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Nanotechnology Tools for Infections Control. Scanning New Horizons on Next-Generation Therapies to Eradicate Pathogens and Fight Drug Resistance. Micro and Nano Technologies

  • Book
  • November 2022
  • Elsevier Science and Technology
  • ID: 5597138

Nanotechnology Tools for Infections Control: Scanning New Horizons on Next-Generation Therapies to Eradicate Pathogens and Fight Drug Resistance provides an overview of recent strategies to build nanotechnology platforms, with a specific focus on biocompatible and biodegradable nanosystems. Particular attention is given to responsive nanoparticles, which are able to sense and respond to specific external stimuli (e.g., temperature, pH). The book includes details of the rationale behind the design of the raw materials, synthetic procedures and characterization techniques. It also introduces a new generation of nanomaterials, commonly named as 'nanobots', which are able to self-propel in response to external stimuli.

Subsequent sections of the book focus on the applications of nanosystems as an alternative approach to standard antibiotics. The chapters describe their pharmokinetic and dynamics within the body, their ability to cross biological barriers and how they distribute within different body compartments. In this respect, a dedicated section highlights the crucial role of the immune system, as well as of protein corona, in changing the nanoparticles retention within the body. Coverage is also given to describe how nanosystems access different cells and their intracellular trafficking.

Table of Contents

Section 1. The Global Context
1. Pandemic diseases: what are the current global health challenges?
2. Antimicrobial drug resistance a clinical perspective and current available solutions
3. The significant drain in antimicrobial discovery by pharma companies

Section 2. Nanosystems - 'How To'
4. Nanoparticles design for infection control
5. Nanoparticles production for infection control
6. Nanoparticles characterisation and standardisation

Section 3. The Nano-Challenge
7. Principle of body navigation of nanosystems
8. The immune system and how to avoid body clearance
9. The problem of protein corona
10. Intracellular fate of nanosystems, their degradation and body accumulation

Section 4. Antimicrobial Nanosystems
11. State of the art and potential health and environmental risks
12. Molecular targets and pharmacodynamics for bactericidal and bacteriostatic activity
13. How to fight bacteria without inducing drug resistance

Section 5. The clinical drive
14. Pre-clinical characterisation: which animal model is best for infection?
15. Clinical translation of nanoparticles: why is it so difficult?
16. Envisioned impact of nanotech for infection control: economy, government policy and public awareness
17. Concluding remarks What next?

Authors

Alessandro Poma Lecturer, Biomaterials and Allied Subjects. Division of Biomaterials and Tissue Engineering, Eastman Dental Institute, University College London, UK.. Dr Alessandro Poma is a lecturer in Biomaterials and Allied Subjects in the Division of Biomaterials and Tissue Engineering , Eastman Dental Institute, University College London, UK. His research interests are solid-phase synthesis and applications of MIP NPs able to perform as "synthetic antibodies”; the synthesis of MIP NPs as non-animal antibodies substitutes for influenza virus detection and polymeric systems for drug delivery and biological applications. Loris Rizzello Senior Researcher , Nanobioengineering department, Institute of Bioengineering in Catalonia, Barcelona, Spain.. Dr Loris Rizzello is a Marie Curie Fellow at the Institute for Bioengineering of Catalonia (IBEC), Spain. His research interests are in the field of nanobioengineering, such as nanotechnology tools for antibacterial materials, nanosilver-based antibacterial drugs and devices.