Biomechanics of the Aorta: Modelling for Patient Care is a holistic analysis of the aorta towards its biomechanical description. The book addresses topics such as physiology, clinical imaging, tissue and blood flow modeling, along with knowledge that is needed in diagnostics, aortic rupture prediction, assist surgical planning, and more. It encompasses a wide range of topics from the basic sciences (Vascular biology, Continuum mechanics, Image analysis) to clinical applications, as well as describing and presenting computational studies and experimental benches to mimic, understand and propose the best treatment of aortic pathologies. The book begins with an introduction to the fundamental aspects of the anatomy, biology and physiopathology of the aorta and proceeds to present the main computational fluid dynamic studies and biomechanical and mechanobiological models developed over the last decade. With approaches, methodologies and findings from contributors all over the world, this new volume in the Biomechanics of Living Organs series will increase understanding of aortic function as well as improve the design of medical devices and clinical interventions, including surgical procedures.
Table of Contents
PART 1 Anatomy, Biology, Physiopathology 1. Physiopathology 2. Genetics and aortic mechanisms 3. Mechanobiology of aortic cells and extracellular matrix 4. Clinical treatment options PART 2 Imaging and tissue/rheology characterization 5. Novel experimental methods to characterize the mechanical properties of the aorta 6. Imaging aortic flows 4D magnetic resonance imaging 7. Ultrasound imaging for aortic biomechanics 8. Functional imaging, focus on [18F]FDG Positron Emission Tomography 9. Image processing deep learning for model reconstruction PART 3 Tissue modelling and rupture 10. On simulation of the biophysical behavior of the aortic heart valve interstitial cell 11. Abdominal Aortic Aneurysm (AAA) and thrombus modelling 12. Computational modeling of aneurysm growth in mechanobiology 13. Analysis of aortic rupture: a computational biomechanics perspective 14. Multiscale Modeling of Aortic Mechanics: Tissue, Network, and Protein PART 4 Flow modelling and algorithm 15. Multiphysics flow modeling in the aorta 16. Novel Approaches for the Numerical Solution of Fluid-Structure Interaction in the Aorta 17. Turbulence modeling of blood flow 18. Inverse problems in aortic flow modelling 19. Modeling of flow induced mechanosignaling 20. Reduced order modeling PART 5 Applications 21. Transcatheter aortic valve implantation (TAVI) 22. Abdominal Aortic Aneurysm (AAA) rupture prediction 23. (Thoracic) Endovascular Aortic Repair (EVAR) simulation 24. Fluid Structure Interaction (FSI) in aortic dissections 25. Pharmacological treatments, mouse models, and the aorta
Authors
T. Christian Gasser Professor, KTH Solid Mechanics, Stockholm, Sweden. T. Christian Gasser is Professor of Biomechanics at KTH Royal Institute of Technology in Stockholm, Sweden, and Adjunct Professor at the University of Southern Denmark in Odense, Denmark. Professor Gasser is principal founder of VASCOPS GmbH, Graz, Austria and ARTEC Vascular Diagnosis AB, Stockholm Sweden. His scientific interest relates to vascular biomechanical problems, with particular emphasis on numerical techniques to solve clinically-relevant questions. Constitutive models developed by Professor Gasser have been implemented in many major Finite Element simulation packages, and translational research led to diagnostic software that is used at many clinical centers. He has authored almost 100 papers published in peer-reviewed premium journals, two international patents, 15+ book chapters, and gave more than 200 presentations at international conferences. Professor Gasser is amongst the highest-cited researchers in vascular biomechanics. He has taught numerous courses at undergraduate and graduate levels, served as supervisor for many engineering and clinical PhD students, is frequent member of examination and grading committees, and reviewer of several science councils as well as the most relevant scientific journals in the field. St�phane Avril Full Professor, Institut Mines Telecom affiliated, Mines Saint-Etienne, France. St�phane Avril is a distinguished Full Professor at Institut Mines Telecom affiliated at Mines Saint-Etienne in France. St�phane received his PhD in mechanical and civil engineering in 2002 at Mines Saint-Etienne (France). After positions at Arts et M�tiers ParisTech (France) and Loughborough University (UK), St�phane returned to his alma mater in 2008 and extended his experience of inverse problems to soft tissue biomechanics, especially regarding aortic aneurisms in close collaboration with vascular surgeons. St�phane was a visiting Professor at Yale University between 2014 and 2019 and is currently a guest professor at TU Vienna and TU Graz in Austria. St�phane has received many awards and distinctions including an ERC (European Research Council) consolidator grant for the Biolochanics project on: Localization in biomechanics and mechanobiology of aneurysms: Towards personalized medicine. Most of St�phane's research is aimed at improving the treatment of cardiovascular diseases by assisting physicians and surgeons with biomechanical numerical simulations. In 2017, St�phane co-founded Predisurge, a spin-off company of IMT at Mines Saint-Etienne. PrediSurge offers innovative software solutions for patient-specific numerical simulation of surgical procedures with first applications in endovascular aneurysm repair (EVAR). John A. Elefteriades William W.L. Glenn Professor of Surgery; Director, Aortic Institute at Yale-New Haven, Yale University School of Medicine, New Haven Connecticut, USA. John A. Elefteriades serves on multiple scientific advisory and editorial boards. He is a past President of the Connecticut Chapter of the American College of Cardiology and member of the national Board of Governors of the College. Dr. Elefteriades is also past President of the International College of Angiology. He serves on the editorial board of the American Journal of Cardiology, the Journal of Cardiac Surgery, Cardiology, and the Journal of Thoracic and Cardiovascular Surgery as well as being Editor-in-Chief of the journal AORTA. He has been a member of the Thoracic Surgery Director's Association and has been named consistently in The Best Doctors in America. He is a frequently requested international lecturer, visiting professor and guest surgeon. He is the author of over 400 scientific publications on a wide range of cardiac and thoracic topics. He was selected as one of the ten best doctors in America by Men's Health magazine. He has been featured in many dozens of print, radio, and television presentations. He has received the Walter Bleifeld Memorial Award for Distinguished Contribution in Clinical Research in Cardiology and the John B. Chang Research Achievement Award. In 2005 he was selected to lecture at the Leadership in Biomedicine Series at the Yale University School of Medicine. In 2006, he received the Socrates Award from the Thoracic Residents Association, Thoracic Surgery Directors' Association, and the Society of Thoracic Surgeons, recognizing exceptional achievement in teaching and mentorship of residents.Dr. Elefteriades was named the William W.L. Glenn Professor of Cardiothoracic Surgery in 2006. This endowed chair honors the memory of Dr. Elefteriades' mentor, Dr. Glenn. Dr. Elefteriades is the author of the books House Officer Guide to ICU Care (1st, 2nd, and 3rd Editions), Advanced Treatment Options for the Failling Left Ventricle, Your Heart: The Owner's Guide, Acute Aortic Disease, Extraordinary Hearts: A Journey of Cardiac Medicine and the Human Spirit, The Woman's Heart: An Owner's Guide, and the medical ethics thriller Transplant.
In 2017, Dr. Elefteriades was awarded an Honorary Phd degree from the University of Liege (Belgium) in recognition of his work in diagnosis and treatment of aortic diseases.
In 2020, Dr. Elefteriades was recognized by expertscape as the top aortic specialist in the world.
