Lantibiotics as Alternative Therapeutics. Advances in Biotechnology and Bioengineering

Table of Contents

1. Genetics of the development of antibiotic and multi-drug resistance
2. Antimicrobial peptides and the potent mechanism of action
3. Lantibiotics and Gene regulation
4. Biosynthesis of Lantibiotics
5. Optimizations in the productions of Lantibiotics and Scale-Up
6. Analytical Techniques in Identifying & Purifying the proteins
7. Development of Recombinant Lantibiotics and their Potent Uses
8. Mechanism of Action of the Lantibiotics on the Multi-Drug Resistant Organism
9. Mechanism of inhibiting Biofilm associated Chronic Infections by Lantibiotics
10. Lantibiotics & Its Role in Food Preservation
11. In-Silico studies of the Interaction of Lantibiotics with Virulent Proteins
12. Insights at the atomistic resolution of Lantibiotics using Multiscale Simulations
13. Case studies: Applications of such novel drugs
14. Recent updates in understanding of molecular genetics of lantibiotics production
15. In silico molecular modelling approach for better designing and applications
16. Marine microbes as a potential source of novel drugs
17. Combinations of nano-bio molecules as next generation antimicrobial agents

Authors

Sanket Joshi Professor, Amity Institute of Microbial Technology, Amity University, Rajasthan, India. Dr. Sanket Joshi is currently a Professor at the Amity Institute of Microbial Technology, Amity University, Rajasthan, India. He has academic teaching and research experience of about 16 years, and industrial R&D experience of about 4 years in India and Oman. While working in Indian pharma companies, he undertook several turnkey projects. His current research interests encompass energy (In-situ/ex-situ microbial enhanced light/heavy oil recovery; chemical enhanced oil Recovery; biofuels), microbial products (biosurfactants, biopolymers, R&D and scale-up), and environmental bioremediation (crude oil pollution; analysis, mitigation and control of souring by Sulfate reducing bacteria; HPAM contaminated sites). He has about 125 scientific publications in international journals, book chapters, and conference proceedings, and two books to his credit. He is an Academic/Associate Editor for: Frontiers in Microbiology, PeerJ, Ecotoxicology (Springer), Petroleum Science and Technology (Springer), Biotech (Springer), and Open Biotechnology Journal; guest editor for Frontiers in Microbiology, Sustainability, Scientifica, and Open Biotechnology Journal. Rajiv K. Kar Assistant Professor, Jyoti and Bhupat Mehta School of Health Sciences and Technology, Indian Institute of Technology Guwahati, India. Dr. Kar is a Scientist at Technische Universit�t Berlin, Institute for Chemistry, Germany. He works in the Bio-Molecular Modelling Group, on application of classical and quantum mechanical simulations in collaboration with experimental measurements to explore the mechanistic details in flavin-based bifurcating system. He previously worked as a Post-Doctoral Fellow in Fritz Haber Center for Molecular Dynamics Research, in group of Dr. Igor Schapiro, Hebrew University of Jerusalem, Israel. [Apr 2017 - Jun 2020], and as a Project Assistant in Department of Biophysics, Bose Institute, Bose Institute, Kolkata. [July 2011 - Jan 2012]. He received various awards/scholarships. He has more than 55 publications in journals of international reputes, conferences, and book chapters, to his credit. Dibyajit Lahiri Associate Professor, Department of Biotechnology, University of Engineering and Management, Kolkata, India. Dibyajit Lahiri is at present is working as Associate Professor in the Department of Biotechnology, University of Engineering & Management, Kolkata. His research interest is precisely on biofilm isolated from human prosthesis and its inhibition by various novel phyto and nano compounds. He is keen to explore the molecular mechanism behind the removal of biofilm by natural compounds. His research arena also encompasses computational drug development by using of bioinformatic. His work is regularly being presented and appreciated before a number of experts of National and International repute. He has more than 100 publications. Dr. Lahiri has edited 5 books. He is also in the role of associate editors of various journals of international reputes. Moupriya Nag Assistant Professor, Department of Biotechnology, University of Engineering and Management, India. Moupriya Nag, PhD postdoctoral work was focused on exploring the aggregation kinetics and mechanism of action of peptides associated with neurodegenerative diseases in presence of various membrane surfaces with solution NMR, making her gain experience with various state of the art techniques used in a molecular biology research.? Her research interests include single molecule biophysics of protein unfolding/refolding and protein aggregation kinetics and its mechanism of action, especially the amyloid proteins in neurodegenerative disorders. Recently, her research focuses on functional amyloids in bacteria and their relation in forming biofilms. She has about 5 years of teaching experience in Biophysics, Bioinformatics, Bioprocess and Biotechnology, Enzyme Technology, Computing, Molecular Modeling and Drug Design. She has also published many research articles in the peer-reviewed international journal and authored or co-authored numerous book chapters. She is also a member of many scientific societies like Indian Biophysical Society and Indian Science Congress Association