+353-1-416-8900REST OF WORLD
+44-20-3973-8888REST OF WORLD
1-917-300-0470EAST COAST U.S
1-800-526-8630U.S. (TOLL FREE)

New Insights into Glioblastoma. Diagnosis, Therapeutics and Theranostics

  • Book

  • May 2023
  • Elsevier Science and Technology
  • ID: 5709213

New Insights into Glioblastoma: Diagnosis, Therapeutics and Theranostics provides a compendium of recent diagnostic and therapeutic advances in GBM, encompassing a pipeline of compounds and (bio) nanotechnology strategies that have stood out with potential increased antitumoral activity and capability to cross the blood-brain barrier. Issues and challenges related to their translation into the clinical practice and their contribution to the increase in survival rates and well-being of patients are addressed. This is a valuable resource for graduate students, oncologists, cancer researchers and members of the biomedical field who need to learn more on recent developments on the management of glioblastoma.

The book is split in three parts: Diagnosis, focusing on biomarkers and techniques such PET/MRI, infrared thermography, and deep neural networks; Therapeutics, discussing new chemical entities, as natural products and repurposed drugs, and new formulation approaches, as nanotechnology-based and microRNA approaches; and Theranostics, explaining the role of omics, system-based approaches, and glioblastoma microenvironment.

Please Note: This is an On Demand product, delivery may take up to 11 working days after payment has been received.

Table of Contents

I. Introduction1 Introduction: A brief outlook into glioblastoma diagnosis and therapeutics

II. DiagnosisII.1 Biomarkers2. Practice guidelines for the diagnosis of glioblastoma3. Identification of potential biomarkers in glioblastoma through OMICS technologies and Big Data Analysis4. Forging a path to the use of liquid biopsy in the diagnosis of gliomas 5. Secretome analysis of patient-derived glioblastoma cells for potential biomarker identificationII.2 Techniques: updates6. Newly diagnosed glioblastoma: a review on clinical management7. Current status in brain glioma imaging (MRI, CT-Scan)8. Combined PET/MRI in brain glioma imaging9. New surgical approaches in glioblastoma10. The role of radiogenomics

III. TherapeuticsIII.1 New chemical entities11. An overview of molecular targeting of glioblastoma12. Terpenes: a hope for glioblastoma patients13. The artificial intelligence contribution to speed-up the active compounds screening14. Repurposing drugs in glioblastoma15. Glioblastoma heterogeneity and resistance: a glance in biology and therapeutic approach16. Targeting DNA damage response pathways in glioblastoma: from mechanistic insights to advances in the clinic17. Alkaloids: their relevance in cancer treatmentIII.2 New formulation approaches18. An overview of current drug delivery strategies for glioblastoma treatments and barriers to progress19. Nanotechnology-based approaches in glioblastoma treatment: how can the dual blood brain/tumor barriers be overcome?20. Non-coding RNAs in glioblastoma at a glance21. The role of vaccines in glioblastoma updated clinical results22. Dendritic cells and glioblastoma23. Cancer stem cells in glioblastoma an update24. Optimizing the role of immunotherapy for treatment of glioblastoma25. The role of exosomes in glioblastoma treatment

IV. Theranostics26. Theranostic in glioblastoma27. Potential theranostic targets in glioblastoma 28. Radiopharmaceuticals for molecular imaging and theranostics of glioblastoma29. Theranostic strategies synergistically potentiate glioblastoma treatment via nanotechnology30. The effect of glioblastoma microenvironment on theranostics

Authors

Carla Vitorino Assistant Professor, Faculty of Pharmacy, University of Coimbra, Coimbra, Portugal. Professor Carla Vitorino graduated in Pharmaceutical Sciences from the University of Coimbra and obtained the PhD degree in Pharmaceutical Sciences, in the specialty of Pharmaceutics, by the same institution. Currently, she is Assistant Professor at the Faculty of Pharmacy of the University of Coimbra. She has been working on the application of nanotechnology in drug permeation enhancement strategies for transdermal, oral and drug delivery systems to brain targeting, which has resulted in the publication of several scientific papers in peer-reviewed high impact journals. It brings together vast experience in pharmaceutical technology, standing out in the areas of nanotechnology and regulatory science. Her main research interests are nanotechnology, controlled release, and the development of new drug delivery systems in a Quality by Design perspective. Carmen Balana Catalan Institute of Oncology, Badalona/Barcelona, Spain. Carmen Balana created one of the first neuro-oncology committees in Spain and was a founder of the Spanish Neurooncological Group (now GEINO), where she was president and remain an active member. Her first publication as first author in a high-impact journal was in 2003 on liquid biopsies in high-grade gliomas, which has only recently become a strong research line. Other professional accomplishments: EORTC Brain Tumor Study Group (since 2002); reviewer and Editorial Committee member on several journals, including Neuro-Oncology; invited speaker at ESMO 2019 and ESMO ASIA 2020; President, IGTP Internal Scientific Committee (since 2017); President, Catalan-Balearic Oncology Society (since September 2020); PI, 70+ clinical trials (35 in CNS). She coordinated several ISCII grants and recently the Marat� TV3 (665/C/2013) grant (1,690,500?), when she was able to coordinate six Catalan hospitals on a large clinical, radiological, immunohistochemical and molecular study of glioblastoma. C�lia Cabral Coimbra Institute for Clinical and Biomedical Research (iCBR), Center for Innovative Biomedicine and Biotechnology (CIBB), Clinic Academic Center of Coimbra (CACC), Faculty of Medicine, University of Coimbra, Portugal. C�lia Cabral graduated in Biology from the University of Coimbra and obtained her PhD in Biology, in the speciality of Systematics and Morphology, by the same institution, involving the Faculty of Sciences and Technology, the Faculty of Pharmacy and the Royal Botanic Garden Edinburgh (RBGE), UK. Between 2011 and 2017, Dr. Cabral did a 6-year post-doc at the Faculty of Pharmacy of UC. Currently, she is Researcher at the Faculty of Medicine of the University of Coimbra and Invited professor at the Universidade Lus�fona. She has a multidisciplinary scientific path, with emphasis in Phytochemistry, Pharmacognosy, Natural products and Plant-based health solutions. Her main research interests are ethnopharmacology, phytochemistry, drug delivery of natural products, development of food supplements and natural products-based cosmetics.