on other Allergic Disorders
- The Effect of N. Sativa and Its Constituents on Immunologic Disorders
- THE EFFECT OF N. SATIVA ON ALLERGIC AND IMMUNOLOGIC DISORDERS, CLINICAL STUDIES
- The Effect of N. Sativa and Its Constituents on Allergic Disorders
- The Effect of N. Sativa and Its Constituents on Asthma
- DISCUSSION
- CONSENT FOR PUBLICATION
- CONFLICT OF INTEREST
- ACKNOWLEDGEMENTS
- REFERENCES
CHAPTER 5 ASPIRIN DESENSITIZATION/CHALLENGE IN PATIENTS WITH CARDIOVASCULAR DISEASES: CURRENT TRENDS AND ADVANCES
- Aysa Rezabakhsh and Hassan Soleimanpour HISTORY OF ASPIRIN
- THE HISTORY OF CARDIOVASCULAR EFFECT
- THE HISTORY OF ANTITHROMBOTIC/ANTIPLATELET EFFECTS
- PHARMACOLOGIC CHARACTERISTICS OF ASPIRIN
- Chemical Structure
- Pharmacokinetic Properties
- Absorption, Distribution, Metabolism, and Excretion (ADME)
- Aspirin Toxicity
- Pharmacokinetics Points in Pediatrics and Geriatrics
- Adverse Effects Associated with Aspirin Consumption
- ASPIRIN MECHANISMS OF ACTION
- Complementary Mechanisms
- CLINICAL APPLICATIONS OF ASPIRIN
- Coronary Artery Bypass Surgery
- Cerebrovascular Diseases
- Venous Thrombosis
- Peripheral Arterial Disease
- PROPHYLACTIC EFFECT ON CVD
- Primary Prevention of Cardiovascular Events
- HOW DOES ASPIRIN LEAD TO ALLERGIC REACTIONS?
- ASPIRIN SENSITIZATION IN PATIENTS WITH CVD
- Oral Aspirin Challenge
- ASPIRIN DESENSITIZATION IN PATIENTS WITH CVD
- Aspirin Desensitization Procedure in AERD
- Two Types of Aspirin Desensitization in Patients with CVD
- a. Slow Desensitization
- b. Rapid Desensitization
- PROSPECTIVE INSIGHTS OF CLINICAL STRATEGIES FOR PATIENTS WITH ASPIRIN HYPERSENSITIVITY
- CONCLUSION
- LIST OF ABBREVIATIONS
- CONSENT FOR PUBLICATION
- CONFLICT OF INTEREST
- ACKNOWLEDGEMENTS
- REFERENCES
- SUBJECT INDEX
Author
- Atta-ur-Rahman
