Principles of Human Organs-on-Chips covers all aspects of microfluidic organ-on-a-chip systems, from fabrication to application and commercialization. Organ-on-a-chip models are created to mimic the structural, microenvironmental and physiological functions of human organs, providing the potential to bypass some cell and animal testing methods. This is a useful platform with widespread applications, frequently in drug screening and pathological studies.
This book offers a comprehensive and authoritative reference on microfluidic organs-on-chips, spanning all key aspects from fabrication methods, cell culture systems and cell-based analysis, to dedicated chapters on specific tissue types and their associated organ-on-a-chip models, as well as their use as disease models, drug screening platforms and more.
Principles of Human Organs-on-Chips helps materials scientists and biomedical engineers to better understand the specific requirements and challenges in the design and fabrication of organ-on-a-chip devices. This book also bridges the knowledge gap between medical device design and subsequent clinical applications, allowing medical professionals to easily learn about related engineering concepts and techniques.
Table of Contents1. Techniques and Materials for the Fabrication of Microfluidic Chips
2. Critical Factors Affecting Cells Behaviour in Microfluidic Chips
3. Cell-Based Assays on Microfluidic Chips
4. Cell Culture Techniques in Microfluidic Chips
6. Blood Vessels-On-A-Chip
12. Immune Organs-On-Chip
13. Nervous Systems on a Chip
15. Endocrine Organs-On-A-Chip
16. Musculoskeletal Tissue-On-a-Chip
18. Multi Organs-On-A-Chip and Personalized Medicine
19. Computational modelling of organ-on-a-chip devices
20. Commercialized Microfabricated Cell Chips
21. Organs-On-A-Chip: Future perspectives