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Bone Grafts and Substitutes

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  • 75 Pages
  • February 2024
  • Region: Global
  • Citeline
  • ID: 5642897
This analysis includes a discussion of products, current/forecast markets, competitors, and opportunities in the global market for bone grafts and substitutes. Product segments covered by this report include allografts and synthetic bone substitutes, growth factors, and cellular bone matrices. Geographic segments covered include the US, five major European markets (France, Germany, Italy, Spain, and the UK), Japan, and the Rest of World. The forecast range for this report is 2019-25.

The combined global market for bone grafts and substitutes totaled approximately $1.9bn in 2020. Although sales were negatively impacted by the COVID-19 pandemic, the market rebounded in 2021 and is expected to continue to increase in value over the forecast period, returning to more normal levels of growth between 2022 and 2025.

Key drivers of the bone grafts market include the aging of the population and the global burden of musculoskeletal disease, along with rising procedure volumes for spinal fusion and joint replacement surgeries. Market limiters include the high price of premium products such as growth factors and cellular bone matrices, as well as a hesitance in certain countries to use human-based allograft tissue for bone grafting.

Also included in this report:

  • a clinical overview of bone grafting and its current applications
  • spinal fusion procedure volume forecasts by country/region
  • osteoarthritis prevalence forecasts by country/region

Table of Contents

Executive Summary
i. Global market
a. Selected market drivers and limiters
b. Market leaders
ii. Methodology
iii. Bibliography
  • Exhibit ES-1: Bone grafts and substitutes, global market forecast ($m), by product segment, 2019-25
  • Exhibit ES-2: Bone grafts and substitutes market, share by country/region, 2020
1. Clinical Overview
1.1 Spinal fusion
1.2 Osteoarthritis
1.3 Bibliography
  • Exhibit 1-1: Spinal fusion procedure volumes forecast, by country/region, 2018-25
  • Exhibit 1-2: Global osteoarthritis prevalence (knee or hip) forecast, by region, 2020-25
2. Allografts and Bone Graft Substitutes Market
2.1 Bone graft materials
2.2 Allograft US FDA regulations
2.3 Bone allografts and machined bone
2.4 Demineralized bone matrix
2.5 Synthetic grafts
2.6 Market analysis
2.7 Global competitive analysis
2.8 Bibliography
  • Exhibit 2-1: General categories of bone grafts
  • Exhibit 2-2: Clinical applications for bone grafts
  • Exhibit 2-3: Clinical applications for orthopedic allografts and synthetic grafts, by type of graft
  • Exhibit 2-4: Selected structural bone allografts
  • Exhibit 2-5: Prices of selected allografts (chips, crushed, and cubed)
  • Exhibit 2-6: Selected demineralized bone matrix products
  • Exhibit 2-7: Prices of Medtronic’s Grafton DBM gel and putty
  • Exhibit 2-8: Selected synthetic bone grafts
  • Exhibit 2-9: Prices of Medtronic’s Mastergraft synthetic bone graft
  • Exhibit: Global bone allograft products market, share by country/region, 2020
  • Exhibit: Bone allografts market, share by tissue type, 2020
  • Exhibit: Global bone allograft product sales by country/region, market forecast ($m), 2019-25
  • Exhibit: Global bone allografts and synthetic bone graft substitutes market, share by supplier, 2020
3. Market for Bone Growth Factor Grafts
3.1 Bone morphogenetic proteins
3.2 Other growth factors
3.3 Discontinued product
3.4 Emerging products
3.5 Market analysis
3.6 Competitive analysis
3.7 Bibliography
  • Exhibit 3-1: The Infuse Bone Graft
  • Exhibit 3-2: Prices of Infuse bone morphogenetic protein
  • Exhibit 3-3: Selected bone growth factor-based products
  • Exhibit 3-4: OsteoAMP putty
  • Exhibit 3-5: the i-Factor bone graft
  • Exhibit 3-6: Augment bone graft
  • Exhibit 3-7: Growth factor bone graft sales, market forecast, by country/region ($m), 2019-25
  • Exhibit 3-8: Global growth factor bone grafts market, share by country/region, 2020
  • Exhibit 3-9: Growth factor bone grafts, market forecast, by product line ($m), 2019-25
  • Exhibit: Global growth factor bone grafts market, share by supplier, 2020
  • Exhibit: Medtronic net sales ($m), by product category and geography, FY2020-21
4. Cellular Bone Matrices Market
4.1 CBM Products
4.2 Market analysis
4.3 Competitive analysis
4.4 Bibliography
  • Exhibit 4-1: Selected cellular bone matrix products
  • Exhibit 4-2: Prices of selected cellular bone matrix products
  • Exhibit 4-3: Global cellular bone matrix product sales by country/region, combined market forecast ($m), 2019-25
  • Exhibit 4-4: Global cellular bone matrix products market, share by country/region, 2020
  • Exhibit 4-5: Global cellular bone matrix products market, share by supplier, 2020