Biomaterials for Precision Cancer Medicine bridges the gap between materials science and medicine, providing insights into novel biomaterial-based treatments for cancer. The book describes the various smart biomaterial-based treatments available, reviewing how they can be designed to target specific tumor types, adapt to changes in the cell microenvironment and offer smart, personalized therapy for different cancer variants, especially those which are drug-resistant. The book provides a materials-focused look at precision cancer medicine, and is thus useful to materials scientists, biomedical engineers, and biomedical scientists - including cancer and genetic specialists - with an interest in alternative cancer therapies.
Table of Contents
1. Introduction to cancer 2. Cancer therapy in the era of precision medicine 3. Precision medicine: Aspects in translational medicine 4. Biomaterials: Fundamentals, processing, and applications 5. Possible targets for biomaterials in cancer treatment6. Biomaterials-based cancer diagnostics: Recent advances 7. Anti-cancer biomaterials: A special design for precision medicine8. Natural plant-derived anti-cancer biomaterials9. Combination cancer therapy by bio-macromolecules and small molecules 10. Biomaterials for cancer immunotherapy 11. Biomaterials for engineering tumor microenvironment 12. Biomaterials for cancer targeted drug delivery13. Engineered smart biomaterials for anti-cancer gene delivery? 14. Biofunctionalization of materials for targeting cancer cells 15. Reactive oxygen species (ROS)-responsive materials in cancer therapy 16. Natural polymers for diagnosis and treatment of cancers 17. Synthetic polymers for malignancies treatment 18. Polymer-protein and polymer-drug conjugates in cancer therapy 19. Magnetic calcium phosphates for imaging and treating of cancers 20. Hydroxyapatite nanoparticles as anti-cancer agents 21. Bioactive magnetic glass-ceramics for cancer treatment 22. Mesoporous glasses in cancer therapy ?23. Carbon biomaterials for cancer therapy: opportunities and challenges 24. Metals and metal compounds for cancer photothermal therapy 25. Smart nanoparticles for the treatment of drug-resistant tumors 26. Managing malignancies by magnetic electrospun nanofibers 27. Multiparametric preclinical assessment of theranostics materials 28. Health risk assessment of anti-cancer biomaterials 29. Future perspectives and challenges for biomaterialsAuthors
Saeid Kargozar UT Southwestern Medical Center.Saeid Kargozar is a Fellow of the University of Texas Southwestern Medical Center (UTSW), USA. He was previously a Senior Assistant Professor of Tissue Engineering in the Department of Anatomy and Cell Biology, at Mashhad University of Medical Sciences in Iran. He received his M.S. in Medical Biotechnology in 2012 and his Ph.D. in Tissue Engineering in 2016, both from Tehran University of Medical Sciences, Iran. His current research interests include biocompatible materials and tissue engineering with special focus on bioactive glasses and the decellularized extracellular matrix (ECM). He is an active member of the American Ceramic Society and has published more than 118 peer-reviewed publications. According to a recent scientometric study published in PLOS Biology in 2021, he is listed amongst the top 2% of cited scientists in the world.
Masoud Mozafari Research Fellow, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, University of Toronto, Canada. Dr. Masoud Mozafari is a Fellow at Lunenfeld Tanenbaum Research Institute, Mount Sinai Health Hospital, University of Toronto. He was previously Assistant Professor and Director of the Bioengineering Lab, at the Nanotechnology and Advanced Materials Department, Materials and Energy Research Center, Cellular and Molecular Research Center, and Department of Tissue Engineering and Regenerative Medicine of the Iran University of Medical Sciences (IUMS), Tehran, Iran. Dr. Mozafari's research interests range across biomaterials, nanotechnology, and tissue engineering, and he is known for the development of strategies for the treatment of damaged tissues and organs, and controlling biological substances for targeted delivery into the human body. Dr. Mozafari has received several awards, including the Khwarizmi Award and the Julia Polak European Doctorate Award for outstanding translational research contributions to the field of biomaterials. He has also received the WIPO Medal for Inventors from The World Intellectual Property Organization (WIPO), in recognition of his contributions to economic and technological development. Dr. Mozafari is currently working on the editorial board of several journals.
