Regenerative Hepatology and Liver Transplantation. Regenerative and Transplant Medicine Volume 2

Table of Contents

Part 1 The Liver and Liver Diseases 1. The Liver: structure, physiology and metabolism 2. Prevalence of liver disease around the world 3. Viral Hepatitis4. Non-alcoholic steatohepatitis 5. Alcoholic liver disease 6. Inborn errors of metabolism 7. Liver fibrosis/cirrhosis 8. Biomarkers in liver diseases / Precision Medicine Part 2 Liver Transplantation 9.Living donor Liver Transplantation 10.Pediatric Liver transplantation 11.Small-for-size syndrome in Liver transplantation 12.New Indications for Liver Transplant 13.Clinical trials design and endpoints in liver transplantation 14.Oncologic liver Transplantation 15. Hepatocellular carcinoma Management16.Marginal Donors to Expand the donor Pool 17.Domino Transplantation 18.Xenotransplantation Part 3 Cell Transplantation 19. Hepatocyte Transplantation 20. Alginate encapsulated hepatocyte transplantation 21. Mesenchymal Stem Cell Transplantation 22. Fetal Hepatoblast Transplantation 23. Biliary Tree Stem Cell Transplantation 24. Liver Organoids Part 4 Liver Preservation and Machine perfusion 25. General Principles of Organ Preservation in Liver transplantation 26. Machine perfusion preservation Types and Principles 27. Ischemia-Reperfusion injury 28. Clinical trials with liver machine preservation Part 5 Regenerative Medicine in Liver Disease and Transplantation 29. Liver Regeneration 30. Gene Therapy in Liver Transplantation 31. Liver Bioengineering 32. Bioprinting of livers 33. Nanotechnology application in Liver Transplantation 34. Acute Liver Failure and Bioreactors/Liver Assist devices 35. Liver Organoids 36. Liver Bud 37. hPSC-derived liver cells for transplantation 38. Genome edited humanized pigs for human liver generation 39. Liver aging

Authors

Paulo Martins Associate Professor of Surgery, University of Massachusetts, USA. Dr. Paulo Martins is an Associate Professor of Surgery at University of Massachusetts. Since 2013, Dr. Martins has been working as a transplant Surgeon at the University of Massachusetts and principal investigator at a transplant laboratory in the same institution. During his career he has obtained several research awards and grants and in 2015, he was indicted fellow of the American Society of Transplantation and 2017 fellow of the American College of Surgeons. He has worked on experimental surgery since medical school and has focused his research on ischemia reperfusion injury and donor/graft modulation using small and large animal transplant models. Dr. Martins has trained microsurgeons and supervised several graduate students, residents, PhD students in the hospital and in his laboratory. He is an editorial board member of 3 scientific journals, ad-hoc reviewer of 10 medical journals, committee member of several organizations and member of 6 scientific/professional associations. Pedro Baptista Assistant Professor, Department of Biomedical and Aerospace Engineering, University Carlos III of Madrid, Spain. Dr. Pedro Baptista is originally from Portugal, where he graduated from the School of Pharmacy of the University of Lisbon. He completed his doctoral dissertation at the Gulbenkian Ph.D. Program in Biomedicine. He is currently a Group Leader at the Health Research Institute of Aragon in Zaragoza, Spain and the founder of the Organ Bioengineering and Regenerative Medicine Laboratory at this institution. He is also an Assistant Professor at the Department of Biomedical and Aerospace Engineering at University Carlos III of Madrid, Spain. He is one of the founders and the Deputy Chairman of the European Association for the Study of the Liver Consortium for Regenerative Hepatology and currently the Deputy Secretary General and an elected Board Governor of the European Society for Artificial Organs. His current research focuses on creating bioengineered livers that can finally make the long-term transplantation of these lab-grown organs a reality.Dr. Pedro Baptista is originally from Portugal, where he graduated from the School of Pharmacy of the University of Lisbon. He completed his doctoral dissertation at the Gulbenkian Ph.D. Program in Biomedicine. He is currently a Group Leader at the Health Research Institute of Aragon in Zaragoza, Spain and the founder of the Organ Bioengineering and Regenerative Medicine Laboratory at this institution. He is also an Assistant Professor at the Department of Biomedical and Aerospace Engineering at University Carlos III of Madrid, Spain. He is one of the founders and the Deputy Chairman of the European Association for the Study of the Liver Consortium for Regenerative Hepatology and currently the Deputy Secretary General and an elected Board Governor of the European Society for Artificial Organs. His current research focuses on creating bioengineered livers that can finally make the long-term transplantation of these lab-grown organs a reality.