The Regulatory Genome in Adaptation, Evolution, Development, and Disease synthesizes insights from recent genomic and gene expression studies across organisms, from humans to plants, animals, and single cell life, exploring common roles gene regulation plays in adaptive evolution, developmental biology and susceptibility to disease. The book sheds light on gene regulation across evolutionary timelines, illuminating new areas of focus and future research. Chapters consider key elements in gene expression regulation, fundamentals of genomic alterations over time, and in response to environmental and local conditions, epigenetics in adaptive evolution, and adaptive gene regulation in healthy processes and developmental biology, and in disease biology.
Throughout the book, a comparative approach is adopted across organisms to highlight common evolutionary themes and genome diversity revealed by recent sequencing and GWAS studies, as well as how this informs our understanding of human adaptive evolution. The book finishes by detailing how we can use this knowledge to impact disease outcomes and healthy human metabolism, development, and physiology.
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Table of Contents
Part I. Progress in determining key elements in regulation of gene expression 1. Gene regulation in physiological processes 2. Epigenetics, the nonprotein coding genome, and human accelerated sequences
Part II. Evolution and adaptation 3. Gene expression and regulation relative to specific tissues and functions 4. Evo-Devo and morphological diversity 5. Adaptation and evolution 6. Adaptations metabolic and genomic to environmental changes
Part III. Adaptation 7. Regulatory elements relevant to brain, connectome, and neurodevelopmental disorders 8. Altered gene expression associated with developmental defects and disease 9. Metabolic, epigenetic functions and correlations with phenotype 10. Aging, genomic, mitochondrial, and regulatory changes
Part IV. Altered gene expression associated with developmental defects and disease 11. The regulatory genome and defects in monogenic diseases 12. Epigenetics and human disease 13. Connecting developmental defects and evolutionary findings 14. The regulatory genome and complex common diseases
