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Artificial Intelligence in Tissue and Organ Regeneration

  • Book

  • August 2023
  • Elsevier Science and Technology
  • ID: 5755664

Artificial Intelligence in Tissue and Organ Regeneration discusses the role of artificial intelligence as a highly sought-after technology in the area of organ and tissue regeneration. Certain groups have made significant progress in mass producing mini organs and organoids from stem cells utilizing such techniques. As time goes on, there will be a need to improve these procedures, protocols, regulatory guidelines, and their clinical implications.

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Table of Contents

Section 1. Machine learning and artificial concepts
1. Artificial intelligence in tissue and organ regeneration: An introduction
2. Introduction to AI and ML algorithms
3. Machine learning and AI approaches for design of tissue scaffolds
4. Use of artificial intelligence in assistive devices

Section 2. AI applications in organ regeneration
5. Applying artificial intelligence in solid organ failure, organ transplant selection, preservation, and regeneration
6. AI in angiogenesis moving toward designer vasculature
7. Prospects of artificial intelligence in endogenous and exogenous regeneration and repair of organs
8. AI on DDS for regenerative medicine
9. Optimization of bio-ink using machine learning
10. Artificial intelligence in stem cell therapies and organ regeneration

Section 3. AI applications and bio-manufacturing
11. AI in multiscale scaffolds for cancer organoids testbed
12. Complex data representation, modeling and computational power for a personalized dialysis
13. Neural encoding of artificial sensations evoked by peripheral nerve stimulation for neuroprosthetic applications
14. Applying AI to advanced biomanufacturing
15. Regulatory pathways for ML and AI devices
16. AI and ML: future challenges and perspective in artificial organs realm

Authors

Chandra P. Sharma Former Senior Scientist G & Head, Biomedical Technology Wing, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum ,Kerala , India. Dr. Chandra P. Sharma is an Adjunct Professor, Department of Pharmaceutical Biotechnology, Manipal College of Pharmaceutical Sciences, Manipal University, and Hon. Emeritus Professor, College of Biomedical Engineering & Applied Sciences, Purbanchal University, Kathmandu, Nepal. Dr. Sharma is a Solid-State Physicist from IIT Delhi and received his training in Biomaterials area in the University of Utah with Prof. D.J. Lyman as a graduate student and in the University of Liverpool, England with Prof. D.F. Williams as a Post-Doctoral Research Associate. Dr. Sharma has been awarded FBSE (Fellow Biomaterials Science & Engineering) by The International Union of Societies for Biomaterials Science & Engineering (IUS-BSE) in 2008 and FBAO (Fellow Biomaterials and Artificial Organs) by Society for Biomaterials & Artificial Organs (India) (SBAOI) in 2011 and shares Whitaker and National Science Foundation Award - International Society for Artificial Organs (ISAO) USA, invited member ACS (2015-2018). Thomas Chandy Senior Test Engineer and Project Lead, Phillips Medisize, Hudson, Wisconsin, USA. Dr. Thomas Chandy is a biomaterial expert with unique combination of medical device and technical knowledge. He has strong academic credentials in human physiology and bio-compatible materials with test methods and model development. Dr. Chandy has published over 80 scientific papers in international Journals and 3 patents in the medical device and drug delivery area. Reviewer to 7+ international journals of repute in Drug delivery and Biomedical Research. Twenty-Five years of experience as a project lead in medical device and technology development. Strong experience with broad range of medical products including polymeric and tissue-based implantable, site specific drug delivery, medical diagnostics and combination devices. Product/process development skills with demonstrated success from concept through commercialization involving selection of materials, characterization, biological evaluation of materials, bench, feasibility tests and pre-clinical (animal) testing. Vinoy Thomas Assistant Professor, Department of Materials Science and Engineering, University of Alabama, Birmingham, USA. Dr. Vinoy Thomas is an Associate Professor and Graduate Program Director in the Department of Mechanical and Materials Engineering at the University of Alabama at Birmingham, with secondary appointments in Biomedical Engineering, Physics, and Environmental Science & Health. He's also an Associate Scientist at the Center for Nanoscale Materials and Biointegration and the Center for Clinical and Translational Sciences. Following his PhD in Biomaterials & Technology, he completed postdoctoral training at Friedrich-Schiller University, Germany, and the National Institute of Standards and Technology (NIST), USA. His research focuses on biomaterials processing-property relationships and nanomaterials for tissue engineering and drug delivery. Dr. Thomas has published over 120 articles and co-edited two books on tissue engineering and AI in regenerative medicine. He serves as Associate Editor of Heliyon (Engineering) and has received multiple honors, including FBAO, FAAS, and the IAAM Scientist Medal. He currently leads several professional organizations in biomaterials and materials science.