In 2020 we lost Noel Rose, co-editor of the classic Infection and Autoimmunity. To honor and respect his work, a group of experts in the field have taken the initiative to make this book perpetual.
The third edition of Infection and Autoimmunity updates all the recent and leading papers on infection and autoimmunity, in addition to a dedicated section on to the correlation between SARS-CoV-2 infection and autoimmunity. From the very beginning of the COVID-19 pandemic, numerous papers have been published, including studies conducted by the editors and authors of the book, on COVID-19 and autoimmunity, and therefore this knowledge has been incorporated into this new edition. The addition and extended coverage on SARS-CoV-2/COVID-19 and autoimmunity are pivotal for the third edition of the book due to the COVID-19 pandemic.
Medical students and practitioners, as well as academic staff in medical schools globally, are enthusiastic in searching for better understanding of the correlation between infection and autoimmunity in general, and the long-term effects of SARS-CoV-2 and COVID-19 on the immunce system in particular, especially in terms of autoimmunity related to the virus.
Table of Contents
1. Introduction
Part 1: Mechanisms of Autoimmunity induction by infectious agents and vaccination 2. Molecular Mimicry and Autoimmunity 3. Epitope Spreading in Autoimmune Diseases 4. The immune neuroendocrine system, infections, and rheumatic diseases 5. CD5-Expressing B-1 Cells and Infection 6. Lymphocytes and Infection in Autoimmune Diseases 7. Endothelial Cell Autoreactivity and Infection 8. Microbiota and Autoimmunity 9. Infection, Autoimmunity, and Vitamin D 10. Seasonality and Autoimmunity 11. The Protective Role of Helminths in Autoimmunity 12. Vaccination and Autoimmunity 13. BCG Vaccination 14. Opportunistic Infections and Autoimmune Diseases 15. Can Antibiotics Cure Autoimmune Diseases?
Part 2: Viruses and Autoimmunity 16. Anti-Viral Therapy, Epstein-Barr Virus, Autoimmunity, and Chaos (The Butterfly Effect) 17. Roles for Cytomegalovirus in Infection, Inflammation, and Autoimmunity 18. Hepatitis C and Mixed Cryoglobulinemia: An Update 19. HIV Spectrum and Autoimmune Diseases 20. Parvovirus Infection and Its Association with Autoimmune Diseases 21. Human T-lymphotropic Virus Type 1 and Rheumatic Diseases: A Link Between Infection and Autoimmunity 22. Sj�gren's Syndrome: Role of Viruses and Viral-Like Sequences 23. Viral Infection and Heart Disease: Autoimmune Mechanisms 24. Celiac Disease and Rotavirus Infection 25. Theiler's Murine Encephalomyelitis Virus-Induced Demyelinating Disease (TMEV-IDD) and Autoimmunity
Part 3: Bacteria and Autoimmunity 26. Rheumatic Fever: How Streptococcal Throat Infection Triggers an Autoimmune Disease 27. Helicobacter pylori Infection and Gastric Autoimmunity: Coincidence or a Cause and Effect Relationship? 28. Multiple Sclerosis and Creutzfeldt-Jakob Disease are Autoimmune Diseases Probably Caused by Exposure to the Nasal Microbe Acinetobacter 29. Infection and Autoimmunity in Antibiotic-Refractory Lyme Arthritis 30. Streptococcus Pneumoniae and Autoimmunity: A Systematic Review of the Literature: How Pneumococcal Infection Might Be Related to Rheumatic Diseases 31. Mycobacteria and Autoimmunity 32. Mycobacterium avium Subspecies Paratuberculosis and Human Disease: Bridging Infection and Autoimmunity 33. Leprosy and Autoimmunity
Part 4: Parasites and autoimmunity 34. Parasitic Infection and Autoimmunity 35. Toxoplasma and Autoimmunity 36. Malaria and Systemic Lupus Erythematosus: Complex Interactions and Reciprocal Influences
Part 5: Autoimmune diseases and infections 37. Anti-Saccharomyces cerevisiae Antibodies Autoimmune Diseases 38. The Infectious Origin of the Anti-Phospholipid Syndrome 39. Infections and Systemic Lupus Erythematosus 40. Infections and Idiopathic Inflammatory Myopathies 41. Rheumatoid Arthritis and Infections: More Than an Association? 42. Infection and Systemic Sclerosis 43. Infection and Spondyloarthropathies 44. Infection and Beh�et Disease 45. Vasculitides and Hepatitis C Infection 46. The Role of Infection in Inflammatory Bowel Disease: Initiation, Exacerbation and Protection 47. Post-Infectious Arthritis and Reactive Arthritis 48. Infection and Autoimmune Liver Diseases 49. The Role of infection in Immune-mediated Thrombocytopenia 50. Viral Infections and Type 1 Diabetes 51. Infection and Autoimmune Thyroid Diseases 52. Pemphigus and Infection 53. Infections and Autoimmune Renal Diseases 54. Infections Associated with Retinal Autoimmunity 55. Oral Infections and Autoimmune Diseases 56. infection and Guillain-Barr� Syndrome 57. Acute Disseminated Encephalomyelitis
Part 6: COVID-19 and autoimmunity SARS-CoV-2 (COVID-19) and Autoimmunity 58. COVID-19 and autoimmunity 59. COVID-19 and autoantibodies 60. COVID-19 and vasculitis 61. COVID-19 vaccines and autoimmunity
Authors
Naim Mahroum International School of Medicine, Istanbul Medipol University, Istanbul, Turkey.Dr Naim Mahroum specialized in internal medicine, infectious diseases and HIV in Sheba medical center. He worked in Sheba medical center for more than 13 years, one of the top 10 hospitals in the world for a third year consequently according to Newsweek. Moreover, Dr. Mahroum, worked at COVID-19 department more than 9 months during the COVID-19 pandemic, which earned him as an infectious disease specialist. He was a member of the teaching committee in Sackler faculty of medicine at Tel-Aviv university since 2012. Has received a senior lecturer degree at the university due to its scientific, academic and research works. In 2022, Dr. Mahroum joined the teaching committee of the international medical school, at Istanbul Medipol University, Istanbul, Turkey. Published more than 75 scientific papers in infections and its relation to autoimmune and rheumatologic diseases. Dr. Mahroum has presented his works in several national and international conferences.
Abdulla Watad Autoimmune Diseases Sheba Medical Center, Sackler Faculty of Medicine, Tel-Aviv University, Israel. Abdulla Watad specialized in internal medicine (Tel-Aviv, Israel) and research in rheumatology and immunology at the Autoimmune Diseases Sheba Medical Center, affiliated with the Sackler Faculty of Medicine in Tel-Aviv University. He is also visiting researcher at the University of Leeds, UK. His works focused on the role of entheseal immune resident cells in the pathogenesis of spondyloarthritis, prevention of psoriatic arthritis, link between cancer and autoimmunity, and the impact of fasting on the immune system. He has published more than 150 papers in high impacted journals and written more than 10 chapters in books in the field of autoimmunity. He received various awards such as excellence in residency and research in internal medicine - Israel, 2014, Shelbi award-2015, outstanding tutor of medical students-2015, and 1st prize for best basic clinical research -2016. He has been invited to numerous international congresses such as EULAR, and the international congress of autoimmunity. Yehuda Shoenfeld Zabludowitcz Center of Autoimmunity, Sheba Medical Center and Reichman University, Herzelya, Israel. Professor Yehuda Shoenfeld is the President of the Center for Autoimmune Diseases (present), incumbent of the Laura Schwarz-Kipp Chair for Research of Autoimmune Diseases in Tel Aviv University (since 2002-Present), Emeritus Professor of the Sackler School of Medicine in Tel Aviv University and teaches medical studies and MSc and PhD students (since 1985). Prof. Shoenfeld has edited a series of textbooks entailing "The Mosaic of Autoimmunity," "Autoantibodies," "Infection and Autoimmunity," and "Diagnostic Criteria of Autoimmune Diseases" (Elsevier Pub.). He has served on 36 editorial boards and is the organizer of more than 25 international congresses on autoimmunity. He is the author of > 2000 peer-reviewed papers reported in the field of autoimmunity and internal medicine. More than 65,000 citations.
