Mitochondrial Transplantation and Transfer: Biology, Methods, Applications, and Disease, a volume in the Translational and Applied Bioenergetics series, offers a detailed overview of mitochondrial transplantation across fundamental biology, disease and early therapeutics research. Here, more than twenty experts in the field discuss transplantation and transfer of healthy mitochondria and define future steps to improve new therapeutic applications across a variety of diseases. Emphasis is placed on the physiology of mitochondrial transfer, isolation processes and their applications, transfer methods, and diagnostic and treatment use across cardiovascular, metabolic, and neurological diseases, among other disease types.
Step-by-step instruction is provided around research protocols and methods discussed, along with careful attention to the ethical implications of mitochondrial transplantation research and application.
Table of Contents
Part 1: Introduction 1. Mitochondrial Transplantation: Methods and Mitochondrial Dysfunction Diseases: An Overview 2. Mitochondria and Cell Metabolism 3. Mitochondrial Dynamics and Mitochondrial Biogenesis 4. Mitochondrial DNA and Heteroplasmy
Part 2: Physiological Mitochondrial Transfer 5. Tunnelling Nano Tube (TNT) 6. Microvesicles and Gap Junctions
Part 3: Mitochondrial Transplantation from Isolation Process to Application 7. Isolation Process for Mitochondrial Transplantation 8. Determination of Mitochondrial Number and Function 9. Storage of Isolated Mitochondria10. Mitochondrial Transplantation Methods 11. Application Route of Mitochondrial Transplantation 12. Limitations of Mitochondrial Transplantation 13. Ethical Issues about Mitochondrial Transplantation
Part 4: Cardiovascular Diseases and Mitochondrial Transplantation 14. Cardiovascular Diseases and Pathophysiology 15. Pre-clinical Studies 16. Clinical Studies
Part 5: Neurological Diseases and Mitochondrial Transplantation 17. Neurological Diseases and Pathophysiology 18. Pre-clinical Studies
Part 6: Other Diseases and Mitochondrial Transplantation 19. Hereditary Mitochondrial Diseases and Mitochondrial Transplantation 20. Kidney Injury and Mitochondrial Transplantation 21. Cancer and Mitochondrial Transplantation 22. Diabetes and Mitochondrial Transplantation 24. Aging and Mitochondrial Transplantation 25. Future Aspects of Mitochondrial Transplantation
Authors
Gokhan Burcin Kubat Department of Mitochondria and Cellular Research, Gulhane Health Sciences Institute, University of Health Sciences, Ankara, Turkey.Gokhan Burcin Kubat currently serves as a Unit Manager in the Department of Mitochondria and Cellular Research, Gulhane Health Sciences Institute, University of Health Sciences, Turkey. He also attended the "Molecular Diagnostic Practicum" training at Virginia Commonwealth University, USA, and worked in the field of molecular pathology. He has contributed to research in mitochondrial transplantation and mitochondrial biogenesis with 10 peer reviewed publications, including in the Journal Molecular Medicine, Mitochondrion, Life Sciences, Biochimie, Journal of Biochemical and Molecular Toxicology, Toxicology and Applied Pharmacology, Cardiovascular Drugs and Therapy and Turk J Sports Med.
Oner Ulger Department of Mitochondria and Cellular Research, Gulhane Health Sciences Institute, University of Health Sciences, Ankara, Turkey.Oner Ulger currently serves in the Department of Mitochondria and Cellular Research, Gulhane Health Sciences Institute, University of Health Sciences in Ankara, Turkey. He got his doctorate from the Department of Physiology, Health Sciences Institute, University of Health Sciences in Turkey. He studies mitochondrial transplantation with high-impact research and review articles including in published in the Life Sciences, Biochimie, Journal of Biochemical and Molecular Toxicology, Toxicology and Applied Pharmacology, Mitochondrion, and Journal of Molecular Medicine.
Serdar Gunaydin Professor of Cardiovascular Surgery, University of Health Sciences, Ankara City Hospital Campus, Turkey. Dr Gunaydin currently serves as a faculty and clinical professor in the Department of Cardiovascular Surgery in Ankara City Hospital Campus, University of Health Sciences, Turkey. He studied histology and embryology and received PhD in Biomaterial Sciences in Tokyo Heart Institute, Japan. He is the Vice President for International Society of Minimally Invasive Extracorporeal Circulation (MiECTIS) and General Secretary of Turkish Enhanced recovery After Surgery (ERAS) Society. He also works as the scientific board member in Giganode Foundation and Heart Team Education Association. He directs international scientific projects on clinical evaluation and biomaterial confirmation of novel cardiopulmonary bypass-related technologies based on the prevention of inflammatory response, patient blood management and ERAS.
