Bone Grafts And Substitutes Market Size, Market Share, Application Analysis, Regional Outlook, Growth Trends, Key Players, Competitive Strategies and Forecasts, 2021 to 2029

This report on global bone grafts and substitutes studies the market in terms of various materials and applications. The market is driven by key factors such as increase in the number of traumatic injuries, rising geriatric population suffering with osteoporosis, rheumatoid arthritis and periodontal diseases. Additionally the increasing number of minimally invasive surgeries performed for complications such disc herniation, burst fractures etc. will have a positive influence on the growth of bone grafts and substitutes products. The limiting factors related to this market are the immune response generated during surgical procedures, post-operative pain and stringent regulatory guidelines regarding the approval of the bone grafts and substitutes.

For the purpose of this study, the various materials studied are bone graft substitutes and allografts. Bone graft substitutes are further categorized into bone morphogenic proteins, synthetic bone grafts and others. Allografts are further sub-segmented as demineralized bone matrix and others. Applications studied for the purpose of this research includes spinal fusion, long bone, foot and ankle, craniomaxilofacial, joint reconstruction and dental. Market size estimates and forecast for these segments for the period 2019 to 2029 are provided in terms of US$ Mn along with the respective CAGRs for the period 2021 to 2029, considering 2020 as the base year.

Geographic segmentation of the global bone grafts and substitutes market is performed for the regions North America, Europe, Asia Pacific, Latin America and Middle East and Africa. The regions are also further sub-segmented on the basis of major countries:

• North America
• U.S.
• Canada
• Europe
• U.K.
• Germany
• Rest of Europe
• Asia Pacific
• China
• Japan
• India
• Rest of Asia Pacific
• Latin America
• Mexico
• Brazil
• Rest of LATAM
• Middle East and Africa
• GCC
• Rest of Middle East and Africa

Market size estimates and forecast for these segments for the period 2019 to 2029 are provided in terms of US$ Mn along with the respective CAGRs for the period 2021 to 2029, considering 2020 as the base year.

This report also includes qualitative assessment factors such as market dynamics (drivers, restraints and opportunities) to have a good understanding of the current and anticipated trends in the global bone grafts and substitutes market. Market attractiveness assessment, Porter’s five forces model and competitive landscape analysis by key players are also presented in the study. Furthermore, this report concludes with profiling of key market players currently enjoying prominent position in the global bone grafts and substitutes market. The major players in global bone grafts and substitutes market are AlloSource, Baxter Healthcare Corporation, DePuy Synthes, Medtronic plc, NuVasive, Inc., Orthofix Holdings, Inc., Orthovita, Inc., Stryker Corporation, Smith & Nephew, Inc. and Wright Medical Group N.V.

Based on application, the bone graft and substitutes market is categorized into

• Spinal Fusion
• Long Bone
• Foot and Ankle
• Craniomaxilofacial
• Joint Reconstruction
• Dental

The ideal bone graft substitutes should consists of the following essential features such as osteoconductive matrix, osteoinductive properties and osteogenic cells. Autogenous cancellous bone grafting has been considered as the gold standard in bone transplantation, but the limitations imposed were enhanced operative blood loss, donor site morbidity and limited availability for harvest. Spinal fusion provides a lucrative market and dominates the market share due to factors such as rising prevalence of low spine disc herniation, burst fractures, osteoporosis etc. and increasing number of patients suffering with cauda equine syndrome are preferring spinal fusion surgeries to release pressure on many spinal nerves, which causes paralysis in lower extremities. Dental surgeries are anticipated to be the fastest growing market majorly due to factors such as rising prevalence of periodontal disease, vehicular accidents resulting dental trauma resulting in loss of teeth and gum causing deformation in outward cosmetic appearance and dental bone grafting is also employed to maintain bone structure after tooth extraction. Dental implants also impart other benefits such as improved speech, convenience during eating and improved oral health.

For the purpose of this study, the global bone grafts and substitutes market is categorized into the following regional and country specific markets:

• North America
• U.S.
• Canada
• Europe
• U.K.
• Germany
• Rest of Europe
• Asia Pacific
• China
• Japan
• India
• Rest of Asia Pacific
• Latin America
• Brazil
• Mexico
• Rest of Latin America
• Middle East and Africa
• GCC
• Rest of Middle East and Africa

North America was observed to be the largest bone grafts and substitutes market in the base year 2020. According to the Centers for Disease Control and Prevention 2017-16 survey, the prevalence of osteoporosis in U.S. were 5.1% for men over 65 years of age and 24.5 % for women. The dominance of North America is mainly attributed to the presence of key drivers such as rising prevalence of traumatic accidents, osteoporosis, existence of developed healthcare infrastructure with orthopedic facility and domicile of key players pioneering in manufacture of bone grafts and substitutes. The market growth in Europe is mainly attributed to increase in the number of geriatric patients suffering with osteoporosis and periodontal diseases and presence of manufacturers focusing on the research and development activities required to produce next generation of bone grafts and substitutes. Asia Pacific is observed to be the fastest growing regional segment throughout the forecast period 2021-2029. Factors that are anticipated to propel the market growth in Asia Pacific are the increasing number of traumatic injuries inflicted due to car accidents, violence and sports injuries requiring surgical procedures, increasing disposable incomes makes it feasible to avail for healthcare services, flourishing e-commerce industry to promote sales and supportive regulatory environment for bone grafts and substitutes. Moreover, factors such as developing healthcare infrastructure, health awareness campaigns to promote sales and establishment of subsidiaries by major players in the untapped markets are going to fuel the rapid growth of bone grafts and substitutes market in Latin America, and Middle East and Africa in the near future.

Based on material, the global bone grafts and substitutes market is categorized into:

• Bone Grafts Substitutes
• Bone Morphogenic Proteins (BMP)
• Synthetic Bone Grafts
• Others
• Allografts
• Demineralized Bone Matrix
• Others

The bone grafts and substitutes market is driven by key factors such as rising prevalence of lumbar spine trauma, joint trauma and craniomaxillofacial surgeries required due to increase in road accidents, sports injuries, workplace injuries, falls and violence, increasing geriatric population with joint disorders and increasing number of minimally invasive procedures. Manufacturers involved in the production of bone grafts and substitutes are intensively focusing on imparting aesthetic values to their products such as distinctive and versatile handling features that helps the surgeon techniques. Presently, allografts hold the largest market share due to key drivers such as rising prevalence of traumatic bone injuries such as spine, hips, knees etc., cost efficient procedures due to smaller hospital stay, quick surgical procedure and early wound recovery period. Bone graft substitutes show a promising sales forecast and will be the fastest growing segment majorly due to factors such as accelerated bone formation due to inherent features of bone substitutes such as negative surface charge, increased protein fusion, enhanced cell attachment and favorable natural remodeling and graft resorption. The major players in bone grafts and substitutes market are AlloSource, Baxter Healthcare Corporation, DePuy Synthes, Medtronic plc, NuVasive, Inc., Orthofix Holdings, Inc., Orthovita, Inc., Stryker Corporation, Smith & Nephew, Inc. and Wright Medical Group N.V.


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