Ionotropic Cross-Linking of Biopolymers: Applications in Drug Delivery provides in-depth insights and presents the latest advances in ionotropic cross-linked biopolymeric systems for drug delivery and related applications. Sections introduce the fundamentals of ionotropic cross-linking of biopolymers, including mechanisms, chemistry, cross-linking methods and gelation. Additional content delves into ionotropically cross-linked biopolymers based on a range of sources, including alginate, pectinate, carboxymethyl cellulose, gellan gum, chitosan, carboxymethylated gums, plant polysaccharide blends, and synthetic polymer blends. This is followed by a section focusing on ionotropically cross-linked biopolymeric systems, such as polymeric nanoparticles, microparticles, beads, and reinforced matrices.
The last part of the book explores specific advanced drug delivery applications, before considering future opportunities and challenges in the field. This is a valuable resource for researchers and advanced students across polymer science, biomaterials, biomedicine, pharmaceutics, biotechnology, and chemistry, as well as scientists and R&D personnel working in pharmacy, drug delivery, and materials for biomedicine.
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Table of Contents
Section 1: Introduction and fundamentals1. Ionotropic cross-linking of biopolymers: Basics and mechanism
2. Fundamentals and applications of ionic biopolymers
3. Ionic biopolysaccharides and their uses in ionotropically cross-linked hydrogels for controlled drug delivery
4. Ionotropic cross-linking methods of different types of biopolymeric hydrogels
5. Ionotropic gelation in advanced drug delivery
Section 2: Ionotropically cross-linked biopolymers
6. Ionotropically cross-linked alginate-based systems in drug delivery
7. Ionotropically cross-linked pectinate-based systems for drug delivery
8. Ionotropically cross-linked carboxymethyl cellulose-based systems for drug delivery
9. Ionotropically cross-linked gellan gum-based matrices in drug delivery
10. Ionotropically cross-linked chitosan-based drug delivery systems
11. Ionotropically cross-linked carboxymethylated gums-based systems in drug delivery
12. Plant polysaccharides-blended ionotropically cross-linked biopolymeric matrices for sustained drug release
13. Synthetic polymers-blended ionotropically cross-linked biopolymeric matrices for sustained drug release
Section 3: Ionotropically cross-linked biopolymeric systems
14. Ionotropically cross-linked polymeric nanoparticles for drug delivery
15. Ionotropically cross-linked polymeric microparticles for drug delivery
16. Ionotropically cross-linked polymeric beads for drug delivery
17. Clay-reinforced ionotropically cross-linked biopolymeric matrices for drug release
18. Ceramics-reinforced ionotropically cross-linked biopolymeric matrices for drug release
19. Ionotropically cross-linked interpenetrated polymeric networks for drug delivery
20. Ionotropically cross-linked biopolymeric polyelectrolyte complex matrices for drug delivery
21. Ionotropically cross-linked drug delivery carriers made of grafted biopolymers
Section 4: Specific drug delivery applications
22. Ionotropically cross-linked buoyant polymeric matrices for gastroretentive drug delivery
23. Ionotropically cross-linked polymeric matrices for colon-specific drug delivery
24. Ionotropically cross-linked polymeric particulates in mucoadhesive drug delivery
25. Ionotropically cross-linked biopolymeric carriers for protein and peptide drug delivery
26. Applications of ionotropic cross-linking of biopolymers in cell delivery
27. Ionotropic cross-linking of biopolymers for drug delivery in wound management
28. Ionotropic cross-linking of biopolymers for drug delivery in tissue engineering
29. Future perspectives, challenges, and opportunities of ionotropic cross-linking of biopolymers in drug delivery
Authors
Amit Kumar Nayak Department of Pharmaceutics, School of Pharmaceutical Sciences, Siksha 'O' Anusandhan (Deemed to be University), Bhubaneswar, Odisha, India.Dr. Amit Kumar Nayak (MPharm, PhD) is working as a professor, at the Department of Pharmaceutics, School of Pharmaceutical Sciences, Siksha 'O' Anusandhan (Deemed to be University), Odisha, India. He has earned his PhD from IFTM University, Moradabad, Uttar Pradesh, India. He has over 14 years of research experiences in the field of pharmaceutics, especially in the development and characterization of novel biopolymeric and nanostructured drug delivery systems. Till date, he has authored more than 138 research and review publications in various high-impact peer-reviewed journals and 135 book chapters. He has edited/authored 23 international books to his credit. Dr. Nayak has presented his research work at several conferences. He has received University Foundation Day Research Award, 2019 and 2022 by Biju Patnaik University of Technology, Odisha. Dr. Nayak is a life member of the Association of Pharmaceutical Teachers of India (APTI) and a registered pharmacist.
Md Saquib Hasnain Department of Pharmacy, Palamau Institute of Pharmacy, Daltonganj, Jharkhand, India. Prof. (Dr.) Md Saquib Hasnain has over 10 years of research experience in the field of drug delivery and pharmaceutical formulation analyses, especially systematic development and characterization of diverse nanostructured drug delivery systems, controlled release drug delivery systems, bioenhanced drug delivery systems, nanomaterials and nanocomposites employing Quality by Design approaches and many more. Till date he has authored over 70 publications in various high impact peer-reviewed journals, more than 100 book chapters and 16 books to his credit. He is also serving as the reviewer of several prestigious journals. Overall, he has earned a highly impressive publishing and cited record in Google Scholar (h-index: 32). He has also participated and presented his research work at over ten conferences in India, and abroad. He was also a member of scientific societies i.e., Royal Society of Chemistry, Great Britain, International Association of Environmental and Analytical Chemistry, Switzerland and Swiss Chemical Society, Switzerland.
