Peptide and Protein Drug Delivery Using Polysaccharides offers an interdisciplinary discussion of polysaccharides applied in peptide and protein drug delivery. Chapters consider basic biology of different polysaccharides of current interest and their production at pilot and large-scale stages by various techniques including, but not limited to, cell and hairy root cultures. Other sections examine factors affecting polysaccharide absorption, metabolism, and excretion in nascent, encapsulated, or conjugated forms, with unique coverage of vaccine absorption, metabolism, and drug delivery. A final section considers analytical methods for detection in tissue fluids and homogenates. Accessible figures, tables, and graphical abstracts are included throughout to support understanding.
Specific polysaccharides discussed for therapeutic purposes include cellulose, hyaluronic acid, heparin, carageenan, alginic acid, agar and myrrh, acacia, tragacanth, ghatti gum, chitin, chitosan, starch, glycogen and dextran.
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Table of Contents
1. Peptide and Protein in Therapeutics 2. Hairy root culture: a reliable bioreactor from transgenic plants 3. Strategies for the ameliorated production of pharmaceutically important glycosides via plant cell culture 4. Peptide and protein delivery through cellulose, hyaluronic acid and Heparin 5. Peptide and protein delivery through Carageenan, Alginic acid, Agar and Myrrh 6. Peptide and protein delivery through acacia, tragacanth, and ghatti gum 7. Peptide and protein delivery through Chitin, chitosan and Starch 8. Peptide and protein delivery through Glycogen and Dextran 9. Peptide and protein in vaccine delivery 10. Analytical methods in detection of proteins and peptides in tissue fluids and homogenates 11. Factors affecting Peptide and protein absorption, metabolism and excretion
