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Global Seborrheic Keratosis Treatment Market 2022-2026

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    Report

  • May 2022
  • Region: Global
  • TechNavio
  • ID: 5600519
1h Free Analyst Time
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The publisher has been monitoring the seborrheic keratosis treatment market and it is poised to grow by $ 786.38 mn during 2022-2026, accelerating at a CAGR of 6.45% during the forecast period. The report on the seborrheic keratosis treatment market provides a holistic analysis, market size and forecast, trends, growth drivers, and challenges, as well as vendor analysis covering around 25 vendors.

The report offers an up-to-date analysis regarding the current global market scenario, latest trends and drivers, and the overall market environment. The market is driven by the growing preference for the aesthetic quotient, high prevalence of seborrheic keratosis, and surge in geriatric population.

The seborrheic keratosis treatment market analysis includes the application segment and geographic landscape.

The analyst's seborrheic keratosis treatment market is segmented as below:

By Application:

  • Cryotherapy
  • Electrocautery
  • Others

By Geographical Landscape:

  • North America
  • Europe
  • Asia
  • Rest of World (ROW)

This study identifies the technological advances in cryotherapy as one of the prime reasons driving the seborrheic keratosis treatment market growth during the next few years. Also, emergence of non-invasive treatments and use of laser therapy will lead to sizable demand in the market.

The publisher presents a detailed picture of the market by the way of study, synthesis, and summation of data from multiple sources by an analysis of key parameters. The report on seborrheic keratosis treatment market covers the following areas:
  • Seborrheic keratosis treatment market sizing
  • Seborrheic keratosis treatment market forecast
  • Seborrheic keratosis treatment market industry analysis

The analyst's robust vendor analysis is designed to help clients improve their market position, and in line with this, this report provides a detailed analysis of several leading seborrheic keratosis treatment market vendors that include Aclaris Therapeutics Inc., BioLineRx Ltd., Brymill Cryogenic Systems, Cortex Technology, Cryo Innovations, CryoConcepts LP, Cryoswiss GmbH, Erbe Elektromedizin GmbH, H and O Equipments, and Special Medical Technology s.r.o. Also, the seborrheic keratosis treatment market analysis report includes information on upcoming trends and challenges that will influence market growth. This is to help companies strategize and leverage all forthcoming growth opportunities.

The study was conducted using an objective combination of primary and secondary information including inputs from key participants in the industry. The report contains a comprehensive market and vendor landscape in addition to an analysis of the key vendors.

The publisher presents a detailed picture of the market by the way of study, synthesis, and summation of data from multiple sources by an analysis of key parameters such as profit, pricing, competition, and promotions. It presents various market facets by identifying the key industry influencers. The data presented is comprehensive, reliable, and a result of extensive research - both primary and secondary.

The analyst's market research reports provide a complete competitive landscape and an in-depth vendor selection methodology and analysis using qualitative and quantitative research to forecast the accurate market growth.

Table of Contents

1 Executive Summary
1.1 Market overview
Exhibit 01: Executive Summary - Chart on Market Overview
Exhibit 02: Executive Summary - Data Table on Market Overview
Exhibit 03: Executive Summary - Chart on Global Market Characteristics
Exhibit 04: Executive Summary - Chart on Market By Geographical Landscape
Exhibit 05: Executive Summary - Chart on Market Segmentation by Application
Exhibit 06: Executive Summary - Chart on Incremental Growth
Exhibit 07: Executive Summary - Data Table on Incremental Growth
Exhibit 08: Executive Summary - Chart on Vendor Market Positioning
2 Market Landscape
2.1 Market ecosystem
Exhibit 09: Parent market
Exhibit 10: Market Characteristics
3 Market Sizing
3.1 Market definition
Exhibit 11: Offerings of vendors included in the market definition
3.2 Market segment analysis
Exhibit 12: Market segments
3.3 Market size 2021
3.4 Market outlook: Forecast for 2021-2026
Exhibit 13: Chart on Global - Market size and forecast 2021-2026 ($ million)
Exhibit 14: Data Table on Global - Market size and forecast 2021-2026 ($ million)
Exhibit 15: Chart on Global Market: Year-over-year growth 2021-2026 (%)
Exhibit 16: Data Table on Global Market: Year-over-year growth 2021-2026 (%)
4 Five Forces Analysis
4.1 Five forces summary
Exhibit 17: Five forces analysis - Comparison between 2021 and 2026
4.2 Bargaining power of buyers
Exhibit 18: Chart on Bargaining power of buyers - Impact of key factors 2021 and 2026
4.3 Bargaining power of suppliers
Exhibit 19: Bargaining power of suppliers - Impact of key factors in 2021 and 2026
4.4 Threat of new entrants
Exhibit 20: Threat of new entrants - Impact of key factors in 2021 and 2026
4.5 Threat of substitutes
Exhibit 21: Threat of substitutes - Impact of key factors in 2021 and 2026
4.6 Threat of rivalry
Exhibit 22: Threat of rivalry - Impact of key factors in 2021 and 2026
4.7 Market condition
Exhibit 23: Chart on Market condition - Five forces 2021 and 2026
5 Market Segmentation by Application
5.1 Market segments
Exhibit 24: Chart on Application - Market share 2021-2026 (%)
Exhibit 25: Data Table on Application - Market share 2021-2026 (%)
5.2 Comparison by Application
Exhibit 26: Chart on Comparison by Application
Exhibit 27: Data Table on Comparison by Application
5.3 Cryotherapy - Market size and forecast 2021-2026
Exhibit 28: Chart on Cryotherapy - Market size and forecast 2021-2026 ($ million)
Exhibit 29: Data Table on Cryotherapy - Market size and forecast 2021-2026 ($ million)
Exhibit 30: Chart on Cryotherapy - Year-over-year growth 2021-2026 (%)
Exhibit 31: Data Table on Cryotherapy - Year-over-year growth 2021-2026 (%)
5.4 Electrocautery - Market size and forecast 2021-2026
Exhibit 32: Chart on Electrocautery - Market size and forecast 2021-2026 ($ million)
Exhibit 33: Data Table on Electrocautery - Market size and forecast 2021-2026 ($ million)
Exhibit 34: Chart on Electrocautery - Year-over-year growth 2021-2026 (%)
Exhibit 35: Data Table on Electrocautery - Year-over-year growth 2021-2026 (%)
5.5 Others - Market size and forecast 2021-2026
Exhibit 36: Chart on Others - Market size and forecast 2021-2026 ($ million)
Exhibit 37: Data Table on Others - Market size and forecast 2021-2026 ($ million)
Exhibit 38: Chart on Others - Year-over-year growth 2021-2026 (%)
Exhibit 39: Data Table on Others - Year-over-year growth 2021-2026 (%)
5.6 Market opportunity by Application
Exhibit 40: Market opportunity by Application ($ million)
6 Customer Landscape
6.1 Customer landscape overview
Exhibit 41: Analysis of price sensitivity, lifecycle, customer purchase basket, adoption rates, and purchase criteria
7 Geographic Landscape
7.1 Geographic segmentation
Exhibit 42: Chart on Market share By Geographical Landscape 2021-2026 (%)
Exhibit 43: Data Table on Market share By Geographical Landscape 2021-2026 (%)
7.2 Geographic comparison
Exhibit 44: Chart on Geographic comparison
Exhibit 45: Data Table on Geographic comparison
7.3 North America - Market size and forecast 2021-2026
Exhibit 46: Chart on North America - Market size and forecast 2021-2026 ($ million)
Exhibit 47: Data Table on North America - Market size and forecast 2021-2026 ($ million)
Exhibit 48: Chart on North America - Year-over-year growth 2021-2026 (%)
Exhibit 49: Data Table on North America - Year-over-year growth 2021-2026 (%)
7.4 Europe - Market size and forecast 2021-2026
Exhibit 50: Chart on Europe - Market size and forecast 2021-2026 ($ million)
Exhibit 51: Data Table on Europe - Market size and forecast 2021-2026 ($ million)
Exhibit 52: Chart on Europe - Year-over-year growth 2021-2026 (%)
Exhibit 53: Data Table on Europe - Year-over-year growth 2021-2026 (%)
7.5 Asia - Market size and forecast 2021-2026
Exhibit 54: Chart on Asia - Market size and forecast 2021-2026 ($ million)
Exhibit 55: Data Table on Asia - Market size and forecast 2021-2026 ($ million)
Exhibit 56: Chart on Asia - Year-over-year growth 2021-2026 (%)
Exhibit 57: Data Table on Asia - Year-over-year growth 2021-2026 (%)
7.6 Rest of World (ROW) - Market size and forecast 2021-2026
Exhibit 58: Chart on Rest of World (ROW) - Market size and forecast 2021-2026 ($ million)
Exhibit 59: Data Table on Rest of World (ROW) - Market size and forecast 2021-2026 ($ million)
Exhibit 60: Chart on Rest of World (ROW) - Year-over-year growth 2021-2026 (%)
Exhibit 61: Data Table on Rest of World (ROW) - Year-over-year growth 2021-2026 (%)
7.7 US - Market size and forecast 2021-2026
Exhibit 62: Chart on US - Market size and forecast 2021-2026 ($ million)
Exhibit 63: Data Table on US - Market size and forecast 2021-2026 ($ million)
Exhibit 64: Chart on US - Year-over-year growth 2021-2026 (%)
Exhibit 65: Data Table on US - Year-over-year growth 2021-2026 (%)
7.8 Germany - Market size and forecast 2021-2026
Exhibit 66: Chart on Germany - Market size and forecast 2021-2026 ($ million)
Exhibit 67: Data Table on Germany - Market size and forecast 2021-2026 ($ million)
Exhibit 68: Chart on Germany - Year-over-year growth 2021-2026 (%)
Exhibit 69: Data Table on Germany - Year-over-year growth 2021-2026 (%)
7.9 Japan - Market size and forecast 2021-2026
Exhibit 70: Chart on Japan - Market size and forecast 2021-2026 ($ million)
Exhibit 71: Data Table on Japan - Market size and forecast 2021-2026 ($ million)
Exhibit 72: Chart on Japan - Year-over-year growth 2021-2026 (%)
Exhibit 73: Data Table on Japan - Year-over-year growth 2021-2026 (%)
7.10 Canada - Market size and forecast 2021-2026
Exhibit 74: Chart on Canada - Market size and forecast 2021-2026 ($ million)
Exhibit 75: Data Table on Canada - Market size and forecast 2021-2026 ($ million)
Exhibit 76: Chart on Canada - Year-over-year growth 2021-2026 (%)
Exhibit 77: Data Table on Canada - Year-over-year growth 2021-2026 (%)
7.11 China - Market size and forecast 2021-2026
Exhibit 78: Chart on China - Market size and forecast 2021-2026 ($ million)
Exhibit 79: Data Table on China - Market size and forecast 2021-2026 ($ million)
Exhibit 80: Chart on China - Year-over-year growth 2021-2026 (%)
Exhibit 81: Data Table on China - Year-over-year growth 2021-2026 (%)
7.12 Market opportunity By Geographical Landscape
Exhibit 82: Market opportunity By Geographical Landscape ($ million)
8 Drivers, Challenges, and Trends
8.1 Market drivers
8.2 Market challenges
8.3 Impact of drivers and challenges
Exhibit 83: Impact of drivers and challenges in 2021 and 2026
8.4 Market trends
9 Vendor Landscape
9.1 Overview
9.2 Vendor landscape
Exhibit 84: Overview on Criticality of inputs and Factors of differentiation
9.3 Landscape disruption
Exhibit 85: Overview on factors of disruption
9.4 Industry risks
Exhibit 86: Impact of key risks on business
10 Vendor Analysis
10.1 Vendors covered
Exhibit 87: Vendors covered
10.2 Market positioning of vendors
Exhibit 88: Matrix on vendor position and classification
10.3 Aclaris Therapeutics Inc.
Exhibit 89: Aclaris Therapeutics Inc. - Overview
Exhibit 90: Aclaris Therapeutics Inc. - Business segments
Exhibit 91: Aclaris Therapeutics Inc. - Key news
Exhibit 92: Aclaris Therapeutics Inc. - Key offerings
Exhibit 93: Aclaris Therapeutics Inc. - Segment focus
10.4 BioLineRx Ltd.
Exhibit 94: BioLineRx Ltd. - Overview
Exhibit 95: BioLineRx Ltd. - Product / Service
Exhibit 96: BioLineRx Ltd. - Key offerings
10.5 Brymill Cryogenic Systems
Exhibit 97: Brymill Cryogenic Systems - Overview
Exhibit 98: Brymill Cryogenic Systems - Product / Service
Exhibit 99: Brymill Cryogenic Systems - Key offerings
10.6 Cortex Technology
Exhibit 100: Cortex Technology - Overview
Exhibit 101: Cortex Technology - Product / Service
Exhibit 102: Cortex Technology - Key offerings
10.7 Cryo Innovations
Exhibit 103: Cryo Innovations - Overview
Exhibit 104: Cryo Innovations - Product / Service
Exhibit 105: Cryo Innovations - Key offerings
10.8 CryoConcepts LP
Exhibit 106: CryoConcepts LP - Overview
Exhibit 107: CryoConcepts LP - Product / Service
Exhibit 108: CryoConcepts LP - Key offerings
10.9 Cryoswiss GmbH
Exhibit 109: Cryoswiss GmbH - Overview
Exhibit 110: Cryoswiss GmbH - Product / Service
Exhibit 111: Cryoswiss GmbH - Key offerings
10.10 Erbe Elektromedizin GmbH
Exhibit 112: Erbe Elektromedizin GmbH - Overview
Exhibit 113: Erbe Elektromedizin GmbH - Product / Service
Exhibit 114: Erbe Elektromedizin GmbH - Key offerings
10.11 H and O Equipments
Exhibit 115: H and O Equipments - Overview
Exhibit 116: H and O Equipments - Product / Service
Exhibit 117: H and O Equipments - Key offerings
10.12 Special Medical Technology s.r.o
Exhibit 118: Special Medical Technology s.r.o - Overview
Exhibit 119: Special Medical Technology s.r.o - Product / Service
Exhibit 120: Special Medical Technology s.r.o - Key offerings
11 Appendix
11.1 Scope of the report
11.2 Inclusions and exclusions checklist
Exhibit 121: Inclusions checklist
Exhibit 122: Exclusions checklist
11.3 Currency conversion rates for US$
Exhibit 123: Currency conversion rates for US$
11.4 Research methodology
Exhibit 124: Research methodology
Exhibit 125: Validation techniques employed for market sizing
Exhibit 126: Information sources
11.5 List of abbreviations
Exhibit 127: List of abbreviations
List of Exhibits
Exhibits 1: Executive Summary - Chart on Market Overview
Exhibits 2: Executive Summary - Data Table on Market Overview
Exhibits 3: Executive Summary - Chart on Global Market Characteristics
Exhibits 4: Executive Summary - Chart on Market By Geographical Landscape
Exhibits 5: Executive Summary - Chart on Market Segmentation by Application
Exhibits 6: Executive Summary - Chart on Incremental Growth
Exhibits 7: Executive Summary - Data Table on Incremental Growth
Exhibits 8: Executive Summary - Chart on Vendor Market Positioning
Exhibits 9: Parent market
Exhibits 10: Market Characteristics
Exhibits 11: Offerings of vendors included in the market definition
Exhibits 12: Market segments
Exhibits 13: Chart on Global - Market size and forecast 2021-2026 ($ million)
Exhibits 14: Data Table on Global - Market size and forecast 2021-2026 ($ million)
Exhibits 15: Chart on Global Market: Year-over-year growth 2021-2026 (%)
Exhibits 16: Data Table on Global Market: Year-over-year growth 2021-2026 (%)
Exhibits 17: Five forces analysis - Comparison between 2021 and 2026
Exhibits 18: Chart on Bargaining power of buyers - Impact of key factors 2021 and 2026
Exhibits 19: Bargaining power of suppliers - Impact of key factors in 2021 and 2026
Exhibits 20: Threat of new entrants - Impact of key factors in 2021 and 2026
Exhibits 21: Threat of substitutes - Impact of key factors in 2021 and 2026
Exhibits 22: Threat of rivalry - Impact of key factors in 2021 and 2026
Exhibits 23: Chart on Market condition - Five forces 2021 and 2026
Exhibits 24: Chart on Application - Market share 2021-2026 (%)
Exhibits 25: Data Table on Application - Market share 2021-2026 (%)
Exhibits 26: Chart on Comparison by Application
Exhibits 27: Data Table on Comparison by Application
Exhibits 28: Chart on Cryotherapy - Market size and forecast 2021-2026 ($ million)
Exhibits 29: Data Table on Cryotherapy - Market size and forecast 2021-2026 ($ million)
Exhibits 30: Chart on Cryotherapy - Year-over-year growth 2021-2026 (%)
Exhibits 31: Data Table on Cryotherapy - Year-over-year growth 2021-2026 (%)
Exhibits 32: Chart on Electrocautery - Market size and forecast 2021-2026 ($ million)
Exhibits 33: Data Table on Electrocautery - Market size and forecast 2021-2026 ($ million)
Exhibits 34: Chart on Electrocautery - Year-over-year growth 2021-2026 (%)
Exhibits 35: Data Table on Electrocautery - Year-over-year growth 2021-2026 (%)
Exhibits 36: Chart on Others - Market size and forecast 2021-2026 ($ million)
Exhibits 37: Data Table on Others - Market size and forecast 2021-2026 ($ million)
Exhibits 38: Chart on Others - Year-over-year growth 2021-2026 (%)
Exhibits 39: Data Table on Others - Year-over-year growth 2021-2026 (%)
Exhibits 40: Market opportunity by Application ($ million)
Exhibits 41: Analysis of price sensitivity, lifecycle, customer purchase basket, adoption rates, and purchase criteria
Exhibits 42: Chart on Market share By Geographical Landscape 2021-2026 (%)
Exhibits 43: Data Table on Market share By Geographical Landscape 2021-2026 (%)
Exhibits 44: Chart on Geographic comparison
Exhibits 45: Data Table on Geographic comparison
Exhibits 46: Chart on North America - Market size and forecast 2021-2026 ($ million)
Exhibits 47: Data Table on North America - Market size and forecast 2021-2026 ($ million)
Exhibits 48: Chart on North America - Year-over-year growth 2021-2026 (%)
Exhibits 49: Data Table on North America - Year-over-year growth 2021-2026 (%)
Exhibits 50: Chart on Europe - Market size and forecast 2021-2026 ($ million)
Exhibits 51: Data Table on Europe - Market size and forecast 2021-2026 ($ million)
Exhibits 52: Chart on Europe - Year-over-year growth 2021-2026 (%)
Exhibits 53: Data Table on Europe - Year-over-year growth 2021-2026 (%)
Exhibits 54: Chart on Asia - Market size and forecast 2021-2026 ($ million)
Exhibits 55: Data Table on Asia - Market size and forecast 2021-2026 ($ million)
Exhibits 56: Chart on Asia - Year-over-year growth 2021-2026 (%)
Exhibits 57: Data Table on Asia - Year-over-year growth 2021-2026 (%)
Exhibits 58: Chart on Rest of World (ROW) - Market size and forecast 2021-2026 ($ million)
Exhibits 59: Data Table on Rest of World (ROW) - Market size and forecast 2021-2026 ($ million)
Exhibits 60: Chart on Rest of World (ROW) - Year-over-year growth 2021-2026 (%)
Exhibits 61: Data Table on Rest of World (ROW) - Year-over-year growth 2021-2026 (%)
Exhibits 62: Chart on US - Market size and forecast 2021-2026 ($ million)
Exhibits 63: Data Table on US - Market size and forecast 2021-2026 ($ million)
Exhibits 64: Chart on US - Year-over-year growth 2021-2026 (%)
Exhibits 65: Data Table on US - Year-over-year growth 2021-2026 (%)
Exhibits 66: Chart on Germany - Market size and forecast 2021-2026 ($ million)
Exhibits 67: Data Table on Germany - Market size and forecast 2021-2026 ($ million)
Exhibits 68: Chart on Germany - Year-over-year growth 2021-2026 (%)
Exhibits 69: Data Table on Germany - Year-over-year growth 2021-2026 (%)
Exhibits 70: Chart on Japan - Market size and forecast 2021-2026 ($ million)
Exhibits 71: Data Table on Japan - Market size and forecast 2021-2026 ($ million)
Exhibits 72: Chart on Japan - Year-over-year growth 2021-2026 (%)
Exhibits 73: Data Table on Japan - Year-over-year growth 2021-2026 (%)
Exhibits 74: Chart on Canada - Market size and forecast 2021-2026 ($ million)
Exhibits 75: Data Table on Canada - Market size and forecast 2021-2026 ($ million)
Exhibits 76: Chart on Canada - Year-over-year growth 2021-2026 (%)
Exhibits 77: Data Table on Canada - Year-over-year growth 2021-2026 (%)
Exhibits 78: Chart on China - Market size and forecast 2021-2026 ($ million)
Exhibits 79: Data Table on China - Market size and forecast 2021-2026 ($ million)
Exhibits 80: Chart on China - Year-over-year growth 2021-2026 (%)
Exhibits 81: Data Table on China - Year-over-year growth 2021-2026 (%)
Exhibits 82: Market opportunity By Geographical Landscape ($ million)
Exhibits 83: Impact of drivers and challenges in 2021 and 2026
Exhibits 84: Overview on Criticality of inputs and Factors of differentiation
Exhibits 85: Overview on factors of disruption
Exhibits 86: Impact of key risks on business
Exhibits 87: Vendors covered
Exhibits 88: Matrix on vendor position and classification
Exhibits 89: Aclaris Therapeutics Inc. - Overview
Exhibits 90: Aclaris Therapeutics Inc. - Business segments
Exhibits 91: Aclaris Therapeutics Inc. - Key news
Exhibits 92: Aclaris Therapeutics Inc. - Key offerings
Exhibits 93: Aclaris Therapeutics Inc. - Segment focus
Exhibits 94: BioLineRx Ltd. - Overview
Exhibits 95: BioLineRx Ltd. - Product / Service
Exhibits 96: BioLineRx Ltd. - Key offerings
Exhibits 97: Brymill Cryogenic Systems - Overview
Exhibits 98: Brymill Cryogenic Systems - Product / Service
Exhibits 99: Brymill Cryogenic Systems - Key offerings
Exhibits 100: Cortex Technology - Overview
Exhibits 101: Cortex Technology - Product / Service
Exhibits 102: Cortex Technology - Key offerings
Exhibits 103: Cryo Innovations - Overview
Exhibits 104: Cryo Innovations - Product / Service
Exhibits 105: Cryo Innovations - Key offerings
Exhibits 106: CryoConcepts LP - Overview
Exhibits 107: CryoConcepts LP - Product / Service
Exhibits 108: CryoConcepts LP - Key offerings
Exhibits 109: Cryoswiss GmbH - Overview
Exhibits 110: Cryoswiss GmbH - Product / Service
Exhibits 111: Cryoswiss GmbH - Key offerings
Exhibits 112: Erbe Elektromedizin GmbH - Overview
Exhibits 113: Erbe Elektromedizin GmbH - Product / Service
Exhibits 114: Erbe Elektromedizin GmbH - Key offerings
Exhibits 115: H and O Equipments - Overview
Exhibits 116: H and O Equipments - Product / Service
Exhibits 117: H and O Equipments - Key offerings
Exhibits 118: Special Medical Technology s.r.o - Overview
Exhibits 119: Special Medical Technology s.r.o - Product / Service
Exhibits 120: Special Medical Technology s.r.o - Key offerings
Exhibits 121: Inclusions checklist
Exhibits 122: Exclusions checklist
Exhibits 123: Currency conversion rates for US$
Exhibits 124: Research methodology
Exhibits 125: Validation techniques employed for market sizing
Exhibits 126: Information sources
Exhibits 127: List of abbreviations

Executive Summary

The publisher recognizes the following companies as the key players in the global seborrheic keratosis treatment market: Aclaris Therapeutics Inc., BioLineRx Ltd., Brymill Cryogenic Systems, Cortex Technology, Cryo Innovations, CryoConcepts LP, Cryoswiss GmbH, Erbe Elektromedizin GmbH, H and O Equipments, and Special Medical Technology s.r.o.

Commenting on the report, an analyst said: "The latest trend gaining momentum in the market is technological advances in cryotherapy."

According to the report, one of the major drivers for this market is the growing preference for the aesthetic quotient.

The study was conducted using an objective combination of primary and secondary information including inputs from key participants in the industry. The report contains a comprehensive market and vendor landscape in addition to a SWOT analysis of the key vendors.


Companies Mentioned

A selection of companies mentioned in this report includes:

  • Aclaris Therapeutics Inc.
  • BioLineRx Ltd.
  • Brymill Cryogenic Systems
  • Cortex Technology
  • Cryo Innovations
  • CryoConcepts LP
  • Cryoswiss GmbH
  • Erbe Elektromedizin GmbH
  • H and O Equipments
  • Special Medical Technology s.r.o