Rare Kidney Diseases Market: Growth and Trends
Kidney illnesses encompass various disorders that impair the kidneys' natural function of effectively filtering waste and surplus fluid from the bloodstream. These ailments also affect the kidneys' ability to control blood pressure and sustain the body's fluid balance. Importantly, in the initial phases, kidney disorders frequently show no signs, complicating the diagnosis. Nonetheless, as toxins build up in the body, individuals might encounter symptoms such as elevated blood pressure, anemia, inadequate nutritional health, and nerve injury. As per the US Centers for Disease Control and Prevention, around 35.5 million individuals in the US are projected to be impacted by kidney diseases in the recent year, representing nearly 14% of the total population. A portion of these conditions, infrequent kidney disorders, impact a smaller percentage of people globally. According to the Orphan Drug Act, a condition is considered rare in the US if it impacts fewer than 200,000 individuals. In the European Union, rare diseases are characterized as affecting approximately 5 out of every 10,000 Europeans.Rare kidney disorders mainly impact the filtering units of the kidneys (referred to as glomeruli), resulting in the leakage of protein elements and blood into the urine. These conditions may be congenital, acquired, or inherited, which complicates the identification of specific biomarkers for diagnosis and treatment. In the absence of effective treatment methods, rare kidney disorders frequently result in kidney failure, requiring dialysis or organ transplant. It is notable that kidney failure stemming from a rare chronic kidney disease has been seen in at least 3 of 5 children and 1 in 9 adults affected by kidney diseases. To tackle these issues, considerable progress has been achieved in identifying and managing rare kidney disorders. Precision treatments, such as genomic analysis and tailored therapies, have facilitated the focused management of these conditions. Further, the incorporation of big data and machine learning has aided numerous drug developers and researchers by enhancing patient recruitment for clinical trials and identifying precise urinary biomarkers for personalized treatment.
Additionally, significant funding from both public and private sectors speeds up research and development in this area. Currently, pharmaceutical companies have obtained more than USD 12 billion in financing for research and treatment advancements for rare kidney conditions. Moreover, as there is an increasing emphasis on effective diagnosis and treatment, the market for therapies and drugs for rare kidney diseases is set for substantial growth, offering considerable opportunities for stakeholders in the years ahead.
Rare Kidney Diseases Market: Key Insights
The report delves into the current state of the rare kidney diseases market and identifies potential growth opportunities within the industry. Some key findings from the report include:
- Over 70% of the rare kidney drugs / therapies are in clinical stages of development; notably, most of the drugs / therapies are being investigated for the treatment of immunoglobulin A nephropathy and lupus nephritis.
- The rising interest in this domain is evident from the wide array of partnerships established between various stakeholders in the recent past; in fact, 65% of the total deals were inked in the last three years.
- Several investors, having realized the opportunity within this domain, have invested significant capital across various funding rounds; 45% of the investments in this domain were made through secondary offerings.
- Nearly 40% of the drugs targeting rare kidney diseases are currently in Phase II of clinical development; notably, around 60% of the trials have been sponsored by industry players.
- The rare kidney disease market is likely to grow at an annualized rate (CAGR) of 15.2%, till 2035; the majority of the market share (~70%) is expected to be captured by North America by 2035.
- Currently, the monoclonal antibodies dominate the market; notably, oral route of administration is anticipated to capture the majority share in the market by 2035.
Rare Kidney Diseases Market: Key Segments
Lupus Nephritis is the Fastest Growing Segment in the Rare Kidney Diseases Market
In terms of the type of target disease indication, the global rare kidney disease market is segmented into atypical hemolytic uremic syndrome, Fabry disease, focal segmental glomerulosclerosis, immunoglobulin A nephropathy, lupus nephritis, and others. Currently, lupus nephritis holds the largest portion of the rare kidney disease market, owing to the growing awareness of the disease's severity among both patients and healthcare providers.Small Molecules are Likely to Hold the Largest Share of the Rare Kidney Diseases Market During the Forecast Period
In terms of the type of molecule, the global market is segmented into small molecules and biologics. Within these categories, the small molecules segment holds the largest portion of the current market. However, it is important to note that biologics are projected to develop into a viable option that can address the fundamental biological mechanisms linked rare kidney diseases, thus obtaining a greater market share in the near future.Rare Kidney Diseases Market for Proteins is Likely to Grow at a Relatively Faster Pace During the Forecast Period
Based on the type of biologic, the global market value is segmented across enzymes, hormones, monoclonal antibodies, and proteins. Notably, the monoclonal antibodies segment dominates the current market. Moreover, this trend is unlikely to change in the foreseen future owing to their proven precision in treating rare kidney diseases.Oral Route of Administration Holds the Largest Share of the Rare Kidney Diseases Market
Based on the route of administration, the global market is segmented across intravenous, oral and subcutaneous routes of administration. Currently, the oral route is expected to hold the majority rare kidney disease market share owing to its non-invasive nature and increased patient compliance as compared to other routes. However, it is worth mentioning that this trend is expected to change during the forecast period, with the subcutaneous route of administration capturing a larger share of the overall market in the coming years.By Type of Therapy, Monotherapy Segment is Likely to Dominate the Market During the Forecast Period
Based on the type of therapy, the global market for rare kidney diseases is segmented across monotherapy and combination therapy. At present, the monotherapy segment holds the maximum share in the overall market. However, the market for combination therapy is likely to grow at a relatively higher CAGR during the forecast period.North America Accounts for the Largest Share of the Market
Based on key geographical regions, the market is segmented into North America, Europe, and Asia-Pacific. In the current scenario, North America is likely to capture the largest market share. However, the Asia-Pacific market is anticipated to expand more quickly during the forecast period due to rising incidence rates of rare kidney diseases in several Asian countries, including China, Japan, Korea, and India, which require improved treatment management systems in these countries.Example Players in the Rare Kidney Diseases Market
- Alexion Pharmaceuticals
- Amicus Therapeutics
- Apellis Pharmaceuticals
- Aurinia Pharmaceuticals
- GlaxoSmithKline
- Novartis
- Roche
- Travere Therapeutics
- Vera Therapeutics
Rare Kidney Diseases Market: Research Coverage
The report on rare kidney diseases market features insights into various sections, including:
- Market Sizing and Opportunity Analysis: An in-depth analysis of the rare kidney diseases market, focusing on key market segments, including [A] type of disease indication, [B] type of molecule, [C] type of biologic, [D] route of administration, [E] type of therapy, [F] key geographical regions, and [G] key players.
- Market Landscape: A comprehensive evaluation of rare kidney diseases drugs / therapies developers, based on several relevant parameters, such as [A] stage of development, [B] target indication, [C] route of administration, [D] type of molecule, [E] type of biologic, [F] dosing frequency, [G] target patient population, and [H] type of therapy.
- Rare Kidney Diseases Drug / Therapies Developer Landscape: The report features a list of leading players engaged in the rare kidney diseases domain, along with analyses based on [A] year of establishment, [B] company size, [C] location of headquarters, and [D] most active players (in terms of number of drugs / therapies developed).
- Company Competitiveness Analysis: An insightful competitiveness analysis of the companies engaged in the rare kidney diseases domain, based on various relevant parameters, such as [A] company strength, [B] portfolio strength, and [C] pipeline diversity.
- Company Profiles: In-depth profiles of key industry players offering rare kidney drugs / therapies across various geographies, focusing on [A] company overviews, [B] drug portfolio, [C] financial information (if available), [D] recent developments and [E] an informed future outlook.
- Partnerships and Collaborations: A detailed analysis of partnerships inked between stakeholders in the rare kidney diseases market, since 2019, based on several relevant parameters, such as [A] year of partnership, [B] type of partnership, [C] target disease indication, [D] type of partner, [E] most active players (in terms of number of partnerships), and [F] geography.
- Funding and Investments Analysis: A detailed analysis of the various funding and investments raised in the rare kidney diseases domain, based on several relevant parameters, such as [A] year of funding, [B] type of funding, [C] amount of funding, [D] target disease indication, [E] geography, and [F] most active players (in terms of number of funding instances).
- Clinical Trial Analysis: An in-depth analysis of completed / ongoing clinical trials related to rare kidney diseases drugs / therapies, based on various relevant parameters, such as [A] trial registration year, [B] trial status, [C] number of patients enrolled, [D] trial phase, [E] study design (type of trial masking, type of intervention model, trial purpose and design allocation), [F] type of sponsor, [G] patient gender, [H] most active sponsor / collaborator (leading industry and non-industry players based on the number of registered trials), and [I] geography.
- Clinical Commercial Attractiveness: A detailed analysis of the clinical and commercial attractiveness for phase III drugs / therapies targeting rare kidney diseases, based on several parameters, such as [A] type of molecule, [B] dosing frequency, [C] route of administration, [D] number of patients enrolled, [E] company size, [F] patient population, and [G] location of clinical trials.
- KOL Analysis: An insightful analysis, highlighting the key opinion leaders investigating the clinical trials related to rare kidney diseases, based on several parameters, such as [A] type of KOL, [B] qualification, [C] type of organization, [D] geographical location of KOLs, [E] target disease indication, and [F] most prominent KOLs (based on our proprietary and third-party scoring criteria).
- Case Study: An insightful case study highlighting the developers engaged in offering kidney care services, along with information on [A] year of establishment, [B] company size, [C] location of headquarters, [D] target indications, [E] benefits offered by the kidney care companies, and [F] recent developments in the domain.
- Market Impact Analysis: A thorough analysis of various factors, such as drivers, restraints, opportunities, and existing challenges that are likely to impact market growth.
Key Questions Answered in this Report
- How many companies are currently engaged in this market?
- Which are the leading companies in this market?
- What factors are likely to influence the evolution of this market?
- What is the current and future market size?
- What is the CAGR of this market?
- How is the current and future market opportunity likely to be distributed across key market segments?
- What is the patent filing activity trend in the market?
Reasons to Buy this Report
- The report provides a comprehensive market analysis, offering detailed revenue projections of the overall market and its specific sub-segments. This information is valuable to both established market leaders and emerging entrants.
- Stakeholders can leverage the report to gain a deeper understanding of the competitive dynamics within the market. By analyzing the competitive landscape, businesses can make informed decisions to optimize their market positioning and develop effective go-to-market strategies.
- The report offers stakeholders a comprehensive overview of the market, including key drivers, barriers, opportunities, and challenges. This information empowers stakeholders to stay abreast of market trends and make data-driven decisions to capitalize on growth prospects.
Additional Benefits
- Complimentary Excel Data Packs
- 15% Free Content Customization
- Detailed Report Walkthrough Session with the Research Team
- Free Update if the Report is 6+ Months Old
Table of Contents
Companies Mentioned (Partial List)
A selection of companies mentioned in this report includes, but is not limited to:
- 4D Molecular Therapeutics
- 5AM Ventures
- AbbVie
- Abingworth
- AceLink Therapeutics
- ACELYRIN
- Achillion Pharmaceuticals
- Adage Capital Management
- Aduro Biotech
- ADVANZ PHARMA
- Advicenne
- Alexandria Biotech
- Alexion Pharmaceuticals (a subsidiary of AstraZeneca)
- Alpine Immune Sciences
- Alrov
- Amgen
- Amicus Therapeutics
- Amyndas Pharmaceuticals
- Annexon Biosciences
- Apellis Pharmaceuticals
- APIE Therapeutics
- ARCH Venture Partners
- argenx
- Arrowhead Pharmaceuticals
- Artiva Biotherapeutics
- ARYA Sciences Acquisition Corp IV
- Asahi Kasei
- Astellas Pharma
- AstraZeneca
- Athyrium Capital Management
- Aurinia Pharmaceuticals
- Avanzanite
- Bain Capital Life Sciences
- Bayer
- BeiGene
- BioCity Biopharma
- Biocon
- Biogen
- Biohaven
- Birch Therapeutics
- Blackstone
- BNP Paribas
- Boehringer Ingelheim
- Boxer Capital
- BPI France
- Bristol-Myers Squibb
- Cabaletta Bio
- California Institute for Regenerative Medicine (CIRM)
- Calliditas Therapeutics
- CANbridge Life Sciences
- Catalent
- Cellares
- CellGenTech
- Cerium Pharmaceuticals
- Certa Therapeutics
- ChemoCentryx
- Chiesi Farmaceutici
- Chimagen Biosciences
- Chinook Therapeutics
- Children's Hospital of Zhejiang University School of Medicine
- Chugai Pharmaceutical (a subsidiary of Roche)
- Climb Bio
- Codexis
- Columbia University
- Cormorant Capital
- CSL
- DARUI Biopharma
- Deep Track Capital
- Deerfield Management
- Dimerix
- Elaiapharm
- Eleva
- ElevateBio
- Eloxx Pharmaceuticals
- ENYO Pharma
- Equillium
- European Investment Bank
- Everest Medicines
- Evotec
- ExCEEd Orphan
- Exegenesis Bio
- Fortress Biotech
- Frazier Healthcare Partners
- FrostPharma
- GC Biopharma
- Generium
- Genpharm Services
- Gilead Sciences
- GlaxoSmithKline
- Goldfinch Bio
- GordonMD Global Investments
- Guangdong Academy of Medical Sciences
- Hanmi Pharmaceutical
- Hansoh Pharmaceutical
- Hayfin Capital Management
- HI-Bio
- Highbridge Capital
- Hillhouse Capital
- IASO Biotherapeutics
- Idorsia Pharmaceuticals
- IgA Nephropathy Foundation
- ImmPACT Bio (a subsidiary of Lyell Immunopharma)
- Inmunova
- Ionis Pharmaceuticals
- Janchor Partners
- Janus Henderson Investors
- JCR Pharmaceuticals
- Jiangsu Hengrui Pharmaceuticals
- Jiangsu Ruiyuan Biotechnology
- Just - Evotec Biologics (a subsidiary of Evotec)
- Keymed Biosciences
- Kezar Life Sciences
- Kira Pharmaceuticals
- Komodo Health
- Kyorin Pharmaceutical
- Kyverna Therapeutics
- Lake Bleu Capital
- Lilly Asia Ventures
- LogicBio Therapeutics
- Lonza
- Lupus Therapeutics
- M6P Therapeutics
- MAB WORKS
- Mallinckrodt Pharmaceuticals
- Medical Research Future Fund
- Medison Pharma
- Medpace
- Merck
- Monograph Capital
- More Investment House
- Morehouse School of Medicine
- Morningside Ventures
- MorphoSys
- Nacuity Pharmaceuticals
- Nagoya University
- Nanjing Drum Tower Hospital
- National Institute of Allergy and Infectious Diseases (NIAID)
- National Institutes of Health
- NephCure
- Nkarta
- Northpond Ventures
- Novartis
- NovelMed
- OccuRx
- Ocelot Bio
- Omeros
- ONO Pharmaceutical
- Oraxion Therapeutics (a spin-off of Aten Porus Lifesciences)
- OrbiMed
- Otsuka Pharmaceutical
- Oxford Biomedica
- Papillon Therapeutics
- Peking Union Medical College Hospital
- Pfizer
- Pivotal bioVenture Partners
- Pontifax
- Protalix Biotherapeutics
- Psagot Investment House
- Q32 Bio
- RA Capital Management
- Recordati Rare Diseases
- Redmile Group
- RemeGen Biosciences
- Renalys Pharma
- River Renal
- Roche
- ROHTO Pharmaceutical
- Rona Therapeutics
- Rosalind Capital
- Samsara BioCapital
- Sangamo Therapeutics
- Sanofi
- SCOHIA PHARMA
- Selexis
- Shanghai Pharmaceuticals
- Shanghai Shengdi Pharmaceutical
- Skyline Therapeutics
- Società Prodotti Antibiotici
- STADA Arzneimittel
- Sumitomo Dainippon Pharma
- SVB Leerink
- Swedish Orphan Biovitrum
- SynAct Pharma
- Synlogic
- Taiba Healthcare
- Takeda
- Tenet Medicines
- TJ Biopharma
- Travere Therapeutics (formerly known as Retrophin Therapeutics)
- Truveta
- TwinPharma
- UBS
- UCB Ventures
- uniQure
- University of Michigan
- venBio Partners
- Venrock Healthcare Capital Partners
- Vera Therapeutics
- Verily
- Versant Ventures
- Vertex Pharmaceuticals
- Viatris
- Vida Ventures
- Viking Global Investors
- Visterra (a subsidiary of Otsuka Pharmaceutical)
- Vivo Capital
- Walden Biosciences
- Westlake Village BioPartners
- WuXi Advanced Therapies
- WuXi Biologics
- Zai Lab
- ZyVersa Therapeutics (formerly known as Variant Pharmaceuticals)
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