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Single-Use Bioprocessing Probes And Sensors Market - Global Outlook & Forecast 2022-2027

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  • 327 Pages
  • June 2022
  • Region: Global
  • Arizton
  • ID: 5617337
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Single-use bioprocessing probes and sensors are effective alternatives to traditional biopharmaceutical development and manufacturing methods. They are well-positioned to support the growing interest in the product's implementation of continuous bioprocessing. Conventional bioreactors and fermenters are made up of stainless steel or glass. In contrast, the vessels for single-use bioreactors and single-use fermenters are disposable plastic bags installed into outer metal containers. The increasing adoption of single-use technologies in the biopharmaceutical industry for biologics, vaccines, and cell therapy production indicates that such technology has moved far beyond its novelty stage.

The rise of bioprocessing in biopharmaceutical manufacturing, combined with the advantages of single-use systems, is driving up demand for single-use bioprocessing probes and sensors with a track record of long-term performance. The challenges for single-use technology in bioprocessing include the time for a sensor when the bioprocess has a long duration and whether the materials are durable enough to be exposed to process fluids for a more extended period.

The rising popularity of single-use bioreactors and fermenters because of its increasing demand in the development of therapeutics has drawn several vital stakeholders' attention to the single-use bioprocessing probes and sensors market. The bioreactors and fermenters meet the need of the biopharmaceutical industry for lower costs, increased efficiency, and overall greater flexibility. This is because single-use equipment can be pre-sterilized by the supplier before use, and there is the potential to eliminate classified environments from the manufacturing process. In addition, the reduced risk of cross-contamination helps companies avoid costly downtime and material waste.

Expanding the use of single-use bioreactors and fermenters has fueled the growth of the single-use bioprocessing probes and sensors market. There will be substantial growth in the utilization of single-use bioprocessing probes and sensors by 2023, with a 214.29% increase in revenue from 2018.

The global single-use bioprocessing market is moderately competitive and offers significant growth opportunities for vendors. Thermo Fisher Scientific, Sartorius, Danaher, and Merck are some of the key companies dominating the market.

Vendors' Activities in the Market

  • Expansion activities (regional business and facility expansions) are helping players strengthen the global distribution networks and thus allowing the players to explore untapped opportunities.

- Large scale investments in the single-use bioprocessing probes and sensors market through varied conglomerates and acquisitions firms

  • Forging partnerships with well-established manufacturers, cementing the footprints of the players.

  • Active Mergers and acquisitions play a vital role in the smooth functioning of the growth cycle.

Key Vendors

  • Thermo Fisher Scientific
  • Sartorius
  • Danaher
  • Merck KGAA

Other Prominent Vendors

  • Aber Instruments
  • Avantor
  • Broadley-James
  • CerCell
  • Cole-Parmer Instrument Company
  • Distek
  • Emerson Electric
  • ESI Technologies Group
  • Hamilton Company
  • High Purity New England
  • Levitronix
  • Liquidyne Process Technologies
  • Malema Engineering
  • PreSens Precision Sensing
  • PSG
  • Saint-Gobain


To cater to the growing demand for single-use probes and sensors, vendors focus more on developing advanced single-use probes and sensors to meet the current requirements. As a result, several companies are engaged in focusing on developing improved single-use sensors. For instance, Emerson Electric's Rosemount 550 Ph single-use sensor and connector offers storage, installation, gamma sterilization, and standardization in moist conditions. The non-invasive single-use probes and sensors reduce the risk of cross-contamination as the sensors are read out contactless via an optical fiber. SONOTEC offers an ultrasonic clamp-on flow meter, i.e., SONOFLOW CO.55, which is non-invasive and does the contamination-free flow metering on flexible tubes. Other vendors such as PreSens Precision Sensing and HIGH PURITY NEW ENGLAND recently started offering non-invasive probes and sensors. Smart single-use probes and sensors, consisting of memory devices with gamma stability to record calibration data and carry sensor-specific information, have emerged, with applications in growth media preparation, bioreactor maintenance, cell culture harvest, buffer preparation, and tangential flow filtration.

Some smart single-use sensors are developed with better shelf life and no recalibration requirement. For instance, Emerson's Rosemount 550pH single-use sensor has sensor stability of


The outbreak of the COVID-19 pandemic has led to a boost in demand for single-use bioprocessing probes and sensors. The demand for COVID-19 vaccine, cell and gene therapies, and monoclonal antibody manufacturing is likely to influence the market because most biopharmaceutical companies rely on advanced technologies such as single-use systems to develop therapeutic agents.

The vaccine segment has shown the highest CAGR of 16.99%, which is expected to be because of the increasing demand for vaccine development in several therapeutic areas, mainly during the COVID-19 pandemic.


CMOs play an important role in biopharma companies and help create a valuable investment. Companies with significant financial clout, reputation, and ability to take the risk are well-positioned to lead in the market. CMOs with adequate scale and special operations dominate the market and potentially realize high economic returns.

The wide acceptance of single-use bioreactors among CMOs is increasing the demand for single-use probes and sensors in recent years because CMOs prefer higher flexibility manufacturing with the aim of time and cost savings. It is estimated that about 60% of CMOs are currently using single-use probes and sensors for their single-use bioreactors to produce biologics. Thus, increasing the growth and manufacturing of biopharmaceuticals is boosting the demand for single-use probes and sensors.

CMOs have been among the earliest adopters of single-use bioprocessing probes and sensors. CMOs are more likely than drug manufacturers to adopt single-use bioprocessing probes and sensors - 86% vs. 66% in 2019. More than 30% of bio manufacturers and 39% of CMOs have considered probes and sensors as their interest in new product development.


Among the single-use bioprocessing probes and sensors, pH sensors are the most used sensors in the bioprocessing industry. These pH sensors have enabled enhanced equipment inventory control for the process device manufacturer and end-user sites. The pH sensor segment has accounted for the highest market share of 23.23% among the other types of sensors.


The upstream segment is dominating the single-use bioprocessing probes and sensors and has accounted for the largest revenue of 4712.96 million in 2021. The increasing adoption of single-use bioreactors for upstream bioprocessing has significantly increased the usage of single-use bioprocessing probes and sensors.

In the downstream processing, the affinity capture step and purification are intensive and costly. Overall, less penetration of single-use systems in downstream processing has resulted in less market revenue share in this segment. However, the operating players are constantly attempting to expand the use of single-use systems in the downstream process; this segment is expected to witness considerable growth during the forecast period.

Segmentation by Type of Sensors

  • pH
  • Oxygen
  • Pressure
  • Temperature
  • Flow Meters & Sensor
  • Other

Segmentation by Workflow

  • Upstream
  • Downstream

Segmentation by Application

  • Monoclonal Antibody
  • Vaccines
  • Cell Therapies
  • Others

Segmentation by End-User

  • Biopharmaceutical Manufacturers
  • R&D Companies & Institutes


Increasing expenditure on R&D for biopharmaceutical products is contributing to the high utilization of single-use bioreactors, in turn contributing to the growth of the single-use bioprocessing probes and sensors market. The increasing demand for single-use bioprocessing probes and sensors can be observed in North America and Europe. With $409.58 million, North America was the highest revenue generator region in 2021.

In North America, the majority of the companies hold strong positions in these regions. Collaborations between the sensor's original equipment manufacturers and independent sensor suppliers contribute to growing the market. Major players such as Avantor, High Purity New England, and Merck play an essential role in the growth of the single-use bioprocessing sensors market in the United States, accompanied by rising investments by large companies to expand single-use bioprocessing facilities in the United States.

The major suppliers from North America and Europe are helping the market grow at a good pace and contributing to the market's growth in APAC, Latin America, and the Middle East & Africa.

Because of the increasing demand and expansion in usage of single-use bioreactors throughout North America and Europe is driving the growth of the market in these regions majorly. North America and Europe also dominate other areas in increasing investments to develop and distribute advanced single-use bioprocessing probes and sensors.

In recent years, the increasing expansion of manufacturing facilities for single-use bioprocessing can be witnessed in several countries from Latin America and the Middle East & to Africa, bringing great opportunities for the market's growth.

The rising emphasis on research activities and high R&D spending in APAC leads to increased use of single-use bioprocessing technologies to manufacture biopharmaceuticals, propelling the APAC single-use bioprocessing probes and sensors market with a CAGR of 17.86%.

Segmentation by Region

  • North America
  • US
  • Canada
  • Europe
  • Germany
  • France
  • Switzerland
  • UK
  • Italy
  • Spain
  • APAC
  • China
  • Japan
  • Australia
  • South Korea
  • India
  • Latin America
  • Brazil
  • Mexico
  • Colombia
  • Argentina
  • Middle East & Africa
  • Turkey
  • Saudi Arabia
  • UAE
  • South Africa



Table of Contents

1 Research Methodology2 Research Objectives3 Research Process
4 Scope & Coverage
4.1 Market Definition
4.1.1 Inclusions
4.1.2 Exclusions
4.1.3 Market Estimation Caveats
4.2 Base Year
4.3 Scope of the Study
4.3.1 Market Segmentation by Type of Sensors
4.3.2 Market Segmentation by Workflow
4.3.3 Market Segmentation by Application
4.3.4 Market Segmentation by End-user
4.3.5 Market Segmentation by Geography
5 Report Assumptions & Caveats
5.1 Key Caveats
5.2 Currency Conversion
5.3 Market Derivation
6 Market at a Glance
7 Introduction
7.1 Overview
7.1.1 Evolution of Cmos & Cdmos
8 Market Opportunities & Trends
8.1 Focus on Development of Non-Invasive Single-Use Sensors
8.2 Launch of Smart Single-Use Sensors
8.3 Development of Single-Use Dissolved Oxygen Sensors
9 Market Growth Enablers
9.1 Growing Demand for Biopharmaceuticals
9.2 Expanding Use of Single-Use Bioreactors
9.3 Rising Investment in Single-Use Bioprocessing Facility Expansions
10 Market Restraints
10.1 Environmental Concerns Regarding Safe Disposables and Technical Issues
10.2 Traces of Leachables & Extractables in Final Product
10.3 Limitations Associated With Single-Use Technologies in Bioprocessing
11 Market Landscape
11.1 Market Overview
11.2 Market Size & Forecast
11.2.1 Insights by Type of Sensors
11.2.2 Insights by Application
11.2.3 Insights by End-users
11.2.4 Insights by Workflow
11.2.5 Insights by Geography
11.3 Five Forces Analysis
11.3.1 Threat of New Entrants
11.3.2 Bargaining Power of Suppliers
11.3.3 Bargaining Power of Buyers
11.3.4 Threat of Single-Use Substitutes
11.3.5 Competitive Rivalry
12 Type of Sensors
12.1 Market Snapshot & Growth Engine
12.2 Market Overview
12.3 Ph Sensor
12.3.1 Market Overview
12.3.2 Market Size & Forecast
12.3.3 Market by Geography
12.4 Oxygen Sensor
12.4.1 Market Overview
12.4.2 Market Size & Forecast
12.4.3 Market by Geography
12.5 Pressure Sensor
12.5.1 Market Overview
12.5.2 Market Size & Forecast
12.5.3 Market by Geography
12.6 Temperature Sensor
12.6.1 Market Overview
12.6.2 Market Size & Forecast
12.6.3 Market by Geography
12.7 Flow Meter/Sensor
12.7.1 Market Overview
12.7.2 Market Size & Forecast
12.7.3 Market by Geography
12.8 Others
12.8.1 Market Overview
12.8.2 Market Size & Forecast
12.8.3 Market by Geography
13 Workflow
13.1 Market Snapshot & Growth Engine
13.2 Market Overview
13.3 Upstream
13.3.1 Market Overview
13.3.2 Market Size & Forecast
13.3.3 Market by Geography
13.4 Downstream
13.4.1 Market Overview
13.4.2 Market Size & Forecast
13.4.3 Market by Geography
14 Application
14.1 Market Snapshot & Growth Engine
14.2 Market Overview
14.3 Monoclonal Antibodies
14.3.1 Market Overview
14.3.2 Market Size & Forecast
14.3.3 Market by Geography
14.4 Vaccines
14.4.1 Market Overview
14.4.2 Market Size & Forecast
14.4.3 Market by Geography
14.5 Cell Therapies
14.5.1 Market Overview
14.5.2 Market Size & Forecast
14.5.3 Market by Geography
14.6 Others
14.6.1 Market Overview
14.6.2 Market Size & Forecast
14.6.3 Market by Geography
15 End-user
15.1 Market Snapshot & Growth Engine
15.2 Market Overview
15.3 Biopharmaceutical Manufacturers
15.3.1 Market Overview
15.3.2 Market Size & Forecast
15.3.3 Market by Geography
15.4 Cmos & Cdmos
15.4.1 Market Overview
15.4.2 Market Size & Forecast
15.4.3 Market by Geography
15.5 R&D Companies & Institutes
15.5.1 Market Overview
15.5.2 Market Size & Forecast
15.5.3 Market by Geography
16 Geography
16.1 Market Snapshot & Growth Engine
16.2 Geographic Overview
17 North America
17.1 Market Overview
17.2 Market Size & Forecast
17.3 North America: Type of Sensors
17.4 North America: Workflow
17.5 North America: Application
17.6 North America: End-user
17.7 Key Countries
17.7.1 Us: Market Size & Forecast
17.7.2 Canada: Market Size & Forecast
18 Europe
18.1 Market Overview
18.2 Market Size & Forecast
18.3 Europe: Type of Sensors
18.4 Europe: Workflow
18.5 Europe: Application
18.6 Europe: End-user
18.7 Key Countries
18.7.1 Germany: Market Size & Forecast
18.7.2 France: Market Size & Forecast
18.7.3 Switzerland: Market Size & Forecast
18.7.4 Uk: Market Size & Forecast
18.7.5 Italy: Market Size & Forecast
18.7.6 Spain: Market Size & Forecast
19 Apac
19.1 Market Overview
19.2 Market Size & Forecast
19.3 Apac: Type of Sensors
19.4 Apac: Workflow
19.5 Apac: Application
19.6 Apac: End-user
19.7 Key Countries
19.7.1 China: Market Size & Forecast
19.7.2 Japan: Market Size & Forecast
19.7.3 Australia: Market Size & Forecast
19.7.4 South Korea: Market Size & Forecast
19.7.5 India: Market Size & Forecast
20 Latin America
20.1 Market Overview
20.2 Market Size & Forecast
20.3 Latin America: Type of Sensors
20.4 Latin America: Workflow
20.5 Latin America: Application
20.6 Latin America: End-user
20.7 Key Countries
20.7.1 Brazil: Market Size & Forecast
20.7.2 Mexico: Market Size & Forecast
20.7.3 Colombia: Market Size & Forecast
20.7.4 Argentina: Market Size & Forecast
21 Middle East & Africa
21.1 Market Overview
21.2 Market Size & Forecast
21.3 Middle East & Africa: Type of Sensors
21.4 Middle East & Africa: Workflow
21.5 Middle East & Africa: Application
21.6 Middle East & Africa: End-user
21.7 Key Countries
21.7.1 Turkey: Market Size & Forecast
21.7.2 Saudi Arabia: Market Size & Forecast
21.7.3 Uae: Market Size & Forecast
21.7.4 South Africa: Market Size & Forecast
22 Competitive Landscape
22.1 Competition Overview
22.2 Market Share Analysis
22.2.1 Thermo Fisher Scientific
22.2.2 Sartorius
22.2.3 Danaher
22.2.4 Merck Kgaa
23 Key Company Profiles
23.1 Thermo Fisher Scientific
23.1.1 Business Overview
23.1.2 Product Offerings
23.1.3 Key Strategies
23.1.4 Key Strengths
23.1.5 Key Opportunities
23.2 Sartorius
23.2.1 Business Overview
23.2.2 Product Offerings
23.2.3 Key Strategies
23.2.4 Key Strengths
23.2.5 Key Opportunities
23.3 Danaher
23.3.1 Business Overview
23.3.2 Product Offerings
23.3.3 Key Strategies
23.3.4 Key Strengths
23.3.5 Key Opportunities
23.4 Merck Kgaa
23.4.1 Business Overview
23.4.2 Product Offerings
23.4.3 Key Strategies
23.4.4 Key Strengths
23.4.5 Key Opportunities
24 Other Prominent Vendors
24.1 Aber Instruments
24.1.1 Business Overview
24.1.2 Product Offerings
24.2 Avantor
24.2.1 Business Overview
24.2.2 Product Offerings
24.3 Broadley-James
24.3.1 Business Overview
24.3.2 Product Offerings
24.4 Cercell
24.4.1 Business Overview
24.4.2 Product Offerings
24.5 Cole-Parmer Instrument Company
24.5.1 Business Overview
24.5.2 Product Offerings
24.6 Distek
24.6.1 Business Overview
24.6.2 Product Offerings
24.7 Emerson Electric
24.7.1 Business Overview
24.7.2 Product Offerings
24.8 Esi Technologies Group
24.8.1 Business Overview
24.8.2 Product Offerings
24.9 Hamilton Company
24.9.1 Business Overview
24.9.2 Product Offerings
24.10 High Purity New England
24.10.1 Business Overview
24.10.2 Product Offerings
24.11 Levitronix
24.11.1 Business Overview
24.11.2 Product Offerings
24.12 Liquidyne Process Technologies
24.12.1 Business Overview
24.12.2 Product Offerings
24.13 Malema Engineering
24.13.1 Business Overview
24.13.2 Product Offerings
24.14 Mettler Toledo
24.14.1 Business Overview
24.14.2 Product Offerings
24.15 Parker Hannifin
24.15.1 Business Overview
24.15.2 Product Offerings
24.16 Presens Precision Sensing
24.16.1 Business Overview
24.16.2 Product Offerings
24.17 Psg
24.17.1 Business Overview
24.17.2 Product Offerings
24.18 Saint-Gobain
24.18.1 Business Overview
24.18.2 Product Offerings
24.19 Sonotec
24.19.1 Business Overview
24.19.2 Product Offerings
25 Report Summary
25.1 Key Takeaways
25.2 Strategic Recommendations
26 Quantitative Summary
26.1 Market by Geography
26.2 Market by Type of Sensors
26.3 Market by Application
26.4 Market by End-user
26.5 Market by Workflow
26.6 North America by Type of Sensors
26.7 North America by Application
26.8 North America by End-user
26.9 North America by Workflow
26.10 Europe by Type of Sensors
26.11 Europe by Application
26.12 Europe by End-user
26.13 Europe by Workflow
26.14 APAC by Type of Sensors
26.15 APAC by Application
26.16 APAC by End-user
26.17 APAC by Workflow
26.18 Latin America by Type of Sensors
26.19 Latin America by Application
26.20 Latin America by End-user
26.21 Latin America by Workflow
26.22 Middle East & Africa by Type of Sensors
26.23 Middle East & Africa by Application
26.24 Middle East & Africa by End-user
26.25 Middle East & Africa by Workflow
27 Appendix
27.1 Abbreviations

Companies Mentioned

  • Thermo Fisher Scientific
  • Sartorius
  • Danaher
  • Merck KGAA
  • Aber Instruments
  • Avantor
  • Broadley-James
  • CerCell
  • Cole-Parmer Instrument Company
  • Distek
  • Emerson Electric
  • ESI Technologies Group
  • Hamilton Company
  • High Purity New England
  • Levitronix
  • Liquidyne Process Technologies
  • Malema Engineering
  • PreSens Precision Sensing
  • PSG
  • Saint-Gobain


Our research comprises a mix of primary and secondary research. The secondary research sources that are typically referred to include, but are not limited to, company websites, annual reports, financial reports, company pipeline charts, broker reports, investor presentations and SEC filings, journals and conferences, internal proprietary databases, news articles, press releases, and webcasts specific to the companies operating in any given market.

Primary research involves email interactions with the industry participants across major geographies. The participants who typically take part in such a process include, but are not limited to, CEOs, VPs, business development managers, market intelligence managers, and national sales managers. We primarily rely on internal research work and internal databases that we have populated over the years. We cross-verify our secondary research findings with the primary respondents participating in the study.