Multiscale Cell-Biomaterials Interplay in Musculoskeletal Tissue Engineering and Regenerative Medicine

Table of Contents

Section 1: Fundamentals of cell-biomaterials interactions 1. Introduction 2. Fundamentals and mechanisms 3. Cellular signaling processes 4. Cell-protein interactions 5. The microenvironment: Recreate the ECM 6. Surface modifications topography, porosity 7. Chemotaxis: Soluble morphogens and Growth factors 8. Cell-biomaterials: Vascularization 9. Cell-biomaterials in Immunomodulation 10. Mechanobiology regulation 11. Electrical/Magnetic stimulation

Section 2: Multiscale design, structure/function and processing technologies 12. Introduction 13. Design of polymeric biomaterials at multiscale 14. Design of Calcium phosphates cements: Structure/function 15. Biomimetic micro-/nano- scales design 16. Cells-biomaterials structure-function at different length scales 17. Computational modelling involved in multiscale design 18. Hydrogel systems design: Structure/function 19. Scaffolding design and structure/function: Electrospinning 20. Scaffolding design and structure/function: Advanced manufacturing 21. Scaffolding design and structure/function: Bioprinting 22. Dynamic models for investigating structure/function of biomaterials: Bioreactors 23. Dynamic models for investigating cell-biomaterials interactions: Microfluidics 24. Complex in vitro models for studying cell-biomaterials interactions 25. In vivo animal models 26. Regulatory and clinical translation

Authors

J. Miguel Oliveira Principal Investigator with Habilitation and Vice President of Institute 3B's, 3B's Research Group, Institute 3B's, University of Minho, Braga, Portugal. J. Miguel Oliveira, BSc, PhD is the Director of Pre-Clinical Research at the FIFA MEDICAL CENTER, Est�dio do Drag�o, Porto, PT since Fev. 2013. Currently, he is a Lecturer in Doctoral Programme in Tissue Engineering, Regenerative Medicine and Stem Cells at UMinho, PT. He is also an Invited lecturer at the Faculty of Medicine, U. Porto (since Sept. 2013) and Dept. of Polymer Eng., UM, PT. Dr. Oliveira has published over 220 scientific contributions in scientific journals. Miguel Oliveira was approved 17 patents, published 5 books, 3 special issue in scientific journals, and more than 90 book chapters in books with international circulation. In addition, he is member of the advisory board of the Journal of Materials Science: Materials in Medicine, International Journal of Tissue Engineering, Journal ISRN Biomaterials, The Journal of Experimental Orthopaedics, Journal "Recent Patents on Corrosion Science�, and referee in more than 40 international journals. Rui L. Reis President of Institute 3B's, University of Minho; Director of the Associated Laboratory ICVS/3B's and of the European Institute of Excellence in Tissue Engineering and Regenerative Medicine (EXPERTISSUES); Full Professor of Tissue Engineering, Regenerative Medicine and Stem Cells, University of Minho, Barco, Portugal. Dr. Rui Reis is Vice-President for Research and Innovation of University of Minho, Portugal, Director of 3B's Research Group and Director of ICVS/3B�s Associate Laboratory, both of UMinho. He's the CEO of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, the Coordinator of the Discoveries Centre for Regenerative and Precision Medicine, the Global Past-President of the Tissue Engineering and Regenerative Medicine International Society and the Editor-in-chief of the Journal of Tissue Engineering and Regenerative Medicine. He's edited 18 books, 10 special issue journals, 280 book chapters and has more than 1225 published works listed on ISI Web of Knowledge, being an inventor of around 70 patents. He's been awarded many important international prizes, including the TERMIS-EU contributions to the literature Award and the TERMIS-EU Career Achievement Award, and recently the UNESCO- International Life Sciences Award and the IET A. F. Harvey Engineering Research Prize. Sandra Pina Assistant Researcher, 3B's Research Group, Institute 3B's, University of Minho, Barco, Portugal. Sandra Pina is Assistant Researcher at 3B's Research Group, Institute 3B's, University of Minho, Barco, Portugal.