Artificial Intelligence in Tissue and Organ Regeneration

Table of Contents

Section 1. Machine learning and artificial concepts 1. Artificial intelligence in tissue and organ regeneration: An introduction 2. Introduction to AI and ML algorithms 3. Machine learning and AI approaches for design of tissue scaffolds 4. Use of artificial intelligence in assistive devices

Section 2. AI applications in organ regeneration 5. Applying artificial intelligence in solid organ failure, organ transplant selection, preservation, and regeneration 6. AI in angiogenesis moving toward designer vasculature 7. Prospects of artificial intelligence in endogenous and exogenous regeneration and repair of organs 8. AI on DDS for regenerative medicine 9. Optimization of bio-ink using machine learning 10. Artificial intelligence in stem cell therapies and organ regeneration

Section 3. AI applications and bio-manufacturing 11. AI in multiscale scaffolds for cancer organoids testbed 12. Complex data representation, modeling and computational power for a personalized dialysis 13. Neural encoding of artificial sensations evoked by peripheral nerve stimulation for neuroprosthetic applications 14. Applying AI to advanced biomanufacturing 15. Regulatory pathways for ML and AI devices 16. AI and ML: future challenges and perspective in artificial organs realm

Authors

Chandra P. Sharma Adjunct Professor, Department of Pharmaceutical Biotechnology, Manipal College of Pharmaceutical Sciences, Manipal University, India. Dr. Chandra P. Sharma is Adjunct Professor, Department of Pharmaceutical Biotechnology, Manipal College of Pharmaceutical Sciences, Manipal University, and Hon. Emeritus Professor, College of Biomedical Engineering & Applied Sciences, Purbanchal University, Kathmandu, Nepal. Dr. Sharma is a Solid-State Physicist from IIT Delhi and received his training in Biomaterials area in the University of Utah with Prof. D.J. Lyman as a graduate student and in the University of Liverpool, England with Prof. D.F. Williams as a Post-Doctoral Research Associate. Dr. Sharma has been awarded FBSE (Fellow Biomaterials Science & Engineering) by The International Union of Societies for Biomaterials Science & Engineering (IUS-BSE) in 2008 and FBAO (Fellow Biomaterials and Artificial Organs) by Society for Biomaterials & Artificial Organs (India) (SBAOI) in 2011 and shares Whitaker and National Science Foundation Award - International Society for Artificial Organs (ISAO) USA, invited member ACS (2015-2018). Thomas Chandy Senior Test Engineer and Project Lead, Phillips Medisize, Hudson, Wisconsin, USA. Dr. Thomas Chandy is a biomaterial expert with unique combination of medical device and technical knowledge. He has strong academic credentials in human physiology and bio-compatible materials with test methods and model development. Dr. Chandy has published over 80 scientific papers in international Journals and 3 patents in the medical device and drug delivery area. Reviewer to 7+ international journals of repute in Drug delivery and Biomedical Research. Twenty-Five years of experience as a project lead in medical device and technology development. Strong experience with broad range of medical products including polymeric and tissue-based implantable, site specific drug delivery, medical diagnostics and combination devices. Product/process development skills with demonstrated success from concept through commercialization involving selection of materials, characterization, biological evaluation of materials, bench, feasibility tests and pre-clinical (animal) testing. Vinoy Thomas Assistant Professor, Department of Materials Science and Engineering, University of Alabama, Birmingham, USA. Dr. Vinoy Thomas is an assistant professor in the Department of Materials Science and Engineering at the University of Alabama at Birmingham. training spans from Chemistry/Polymers to Materials Science and Nanotechnology with specific training and expertise in Polymers and Biomaterials. He also holds secondary appointments at the Department of Biomedical Engineering and Department of Environmental Science & Health. He is also a Senior Research Scientist at the Center for Nanoscale Materials and Biointegration. After his PhD in Biomaterials & Technology he completed postdoctoral training at Friedrich-Schiller University, Germany, and at the National Institute of Standards & Technology (NIST). His research focuses on biomaterials processing-property relationships, nanomaterials for tissue engineering, and nanodiamonds for joint-implants.