Cell Culture Monitoring Biosensors Market Size, Market Share, Application Analysis, Regional Outlook, Growth Trends, Key Players, Competitive Strategies and Forecasts, 2021 to 2029

Cell cultures are an important and fundamental tool essential for the development of target based therapies such as biosimilars, biologics and personalized medicine. The current trend for developing medication is making it more patient centric thus personalized medicines are in greater demand for treating various chronic conditions and orphan indications. The development of target based therapies for the above-mentioned conditions require to be carried at a faster pace with no scope for errors during the development stages. Cell culture monitoring biosensors enable minimizing the risks accompanied with cell culturing by providing information pertaining to changes in temperature, release of toxic substance, formation of a pre-determined metabolite and increase in cell density. These changes, when monitored manually, could lead to increased risk of contamination, reading errors, difficulty in sample scale up for molecule development and render loss of time, money and cell samples. Thus the increase in development for target based therapies fuels the need for cell culture monitoring biosensors.

The current study report on cell culture monitoring biosensors comprehends a complete understanding on the current market trends and dynamics across the duration, 2019-2029. The report provides an elaborative information on the market strategies and provide thorough analysis of the current market scenario and future trends for the time scale 2021-2029.

The global cell culture monitoring biosensors market has been studied by bifurcating the market base on the various electrodes utilized in the biosensors, the varied analytes that could be detected using the biosensors and its application across various industries. The cell culture monitoring biosensors market segmentation is as follows:

• Electrode
• Electrochemical
• Thermometric
• Optical
• Piezoelectric
• Analyte
• ATP
• Adenosine
• Hypoxanthine
• Glutamate
• Glucose
• Lactate
• Others (Ionosine, Acetylcholine, Choline & D-Serine)
• End User
• Pharmaceutical Industry
• Research labs
• Food & Beverages

The current report also provides an outlook of cell culture monitoring biosensors across geographies which are as follows:

• North America
• U.S.
• Canada
• Europe
• U.K
• Germany
• Rest of Europe
• Asia Pacific
• Japan
• China
• Rest of Asia Pacific
• Latin America
• Brazil
• Mexico
• Rest of Latin America
• Middle East and Africa (MEA)
• GCC
• Rest of MEA

Market estimation and forecast evaluation for the above mentioned segments have been inculcated in the current report for the duration 2019-2029 and is valued in terms of US$ Mn. Furthermore, the respective annual growth rates for each of the segments has been provided for the period, 2021-2029, by retaining 2020 as the base year.

The report also comprises of various qualitative factors that would give an insight into the cell culture monitoring biosensors market and would assist the emerging players to take strategic decisions to enter the market. The factors included are market drivers, opportunities and restraints. A competitive landscape depicting the market leaders, emerging market players and promising players have also been incorporated in this report. A complete profile of the key players in this market has also been provided with information of financial performance, marketed products and company activities. The industrial leaders profiled are Lifeonics, Lonza, Nova Biomedical, Sarissa Biomedical Ltd., Nanomedical Diagnostics, Sierra Sensors GmbH, Conductive Technologies Inc., C-CIT Sensors AG and VacciXcell.

Based on electrode types, the global cell culture monitoring biosensors market is segmented as follows:

• Electrochemical
• Thermometric
• Optical
• Piezoelectric

Electrodes form the main component of biosensors that help in the detection of any changes in the cell cultures. The sensors enables detection of microscopic changes, hydrogen peroxide presence, glucose, glutamate, lactate, change in temperature and cell density. The cell culture monitoring biosensors market has been categorized based on the various types of electrodes utilized in the biosensors available in the market viz., electrochemical, thermometric, optical and piezoelectric. Of the aforementioned types of electrodes, electrochemical electrodes dominate the market as they are most widely utilized sensors and have lower pricing thus catapults demand for the same. These sensors permit in situ and online measurements. However these devices face certain drawbacks such as thermal stability of the immobilized enzyme during sterilization process, electrode degradation due to continuous contact with the sample solution and may increase the risk for contamination and interfere in the bioprocess. Optical sensors are gaining demand in the current market is expected to have a steady growth in forecast period, 2021-2029. Optical sensors need minimal invasion in the cell sample thus have lesser interference with the bioprocess and provide faster optimization of the sample.

Based on the type of analytes, the global cell culture monitoring biosensors market is segmented as follows:

• ATP
• Adenosine
• Hypoxanthine
• Glutamate
• Glucose
• Lactate
• Others (Ionosine, Acetylcholine, Choline & D-Serine)

Cell culture requires continuous monitoring to ensure predetermined cell density and desired metabolic reactions to take place accurately. Manual monitoring of the changes in cell culture media, temperature changes and cell density is time consuming and increases the risk for contamination as periodic samples needs to be taken for testing. To ease this process, various biosensors are available pertaining to detection and measurement of specific analytes. The cell culture monitoring biosensors market is thus segmented based on the various analytes it could detect and measure viz., ATP, adenosine, hypoxanthine, glutamate, glucose, lactate and others. Of the mentioned analytes, glucose is predominantly monitored on a larger scale in every cell culturing followed by glutamate and lactate levels. Glucose is essential in any cell culture as it is the only source for carbon and is essential for cell growth. The glucose consumption levels could also determine the approximate cell density levels. Glucose testing biosensors thus encapsulate the cell culture monitoring biosensors market in current and in the forecast period, 2021-2029. Accurate concentration of glutamate is essential as it is required for the growth of cell culture, but it requires constant monitoring as it is unstable in physiological pH and may lead to the production of ammonium which is toxic to the cell cultures.

Based on type of end users, the global cell culture monitoring biosensors market is segmented as follows:

• Pharmaceutical Industry
• Research labs
• Food & Beverages

The pharmaceutical industry among the rest holds a dominant position in the cell culture monitoring biosensors market. There is a current rise in development for biosimilars, biologics and personalized medicine for the treatment of chronic conditions and orphan indications. For example, the development of the drug kalydeco which is approved for the treatment of cystic fibrosis in patients with a specific gene mutation. The newer therapies in cancer treatment are based on personalized medicine concept, which requires patient’s stem cell to develop the molecule for treatment. The fundamental need for the development of such drugs is cell culture which require close monitoring. Thus with the rise for target based therapies, the demand for cell culture monitoring biosensors also increases to attain accurate and efficient cell samples. Stem cell research is also on the rise with various studies carried out based on stem cell therapy. Thus research labs also acquire a decent share in the cell culture monitoring biosensors market.

For the purpose of this study, the global cell culture monitoring biosensors market is categorized into:

• North America
• Europe
• Asia Pacific
• Latin America (LATAM)
• Middle East and Africa (MEA)

Cell culture studies are carried out across geographies in industries and research institutes. It is an essential part of the drug development process for biologics, biosimilars and personalized medicines. Thus cell culture monitoring biosensors have a global existence. Among the geographies researched, North America comprises extensive R&D activities in biologics, biosimilars and personalized medicines which propel the growth of cell culture monitoring biosensors. Constant development of healthcare infrastructure in terms of laboratory facilities, increased healthcare expenditure and the presence of key players in North America have also functioned as market catalysts creating demand for cell culture monitoring biosensors in this region. Europe also holds a key position in the cell culture monitoring biosensors market owing to the presence of key market players in these region namely Sarissa Biomedical Ltd. and C-CIT Sensors AG that provide easy access to cell culture monitoring biosensors. Asia Pacific observes a steady increase in development of biosimilars. As per the Biosimilars APAC summit, Asia Pacific solely develops higher number of biosimilar products than any other nation globally. Regulatory bodies are taking initiatives and are promoting the growth of more biosimilar products in Asia Pacific. The aforementioned development has a positive impact on the growth of cell culture monitoring biosensors. However, cell culture monitoring biosensors are expensive which could have a negative impact on its growth in the developing economies.


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