This volume is a comprehensive compilation of contributions on the state of the art knowledge about bioactive compounds including their sources, isolation methods, biological effects, health benefits and potential applications. These bioactive compounds could serve as alternatives in the prevention or treatment of multifactorial diseases for vulnerable population groups. Chapters in the book incorporate the knowledge based on traditional medicine with recent findings on bioactive molecules and their pharmaceutical implications in neurodegenerative diseases, cancer, COVID 19, diabetes, immunomodulation and farm animal diseases. The book also highlights the latest breakthroughs in the field of screening, characterization, and novel applications of natural bioactive compounds from diverse group of organisms ranging from bacteria, algae, fungi, higher plants, and marine sources. Authors from renowned institutions of India, Japan and China have shared their expertise in the contributed chapters with the goal of enhancing readers’ knowledge about the significance of use of bioactives in therapeutics and nutraceuticals. It is an informative reference for researchers, professors, graduate students, science enthusiasts, and all those who wish to gain insights into various aspects of bioactive compounds, and the development of new pharmaceutical constituents and nutraceuticals.
Table of Contents
- Foreword
- Preface
- List of Contributors
- S.J.S. Flora, Rahul Shukla and Mayank Handa
- Introduction
- Flavonoids Chemistry and Its Classification
- Flavonoids Classification
- Isoflavones
- Neoflavonoids
- Flavones
- Flavonols
- Flavanones and Flavanonols
- Flavanols
- Anthocyanidins
- Chalcones
- Flavonoids and Its Abundancy in Nature
- Flavonoids and Its Pathological Targets in Neurological Disorders
- Cholinesterase Inhibitors
- Scavengers of Free Radical
- Memory Enhancers
- Tau Targeting
- Neuro Anti-Inflammation and Detoxifier
- Targeting Other Pathways
- Pathways of Various Signaling Proteins
- Toxicological Aspects of Flavonoids
- Conclusion
- Consent for Publication
- Conflict of Interest
- Acknowledgements
- References
- Neha Jain, Mukesh Kumar Sharma, Yoshihisa Matsumoto and Pallavi Kaushik
- Introduction
- Plants Derived Bioactive Compounds
- Curcumin
- Camptothecin
- Homoharringtonine
- Piperine (1-Piperoyl Piperidine)
- Podophyllotoxin
- Resveratrol (Trans-3,5,4'-Trihydroxystilbene)
- Vinca Alkaloids (Catharanthus Alkaloids)
- 6-Shogaol
- Bioactives Obtained from Marine Organisms
- Trabectedin (Ecteinascidin-743 or Et-743)
- Dolastatins 10
- Monanchocidin
- Fucoidan
- Bryostatin 1
- Hesa-A
- Halichondrin B
- Conclusion and Future Prospectives
- Consent for Publication
- Conflict of Interest
- Acknowledgements
- References
- Amrita C. Bhagwat, Amrita M. Patil and Sunil D. Saroj
- Introduction
- Natural Bioactives Against Acinetobacter Baumannii Biofilms
- Natural Bioactive Against Pseudomonas Aeruginosa Biofilm
- Natural Bioactive Against Enterobacteriaceae Biofilm
- Natural Bioactives Against Shigella Spp. Biofilm
- Natural Bioactives Against Escherichia Coli Biofilm
- Natural Bioactives Against Klebsiella Pneumonia Biofilm
- Natural Bioactives Against Salmonella Spp. Biofilm
- Limitations and Research Gaps in the Discovery of Natural
- Bioactives Against Biofilms
- Conclusion
- Consent for Publication
- Conflict of Interest
- Acknowledgements
- References
- Prachi Jain, Mukesh Kumar Sharma, Sicheng Liu, Rajani Sharma and Pallavi
- Kaushik
- Introduction
- Covid-19: Features and Characteristics
- Causative Agent
- Life Cycle and Pathogenicity of Coronavirus
- Overview of Covid-19 Therapeutics in Practice
- Food Supplements Efficacious During Covid-19
- Some Natural Products and Phytomedicines Used for Treatment of Covid-19
- Quercetin
- Glycyrrhizic Acid
- Baicalin and Baicalein
- Luteolin
- Andrographolide
- Propolis
- Cepharanthine (Cep)
- Theaflavin (Tf) and Epigallocatechin Gallate (Egcg)
- Emodin
- Resveratrol
- Tanshinones
- Targets of Bioactive Compounds Against Covid-19
- (I) Inhibition of Host Cell Attachment and Penetration of Covid-19
- (Ii) Viral Genome Replication and Protein Synthesis Machinery
- Vaccines Development by Natural Product
- Conclusion
- Consent for Publication
- Conflict of Interest
- Acknowledgements
- References
- Amit Kumar Dixit, Qadir Alam, Deepti Dixit, Parvathy G. Nair and P.V.V. Prasad
- Introduction
- Bioactives Compounds With Their Pharmacological Actions Involved in the Regulation Of
- Blood Glucose
- Alkaloids
- Glycosides
- Phenolic
- Flavonoids
- Coumarins
- Saponins
- Vitamins
- Other Compounds/Metabolites
- Seaweeds
- Concluding Remarks
- Consent for Publication
- Conflict of Interest
- Acknowledgements
- References
- Neetu Kachhwaha, Mukesh Kumar Sharma, Renu Khandelwal and Pallavi Kaushik
- Introduction
- Valuable Bioactive Compounds Derived from Algae
2. Fucoidan
3. Algal Alginates
4. Fucoxanthin
5. Astaxanthin
6. Nonyl 8-Acetoxy-6-Methyloctanoate (Namo)
7. Violaxanthin
8. Coibamide a
- Conclusion
- Consent for Publication
- Conflict of Interest
- Acknowledgements
- References
- Vulgare Mill. (Fennel) and Trachyspermum Ammi L. (Ajwain)
- Nandini Goswami, Shalini Jain and Sreemoyee Chatterjee
- Introduction
- Phytochemistry of F. Vulgare and T. Ammi
- Organoleptic Properties
- Pharmacological Activities
- Fennel (F.Vulgare)
- Antioxidant Activity
- Effect on Uterine Contraction
- Acaricidal Activity
- Antibacterial Activity
- Antihirutism Activity
- Hepatoprotective Activity
- Anti-Inflammatory Activity
- Antifungal Activity
- Antithrombotic Activity
- Antimutagenic and Chemopreventive Potential
- Antidiabetic Activity
- Ajwain (T.Ammi)
- Hepatoprotective Activity
- Antioxidant Activity
- Antilithiasis and Diuretic Activity
- Antiplatelet-Aggregatory Potential
- Anti-Inflammatory Potential
- Antitussive Effects
- Antifilarial Activity
- Gastro Protective Activity
- Detoxification of Aflatoxins
- Antimicrobial Actions in Vitro
- Hypolipidemic Action in Vivo
- Digestive Stimulant Actions in Vivo and in Vitro
- Nematicidal Activity
- Antihelmintic Activity
- Conclusion
- Consent for Publication
- Conflict of Interest
- Acknowledgements
- References
- Sneha Keelka, Pallavi Kaushik and Mukesh Kumar Sharma
- Introduction
- Plant-Based Bioactive Compound for the Treatment of Livestock Diseases and Their Mechanism of Action
- Natural Phenolic Compounds
- Tannins
- Flavonoids
- Phenolic Acids
- Saponin
- Essential Oils
- Terpenes
- Vitamins
- Bioactive Compounds Isolated from Other Sources
- Polysaccharides
- Sulfated Galactans
- Fucoidan
- Laminarin
- Polyphenol
- Phlorotannins
- Bromophenols
- Flavonoids
- Phenolic Terpenoids
- Carotenoids
- Phycobiliproteins
- Peptides
- Uses of Bioactive Compounds
- Chemical Structure of Bioactive Compounds
- Conclusion and Future Prospectives
- Consent for Publication
- Conflict of Interest
- Acknowledgements
- References
- Amit Kumar Dixit, Avijit Banerji, Julie Banerji, Deepti Dixit, Parvathy G. Nair
- And Damodar Gupta
- Introduction
- Phytochemical Investigations on H. Indicus
- Preliminary Phytochemical Screening of Phytochemicals in Extracts
- Simple Aliphatic and Aromatic Compounds; Volatile Constituents
- Chromatographic Studies and Quantification of Components in H.Indicus
- Terpenoids - Triterpenoids, Sesterterpenoids, Diterpenoids, Sesquiterpenoids,
- Monoterpenoids
- Monoterpenoids and Sesquiterpenoids
- Monoterpenoids
- Sesquiterpenoids
- Triterpenoids
- Steroids
- Glycosides
- Polyphenolics - Coumarino-Lignoids, Flavonoids
- Coumarino-Lignoids
- Phenylpropanoid Glucoside
- Flavonoids
- Anti-Diabetic Activity of H. Indicus
- Treatment of Diabetes-Induced Cataract and Wounds With Hemidesmus Indicus Extracts
- Isolation of Active Anti-Diabetic Compounds and Their Activity
- ß-Amyrin Palmitate
- 2-Hydroxy 4-Methoxy Benzoic Acid (Hmba)
Contributors
- Mukesh Kumar Sharma
- Pallavi Kaushik
